Serum urate as a predictor of clinical and radiographic progression in Parkinson disease.
Identifieur interne : 000140 ( PubMed/Corpus ); précédent : 000139; suivant : 000141Serum urate as a predictor of clinical and radiographic progression in Parkinson disease.
Auteurs : Michael. Schwarzschild ; Steven. Schwid ; Kenneth Marek ; Arthur Watts ; Anthony. Lang ; David Oakes ; Ira Shoulson ; Alberto Ascherio ; Christopher Hyson ; Emily Gorbold ; Alice Rudolph ; Karl Kieburtz ; Stanley Fahn ; Lisa Gauger ; Christopher Goetz ; John Seibyl ; Misser Forrest ; John OndrasikSource :
- Archives of neurology ; 2008.
English descriptors
- KwdEn :
- Biomarkers (blood), Cohort Studies, Disease Progression, Double-Blind Method, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Parkinson Disease (blood), Parkinson Disease (diagnosis), Parkinson Disease (radiography), Predictive Value of Tests, Prospective Studies, Uric Acid (blood).
- MESH :
- chemical , blood : Biomarkers, Uric Acid.
- blood : Parkinson Disease.
- diagnosis : Parkinson Disease.
- radiography : Parkinson Disease.
- Cohort Studies, Disease Progression, Double-Blind Method, Female, Follow-Up Studies, Humans, Longitudinal Studies, Male, Middle Aged, Predictive Value of Tests, Prospective Studies.
Abstract
To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD.
DOI: 10.1001/archneur.2008.65.6.nct70003
PubMed: 18413464
Links to Exploration step
pubmed:18413464Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum urate as a predictor of clinical and radiographic progression in Parkinson disease.</title><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael" last="Schwarzschild">Michael. Schwarzschild</name><affiliation><nlm:affiliation>MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schwid, Steven R" sort="Schwid, Steven R" uniqKey="Schwid S" first="Steven" last="Schwid">Steven. Schwid</name></author><author><name sortKey="Marek, Kenneth" sort="Marek, Kenneth" uniqKey="Marek K" first="Kenneth" last="Marek">Kenneth Marek</name></author><author><name sortKey="Watts, Arthur" sort="Watts, Arthur" uniqKey="Watts A" first="Arthur" last="Watts">Arthur Watts</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony" last="Lang">Anthony. Lang</name></author><author><name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name></author><author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name></author><author><name sortKey="Hyson, Christopher" sort="Hyson, Christopher" uniqKey="Hyson C" first="Christopher" last="Hyson">Christopher Hyson</name></author><author><name sortKey="Gorbold, Emily" sort="Gorbold, Emily" uniqKey="Gorbold E" first="Emily" last="Gorbold">Emily Gorbold</name></author><author><name sortKey="Rudolph, Alice" sort="Rudolph, Alice" uniqKey="Rudolph A" first="Alice" last="Rudolph">Alice Rudolph</name></author><author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name></author><author><name sortKey="Gauger, Lisa" sort="Gauger, Lisa" uniqKey="Gauger L" first="Lisa" last="Gauger">Lisa Gauger</name></author><author><name sortKey="Goetz, Christopher" sort="Goetz, Christopher" uniqKey="Goetz C" first="Christopher" last="Goetz">Christopher Goetz</name></author><author><name sortKey="Seibyl, John" sort="Seibyl, John" uniqKey="Seibyl J" first="John" last="Seibyl">John Seibyl</name></author><author><name sortKey="Forrest, Misser" sort="Forrest, Misser" uniqKey="Forrest M" first="Misser" last="Forrest">Misser Forrest</name></author><author><name sortKey="Ondrasik, John" sort="Ondrasik, John" uniqKey="Ondrasik J" first="John" last="Ondrasik">John Ondrasik</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1001/archneur.2008.65.6.nct70003</idno><idno type="RBID">pubmed:18413464</idno><idno type="pmid">18413464</idno><idno type="wicri:Area/PubMed/Corpus">000140</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Serum urate as a predictor of clinical and radiographic progression in Parkinson disease.