Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.
Identifieur interne : 000129 ( PubMed/Corpus ); précédent : 000128; suivant : 000130Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.
Auteurs : W Nichols ; N. Pankratz ; D Marek ; M Pauciulo ; V Elsaesser ; C Halter ; A. Rudolph ; J. Wojcieszek ; R Pfeiffer ; T. ForoudSource :
- Neurology ; 2009.
English descriptors
- KwdEn :
- Adolescent, Adult, Age of Onset, Aged, Aged, 80 and over, Female, Genetic Predisposition to Disease (epidemiology), Genetic Predisposition to Disease (genetics), Genetic Variation (genetics), Glucosylceramidase (genetics), Humans, Male, Middle Aged, Mutation (genetics), Parkinson Disease (enzymology), Parkinson Disease (epidemiology), Parkinson Disease (genetics).
- MESH :
- chemical , genetics : Glucosylceramidase.
- enzymology : Parkinson Disease.
- epidemiology : Genetic Predisposition to Disease, Parkinson Disease.
- genetics : Genetic Predisposition to Disease, Genetic Variation, Mutation, Parkinson Disease.
- Adolescent, Adult, Age of Onset, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.
Abstract
To characterize sequence variation within the glucocerebrosidase (GBA) gene in a select subset of our sample of patients with familial Parkinson disease (PD) and then to test in our full sample whether these sequence variants increased the risk for PD and were associated with an earlier onset of disease.
DOI: 10.1212/01.wnl.0000327823.81237.d1
PubMed: 18987351
Links to Exploration step
pubmed:18987351Le document en format XML
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<author><name sortKey="Pankratz, N" sort="Pankratz, N" uniqKey="Pankratz N" first="N" last="Pankratz">N. Pankratz</name>
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<author><name sortKey="Rudolph, A" sort="Rudolph, A" uniqKey="Rudolph A" first="A" last="Rudolph">A. Rudolph</name>
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<author><name sortKey="Wojcieszek, J" sort="Wojcieszek, J" uniqKey="Wojcieszek J" first="J" last="Wojcieszek">J. Wojcieszek</name>
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<series><title level="j">Neurology</title>
<idno type="e-ISSN">1526-632X</idno>
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<term>Adult</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Genetic Predisposition to Disease (epidemiology)</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genetic Variation (genetics)</term>
<term>Glucosylceramidase (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation (genetics)</term>
<term>Parkinson Disease (enzymology)</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (genetics)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glucosylceramidase</term>
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<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Genetic Predisposition to Disease</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term>
<term>Genetic Variation</term>
<term>Mutation</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">To characterize sequence variation within the glucocerebrosidase (GBA) gene in a select subset of our sample of patients with familial Parkinson disease (PD) and then to test in our full sample whether these sequence variants increased the risk for PD and were associated with an earlier onset of disease.</div>
</front>
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<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18987351</PMID>
<DateCreated><Year>2009</Year>
<Month>01</Month>
<Day>27</Day>
</DateCreated>
<DateCompleted><Year>2009</Year>
<Month>02</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>04</Month>
<Day>08</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>72</Volume>
<Issue>4</Issue>
<PubDate><Year>2009</Year>
<Month>Jan</Month>
<Day>27</Day>
</PubDate>
</JournalIssue>
<Title>Neurology</Title>
<ISOAbbreviation>Neurology</ISOAbbreviation>
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<ArticleTitle>Mutations in GBA are associated with familial Parkinson disease susceptibility and age at onset.</ArticleTitle>
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<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To characterize sequence variation within the glucocerebrosidase (GBA) gene in a select subset of our sample of patients with familial Parkinson disease (PD) and then to test in our full sample whether these sequence variants increased the risk for PD and were associated with an earlier onset of disease.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We performed a comprehensive study of all GBA exons in one patient with PD from each of 96 PD families, selected based on the family-specific lod scores at the GBA locus. Identified GBA variants were subsequently screened in all 1325 PD cases from 566 multiplex PD families and in 359 controls.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Nine different GBA variants, five previously reported, were identified in 21 of the 96 PD cases sequenced. Screening for these variants in the full sample identified 161 variant carriers (12.2%) in 99 different PD families. An unbiased estimate of the frequency of the five previously reported GBA variants in the familial PD sample was 12.6% and in the control sample was 5.3% (odds ratio 2.6; 95% confidence interval 1.5-4.4). Presence of a GBA variant was associated with an earlier age at onset (p = 0.0001). On average, those patients carrying a GBA variant had onset with PD 6.04 years earlier than those without a GBA variant.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This study suggests that GBA is a susceptibility gene for familial Parkinson disease (PD) and patients with GBA variants have an earlier age at onset than patients with PD without GBA variants.</AbstractText>
</Abstract>
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<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000293">Adolescent</DescriptorName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jankovic</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hunter</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Simon</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ryan</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Scollins</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Saunders-Pullman</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Boyar</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Costan-Toth</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ohmann</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sudarsky</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Joubert</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Friedman</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Chou</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Fernandez</LastName>
<ForeName>H</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Lannon</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Galvez-Jimenez</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Podichetty</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lewitt</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>DeAngelis</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>O'Brien</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Seeberger</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Dingmann</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Judd</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Marder</LastName>
<ForeName>K</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Fraser</LastName>
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<Investigator ValidYN="Y"><LastName>Harris</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Bertoni</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Peterson</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Rezak</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Medalle</LastName>
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<Investigator ValidYN="Y"><LastName>Chouinard</LastName>
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<Investigator ValidYN="Y"><LastName>Panisset</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Hall</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Poiffaut</LastName>
<ForeName>H</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Calabrese</LastName>
<ForeName>V</ForeName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Roberge</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Wojcieszek</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Belden</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Halter</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jennings</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marek</LastName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mendick</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Reich</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dunlop</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jog</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Horn</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rao</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cook</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Uitti</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Turk</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ajax</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mannetter</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Panisset</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hall</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sethi</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Carpenter</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dill</LastName>
