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Posteroventral medial pallidotomy in levodopa-unresponsive parkinsonism.

Identifieur interne : 000285 ( PubMed/Corpus ); précédent : 000284; suivant : 000286

Posteroventral medial pallidotomy in levodopa-unresponsive parkinsonism.

Auteurs : J Krauss ; J. Jankovic ; E Lai ; G Rettig ; R Grossman

Source :

RBID : pubmed:9267978

English descriptors

Abstract

Parkinsonism in a 42-year-old patient, which was presumably related to peripheral trauma, did not respond to levodopa therapy.

PubMed: 9267978

Links to Exploration step

pubmed:9267978

Le document en format XML

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<title xml:lang="en">Posteroventral medial pallidotomy in levodopa-unresponsive parkinsonism.</title>
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<name sortKey="Krauss, J K" sort="Krauss, J K" uniqKey="Krauss J" first="J" last="Krauss">J Krauss</name>
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<nlm:affiliation>Department of Neurosurgery, Baylor College of Medicine, Houston, Tex., USA.</nlm:affiliation>
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<author>
<name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J. Jankovic</name>
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<name sortKey="Lai, E C" sort="Lai, E C" uniqKey="Lai E" first="E" last="Lai">E Lai</name>
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<name sortKey="Rettig, G M" sort="Rettig, G M" uniqKey="Rettig G" first="G" last="Rettig">G Rettig</name>
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<name sortKey="Grossman, R G" sort="Grossman, R G" uniqKey="Grossman R" first="R" last="Grossman">R Grossman</name>
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<title xml:lang="en">Posteroventral medial pallidotomy in levodopa-unresponsive parkinsonism.</title>
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<name sortKey="Krauss, J K" sort="Krauss, J K" uniqKey="Krauss J" first="J" last="Krauss">J Krauss</name>
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<name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J. Jankovic</name>
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<name sortKey="Lai, E C" sort="Lai, E C" uniqKey="Lai E" first="E" last="Lai">E Lai</name>
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<name sortKey="Rettig, G M" sort="Rettig, G M" uniqKey="Rettig G" first="G" last="Rettig">G Rettig</name>
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<name sortKey="Grossman, R G" sort="Grossman, R G" uniqKey="Grossman R" first="R" last="Grossman">R Grossman</name>
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<title level="j">Archives of neurology</title>
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<term>Adult</term>
<term>Brain (pathology)</term>
<term>Globus Pallidus (surgery)</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Parkinson Disease (surgery)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Levodopa</term>
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<term>Brain</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Globus Pallidus</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Adult</term>
<term>Humans</term>
<term>Male</term>
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<div type="abstract" xml:lang="en">Parkinsonism in a 42-year-old patient, which was presumably related to peripheral trauma, did not respond to levodopa therapy.</div>
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<Title>Archives of neurology</Title>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Parkinsonism in a 42-year-old patient, which was presumably related to peripheral trauma, did not respond to levodopa therapy.</AbstractText>
<AbstractText Label="OBSERVATION" NlmCategory="METHODS">We treated the patient with microelectrode-guided unilateral posteroventral medial pallidotomy and followed up with magnetic resonance imaging and prospective clinical evaluation. Pallidotomy resulted in marked improvement of right-sided parkinsonian symptoms and functional disability at 4.5 months after surgery. Microelectrode recording during pallidotomy revealed discharge patterns that were similar to those seen in patients with Parkinson disease. Postoperative magnetic resonance imaging confirmed the location of the lesion in the posteroventral medial pallidum.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Posteroventral pallidotomy usually has limited benefit in patients with degenerative atypical parkinsonism who do not respond to levodopa therapy. Nevertheless, pallidotomy can be an effective treatment for other levodopa-unresponsive parkinsonian disorders.</AbstractText>
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