Head injury, α-synuclein Rep1, and Parkinson's disease.
Identifieur interne : 000060 ( PubMed/Corpus ); précédent : 000059; suivant : 000061Head injury, α-synuclein Rep1, and Parkinson's disease.
Auteurs : Samuel. Goldman ; Freya Kamel ; G Ross ; Sarah. Jewell ; Grace. Bhudhikanok ; David Umbach ; Connie Marras ; Robert. Hauser ; Joseph Jankovic ; Stewart. Factor ; Susan Bressman ; Kelly. Lyons ; Cheryl Meng ; Monica Korell ; Diana. Roucoux ; Jane. Hoppin ; Dale. Sandler ; J Langston ; Caroline. TannerSource :
- Annals of neurology ; 2012.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Craniocerebral Trauma (blood), Craniocerebral Trauma (epidemiology), Craniocerebral Trauma (genetics), Female, Genetic Variation, Humans, Male, Microsatellite Repeats (genetics), Middle Aged, Neurodegenerative Diseases (blood), Neurodegenerative Diseases (epidemiology), Neurodegenerative Diseases (genetics), Parkinson Disease (diagnosis), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Prospective Studies, alpha-Synuclein (biosynthesis), alpha-Synuclein (blood), alpha-Synuclein (genetics).
- MESH :
- chemical , biosynthesis : alpha-Synuclein.
- blood : Craniocerebral Trauma, Neurodegenerative Diseases, alpha-Synuclein.
- diagnosis : Parkinson Disease.
- epidemiology : Craniocerebral Trauma, Neurodegenerative Diseases, Parkinson Disease.
- genetics : Craniocerebral Trauma, Microsatellite Repeats, Neurodegenerative Diseases, Parkinson Disease, alpha-Synuclein.
- Adult, Aged, Aged, 80 and over, Case-Control Studies, Cohort Studies, Female, Genetic Variation, Humans, Male, Middle Aged, Prospective Studies.
Abstract
To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk.
DOI: 10.1002/ana.22499
PubMed: 22275250
Links to Exploration step
pubmed:22275250Le document en format XML
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Bhudhikanok</name></author><author><name sortKey="Umbach, David" sort="Umbach, David" uniqKey="Umbach D" first="David" last="Umbach">David Umbach</name></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name></author><author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert" last="Hauser">Robert. Hauser</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></author><author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart" last="Factor">Stewart. Factor</name></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name></author><author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly" last="Lyons">Kelly. Lyons</name></author><author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name></author><author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name></author><author><name sortKey="Roucoux, Diana F" sort="Roucoux, Diana F" uniqKey="Roucoux D" first="Diana" last="Roucoux">Diana. Roucoux</name></author><author><name sortKey="Hoppin, Jane A" sort="Hoppin, Jane A" uniqKey="Hoppin J" first="Jane" last="Hoppin">Jane. Hoppin</name></author><author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale" last="Sandler">Dale. Sandler</name></author><author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J" last="Langston">J Langston</name></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline" last="Tanner">Caroline. Tanner</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/ana.22499</idno><idno type="RBID">pubmed:22275250</idno><idno type="pmid">22275250</idno><idno type="wicri:Area/PubMed/Corpus">000060</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Head injury, α-synuclein Rep1, and Parkinson's disease.</title><author><name sortKey="Goldman, Samuel M" sort="Goldman, Samuel M" uniqKey="Goldman S" first="Samuel" last="Goldman">Samuel. Goldman</name><affiliation><nlm:affiliation>The Parkinson's Institute, Sunnyvale, CA 94085, USA. sgoldman@thepi.org</nlm:affiliation></affiliation></author><author><name sortKey="Kamel, Freya" sort="Kamel, Freya" uniqKey="Kamel F" first="Freya" last="Kamel">Freya Kamel</name></author><author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G" last="Ross">G Ross</name></author><author><name sortKey="Jewell, Sarah A" sort="Jewell, Sarah A" uniqKey="Jewell S" first="Sarah" last="Jewell">Sarah. Jewell</name></author><author><name sortKey="Bhudhikanok, Grace S" sort="Bhudhikanok, Grace S" uniqKey="Bhudhikanok G" first="Grace" last="Bhudhikanok">Grace. Bhudhikanok</name></author><author><name sortKey="Umbach, David" sort="Umbach, David" uniqKey="Umbach D" first="David" last="Umbach">David