JankovicV1, PubMed, Corpus, bibRecord, 000074

Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease.

Identifieur interne : 000074 ( PubMed/Corpus ); précédent : 000073; suivant : 000075

Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease.

Auteurs : Yi Guo ; Wei Le ; Joseph Jankovic ; Hua Yang ; Hong Xu ; Wen Xie ; Zhi Song ; Hao Deng

Source :

Movement disorders : official journal of the Movement Disorder Society ; 2011.

RBID : pubmed:21469209

English descriptors

KwdEn :
- Aged, Case-Control Studies, Chi-Square Distribution, Female, Gene Frequency, Genetic Association Studies, Genetic Predisposition to Disease (genetics), Genotype, Homeodomain Proteins (genetics), Humans, Male, Middle Aged, Parkinson Disease (genetics), Polymorphism, Single Nucleotide (genetics), Transcription Factors (genetics).
MESH :
- chemical , genetics : Homeodomain Proteins, Transcription Factors.
- genetics : Genetic Predisposition to Disease, Parkinson Disease, Polymorphism, Single Nucleotide.
- Aged, Case-Control Studies, Chi-Square Distribution, Female, Gene Frequency, Genetic Association Studies, Genotype, Humans, Male, Middle Aged.

Abstract

Paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons.

DOI: 10.1002/mds.23693
PubMed: 21469209

Links to Exploration step

pubmed:21469209

Le document en format XML

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<author><name sortKey="Guo, Yi" sort="Guo, Yi" uniqKey="Guo Y" first="Yi" last="Guo">Yi Guo</name>
<affiliation><nlm:affiliation>Center for Experimental Medicine and Department of Neurology, the Third Xiangya Hospital, and Department of Physiology, Xiangya Medical School, Central South University, Changsha, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Le, Wei Dong" sort="Le, Wei Dong" uniqKey="Le W" first="Wei" last="Le">Wei Le</name>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
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<author><name sortKey="Yang, Hua Rong" sort="Yang, Hua Rong" uniqKey="Yang H" first="Hua" last="Yang">Hua Yang</name>
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<author><name sortKey="Xu, Hong Bo" sort="Xu, Hong Bo" uniqKey="Xu H" first="Hong" last="Xu">Hong Xu</name>
</author>
<author><name sortKey="Xie, Wen Jie" sort="Xie, Wen Jie" uniqKey="Xie W" first="Wen" last="Xie">Wen Xie</name>
</author>
<author><name sortKey="Song, Zhi" sort="Song, Zhi" uniqKey="Song Z" first="Zhi" last="Song">Zhi Song</name>
</author>
<author><name sortKey="Deng, Hao" sort="Deng, Hao" uniqKey="Deng H" first="Hao" last="Deng">Hao Deng</name>
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<author><name sortKey="Guo, Yi" sort="Guo, Yi" uniqKey="Guo Y" first="Yi" last="Guo">Yi Guo</name>
<affiliation><nlm:affiliation>Center for Experimental Medicine and Department of Neurology, the Third Xiangya Hospital, and Department of Physiology, Xiangya Medical School, Central South University, Changsha, China.</nlm:affiliation>
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<author><name sortKey="Le, Wei Dong" sort="Le, Wei Dong" uniqKey="Le W" first="Wei" last="Le">Wei Le</name>
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<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
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<author><name sortKey="Yang, Hua Rong" sort="Yang, Hua Rong" uniqKey="Yang H" first="Hua" last="Yang">Hua Yang</name>
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<author><name sortKey="Xu, Hong Bo" sort="Xu, Hong Bo" uniqKey="Xu H" first="Hong" last="Xu">Hong Xu</name>
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<author><name sortKey="Xie, Wen Jie" sort="Xie, Wen Jie" uniqKey="Xie W" first="Wen" last="Xie">Wen Xie</name>
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<author><name sortKey="Song, Zhi" sort="Song, Zhi" uniqKey="Song Z" first="Zhi" last="Song">Zhi Song</name>
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<author><name sortKey="Deng, Hao" sort="Deng, Hao" uniqKey="Deng H" first="Hao" last="Deng">Hao Deng</name>
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<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="e-ISSN">1531-8257</idno>
<imprint><date when="2011" type="published">2011</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Case-Control Studies</term>
<term>Chi-Square Distribution</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genotype</term>
<term>Homeodomain Proteins (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Transcription Factors (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Homeodomain Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term>
<term>Parkinson Disease</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Case-Control Studies</term>
<term>Chi-Square Distribution</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genetic Association Studies</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons.</div>
</front>
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<DateCreated><Year>2011</Year>
<Month>08</Month>
<Day>10</Day>
</DateCreated>
<DateCompleted><Year>2011</Year>
<Month>12</Month>
<Day>08</Day>
</DateCompleted>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>26</Volume>
<Issue>9</Issue>
<PubDate><Year>2011</Year>
<Month>Aug</Month>
<Day>1</Day>
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<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
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<ArticleTitle>Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease.</ArticleTitle>
<Pagination><MedlinePgn>1729-32</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.23693</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">To determine whether genetic variation in the coding region of the paired-like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early-onset Parkinson's disease and familial Parkinson's disease.</AbstractText>
<CopyrightInformation>Copyright © 2011 Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Yi</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Center for Experimental Medicine and Department of Neurology, the Third Xiangya Hospital, and Department of Physiology, Xiangya Medical School, Central South University, Changsha, China.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Le</LastName>
<ForeName>Wei-Dong</ForeName>
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<Author ValidYN="Y"><LastName>Jankovic</LastName>
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<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Hua-Rong</ForeName>
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<Author ValidYN="Y"><LastName>Xu</LastName>
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<Author ValidYN="Y"><LastName>Deng</LastName>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2011</Year>
<Month>04</Month>
<Day>05</Day>
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</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018398">Homeodomain Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C433629">homeobox protein PITX3</NameOfSubstance>
</Chemical>
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<MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020641">Polymorphism, Single Nucleotide</DescriptorName>
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Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease.

Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki