Clinical, biochemical, and neuropathologic findings following transplantation of adrenal medulla to the caudate nucleus for treatment of Parkinson's disease.
Identifieur interne : 000317 ( PubMed/Corpus ); précédent : 000316; suivant : 000318Clinical, biochemical, and neuropathologic findings following transplantation of adrenal medulla to the caudate nucleus for treatment of Parkinson's disease.
Auteurs : J. Jankovic ; R. Grossman ; C. Goodman ; F. Pirozzolo ; L. Schneider ; Z. Zhu ; P. Scardino ; A Garber ; S Jhingran ; S. MartinSource :
- Neurology [ 0028-3878 ] ; 1989.
English descriptors
- KwdEn :
- Activities of Daily Living, Adrenal Medulla (pathology), Adrenal Medulla (transplantation), Caudate Nucleus (pathology), Caudate Nucleus (physiopathology), Caudate Nucleus (surgery), Follow-Up Studies, Homovanillic Acid (cerebrospinal fluid), Humans, Hydroxyindoleacetic Acid (cerebrospinal fluid), Male, Middle Aged, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Severity of Illness Index.
- MESH :
- chemical , cerebrospinal fluid : Homovanillic Acid, Hydroxyindoleacetic Acid.
- pathology : Adrenal Medulla, Caudate Nucleus, Parkinson Disease.
- physiopathology : Caudate Nucleus, Parkinson Disease.
- surgery : Caudate Nucleus.
- therapy : Parkinson Disease.
- transplantation : Adrenal Medulla.
- Activities of Daily Living, Follow-Up Studies, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
We transplanted autologous adrenal medullary tissue into the caudate nucleus of 3 patients with advanced Parkinson's disease. The 1st patient, a 59-year-old man with parkinsonian symptoms for 15 years, had mild improvement in his motor functioning after the operation. However, his postoperative course was characterized by prolonged drowsiness and complex visual hallucinations. The patient died suddenly 8 months after the transplant, and an autopsy revealed coronary atherosclerosis. Examination of the graft site showed necrotic adrenal medullary tissue surrounded by inflammatory cells. The 2nd patient, a 50-year-old man with a 21-year history of parkinsonian symptoms, improved the most after the procedure. The 3rd patient, a 43-year-old man with 12 years of parkinsonian symptoms, had mild improvement in his motor functioning. CSF homovanillic acid increased postoperatively in the 3 patients, but then returned to preoperative levels in all except the 2nd patient. The anatomic, neurochemical, and physiologic basis for the modest clinical improvement shown in these patients is not yet understood.
PubMed: 2475820
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Schneider</name></author><author><name sortKey="Zhu, Z" sort="Zhu, Z" uniqKey="Zhu Z" first="Z" last="Zhu">Z. Zhu</name></author><author><name sortKey="Scardino, P" sort="Scardino, P" uniqKey="Scardino P" first="P" last="Scardino">P. Scardino</name></author><author><name sortKey="Garber, A J" sort="Garber, A J" uniqKey="Garber A" first="A" last="Garber">A Garber</name></author><author><name sortKey="Jhingran, S G" sort="Jhingran, S G" uniqKey="Jhingran S" first="S" last="Jhingran">S Jhingran</name></author><author><name sortKey="Martin, S" sort="Martin, S" uniqKey="Martin S" first="S" last="Martin">S. Martin</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1989">1989</date><idno type="RBID">pubmed:2475820</idno><idno type="pmid">2475820</idno><idno type="wicri:Area/PubMed/Corpus">000317</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical, biochemical, and neuropathologic findings following transplantation of adrenal medulla to the caudate nucleus for treatment of Parkinson's disease.</title><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J. Jankovic</name><affiliation><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX 77030.</nlm:affiliation></affiliation></author><author><name sortKey="Grossman, R" sort="Grossman, R" uniqKey="Grossman R" first="R" last="Grossman">R. Grossman</name></author><author><name sortKey="Goodman, C" sort="Goodman, C" uniqKey="Goodman C" first="C" last="Goodman">C. Goodman</name></author><author><name sortKey="Pirozzolo, F" sort="Pirozzolo, F" uniqKey="Pirozzolo F" first="F" last="Pirozzolo">F. Pirozzolo</name></author><author><name sortKey="Schneider, L" sort="Schneider, L" uniqKey="Schneider L" first="L" last="Schneider">L. Schneider</name></author><author><name sortKey="Zhu, Z" sort="Zhu, Z" uniqKey="Zhu Z" first="Z" last="Zhu">Z. Zhu</name></author><author><name sortKey="Scardino, P" sort="Scardino, P" uniqKey="Scardino P" first="P" last="Scardino">P. Scardino</name></author><author><name sortKey="Garber, A J" sort="Garber, A J" uniqKey="Garber A" first="A" last="Garber">A Garber</name></author><author><name sortKey="Jhingran, S G" sort="Jhingran, S G" uniqKey="Jhingran S" first="S" last="Jhingran">S Jhingran</name></author><author><name sortKey="Martin, S" sort="Martin, S" uniqKey="Martin S" first="S" last="Martin">S. Martin</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Adrenal Medulla (pathology)</term><term>Adrenal Medulla (transplantation)</term><term>Caudate Nucleus (pathology)</term><term>Caudate Nucleus (physiopathology)</term><term>Caudate Nucleus (surgery)</term><term>Follow-Up Studies</term><term>Homovanillic Acid (cerebrospinal fluid)</term><term>Humans</term><term>Hydroxyindoleacetic Acid (cerebrospinal