Examination of the MSX1 gene in patients with Parkinson's disease.
Identifieur interne : 000121 ( PubMed/Checkpoint ); précédent : 000120; suivant : 000122Examination of the MSX1 gene in patients with Parkinson's disease.
Auteurs : H. Deng [République populaire de Chine] ; S Zhu ; W Le ; H Yang ; H Lv ; H Xu ; W Xie ; Joseph Jankovic [États-Unis]Source :
- Acta neurologica Scandinavica ; 2009.
English descriptors
- KwdEn :
- Female, Gene Frequency (genetics), Genetic Predisposition to Disease (genetics), Genetic Variation (genetics), Genotype, Humans, MSX1 Transcription Factor (genetics), Male, Middle Aged, Mutation, Parkinson Disease (diagnosis), Parkinson Disease (genetics), Polymorphism, Genetic (genetics), Reverse Transcriptase Polymerase Chain Reaction.
- MESH :
- chemical , genetics : MSX1 Transcription Factor.
- diagnosis : Parkinson Disease.
- genetics : Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Parkinson Disease, Polymorphism, Genetic.
- Female, Genotype, Humans, Male, Middle Aged, Mutation, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.
DOI: 10.1111/j.1600-0404.2009.01271.x
PubMed: 19922584
Affiliations:
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pubmed:19922584Le document en format XML
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<author><name sortKey="Deng, H" sort="Deng, H" uniqKey="Deng H" first="H" last="Deng">H. Deng</name>
<affiliation wicri:level="1"><nlm:affiliation>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University</wicri:regionArea>
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<author><name sortKey="Zhu, S H" sort="Zhu, S H" uniqKey="Zhu S" first="S" last="Zhu">S Zhu</name>
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<author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name>
<affiliation><country>États-Unis</country>
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<series><title level="j">Acta neurologica Scandinavica</title>
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<term>Gene Frequency (genetics)</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genetic Variation (genetics)</term>
<term>Genotype</term>
<term>Humans</term>
<term>MSX1 Transcription Factor (genetics)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymorphism, Genetic (genetics)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>MSX1 Transcription Factor</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Frequency</term>
<term>Genetic Predisposition to Disease</term>
<term>Genetic Variation</term>
<term>Parkinson Disease</term>
<term>Polymorphism, Genetic</term>
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<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
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<term>Mutation</term>
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<front><div type="abstract" xml:lang="en">Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.</div>
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<DateCreated><Year>2009</Year>
<Month>11</Month>
<Day>20</Day>
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<DateCompleted><Year>2009</Year>
<Month>12</Month>
<Day>16</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1600-0404</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>120</Volume>
<Issue>6</Issue>
<PubDate><Year>2009</Year>
<Month>Dec</Month>
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<Title>Acta neurologica Scandinavica</Title>
<ISOAbbreviation>Acta Neurol. Scand.</ISOAbbreviation>
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<ArticleTitle>Examination of the MSX1 gene in patients with Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>442-4</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1600-0404.2009.01271.x</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.</AbstractText>
<AbstractText Label="AIMS OF THE STUDY" NlmCategory="OBJECTIVE">To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">No mutation in the MSX1 gene was identified in our cohort.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.</AbstractText>
</Abstract>
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<Author ValidYN="Y"><LastName>Le</LastName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName>
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<MeshHeading><DescriptorName MajorTopicYN="N" UI="D020133">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName>
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