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<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ligon</LastName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Narayan</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Woodward</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Blindauer</LastName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Abou-Samra</LastName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Petit</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Elmer</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Aiken</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Davis</LastName>
<ForeName>K</ForeName>
<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Schell</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Wilson</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Velickovic</LastName>
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<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Koller</LastName>
<ForeName>W</ForeName>
<Initials>W</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Phipps</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Feigin</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gordon</LastName>
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<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hamann</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Licari</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marotta-Kollarus</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Shannon</LastName>
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<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Winnick</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Simuni</LastName>
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<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kaczmarek</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Williams</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Wolff</LastName>
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<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rao</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cook</LastName>
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<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hubble</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kostyk</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Campbell</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Reider</LastName>
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<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Seward</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Nutt</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Camicioli</LastName>
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<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Carter</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Andrews</LastName>
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<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Morehouse</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Stone</LastName>
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<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mendis</LastName>
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<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Alcorn-Costa</LastName>
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<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Grimes</LastName>
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<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gray</LastName>
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<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Haas</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Vendette</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Sutton</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hutchinson</LastName>
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<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Young</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rajput</LastName>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Klassen</LastName>
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<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Shirley</LastName>
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<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Manyam</LastName>
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<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Simpson</LastName>
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<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Whetteckey</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Wulbrecht</LastName>
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</Investigator>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Luong</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Tra</LastName>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Vo</LastName>
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<Initials>A</Initials>
</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Kleiner-Fisman</LastName>
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</Investigator>
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<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>So</LastName>
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</Investigator>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Atchison</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Allen</LastName>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Suchowersky</LastName>
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<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Klimek</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Hermanowicz</LastName>
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<Investigator ValidYN="Y"><LastName>Shults</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Fontaine</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Aminoff</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Christine</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Diminno</LastName>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Kang</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Richman</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Uy</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Young</LastName>
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</Investigator>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Gartner</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Sahay</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Schwieterman</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Wolthoff</LastName>
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<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hall</LastName>
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<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Leehey</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Culver</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Derian</LastName>
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<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Demarcaida</LastName>
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<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Belber</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rodnitzky</LastName>
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<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dobson</LastName>
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<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pahwa</LastName>
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<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lyons</LastName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Gales</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Thomas</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Shulman</LastName>
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<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Reich</LastName>
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<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Weiner</LastName>
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<Initials>W</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dustin</LastName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Singer</LastName>
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<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Koller</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Lyons</LastName>
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<Initials>K</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Weiner</LastName>
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</Investigator>
<Investigator ValidYN="Y"><LastName>Zelaya</LastName>
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<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tuite</LastName>
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<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hagen</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
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