</title><author><name sortKey="Schwarzschild, Michael A" sort="Schwarzschild, Michael A" uniqKey="Schwarzschild M" first="Michael" last="Schwarzschild">Michael. Schwarzschild</name><affiliation><nlm:affiliation>MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schwid, Steven R" sort="Schwid, Steven R" uniqKey="Schwid S" first="Steven" last="Schwid">Steven. Schwid</name></author><author><name sortKey="Marek, Kenneth" sort="Marek, Kenneth" uniqKey="Marek K" first="Kenneth" last="Marek">Kenneth Marek</name></author><author><name sortKey="Watts, Arthur" sort="Watts, Arthur" uniqKey="Watts A" first="Arthur" last="Watts">Arthur Watts</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony" last="Lang">Anthony. Lang</name></author><author><name sortKey="Oakes, David" sort="Oakes, David" uniqKey="Oakes D" first="David" last="Oakes">David Oakes</name></author><author><name sortKey="Shoulson, Ira" sort="Shoulson, Ira" uniqKey="Shoulson I" first="Ira" last="Shoulson">Ira Shoulson</name></author><author><name sortKey="Ascherio, Alberto" sort="Ascherio, Alberto" uniqKey="Ascherio A" first="Alberto" last="Ascherio">Alberto Ascherio</name></author><author><name sortKey="Hyson, Christopher" sort="Hyson, Christopher" uniqKey="Hyson C" first="Christopher" last="Hyson">Christopher Hyson</name></author><author><name sortKey="Gorbold, Emily" sort="Gorbold, Emily" uniqKey="Gorbold E" first="Emily" last="Gorbold">Emily Gorbold</name></author><author><name sortKey="Rudolph, Alice" sort="Rudolph, Alice" uniqKey="Rudolph A" first="Alice" last="Rudolph">Alice Rudolph</name></author><author><name sortKey="Kieburtz, Karl" sort="Kieburtz, Karl" uniqKey="Kieburtz K" first="Karl" last="Kieburtz">Karl Kieburtz</name></author><author><name sortKey="Fahn, Stanley" sort="Fahn, Stanley" uniqKey="Fahn S" first="Stanley" last="Fahn">Stanley Fahn</name></author><author><name sortKey="Gauger, Lisa" sort="Gauger, Lisa" uniqKey="Gauger L" first="Lisa" last="Gauger">Lisa Gauger</name></author><author><name sortKey="Goetz, Christopher" sort="Goetz, Christopher" uniqKey="Goetz C" first="Christopher" last="Goetz">Christopher Goetz</name></author><author><name sortKey="Seibyl, John" sort="Seibyl, John" uniqKey="Seibyl J" first="John" last="Seibyl">John Seibyl</name></author><author><name sortKey="Forrest, Misser" sort="Forrest, Misser" uniqKey="Forrest M" first="Misser" last="Forrest">Misser Forrest</name></author><author><name sortKey="Ondrasik, John" sort="Ondrasik, John" uniqKey="Ondrasik J" first="John" last="Ondrasik">John Ondrasik</name></author></analytic><series><title level="j">Archives of neurology</title><idno type="e-ISSN">1538-3687</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biomarkers (blood)</term><term>Cohort Studies</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (radiography)</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Uric Acid (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Uric Acid</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="radiography" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cohort Studies</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Prospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18413464</PMID><DateCreated><Year>2008</Year><Month>06</Month><Day>10</Day></DateCreated><DateCompleted><Year>2008</Year><Month>06</Month><Day>26</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-3687</ISSN><JournalIssue CitedMedium="Internet"><Volume>65</Volume><Issue>6</Issue><PubDate><Year>2008</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Archives of neurology</Title><ISOAbbreviation>Arch. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Serum urate as a predictor of clinical and radiographic progression in Parkinson disease.</ArticleTitle><Pagination><MedlinePgn>716-23</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/archneur.2008.65.6.nct70003</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Prospective study.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">The Parkinson Research Examination of CEP-1347 Trial (PRECEPT) study, which investigated the effects of a potential neuroprotectant on rates of PD progression, was conducted between April 2002 and August 2005 (average follow-up time 21.4 months).</AbstractText><AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">Eight hundred four subjects with early PD enrolled in the PRECEPT study.</AbstractText><AbstractText Label="MAIN OUTCOME MEASURES" NlmCategory="METHODS">The primary study end point was progression to clinical disability sufficient to warrant dopaminergic therapy. Cox proportional hazards models were used to estimate the hazard ratio (HR) of reaching end point according to quintiles of baseline serum urate concentration, adjusting for sex, age, and other potential covariates. Change in striatal uptake of iodine I 123-labeled 2-beta-carbomethoxy-3-beta-(4-iodophenyl)tropane ([(123)I]beta-CIT), a marker for the presynaptic dopamine transporter, was assessed with linear regression for a subset of 399 subjects.