CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases.
Identifieur interne : 000143 ( PubMed/Corpus ); précédent : 000142; suivant : 000144CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases.
Auteurs : Jing Zhang ; Izabela Sokal ; Elaine. Peskind ; Joseph. Quinn ; Joseph Jankovic ; Christopher Kenney ; Kathryn. Chung ; Steven. Millard ; John. Nutt ; Thomas. MontineSource :
- American journal of clinical pathology [ 0002-9173 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Alzheimer Disease (cerebrospinal fluid), Amyloid beta-Peptides, Apolipoproteins (cerebrospinal fluid), Apolipoproteins E (cerebrospinal fluid), Biomarkers (cerebrospinal fluid), Brain-Derived Neurotrophic Factor (cerebrospinal fluid), Cerebrospinal Fluid, Diagnosis, Differential, Female, Humans, Interleukin-8 (cerebrospinal fluid), Male, Middle Aged, Parkinson Disease (cerebrospinal fluid), Peptide Fragments, Protein Precursors (cerebrospinal fluid), Vitamin D-Binding Protein (cerebrospinal fluid), beta 2-Microglobulin, tau Proteins (cerebrospinal fluid).
- MESH :
- chemical , cerebrospinal fluid : Apolipoproteins, Apolipoproteins E, Biomarkers, Brain-Derived Neurotrophic Factor, Interleukin-8, Protein Precursors, Vitamin D-Binding Protein, tau Proteins.
- chemical : Amyloid beta-Peptides, Peptide Fragments, beta 2-Microglobulin.
- cerebrospinal fluid : Alzheimer Disease, Parkinson Disease.
- Aged, Cerebrospinal Fluid, Diagnosis, Differential, Female, Humans, Male, Middle Aged.
Abstract
The therapeutic imperative for Alzheimer disease (AD) and Parkinson disease (PD) calls for discovery and validation of biomarkers. Increased cerebrospinal fluid (CSF) tau and decreased amyloid (A) beta42 have been validated as biomarkers of AD. In contrast, there is no validated CSF biomarker for PD. We validated our proteomics-discovered multianalyte profile (MAP) in CSF from 95 control subjects, 48 patients with probable AD, and 40 patients with probable PD. An optimal 8-member MAP agreed with expert diagnosis for 90 control subjects (95%), 36 patients with probable AD (75%), and 38 patients with probable PD (95%). This MAP consisted of the following (in decreasing order of contribution): tau, brain-derived neurotrophic factor, interleukin 8, Abeta42, beta2-microglobulin, vitamin D binding protein, apolipoprotein (apo) AII, and apoE. This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD.
DOI: 10.1309/W01Y0B808EMEH12L
PubMed: 18343778
Links to Exploration step
pubmed:18343778Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases.</title><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation><nlm:affiliation>Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sokal, Izabela" sort="Sokal, Izabela" uniqKey="Sokal I" first="Izabela" last="Sokal">Izabela Sokal</name></author><author><name sortKey="Peskind, Elaine R" sort="Peskind, Elaine R" uniqKey="Peskind E" first="Elaine" last="Peskind">Elaine. Peskind</name></author><author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph" last="Quinn">Joseph. Quinn</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></author><author><name sortKey="Kenney, Christopher" sort="Kenney, Christopher" uniqKey="Kenney C" first="Christopher" last="Kenney">Christopher Kenney</name></author><author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn" last="Chung">Kathryn. Chung</name></author><author><name sortKey="Millard, Steven P" sort="Millard, Steven P" uniqKey="Millard S" first="Steven" last="Millard">Steven. Millard</name></author><author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John" last="Nutt">John. Nutt</name></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas" last="Montine">Thomas. Montine</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1309/W01Y0B808EMEH12L</idno><idno type="RBID">pubmed:18343778</idno><idno type="pmid">18343778</idno><idno type="wicri:Area/PubMed/Corpus">000143</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases.</title><author><name sortKey="Zhang, Jing" sort="Zhang, Jing" uniqKey="Zhang J" first="Jing" last="Zhang">Jing Zhang</name><affiliation><nlm:affiliation>Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sokal, Izabela" sort="Sokal, Izabela" uniqKey="Sokal I" first="Izabela" last="Sokal">Izabela Sokal</name></author><author><name sortKey="Peskind, Elaine R" sort="Peskind, Elaine R" uniqKey="Peskind E" first="Elaine" last="Peskind">Elaine. Peskind</name></author><author><name sortKey="Quinn, Joseph F" sort="Quinn, Joseph F" uniqKey="Quinn J" first="Joseph" last="Quinn">Joseph. Quinn</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></author><author><name sortKey="Kenney, Christopher" sort="Kenney, Christopher" uniqKey="Kenney C" first="Christopher" last="Kenney">Christopher Kenney</name></author><author><name