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Computerized posturography analysis of progressive supranuclear palsy: a case-control comparison with Parkinson's disease and healthy controls.

Identifieur interne : 000259 ( PubMed/Corpus ); précédent : 000258; suivant : 000260

Computerized posturography analysis of progressive supranuclear palsy: a case-control comparison with Parkinson's disease and healthy controls.

Auteurs : W. Ondo ; D. Warrior ; A. Overby ; J. Calmes ; N. Hendersen ; S. Olson ; J. Jankovic

Source :

RBID : pubmed:11030799

English descriptors

Abstract

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that is frequently mistaken for Parkinson's disease (PD) in its early stages.

PubMed: 11030799

Links to Exploration step

pubmed:11030799

Le document en format XML

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<title xml:lang="en">Computerized posturography analysis of progressive supranuclear palsy: a case-control comparison with Parkinson's disease and healthy controls.</title>
<author>
<name sortKey="Ondo, W" sort="Ondo, W" uniqKey="Ondo W" first="W" last="Ondo">W. Ondo</name>
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<nlm:affiliation>Department of Neurlogy, Baylor College of Medicine, Houston, Texas, USA. wondo@bcm.tmc.edu.</nlm:affiliation>
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<name sortKey="Warrior, D" sort="Warrior, D" uniqKey="Warrior D" first="D" last="Warrior">D. Warrior</name>
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<author>
<name sortKey="Overby, A" sort="Overby, A" uniqKey="Overby A" first="A" last="Overby">A. Overby</name>
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<author>
<name sortKey="Calmes, J" sort="Calmes, J" uniqKey="Calmes J" first="J" last="Calmes">J. Calmes</name>
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<name sortKey="Hendersen, N" sort="Hendersen, N" uniqKey="Hendersen N" first="N" last="Hendersen">N. Hendersen</name>
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<name sortKey="Olson, S" sort="Olson, S" uniqKey="Olson S" first="S" last="Olson">S. Olson</name>
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<name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J. Jankovic</name>
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<title xml:lang="en">Computerized posturography analysis of progressive supranuclear palsy: a case-control comparison with Parkinson's disease and healthy controls.</title>
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<name sortKey="Ondo, W" sort="Ondo, W" uniqKey="Ondo W" first="W" last="Ondo">W. Ondo</name>
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<nlm:affiliation>Department of Neurlogy, Baylor College of Medicine, Houston, Texas, USA. wondo@bcm.tmc.edu.</nlm:affiliation>
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<name sortKey="Warrior, D" sort="Warrior, D" uniqKey="Warrior D" first="D" last="Warrior">D. Warrior</name>
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<name sortKey="Overby, A" sort="Overby, A" uniqKey="Overby A" first="A" last="Overby">A. Overby</name>
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<name sortKey="Calmes, J" sort="Calmes, J" uniqKey="Calmes J" first="J" last="Calmes">J. Calmes</name>
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<name sortKey="Hendersen, N" sort="Hendersen, N" uniqKey="Hendersen N" first="N" last="Hendersen">N. Hendersen</name>
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<name sortKey="Olson, S" sort="Olson, S" uniqKey="Olson S" first="S" last="Olson">S. Olson</name>
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<name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J. Jankovic</name>
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<title level="j">Archives of neurology</title>
<idno type="ISSN">0003-9942</idno>
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<date when="2000" type="published">2000</date>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Aged</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Carbidopa (therapeutic use)</term>
<term>Case-Control Studies</term>
<term>Diagnosis, Computer-Assisted</term>
<term>Diagnosis, Differential</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Postural Balance</term>
<term>Posture</term>
<term>Severity of Illness Index</term>
<term>Supranuclear Palsy, Progressive (drug therapy)</term>
<term>Supranuclear Palsy, Progressive (physiopathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Antiparkinson Agents</term>
<term>Carbidopa</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Parkinson Disease</term>
<term>Supranuclear Palsy, Progressive</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Diagnosis, Computer-Assisted</term>
<term>Diagnosis, Differential</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Postural Balance</term>
<term>Posture</term>
