JankovicV1, PubMed, Corpus, bibRecord, 000129

Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.

Identifieur interne : 000129 ( PubMed/Corpus ); précédent : 000128; suivant : 000130

Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.

Auteurs : W Nichols ; N. Pankratz ; D Marek ; M Pauciulo ; V Elsaesser ; C Halter ; A. Rudolph ; J. Wojcieszek ; R Pfeiffer ; T. Foroud

Source :

Neurology ; 2009.

RBID : pubmed:18987351

English descriptors

KwdEn :
- Adolescent, Adult, Age of Onset, Aged, Aged, 80 and over, Female, Genetic Predisposition to Disease (epidemiology), Genetic Predisposition to Disease (genetics), Genetic Variation (genetics), Glucosylceramidase (genetics), Humans, Male, Middle Aged, Mutation (genetics), Parkinson Disease (enzymology), Parkinson Disease (epidemiology), Parkinson Disease (genetics).
MESH :
- chemical , genetics : Glucosylceramidase.
- enzymology : Parkinson Disease.
- epidemiology : Genetic Predisposition to Disease, Parkinson Disease.
- genetics : Genetic Predisposition to Disease, Genetic Variation, Mutation, Parkinson Disease.
- Adolescent, Adult, Age of Onset, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.

Abstract

To characterize sequence variation within the glucocerebrosidase (GBA) gene in a select subset of our sample of patients with familial Parkinson disease (PD) and then to test in our full sample whether these sequence variants increased the risk for PD and were associated with an earlier onset of disease.