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The adjusted HR of reaching end point declined with increasing baseline concentrations of urate; subjects in the top quintile reached the end point at only half the rate of subjects in the bottom quintile (HR, 0.51; 95% confidence interval [CI], 0.37-0.72; P for trend < .001). This association was markedly stronger in men (HR, 0.39; 95% CI, 0.26-0.60; P for trend < .001) than in women (HR, 0.77; 95% CI, 0.39-1.50; P for trend = .33). The percentage of loss in striatal [(123)I]beta-CIT uptake also improved with increasing serum urate concentrations (overall P for trend = .002; men, P = .001; women, P = .43).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings identify serum urate as the first molecular factor directly linked to the progression of typical PD and suggest that targeting urate or its determinants could be an effective disease-modifying therapy in PD. Trial Registration clinicaltrials.gov Identifier: NCT00040404.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schwarzschild</LastName><ForeName>Michael A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schwid</LastName><ForeName>Steven R</ForeName><Initials>SR</Initials></Author><Author ValidYN="Y"><LastName>Marek</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Watts</LastName><ForeName>Arthur</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>Anthony E</ForeName><Initials>AE</Initials></Author><Author ValidYN="Y"><LastName>Oakes</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Shoulson</LastName><ForeName>Ira</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Ascherio</LastName><ForeName>Alberto</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><CollectiveName>Parkinson Study Group PRECEPT Investigators</CollectiveName></Author><Author ValidYN="Y"><LastName>Hyson</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Gorbold</LastName><ForeName>Emily</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Rudolph</LastName><ForeName>Alice</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Kieburtz</LastName><ForeName>Karl</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Fahn</LastName><ForeName>Stanley</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Gauger</LastName><ForeName>Lisa</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Goetz</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Seibyl</LastName><ForeName>John</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Forrest</LastName><ForeName>Misser</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Ondrasik</LastName><ForeName>John</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00040404</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>ES010804</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS048517</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 ES010804</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 ES010804-05</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS048517</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS048517-03</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>04</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arch Neurol</MedlineTA><NlmUniqueID>0372436</NlmUniqueID><ISSNLinking>0003-9942</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>268B43MJ25</RegistryNumber><NameOfSubstance UI="D014527">Uric Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 1981 Nov;78(11):6858-62</RefSource><PMID Version="1">6947260</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stroke. 2005 Mar;36(3):654-9</RefSource><PMID Version="1">15692110</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 1989 Oct;46(10):1052-60</RefSource><PMID Version="1">2508608</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>JAMA. 1991 Dec 4;266(21):3004-7</RefSource><PMID Version="1">1820473</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2005 Mar 22;64(6):1047-51</RefSource><PMID Version="1">15781824</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Chim Acta. 2005 Jun;356(1-2):35-57</RefSource><PMID Version="1">15936302</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2005 Mar;2(3):e76</RefSource><PMID Version="1">15783260</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Neurosci. 2005;28:57-87</RefSource><PMID Version="1">16022590</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2005 Oct;58(4):495-505</RefSource><PMID Version="1">16178023</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Metabolism. 