Serveur d'exploration autour de Joseph Jankovic

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Short and long-term motor and cognitive outcome of staged bilateral pallidotomy: a retrospective analysis.

Identifieur interne : 000156 ( PubMed/Checkpoint ); précédent : 000155; suivant : 000157

Short and long-term motor and cognitive outcome of staged bilateral pallidotomy: a retrospective analysis.

Auteurs : M York [États-Unis] ; E Lai ; Joseph Jankovic [États-Unis] ; A. Macias ; F. Atassi ; H Levin ; R Grossman

Source :

RBID : pubmed:17624489

English descriptors

Abstract

We investigated retrospectively the short and long-term motor and cognitive functioning of staged bilateral pallidotomy using motor testing and a comprehensive neuropsychological battery before and after each procedure.

DOI: 10.1007/s00701-007-1242-x
PubMed: 17624489


Affiliations:


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pubmed:17624489

Le document en format XML

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<title xml:lang="en">Short and long-term motor and cognitive outcome of staged bilateral pallidotomy: a retrospective analysis.</title>
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<name sortKey="York, M K" sort="York, M K" uniqKey="York M" first="M" last="York">M York</name>
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<nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA. myork@bcm.edu</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<name sortKey="Lai, E C" sort="Lai, E C" uniqKey="Lai E" first="E" last="Lai">E Lai</name>
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<name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name>
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<name sortKey="Macias, A" sort="Macias, A" uniqKey="Macias A" first="A" last="Macias">A. Macias</name>
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<name sortKey="Atassi, F" sort="Atassi, F" uniqKey="Atassi F" first="F" last="Atassi">F. Atassi</name>
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<name sortKey="Levin, H S" sort="Levin, H S" uniqKey="Levin H" first="H" last="Levin">H Levin</name>
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<term>Aged</term>
<term>Cognition</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Movement</term>
<term>Neuropsychological Tests</term>
<term>Pallidotomy (adverse effects)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Reoperation</term>
<term>Retrospective Studies</term>
<term>Severity of Illness Index</term>
<term>Treatment Outcome</term>
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<term>Pallidotomy</term>
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<term>Parkinson Disease</term>
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<term>Parkinson Disease</term>
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<term>Parkinson Disease</term>
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<div type="abstract" xml:lang="en">We investigated retrospectively the short and long-term motor and cognitive functioning of staged bilateral pallidotomy using motor testing and a comprehensive neuropsychological battery before and after each procedure.</div>
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<Month>10</Month>
<Day>30</Day>
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<ArticleTitle>Short and long-term motor and cognitive outcome of staged bilateral pallidotomy: a retrospective analysis.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">We investigated retrospectively the short and long-term motor and cognitive functioning of staged bilateral pallidotomy using motor testing and a comprehensive neuropsychological battery before and after each procedure.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Fifteen patients with idiopathic Parkinson's disease were assessed at baseline and at least 3 months after each of their two staged surgeries. Motor and neuropsychological results were compared to 15 non-surgical Parkinson's disease patients matched for disease stage and mental status. In addition, nine bilateral pallidotomy patients were evaluated for long-term cognitive changes (>2 years).</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">Bilateral pallidotomy patients demonstrated significant improvements in motor functioning in the "on" and "off" states and with dyskinesias after the first surgery, with an additional improvement reported for dyskinesias after the second procedure. On long-term follow-up, dyskinesia improvements were maintained. Bilateral pallidotomy patients did not show significant cognitive declines following both procedures on the short-term follow-up and when compared to the Parkinson's disease group. However, significant cognitive declines were found on the long-term follow-up evaluation.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Parkinson's disease patients received significant short- and long-term motor benefits, particularly reduced dyskinesias, following staged bilateral pallidotomy without significant short-term cognitive consequences. Two years following the second procedure, bilateral pallidotomy patients tended to show an increase in both motor and non-motor symptoms of Parkinson's disease, particularly cognitive decline.</AbstractText>
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