Comparing knowledge and attitudes towards genetic testing in Parkinson's disease in an American and Asian population.
Identifieur interne : 000170 ( PubMed/Corpus ); précédent : 000169; suivant : 000171Comparing knowledge and attitudes towards genetic testing in Parkinson's disease in an American and Asian population.
Auteurs : Eng Tan ; Jennie Lee ; Christine Hunter ; Lina Shinawi ; S. Fook ; Joseph JankovicSource :
- Journal of the neurological sciences [ 0022-510X ] ; 2007.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Asian Continental Ancestry Group (psychology), Attitude to Health, Caregivers (psychology), Caregivers (statistics & numerical data), Cross-Cultural Comparison, Female, Genetic Testing (psychology), Genetic Testing (statistics & numerical data), Humans, Male, Middle Aged, Multivariate Analysis, Parkinson Disease (diagnosis), Parkinson Disease (ethnology), Parkinson Disease (genetics), Predictive Value of Tests, Prospective Studies, Risk Factors, Singapore (epidemiology), United States (epidemiology).
- MESH :
- geographic , epidemiology : Singapore, United States.
- diagnosis : Parkinson Disease.
- ethnology : Parkinson Disease.
- genetics : Parkinson Disease.
- psychology : Asian Continental Ancestry Group, Caregivers, Genetic Testing.
- statistics & numerical data : Caregivers, Genetic Testing.
- Adult, Aged, Aged, 80 and over, Attitude to Health, Cross-Cultural Comparison, Female, Humans, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Prospective Studies, Risk Factors.
Abstract
Recent discoveries of disease-causing genes in Parkinson's disease (PD) have generated considerable interest regarding genetic testing in PD. The attitudes toward genetic testing are largely influenced by knowledge and preconceived notions.
DOI: 10.1016/j.jns.2006.10.016
PubMed: 17174340
Links to Exploration step
pubmed:17174340Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparing knowledge and attitudes towards genetic testing in Parkinson's disease in an American and Asian population.</title><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng" last="Tan">Eng Tan</name><affiliation><nlm:affiliation>Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. gnrtek@sgh.com.sg</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jennie" sort="Lee, Jennie" uniqKey="Lee J" first="Jennie" last="Lee">Jennie Lee</name></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name></author><author><name sortKey="Shinawi, Lina" sort="Shinawi, Lina" uniqKey="Shinawi L" first="Lina" last="Shinawi">Lina Shinawi</name></author><author><name sortKey="Fook Chong, S" sort="Fook Chong, S" uniqKey="Fook Chong S" first="S" last="Fook">S. Fook</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1016/j.jns.2006.10.016</idno><idno type="RBID">pubmed:17174340</idno><idno type="pmid">17174340</idno><idno type="wicri:Area/PubMed/Corpus">000170</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparing knowledge and attitudes towards genetic testing in Parkinson's disease in an American and Asian population.</title><author><name sortKey="Tan, Eng King" sort="Tan, Eng King" uniqKey="Tan E" first="Eng" last="Tan">Eng Tan</name><affiliation><nlm:affiliation>Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. gnrtek@sgh.com.sg</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jennie" sort="Lee, Jennie" uniqKey="Lee J" first="Jennie" last="Lee">Jennie Lee</name></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name></author><author><name sortKey="Shinawi, Lina" sort="Shinawi, Lina" uniqKey="Shinawi L" first="Lina" last="Shinawi">Lina Shinawi</name></author><author><name sortKey="Fook Chong, S" sort="Fook Chong, S" uniqKey="Fook Chong S" first="S" last="Fook">S. Fook</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></author></analytic><series><title level="j">Journal of the neurological sciences</title><idno type="ISSN">0022-510X</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Asian Continental Ancestry Group (psychology)</term><term>Attitude to Health</term><term>Caregivers (psychology)</term><term>Caregivers (statistics & numerical data)</term><term>Cross-Cultural Comparison</term><term>Female</term><term>Genetic Testing (psychology)</term><term>Genetic Testing (statistics & numerical data)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (ethnology)</term><term>Parkinson Disease (genetics)</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Risk Factors</term><term>Singapore (epidemiology)</term><term>United States (epidemiology)</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Singapore</term><term>United States</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Asian Continental Ancestry Group</term><term>Caregivers</term><term>Genetic Testing</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Caregivers</term><term>Genetic Testing</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Attitude to Health</term><term>Cross-Cultural Comparison</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent discoveries of disease-causing genes in Parkinson's disease (PD) have generated considerable interest regarding genetic testing in PD. The attitudes toward genetic testing are largely influenced by knowledge and preconceived notions.