Examination of the MSX1 gene in patients with Parkinson's disease.
Identifieur interne : 000121 ( PubMed/Checkpoint ); précédent : 000120; suivant : 000122Examination of the MSX1 gene in patients with Parkinson's disease.
Auteurs : H. Deng [République populaire de Chine] ; S Zhu ; W Le ; H Yang ; H Lv ; H Xu ; W Xie ; Joseph Jankovic [États-Unis]Source :
- Acta neurologica Scandinavica ; 2009.
English descriptors
- KwdEn :
- Female, Gene Frequency (genetics), Genetic Predisposition to Disease (genetics), Genetic Variation (genetics), Genotype, Humans, MSX1 Transcription Factor (genetics), Male, Middle Aged, Mutation, Parkinson Disease (diagnosis), Parkinson Disease (genetics), Polymorphism, Genetic (genetics), Reverse Transcriptase Polymerase Chain Reaction.
- MESH :
- chemical , genetics : MSX1 Transcription Factor.
- diagnosis : Parkinson Disease.
- genetics : Gene Frequency, Genetic Predisposition to Disease, Genetic Variation, Parkinson Disease, Polymorphism, Genetic.
- Female, Genotype, Humans, Male, Middle Aged, Mutation, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.
DOI: 10.1111/j.1600-0404.2009.01271.x
PubMed: 19922584
Affiliations:
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Deng</name><affiliation wicri:level="1"><nlm:affiliation>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University</wicri:regionArea><wicri:noRegion>Central South University</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, S H" sort="Zhu, S H" uniqKey="Zhu S" first="S" last="Zhu">S Zhu</name></author><author><name sortKey="Le, W D" sort="Le, W D" uniqKey="Le W" first="W" last="Le">W Le</name></author><author><name sortKey="Yang, H R" sort="Yang, H R" uniqKey="Yang H" first="H" last="Yang">H Yang</name></author><author><name sortKey="Lv, H W" sort="Lv, H W" uniqKey="Lv H" first="H" last="Lv">H Lv</name></author><author><name sortKey="Xu, H B" sort="Xu, H B" uniqKey="Xu H" first="H" last="Xu">H Xu</name></author><author><name sortKey="Xie, W J" sort="Xie, W J" uniqKey="Xie W" first="W" last="Xie">W Xie</name></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1111/j.1600-0404.2009.01271.x</idno><idno type="RBID">pubmed:19922584</idno><idno type="pmid">19922584</idno><idno type="wicri:Area/PubMed/Corpus">000102</idno><idno type="wicri:Area/PubMed/Curation">000102</idno><idno type="wicri:Area/PubMed/Checkpoint">000121</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Examination of the MSX1 gene in patients with Parkinson's disease.</title><author><name sortKey="Deng, H" sort="Deng, H" uniqKey="Deng H" first="H" last="Deng">H. Deng</name><affiliation wicri:level="1"><nlm:affiliation>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University</wicri:regionArea><wicri:noRegion>Central South University</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, S H" sort="Zhu, S H" uniqKey="Zhu S" first="S" last="Zhu">S Zhu</name></author><author><name sortKey="Le, W D" sort="Le, W D" uniqKey="Le W" first="W" last="Le">W Le</name></author><author><name sortKey="Yang, H R" sort="Yang, H R" uniqKey="Yang H" first="H" last="Yang">H Yang</name></author><author><name sortKey="Lv, H W" sort="Lv, H W" uniqKey="Lv H" first="H" last="Lv">H Lv</name></author><author><name sortKey="Xu, H B" sort="Xu, H B" uniqKey="Xu H" first="H" last="Xu">H Xu</name></author><author><name sortKey="Xie, W J" sort="Xie, W J" uniqKey="Xie W" first="W" last="Xie">W Xie</name></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j">Acta neurologica Scandinavica</title><idno type="e-ISSN">1600-0404</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female</term><term>Gene Frequency (genetics)</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genetic Variation (genetics)</term><term>Genotype</term><term>Humans</term><term>MSX1 Transcription Factor (genetics)</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Genetic (genetics)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>MSX1 Transcription Factor</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Genetic Variation</term><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19922584</PMID><DateCreated><Year>2009</Year><Month>11</Month><Day>20</Day></DateCreated><DateCompleted><Year>2009</Year><Month>12</Month><Day>16</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1600-0404</ISSN><JournalIssue CitedMedium="Internet"><Volume>120</Volume><Issue>6</Issue><PubDate><Year>2009</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Acta neurologica Scandinavica</Title><ISOAbbreviation>Acta Neurol. Scand.</ISOAbbreviation></Journal><ArticleTitle>Examination of the MSX1 gene in patients with Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>442-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1600-0404.2009.01271.x</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Several genetic variants in transcription factor genes have been reported to be associated with Parkinson's disease (PD). The muscle segment homeobox drosophila homolog of 1 gene (MSX1) is a major upstream regulator of the dopaminergic neuronal subtype specification.</AbstractText><AbstractText Label="AIMS OF THE STUDY" NlmCategory="OBJECTIVE">To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR-single-strand conformation polymorphism (PCR-SSCP) and sequencing.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">No mutation in the MSX1 gene was identified in our cohort.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Center for Experimental Medicine, the Third Xiangya Hospital, Central South University, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>S H</ForeName><Initials>SH</Initials></Author><Author ValidYN="Y"><LastName>Le</LastName><ForeName>W D</ForeName><Initials>WD</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>H R</ForeName><Initials>HR</Initials></Author><Author ValidYN="Y"><LastName>Lv</LastName><ForeName>H W</ForeName><Initials>HW</Initials></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>H B</ForeName><Initials>HB</Initials></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>W J</ForeName><Initials>WJ</Initials></Author><Author 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UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020022">Genetic Predisposition to Disease</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014644">Genetic Variation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005838">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D051957">MSX1 Transcription Factor</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009154">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011110">Polymorphism, Genetic</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000235">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020133">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>11</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">ANE1271</ArticleId><ArticleId IdType="doi">10.1111/j.1600-0404.2009.01271.x</ArticleId><ArticleId IdType="pubmed">19922584</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><noCountry><name sortKey="Le, W D" sort="Le, W D" uniqKey="Le W" first="W" last="Le">W Le</name><name sortKey="Lv, H W" sort="Lv, H W" uniqKey="Lv H" first="H" last="Lv">H Lv</name><name sortKey="Xie, W J" sort="Xie, W J" uniqKey="Xie W" first="W" last="Xie">W Xie</name><name sortKey="Xu, H B" sort="Xu, H B" uniqKey="Xu H" first="H" last="Xu">H Xu</name><name sortKey="Yang, H R" sort="Yang, H R" uniqKey="Yang H" first="H" last="Yang">H Yang</name><name sortKey="Zhu, S H" sort="Zhu, S H" uniqKey="Zhu S" first="S" last="Zhu">S Zhu</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Deng, H" sort="Deng, H" uniqKey="Deng H" first="H" last="Deng">H. Deng</name></noRegion></country><country name="États-Unis"><region name="Texas"><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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