2005 Nov;54(11):1435-41</RefSource><PMID Version="1">16253630</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2005 Nov;58(5):797-800</RefSource><PMID Version="1">16240356</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2006 Jan;54(1):292-300</RefSource><PMID Version="1">16385546</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2006 May 23;66(10 Suppl 4):S24-36</RefSource><PMID Version="1">16717250</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stroke. 2006 Jun;37(6):1503-7</RefSource><PMID Version="1">16675740</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2006 Dec 21;355(25):2615-7</RefSource><PMID Version="1">17182986</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Am Soc Nephrol. 2007 Jan;18(1):287-92</RefSource><PMID Version="1">17167112</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 2007 May 1;165(9):998-1006</RefSource><PMID Version="1">17272289</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2007 Oct 9;69(15):1480-90</RefSource><PMID Version="1">17881719</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Physiol. 2004 Mar 16;555(Pt 3):589-606</RefSource><PMID Version="1">14694147</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cardiovasc Drugs Ther. 2003 Sep-Nov;17(5-6):397-414</RefSource><PMID Version="1">15107595</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Drug Targets CNS Neurol Disord. 2004 Aug;3(4):297-313</RefSource><PMID Version="1">15379606</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Clin Nutr. 1993 Nov;58(5 Suppl):754S-765S</RefSource><PMID Version="1">8213607</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neural Transm Park Dis Dement Sect. 1993;6(2):119-26</RefSource><PMID Version="1">8117408</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res Bull. 1994;33(4):419-25</RefSource><PMID Version="1">8124580</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Pharmacol Exp Ther. 1994 Dec;271(3):1320-6</RefSource><PMID Version="1">7996441</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 1996 Sep 1;144(5):480-4</RefSource><PMID Version="1">8781463</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arthritis Rheum. 2005 Jan;52(1):283-9</RefSource><PMID Version="1">15641075</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Biochem J. 1986 May 1;235(3):747-54</RefSource><PMID Version="1">3753442</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Biochem Biophys. 2000 Apr 15;376(2):333-7</RefSource><PMID Version="1">10775420</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2001 Jan;49(1):139</RefSource><PMID Version="1">11198290</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mult Scler. 2001 Oct;7(5):313-9</RefSource><PMID Version="1">11724447</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2001 Dec 11;57(11):2089-94</RefSource><PMID Version="1">11739831</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurochem. 2002 Jan;80(1):101-10</RefSource><PMID Version="1">11796748</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mol Biol Evol. 2002 May;19(5):640-53</RefSource><PMID Version="1">11961098</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2002 May 23;417(6887):447-52</RefSource><PMID Version="1">12024214</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann N Y Acad Sci. 2002 May;962:242-59</RefSource><PMID Version="1">12076979</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2002 Nov;59(11):1724-8</RefSource><PMID Version="1">12433259</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2002 Dec;52(6):793-801</RefSource><PMID Version="1">12447934</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16303-8</RefSource><PMID Version="1">12451183</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurol Sci. 2002 Sep;23 Suppl 2:S77-8</RefSource><PMID Version="1">12548352</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8</RefSource><PMID Version="1">12666096</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 2003 Aug;54(2):170-5</RefSource><PMID Version="1">12891669</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pharmacol Ther. 2005 Mar;105(3):267-310</RefSource><PMID Version="1">15737407</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Arch Neurol. 2008 Jun;65(6):698-9</RefSource><PMID Version="1">18541788</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015415">Biomarkers</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015331">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018450">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004311">Double-Blind 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