Umbach</name></author><author><name sortKey="Marras, Connie" sort="Marras, Connie" uniqKey="Marras C" first="Connie" last="Marras">Connie Marras</name></author><author><name sortKey="Hauser, Robert A" sort="Hauser, Robert A" uniqKey="Hauser R" first="Robert" last="Hauser">Robert. Hauser</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></author><author><name sortKey="Factor, Stewart A" sort="Factor, Stewart A" uniqKey="Factor S" first="Stewart" last="Factor">Stewart. Factor</name></author><author><name sortKey="Bressman, Susan" sort="Bressman, Susan" uniqKey="Bressman S" first="Susan" last="Bressman">Susan Bressman</name></author><author><name sortKey="Lyons, Kelly E" sort="Lyons, Kelly E" uniqKey="Lyons K" first="Kelly" last="Lyons">Kelly. Lyons</name></author><author><name sortKey="Meng, Cheryl" sort="Meng, Cheryl" uniqKey="Meng C" first="Cheryl" last="Meng">Cheryl Meng</name></author><author><name sortKey="Korell, Monica" sort="Korell, Monica" uniqKey="Korell M" first="Monica" last="Korell">Monica Korell</name></author><author><name sortKey="Roucoux, Diana F" sort="Roucoux, Diana F" uniqKey="Roucoux D" first="Diana" last="Roucoux">Diana. Roucoux</name></author><author><name sortKey="Hoppin, Jane A" sort="Hoppin, Jane A" uniqKey="Hoppin J" first="Jane" last="Hoppin">Jane. Hoppin</name></author><author><name sortKey="Sandler, Dale P" sort="Sandler, Dale P" uniqKey="Sandler D" first="Dale" last="Sandler">Dale. Sandler</name></author><author><name sortKey="Langston, J William" sort="Langston, J William" uniqKey="Langston J" first="J" last="Langston">J Langston</name></author><author><name sortKey="Tanner, Caroline M" sort="Tanner, Caroline M" uniqKey="Tanner C" first="Caroline" last="Tanner">Caroline. Tanner</name></author></analytic><series><title level="j">Annals of neurology</title><idno type="e-ISSN">1531-8249</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Craniocerebral Trauma (blood)</term><term>Craniocerebral Trauma (epidemiology)</term><term>Craniocerebral Trauma (genetics)</term><term>Female</term><term>Genetic Variation</term><term>Humans</term><term>Male</term><term>Microsatellite Repeats (genetics)</term><term>Middle Aged</term><term>Neurodegenerative Diseases (blood)</term><term>Neurodegenerative Diseases (epidemiology)</term><term>Neurodegenerative Diseases (genetics)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (genetics)</term><term>Prospective Studies</term><term>alpha-Synuclein (biosynthesis)</term><term>alpha-Synuclein (blood)</term><term>alpha-Synuclein (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Craniocerebral Trauma</term><term>Neurodegenerative Diseases</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Craniocerebral Trauma</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Craniocerebral Trauma</term><term>Microsatellite Repeats</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term><term>alpha-Synuclein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Cohort Studies</term><term>Female</term><term>Genetic Variation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22275250</PMID><DateCreated><Year>2012</Year><Month>01</Month><Day>25</Day></DateCreated><DateCompleted><Year>2012</Year><Month>03</Month><Day>09</Day></DateCompleted><DateRevised><Year>2015</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8249</ISSN><JournalIssue CitedMedium="Internet"><Volume>71</Volume><Issue>1</Issue><PubDate><Year>2012</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Annals of neurology</Title><ISOAbbreviation>Ann. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Head injury, α-synuclein Rep1, and Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>40-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ana.22499</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To test the hypothesis that variability in SNCA Rep1, a polymorphic dinucleotide microsatellite in the promoter region of the gene encoding α-synuclein, modifies the association between head injury and Parkinson's disease (PD) risk.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Participants in the Farming and Movement Evaluation (FAME) and the Study of Environmental Association and Risk of Parkinsonism using Case-Control Historical Interviews (SEARCH), 2 independent case-control studies, were genotyped for Rep1 and interviewed regarding head injuries with loss of consciousness or concussion prior to Parkinson's disease (PD) diagnosis. Logistic regression modeling adjusted for potential confounding variables and tested interaction between Rep1 genotype and head injury.