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Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease tremor.

Identifieur interne : 000279 ( PubMed/Corpus ); précédent : 000278; suivant : 000280

Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease tremor.

Auteurs : W. Ondo ; J. Jankovic ; K. Schwartz ; M. Almaguer ; R Simpson

Source :

RBID : pubmed:9781530

English descriptors

Abstract

To determine the efficacy and tolerability of unilateral thalamic deep brain stimulation (DBS) for patients with medically refractory essential tremor (ET) and the tremor associated with Parkinson's disease (PD).

PubMed: 9781530

Links to Exploration step

pubmed:9781530

Le document en format XML

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<title xml:lang="en">Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease tremor.</title>
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<name sortKey="Ondo, W" sort="Ondo, W" uniqKey="Ondo W" first="W" last="Ondo">W. Ondo</name>
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<nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX, USA.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J. Jankovic</name>
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<author>
<name sortKey="Schwartz, K" sort="Schwartz, K" uniqKey="Schwartz K" first="K" last="Schwartz">K. Schwartz</name>
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<name sortKey="Almaguer, M" sort="Almaguer, M" uniqKey="Almaguer M" first="M" last="Almaguer">M. Almaguer</name>
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<author>
<name sortKey="Simpson, R K" sort="Simpson, R K" uniqKey="Simpson R" first="R" last="Simpson">R Simpson</name>
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<title xml:lang="en">Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease tremor.</title>
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<name sortKey="Ondo, W" sort="Ondo, W" uniqKey="Ondo W" first="W" last="Ondo">W. Ondo</name>
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<nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX, USA.</nlm:affiliation>
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<name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J. Jankovic</name>
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<name sortKey="Schwartz, K" sort="Schwartz, K" uniqKey="Schwartz K" first="K" last="Schwartz">K. Schwartz</name>
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<name sortKey="Almaguer, M" sort="Almaguer, M" uniqKey="Almaguer M" first="M" last="Almaguer">M. Almaguer</name>
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<author>
<name sortKey="Simpson, R K" sort="Simpson, R K" uniqKey="Simpson R" first="R" last="Simpson">R Simpson</name>
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<title level="j">Neurology</title>
<idno type="ISSN">0028-3878</idno>
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<term>Aged</term>
<term>Arm</term>
<term>Electric Stimulation</term>
<term>Electric Stimulation Therapy</term>
<term>Electrodes</term>
<term>Face</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Leg</term>
<term>Middle Aged</term>
<term>Movement</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson Disease (therapy)</term>
<term>Thalamic Diseases (complications)</term>
<term>Thalamic Diseases (surgery)</term>
<term>Thalamic Diseases (therapy)</term>
<term>Tremor (etiology)</term>
<term>Tremor (surgery)</term>
<term>Tremor (therapy)</term>
<term>Writing</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en">
<term>Parkinson Disease</term>
<term>Thalamic Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Tremor</term>
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<keywords scheme="MESH" qualifier="surgery" xml:lang="en">
<term>Parkinson Disease</term>
<term>Thalamic Diseases</term>
<term>Tremor</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en">
<term>Parkinson Disease</term>
<term>Thalamic Diseases</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Arm</term>
<term>Electric Stimulation</term>
<term>Electric Stimulation Therapy</term>
<term>Electrodes</term>
<term>Face</term>
<term>Functional Laterality</term>
<term>Humans</term>
<term>Leg</term>
<term>Middle Aged</term>
<term>Movement</term>
<term>Writing</term>
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<front>
<div type="abstract" xml:lang="en">To determine the efficacy and tolerability of unilateral thalamic deep brain stimulation (DBS) for patients with medically refractory essential tremor (ET) and the tremor associated with Parkinson's disease (PD).</div>
</front>
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<pubmed>
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<DateCreated>
<Year>1998</Year>
<Month>10</Month>
<Day>30</Day>
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<DateCompleted>
<Year>1998</Year>
<Month>10</Month>
<Day>30</Day>
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<DateRevised>
<Year>2006</Year>
<Month>11</Month>
<Day>15</Day>
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<ISSN IssnType="Print">0028-3878</ISSN>
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<Volume>51</Volume>
<Issue>4</Issue>
<PubDate>
<Year>1998</Year>
<Month>Oct</Month>
</PubDate>
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<Title>Neurology</Title>
<ISOAbbreviation>Neurology</ISOAbbreviation>
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<ArticleTitle>Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson's disease tremor.</ArticleTitle>
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<MedlinePgn>1063-9</MedlinePgn>
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<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine the efficacy and tolerability of unilateral thalamic deep brain stimulation (DBS) for patients with medically refractory essential tremor (ET) and the tremor associated with Parkinson's disease (PD).</AbstractText>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The tremor of ET and PD may produce functional disability despite optimal medical therapy. Several reports have demonstrated efficacy of thalamic DBS in this scenario.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Preoperative and 3-month postoperative tremor ratings were compared in 33 patients (14 ET and 19 PD) with severe tremor. Evaluations included Unified Parkinson's Disease Rating Scale (UPDRS) scores for PD patients and a modified Unified Tremor Rating Scale in ET patients. Open-label and blinded data (unknown activation status) were obtained.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">ET patients demonstrated an 83% reduction (p < 0.0001) in observed contralateral arm tremor. All measures of tremor including writing samples, pouring tests, subjective functional surveys, and disability scores improved significantly. PD patients demonstrated an 82% reduction (p < 0.0001) in contralateral tremor and significant improvement in disability and global impressions. There was, however, no meaningful improvement in other motor aspects of the disease, and the total UPDRS part II (activities of daily living) score did not change. Adverse events, more common in ET patients, were generally mild and were usually eliminated by adjustment of the device parameters.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Thalamic DBS is a safe and effective treatment of ET and the tremor of PD. In PD, its use should be limited to patients in whom high-amplitude tremor results directly in significant functional disability.</AbstractText>
</Abstract>
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<Language>eng</Language>
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