<term>Severity of Illness Index</term>
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<front>
<div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that is frequently mistaken for Parkinson's disease (PD) in its early stages.</div>
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<PMID Version="1">11030799</PMID>
<DateCreated>
<Year>2000</Year>
<Month>11</Month>
<Day>03</Day>
</DateCreated>
<DateCompleted>
<Year>2000</Year>
<Month>11</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised>
<Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
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<Journal>
<ISSN IssnType="Print">0003-9942</ISSN>
<JournalIssue CitedMedium="Print">
<Volume>57</Volume>
<Issue>10</Issue>
<PubDate>
<Year>2000</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>Archives of neurology</Title>
<ISOAbbreviation>Arch. Neurol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Computerized posturography analysis of progressive supranuclear palsy: a case-control comparison with Parkinson's disease and healthy controls.</ArticleTitle>
<Pagination>
<MedlinePgn>1464-9</MedlinePgn>
</Pagination>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that is frequently mistaken for Parkinson's disease (PD) in its early stages.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To compare balance measures using computerized posturography in patients with early PSP and early PD.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We performed computerized posturography (SMART Balance Master; NeuroCom International, Inc, Clackamas, Ore) in 20 patients with clinically diagnosed mild to moderate PSP (ambulatory) and compared results with those from 20 patients with PD of similar age and disease duration who were not receiving medications, and from 20 healthy age- and sex-matched controls. Sensory organization testing (SOT), limits of stability (LOS), and toes-up perturbations (4 degrees at 50 degrees per second) were tested while receiving and not receiving a combination of oral carbidopa (25 mg) and levodopa (250 mg) in the PSP group. Clinical assessment included Unified Parkinson's Disease Rating Scale, Performance-oriented assessments, and functional reach.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">When compared with the PD and control groups, total LOS time (P < .001) and path sway (P < .001) were significantly prolonged in PSP. Total SOT showed significantly worse scores in PSP compared with PD and control groups (F(2,57) = 29.6; P < .001). Univariate follow-up tests comparing PSP and PD showed differences in the following conditions: eyes open and visual sway (P = .003), eyes open and platform sway (P = .003), eyes closed and platform sway (P < .001), and eyes open and platform and visual sway (P < .001). Medium- and long-latency responses to perturbation were similar, but a larger number in the PSP group lacked short-latency responses (chi(2) = 11.3; P = .002). Levodopa administration did not significantly improve any aspect of posturography testing in PSP. In differentiating PSP from PD, LOS time and SOT condition of eyes open and platform and visual sway were nearly 100% sensitive and 100% specific (canonical correlation, 0.91).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Computerized posturography testing reliably differentiated early PSP from early PD and age-matched controls. The PSP group demonstrated severely contracted limits of stability with probable deficits in motor programming. Results of SOT in PSP suggested a vestibular pattern and overreliance on visual cues, even when incorrect. The absence of short-latency responses (monosynaptic reflex arch) suggests an additional disturbance in the spinal cord or peripheral nervous system. Arch Neurol. 2000;57:1464-1469</AbstractText>
</Abstract>
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<LastName>Ondo</LastName>
<ForeName>W</ForeName>
<Initials>W</Initials>
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<Affiliation>Department of Neurlogy, Baylor College of Medicine, Houston, Texas, USA. wondo@bcm.tmc.edu.</Affiliation>
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<Country>UNITED STATES</Country>
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<DescriptorName MajorTopicYN="N" UI="D002230">Carbidopa</DescriptorName>
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<DescriptorName MajorTopicYN="Y" UI="D004856">Postural Balance</DescriptorName>
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<DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName>
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<DescriptorName MajorTopicYN="N" UI="D013494">Supranuclear Palsy, Progressive</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000188">drug therapy</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName>
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