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Consistent with prior reports, relative to medium-length Rep1, short Rep1 genotype was associated with reduced PD risk (pooled odds ratio [OR], 0.7; 95% confidence interval [CI], 0.5-0.9), and long Rep1 with increased risk (pooled OR, 1.4; 95% CI, 0.95-2.2). Overall, head injury was not significantly associated with PD (pooled OR, 1.3; 95% CI, 0.9-1.8). However, head injury was strongly associated with PD in those with long Rep1 (FAME OR, 5.4; 95% CI, 1.5-19; SEARCH OR, 2.3; 95% CI, 0.6-9.2; pooled OR, 3.5; 95% CI 1.4-9.2, p-interaction = 0.02). Individuals with both head injury and long Rep1 were diagnosed 4.9 years earlier than those with neither risk factor (p = 0.03).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">While head injury alone was not associated with PD risk, our data suggest head injury may initiate and/or accelerate neurodegeneration when levels of synuclein are high, as in those with Rep1 expansion. Given the high population frequency of head injury, independent verification of these results is essential.</AbstractText><CopyrightInformation>Copyright © 2011 American Neurological Association.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Goldman</LastName><ForeName>Samuel M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>The Parkinson's Institute, Sunnyvale, CA 94085, USA. sgoldman@thepi.org</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamel</LastName><ForeName>Freya</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Ross</LastName><ForeName>G Webster</ForeName><Initials>GW</Initials></Author><Author ValidYN="Y"><LastName>Jewell</LastName><ForeName>Sarah A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Bhudhikanok</LastName><ForeName>Grace S</ForeName><Initials>GS</Initials></Author><Author ValidYN="Y"><LastName>Umbach</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Marras</LastName><ForeName>Connie</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Hauser</LastName><ForeName>Robert A</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Jankovic</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Factor</LastName><ForeName>Stewart A</ForeName><Initials>SA</Initials></Author><Author ValidYN="Y"><LastName>Bressman</LastName><ForeName>Susan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Lyons</LastName><ForeName>Kelly E</ForeName><Initials>KE</Initials></Author><Author ValidYN="Y"><LastName>Meng</LastName><ForeName>Cheryl</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Korell</LastName><ForeName>Monica</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Roucoux</LastName><ForeName>Diana F</ForeName><Initials>DF</Initials></Author><Author ValidYN="Y"><LastName>Hoppin</LastName><ForeName>Jane A</ForeName><Initials>JA</Initials></Author><Author ValidYN="Y"><LastName>Sandler</LastName><ForeName>Dale P</ForeName><Initials>DP</Initials></Author><Author ValidYN="Y"><LastName>Langston</LastName><ForeName>J William</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Tanner</LastName><ForeName>Caroline M</ForeName><Initials>CM</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 ES010803</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 ES010803-01</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 ES012077-01</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>Z01 CP010119-12</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>Z01 ES044007-07</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>Z01 ES049030-11</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>ZIA ES044007-11</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann Neurol</MedlineTA><NlmUniqueID>7707449</NlmUniqueID><ISSNLinking>0364-5134</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051844">alpha-Synuclein</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Parkinsonism Relat Disord. 2009 Jan;15(1):12-4</RefSource><PMID Version="1">18367422</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Biosci (Landmark Ed). 2009;14:3795-813</RefSource><PMID Version="1">19273311</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2009 Sep 1;18(17):3274-85</RefSource><PMID Version="1">19498036</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2009 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