sortKey="Chung, Kathryn A" sort="Chung, Kathryn A" uniqKey="Chung K" first="Kathryn" last="Chung">Kathryn. Chung</name></author><author><name sortKey="Millard, Steven P" sort="Millard, Steven P" uniqKey="Millard S" first="Steven" last="Millard">Steven. Millard</name></author><author><name sortKey="Nutt, John G" sort="Nutt, John G" uniqKey="Nutt J" first="John" last="Nutt">John. Nutt</name></author><author><name sortKey="Montine, Thomas J" sort="Montine, Thomas J" uniqKey="Montine T" first="Thomas" last="Montine">Thomas. Montine</name></author></analytic><series><title level="j">American journal of clinical pathology</title><idno type="ISSN">0002-9173</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alzheimer Disease (cerebrospinal fluid)</term><term>Amyloid beta-Peptides</term><term>Apolipoproteins (cerebrospinal fluid)</term><term>Apolipoproteins E (cerebrospinal fluid)</term><term>Biomarkers (cerebrospinal fluid)</term><term>Brain-Derived Neurotrophic Factor (cerebrospinal fluid)</term><term>Cerebrospinal Fluid</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Interleukin-8 (cerebrospinal fluid)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (cerebrospinal fluid)</term><term>Peptide Fragments</term><term>Protein Precursors (cerebrospinal fluid)</term><term>Vitamin D-Binding Protein (cerebrospinal fluid)</term><term>beta 2-Microglobulin</term><term>tau Proteins (cerebrospinal fluid)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Apolipoproteins</term><term>Apolipoproteins E</term><term>Biomarkers</term><term>Brain-Derived Neurotrophic Factor</term><term>Interleukin-8</term><term>Protein Precursors</term><term>Vitamin D-Binding Protein</term><term>tau Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Amyloid beta-Peptides</term><term>Peptide Fragments</term><term>beta 2-Microglobulin</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Alzheimer Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cerebrospinal Fluid</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The therapeutic imperative for Alzheimer disease (AD) and Parkinson disease (PD) calls for discovery and validation of biomarkers. Increased cerebrospinal fluid (CSF) tau and decreased amyloid (A) beta42 have been validated as biomarkers of AD. In contrast, there is no validated CSF biomarker for PD. We validated our proteomics-discovered multianalyte profile (MAP) in CSF from 95 control subjects, 48 patients with probable AD, and 40 patients with probable PD. An optimal 8-member MAP agreed with expert diagnosis for 90 control subjects (95%), 36 patients with probable AD (75%), and 38 patients with probable PD (95%). This MAP consisted of the following (in decreasing order of contribution): tau, brain-derived neurotrophic factor, interleukin 8, Abeta42, beta2-microglobulin, vitamin D binding protein, apolipoprotein (apo) AII, and apoE. This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18343778</PMID><DateCreated><Year>2008</Year><Month>03</Month><Day>17</Day></DateCreated><DateCompleted><Year>2008</Year><Month>05</Month><Day>06</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9173</ISSN><JournalIssue CitedMedium="Print"><Volume>129</Volume><Issue>4</Issue><PubDate><Year>2008</Year><Month>Apr</Month></PubDate></JournalIssue><Title>American journal of clinical pathology</Title><ISOAbbreviation>Am. J. Clin. Pathol.</ISOAbbreviation></Journal><ArticleTitle>CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases.</ArticleTitle><Pagination><MedlinePgn>526-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1309/W01Y0B808EMEH12L</ELocationID><Abstract><AbstractText>The therapeutic imperative for Alzheimer disease (AD) and Parkinson disease (PD) calls for discovery and validation of biomarkers. Increased cerebrospinal fluid (CSF) tau and decreased amyloid (A) beta42 have been validated as biomarkers of AD. In contrast, there is no validated CSF biomarker for PD. We validated our proteomics-discovered multianalyte profile (MAP) in CSF from 95 control subjects, 48 patients with probable AD, and 40 patients with probable PD. An optimal 8-member MAP agreed with expert diagnosis for 90 control subjects (95%), 36 patients with probable AD (75%), and 38 patients with probable PD (95%). This MAP consisted of the following (in decreasing order of contribution): tau, brain-derived neurotrophic factor, interleukin 8, Abeta42, beta2-microglobulin, vitamin D binding protein, apolipoprotein (apo) AII, and apoE. This first large-scale validation of a proteomic-discovered MAP suggests a panel of 8 CSF proteins that are highly effective at identifying PD and moderately effective at identifying AD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sokal</LastName><ForeName>Izabela</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Peskind</LastName><ForeName>Elaine