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">17174340</PMID><DateCreated><Year>2007</Year><Month>01</Month><Day>12</Day></DateCreated><DateCompleted><Year>2007</Year><Month>03</Month><Day>27</Day></DateCompleted><DateRevised><Year>2009</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0022-510X</ISSN><JournalIssue CitedMedium="Print"><Volume>252</Volume><Issue>2</Issue><PubDate><Year>2007</Year><Month>Jan</Month><Day>31</Day></PubDate></JournalIssue><Title>Journal of the neurological sciences</Title><ISOAbbreviation>J. Neurol. Sci.</ISOAbbreviation></Journal><ArticleTitle>Comparing knowledge and attitudes towards genetic testing in Parkinson's disease in an American and Asian population.</ArticleTitle><Pagination><MedlinePgn>113-20</MedlinePgn></Pagination><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Recent discoveries of disease-causing genes in Parkinson's disease (PD) have generated considerable interest regarding genetic testing in PD. The attitudes toward genetic testing are largely influenced by knowledge and preconceived notions.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We investigated the relationship between knowledge of and attitude towards predictive genetic testing of PD in two independent centers in America and Asia involving PD patients and caregivers.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In a prospective study involving 515 subjects comprising of PD patients and their caregivers in two independent centers in America and Asia, the level of knowledge about genetic testing and patients' attitudes towards such testing were evaluated using a standardized questionnaire.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">American PD patients had a higher level of knowledge of PD genetics than Asian PD (31.1% vs. 12.3%, p=0.0002). A greater number of American PD patients and caregivers reported a positive attitude towards the potential medical benefits of genetic testing compared to their Asian counterparts (85.4% vs. 42.2%, 92.2% vs. 32.1%, p<0.00005), but a more negative attitude towards potential compromise in getting health and life insurance (43.7% vs. 25.8%, p=0.0002). However, in the Asian cohort, multivariate analysis revealed that a high level of genetics knowledge was associated with a positive attitude response regarding the potential medical benefits of testing (p<0.0005), but a negative attitude towards compromises in healthcare and life insurance, getting a job and starting a family (p<0.0005). These associations were not observed amongst American subjects.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The relationship between level of genetic knowledge and attitude towards potential risks and benefits of predictive genetic testing in PD was distinctly different in two independent, racially and culturally different PD populations and caregivers. These observations have clinical implications in the development of PD genetic counseling programs.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Eng-King</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Department of Neurology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. gnrtek@sgh.com.sg</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jennie</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Hunter</LastName><ForeName>Christine</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Shinawi</LastName><ForeName>Lina</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Fook-Chong</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Jankovic</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2006</Year><Month>12</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Neurol Sci</MedlineTA><NlmUniqueID>0375403</NlmUniqueID><ISSNLinking>0022-510X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D044466">Asian Continental Ancestry Group</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000523">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D001294">Attitude to Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D017028">Caregivers</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000523">psychology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000706">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003431">Cross-Cultural Comparison</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005820">Genetic Testing</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000523">psychology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000706">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015999">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000208">ethnology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011237">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012307">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D012846">Singapore</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D014481">United States</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000453">epidemiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2006</Year><Month>8</Month><Day>8</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2006</Year><Month>10</Month><Day>6</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2006</Year><Month>10</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2006</Year><Month>12</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>12</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>3</Month><Day>28</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>12</Month><Day>19</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">S0022-510X(06)00496-5</ArticleId><ArticleId IdType="doi">10.1016/j.jns.2006.10.016</ArticleId><ArticleId IdType="pubmed">17174340</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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