DOI: 10.1212/01.wnl.0000327823.81237.d1
PubMed: 18987351

Links to Exploration step

pubmed:18987351

Le document en format XML

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<author><name sortKey="Nichols, W C" sort="Nichols, W C" uniqKey="Nichols W" first="W" last="Nichols">W Nichols</name>
<affiliation><nlm:affiliation>Associate Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. bill.nichols@cchmc.org</nlm:affiliation>
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<author><name sortKey="Pankratz, N" sort="Pankratz, N" uniqKey="Pankratz N" first="N" last="Pankratz">N. Pankratz</name>
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<author><name sortKey="Marek, D K" sort="Marek, D K" uniqKey="Marek D" first="D" last="Marek">D Marek</name>
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<author><name sortKey="Pauciulo, M W" sort="Pauciulo, M W" uniqKey="Pauciulo M" first="M" last="Pauciulo">M Pauciulo</name>
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<author><name sortKey="Elsaesser, V E" sort="Elsaesser, V E" uniqKey="Elsaesser V" first="V" last="Elsaesser">V Elsaesser</name>
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<author><name sortKey="Halter, C A" sort="Halter, C A" uniqKey="Halter C" first="C" last="Halter">C Halter</name>
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<author><name sortKey="Rudolph, A" sort="Rudolph, A" uniqKey="Rudolph A" first="A" last="Rudolph">A. Rudolph</name>
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<author><name sortKey="Wojcieszek, J" sort="Wojcieszek, J" uniqKey="Wojcieszek J" first="J" last="Wojcieszek">J. Wojcieszek</name>
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<author><name sortKey="Pfeiffer, R F" sort="Pfeiffer, R F" uniqKey="Pfeiffer R" first="R" last="Pfeiffer">R Pfeiffer</name>
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<author><name sortKey="Foroud, T" sort="Foroud, T" uniqKey="Foroud T" first="T" last="Foroud">T. Foroud</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.</title>
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<author><name sortKey="Marek, D K" sort="Marek, D K" uniqKey="Marek D" first="D" last="Marek">D Marek</name>
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<author><name sortKey="Elsaesser, V E" sort="Elsaesser, V E" uniqKey="Elsaesser V" first="V" last="Elsaesser">V Elsaesser</name>
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<author><name sortKey="Halter, C A" sort="Halter, C A" uniqKey="Halter C" first="C" last="Halter">C Halter</name>
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<author><name sortKey="Rudolph, A" sort="Rudolph, A" uniqKey="Rudolph A" first="A" last="Rudolph">A. Rudolph</name>
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<author><name sortKey="Wojcieszek, J" sort="Wojcieszek, J" uniqKey="Wojcieszek J" first="J" last="Wojcieszek">J. Wojcieszek</name>
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<series><title level="j">Neurology</title>
<idno type="e-ISSN">1526-632X</idno>
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<term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Genetic Predisposition to Disease (epidemiology)</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genetic Variation (genetics)</term>
<term>Glucosylceramidase (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation (genetics)</term>
<term>Parkinson Disease (enzymology)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glucosylceramidase</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Genetic Predisposition to Disease</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term>
<term>Genetic Variation</term>
<term>Mutation</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">To characterize sequence variation within the glucocerebrosidase (GBA) gene in a select subset of our sample of patients with familial Parkinson disease (PD) and then to test in our full sample whether these sequence variants increased the risk for PD and were associated with an earlier onset of disease.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18987351</PMID>
<DateCreated><Year>2009</Year>
<Month>01</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted><Year>2009</Year>
<Month>02</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>04</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>72</Volume>
<Issue>4</Issue>
<PubDate><Year>2009</Year>
<Month>Jan</Month>
<Day>27</Day>
</PubDate>
</JournalIssue>
<Title>Neurology</Title>
<ISOAbbreviation>Neurology</ISOAbbreviation>
</Journal>
<ArticleTitle>Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.</ArticleTitle>
<Pagination><MedlinePgn>310-6</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1212/01.wnl.0000327823.81237.d1</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To characterize sequence variation within the glucocerebrosidase (GBA) gene in a select subset of our sample of patients with familial Parkinson disease (PD) and then to test in our full sample whether these sequence variants increased the risk for PD and were associated with an earlier onset of disease.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We performed a comprehensive study of all GBA exons in one patient with PD from each of 96 PD families, selected based on the family-specific lod scores at the GBA locus. Identified GBA variants were subsequently screened in all 1325 PD cases from 566 multiplex PD families and in 359 controls.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Nine different GBA variants, five previously reported, were identified in 21 of the 96 PD cases sequenced. Screening for these variants in the full sample identified 161 variant carriers (12.2%) in 99 different PD families. An unbiased estimate of the frequency of the five previously reported GBA variants in the familial PD sample was 12.6% and in the control sample was 5.3% (odds ratio 2.6; 95% confidence interval 1.5-4.4). Presence of a GBA variant was associated with an earlier age at onset (p = 0.0001). On average, those patients carrying a GBA variant had onset with PD 6.04 years earlier than those without a GBA variant.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study suggests that GBA is a susceptibility gene for familial Parkinson disease (PD) and patients with GBA variants have an earlier age at onset than patients with PD without GBA variants.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nichols</LastName>
<ForeName>W C</ForeName>
<Initials>WC</Initials>
<AffiliationInfo><Affiliation>Associate Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. bill.nichols@cchmc.org</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pankratz</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Author>
<Author ValidYN="Y"><LastName>Marek</LastName>
<ForeName>D K</ForeName>
<Initials>DK</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pauciulo</LastName>
<ForeName>M W</ForeName>
<Initials>MW</Initials>
</Author>
<Author ValidYN="Y"><LastName>Elsaesser</LastName>
<ForeName>V E</ForeName>
<Initials>VE</Initials>
</Author>
<Author ValidYN="Y"><LastName>Halter</LastName>
<ForeName>C A</ForeName>
<Initials>CA</Initials>
</Author>
<Author ValidYN="Y"><LastName>Rudolph</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wojcieszek</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pfeiffer</LastName>
<ForeName>R F</ForeName>
<Initials>RF</Initials>
</Author>
<Author ValidYN="Y"><LastName>Foroud</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
</Author>
<Author ValidYN="Y"><CollectiveName>Parkinson Study Group-PROGENI Investigators</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>M01 RR-00750</GrantID>
<Acronym>RR</Acronym>
<Agency>NCRR NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 NS37167</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U24 AG021886</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U24 AG021886</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
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<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
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<Month>11</Month>
<Day>05</Day>
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</Article>
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<NlmUniqueID>0401060</NlmUniqueID>
<ISSNLinking>0028-3878</ISSNLinking>
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<NameOfSubstance UI="D005962">Glucosylceramidase</NameOfSubstance>
</Chemical>
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<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000293">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D017668">Age of Onset</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020022">Genetic Predisposition to Disease</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D014644">Genetic Variation</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005962">Glucosylceramidase</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D009154">Mutation</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000201">enzymology</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Marshall</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Oakes</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rudolph</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Shinaman</LastName>
<ForeName>A</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Marder</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Conneally</LastName>
<ForeName>P M</ForeName>
<Initials>PM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Foroud</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Halter</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lyons</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Siemers</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Elmers</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hermanowicz</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Factor</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Higgins</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Evans</LastName>
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<Initials>S</Initials>
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<Initials>H</Initials>
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<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Danielson</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marlor</LastName>
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<Initials>L</Initials>
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<Investigator ValidYN="Y"><LastName>Williamson</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jankovic</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Hunter</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Simon</LastName>
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</Investigator>
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<Investigator ValidYN="Y"><LastName>Scollins</LastName>
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<Investigator ValidYN="Y"><LastName>Saunders-Pullman</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Boyar</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Costan-Toth</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Ohmann</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Sudarsky</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Joubert</LastName>
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<Investigator ValidYN="Y"><LastName>Fernandez</LastName>
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<Investigator ValidYN="Y"><LastName>Lannon</LastName>
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<Investigator ValidYN="Y"><LastName>Galvez-Jimenez</LastName>
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<Investigator ValidYN="Y"><LastName>DeAngelis</LastName>
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<Investigator ValidYN="Y"><LastName>O'Brien</LastName>
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<Investigator ValidYN="Y"><LastName>Seeberger</LastName>
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<Investigator ValidYN="Y"><LastName>Dingmann</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Bertoni</LastName>
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<Investigator ValidYN="Y"><LastName>Peterson</LastName>
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<Investigator ValidYN="Y"><LastName>Rezak</LastName>
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<Investigator ValidYN="Y"><LastName>Chouinard</LastName>
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<Investigator ValidYN="Y"><LastName>Panisset</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Hall</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Poiffaut</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Calabrese</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Roberge</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Wojcieszek</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Belden</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Halter</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Jennings</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Marek</LastName>
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<Investigator ValidYN="Y"><LastName>Mendick</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Reich</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Dunlop</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Jog</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Horn</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Rao</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Cook</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Uitti</LastName>
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<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Turk</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Ajax</LastName>
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<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mannetter</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Panisset</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Hall</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Sethi</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Carpenter</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Dill</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Ligon</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Narayan</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Woodward</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Blindauer</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Abou-Samra</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Petit</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Elmer</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Aiken</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Davis</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Schell</LastName>
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<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Wilson</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Velickovic</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Koller</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Phipps</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Feigin</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gordon</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Hamann</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Licari</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Marotta-Kollarus</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Shannon</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Winnick</LastName>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Kaczmarek</LastName>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Hubble</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Kostyk</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Campbell</LastName>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Carter</LastName>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Leehey</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Culver</LastName>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Demarcaida</LastName>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Rodnitzky</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Dobson</LastName>
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</Investigator>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Gales</LastName>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Hagen</LastName>
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	Serveur d'exploration autour de Joseph Jankovic
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Serveur d'exploration autour de Joseph Jankovic

Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.

Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.

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