R</ForeName><Initials>ER</Initials></Author><Author ValidYN="Y"><LastName>Quinn</LastName><ForeName>Joseph F</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Jankovic</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Kenney</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Kathryn A</ForeName><Initials>KA</Initials></Author><Author ValidYN="Y"><LastName>Millard</LastName><ForeName>Steven P</ForeName><Initials>SP</Initials></Author><Author ValidYN="Y"><LastName>Nutt</LastName><ForeName>John G</ForeName><Initials>JG</Initials></Author><Author ValidYN="Y"><LastName>Montine</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>AG05136</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 AG005136</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 AG005136-25</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D023361">Validation Studies</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Clin Pathol</MedlineTA><NlmUniqueID>0370470</NlmUniqueID><ISSNLinking>0002-9173</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016229">Amyloid beta-Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001053">Apolipoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001057">Apolipoproteins E</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019208">Brain-Derived Neurotrophic Factor</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016209">Interleukin-8</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010446">Peptide Fragments</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011498">Protein Precursors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014809">Vitamin D-Binding Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C075222">amyloid beta-protein (1-42)</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C054949">apolipoprotein II</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001613">beta 2-Microglobulin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016875">tau Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2004 Sep;19(9):1020-8</RefSource><PMID Version="1">15372591</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):140-6</RefSource><PMID Version="1">14559363</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroreport. 2002 Apr 16;13(5):611-5</RefSource><PMID Version="1">11973456</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1984 Jul;34(7):939-44</RefSource><PMID Version="1">6610841</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1999 Jan;56(1):33-9</RefSource><PMID Version="1">9923759</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1998 Dec;51(6):1546-54</RefSource><PMID Version="1">9855500</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int Psychogeriatr. 1997;9 Suppl 1:173-6; discussion 177-8</RefSource><PMID Version="1">9447441</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1999 Mar;56(3):303-8</RefSource><PMID Version="1">10190820</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2005 Mar;8(4):339-46</RefSource><PMID Version="1">16556965</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurol Res. 2006 Mar;28(2):155-63</RefSource><PMID Version="1">16551433</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2006;7:3</RefSource><PMID Version="1">16398926</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2007 Mar;64(3):366-70</RefSource><PMID Version="1">17353378</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2007 Feb;61(2):120-9</RefSource><PMID Version="1">17167789</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2006 Aug;9(3):293-348</RefSource><PMID Version="1">16914840</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Alzheimers Dis. 2005 Apr;7(2):125-33; discussion 173-80</RefSource><PMID Version="1">15851850</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Alzheimer Dis Assoc Disord. 2005 Oct-Dec;19(4):220-5</RefSource><PMID Version="1">16327349</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000544">Alzheimer Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016229">Amyloid beta-Peptides</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001053">Apolipoproteins</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001057">Apolipoproteins E</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015415">Biomarkers</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019208">Brain-Derived Neurotrophic Factor</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002555">Cerebrospinal Fluid</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003937">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016209">Interleukin-8</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000134">cerebrospinal fluid</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000134">cerebrospinal 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