fluid)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Homovanillic Acid</term><term>Hydroxyindoleacetic Acid</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adrenal Medulla</term><term>Caudate Nucleus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Caudate Nucleus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Caudate Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Adrenal Medulla</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We transplanted autologous adrenal medullary tissue into the caudate nucleus of 3 patients with advanced Parkinson's disease. The 1st patient, a 59-year-old man with parkinsonian symptoms for 15 years, had mild improvement in his motor functioning after the operation. However, his postoperative course was characterized by prolonged drowsiness and complex visual hallucinations. The patient died suddenly 8 months after the transplant, and an autopsy revealed coronary atherosclerosis. Examination of the graft site showed necrotic adrenal medullary tissue surrounded by inflammatory cells. The 2nd patient, a 50-year-old man with a 21-year history of parkinsonian symptoms, improved the most after the procedure. The 3rd patient, a 43-year-old man with 12 years of parkinsonian symptoms, had mild improvement in his motor functioning. CSF homovanillic acid increased postoperatively in the 3 patients, but then returned to preoperative levels in all except the 2nd patient. The anatomic, neurochemical, and physiologic basis for the modest clinical improvement shown in these patients is not yet understood.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">2475820</PMID><DateCreated><Year>1989</Year><Month>10</Month><Day>12</Day></DateCreated><DateCompleted><Year>1989</Year><Month>10</Month><Day>12</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3878</ISSN><JournalIssue CitedMedium="Print"><Volume>39</Volume><Issue>9</Issue><PubDate><Year>1989</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Clinical, biochemical, and neuropathologic findings following transplantation of adrenal medulla to the caudate nucleus for treatment of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1227-34</MedlinePgn></Pagination><Abstract><AbstractText>We transplanted autologous adrenal medullary tissue into the caudate nucleus of 3 patients with advanced Parkinson's disease. The 1st patient, a 59-year-old man with parkinsonian symptoms for 15 years, had mild improvement in his motor functioning after the operation. However, his postoperative course was characterized by prolonged drowsiness and complex visual hallucinations. The patient died suddenly 8 months after the transplant, and an autopsy revealed coronary atherosclerosis. Examination of the graft site showed necrotic adrenal medullary tissue surrounded by inflammatory cells. The 2nd patient, a 50-year-old man with a 21-year history of parkinsonian symptoms, improved the most after the procedure. The 3rd patient, a 43-year-old man with 12 years of parkinsonian symptoms, had mild improvement in his motor functioning. CSF homovanillic acid increased postoperatively in the 3 patients, but then returned to preoperative levels in all except the 2nd patient. The anatomic, neurochemical, and physiologic basis for the modest clinical improvement shown in these patients is not yet understood.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jankovic</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX 77030.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grossman</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Goodman</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Pirozzolo</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Z</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Scardino</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Garber</LastName><ForeName>A J</ForeName><Initials>AJ</Initials></Author><Author ValidYN="Y"><LastName>Jhingran</LastName><ForeName>S G</ForeName><Initials>SG</Initials></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>S</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>54-16-0</RegistryNumber><NameOfSubstance UI="D006897">Hydroxyindoleacetic Acid</NameOfSubstance></Chemical><Chemical><RegistryNumber>X77S6GMS36</RegistryNumber><NameOfSubstance UI="D006719">Homovanillic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Neurology. 1990 May;40(5):860-1</RefSource><PMID Version="1">2330121</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000203">Activities of Daily Living</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000313">Adrenal Medulla</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000637">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002421">Caudate Nucleus</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005500">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006719">Homovanillic Acid</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006897">Hydroxyindoleacetic Acid</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1989</Year><Month>9</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1989</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1989</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2475820</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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