Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience.
Identifieur interne : 000031 ( PubMed/Checkpoint ); précédent : 000030; suivant : 000032Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience.
Auteurs : Sotirios. Parashos [États-Unis] ; Sheng Luo ; Kevin. Biglan [États-Unis] ; Ivan Bodis ; Bo He ; Grace. Liang [États-Unis] ; G Ross [États-Unis] ; Barbara. Tilley ; Lisa. Shulman [États-Unis]Source :
- JAMA neurology ; 2014.
Descripteurs français
- Wicri :
- geographic : États-Unis.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Disease Progression, Double-Blind Method, Female, Humans, Male, Middle Aged, National Institutes of Health (U.S.), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Quality of Life, Severity of Illness Index, Surveys and Questionnaires, Tacrolimus (analogs & derivatives), Tacrolimus (therapeutic use), Treatment Outcome, United States.
- MESH :
- chemical , analogs & derivatives : Tacrolimus.
- geographic : United States.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- chemical , therapeutic use : Tacrolimus.
- Adult, Aged, Aged, 80 and over, Disease Progression, Double-Blind Method, Female, Humans, Male, Middle Aged, National Institutes of Health (U.S.), Quality of Life, Severity of Illness Index, Surveys and Questionnaires, Treatment Outcome.
Abstract
Optimizing assessments of rate of progression in Parkinson disease (PD) is important in designing clinical trials, especially of potential disease-modifying agents.
DOI: 10.1001/jamaneurol.2014.391
PubMed: 24711047
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:24711047Le document en format XML
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Parashos</name><affiliation wicri:level="2"><nlm:affiliation>Struthers Parkinson's Center, Golden Valley, Minnesota.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Struthers Parkinson's Center, Golden Valley</wicri:cityArea></affiliation></author><author><name sortKey="Luo, Sheng" sort="Luo, Sheng" uniqKey="Luo S" first="Sheng" last="Luo">Sheng Luo</name><affiliation><nlm:affiliation>Division of Biostatistics, University of Texas at Houston.</nlm:affiliation><wicri:noCountry code="subField">University of Texas at Houston</wicri:noCountry></affiliation></author><author><name sortKey="Biglan, Kevin M" sort="Biglan, Kevin M" uniqKey="Biglan K" first="Kevin" last="Biglan">Kevin. Biglan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Rochester, Rochester, New York.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Neurology, University of Rochester, Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Bodis Wollner, Ivan" sort="Bodis Wollner, Ivan" uniqKey="Bodis Wollner I" first="Ivan" last="Bodis">Ivan Bodis</name><affiliation><nlm:affiliation>State University of New York, Downstate Medical Center, Brooklyn.</nlm:affiliation><wicri:noCountry code="subField">Brooklyn</wicri:noCountry></affiliation></author><author><name sortKey="He, Bo" sort="He, Bo" uniqKey="He B" first="Bo" last="He">Bo He</name><affiliation><nlm:affiliation>Division of Biostatistics, University of Texas at Houston.</nlm:affiliation><wicri:noCountry code="subField">University of Texas at Houston</wicri:noCountry></affiliation></author><author><name sortKey="Liang, Grace S" sort="Liang, Grace S" uniqKey="Liang G" first="Grace" last="Liang">Grace. Liang</name><affiliation wicri:level="2"><nlm:affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>The Parkinson's Institute and Clinical Center, Sunnyvale</wicri:cityArea></affiliation></author><author><name sortKey="Ross, G Webster" sort="Ross, G Webster" uniqKey="Ross G" first="G" last="Ross">G Ross</name><affiliation wicri:level="2"><nlm:affiliation>VA Pacific Islands Health Care System, Honolulu, Hawaii.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Hawaï</region></placeName><wicri:cityArea>VA Pacific Islands Health Care System, Honolulu</wicri:cityArea></affiliation></author><author><name sortKey="Tilley, Barbara C" sort="Tilley, Barbara C" uniqKey="Tilley B" first="Barbara" last="Tilley">Barbara. Tilley</name><affiliation><nlm:affiliation>Division of Biostatistics, University of Texas at Houston.</nlm:affiliation><wicri:noCountry code="subField">University of Texas at Houston</wicri:noCountry></affiliation></author><author><name sortKey="Shulman, Lisa M" sort="Shulman, Lisa M" uniqKey="Shulman L" first="Lisa" last="Shulman">Lisa. Shulman</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University of Maryland School of Medicine, Baltimore.</nlm:affiliation><country>États-Unis</country><placeName><settlement type="city">Baltimore</settlement><region type="state">Maryland</region></placeName><wicri:orgArea>Department of Neurology, University of Maryland School of Medicine</wicri:orgArea></affiliation></author></analytic><series><title level="j">JAMA neurology</title><idno type="e-ISSN">2168-6157</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>National Institutes of Health (U.S.)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Quality of Life</term><term>Severity of Illness Index</term><term>Surveys and Questionnaires</term><term>Tacrolimus (analogs & derivatives)</term><term>Tacrolimus (therapeutic use)</term><term>Treatment Outcome</term><term>United States</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Tacrolimus</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>United States</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Tacrolimus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Disease Progression</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>National Institutes of Health (U.S.)</term><term>Quality of Life</term><term>Severity of Illness Index</term><term>Surveys and Questionnaires</term><term>Treatment Outcome</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>États-Unis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Optimizing assessments of rate of progression in Parkinson disease (PD) is important in designing clinical trials, especially of potential disease-modifying agents.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">24711047</PMID><DateCreated><Year>2014</Year><Month>06</Month><Day>10</Day></DateCreated><DateCompleted><Year>2014</Year><Month>08</Month><Day>15</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2168-6157</ISSN><JournalIssue CitedMedium="Internet"><Volume>71</Volume><Issue>6</Issue><PubDate><Year>2014</Year><Month>Jun</Month></PubDate></JournalIssue><Title>JAMA neurology</Title><ISOAbbreviation>JAMA Neurol</ISOAbbreviation></Journal><ArticleTitle>Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience.</ArticleTitle><Pagination><MedlinePgn>710-6</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/jamaneurol.2014.391</ELocationID><Abstract><AbstractText Label="IMPORTANCE" NlmCategory="OBJECTIVE">Optimizing assessments of rate of progression in Parkinson disease (PD) is important in designing clinical trials, especially of potential disease-modifying agents.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To examine the value of measures of impairment, disability, and quality of life in assessing progression in early PD.</AbstractText><AbstractText Label="DESIGN, SETTING, AND PARTICIPANTS" NlmCategory="METHODS">Inception cohort analysis of data from 413 patients with early, untreated PD who were enrolled in 2 multicenter, randomized, double-blind clinical trials.</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">Participants were randomly assigned to 1 of 5 treatments (67 received creatine, 66 received minocycline, 71 received coenzyme Q10, 71 received GPI-1485, and 138 received placebo). We assessed the association between the rates of change in measures of impairment, disability, and quality of life and time to initiation of symptomatic treatment.</AbstractText><AbstractText Label="MAIN OUTCOMES AND MEASURES" NlmCategory="METHODS">Time between baseline assessment and need for the initiation of symptomatic pharmaceutical treatment for PD was the primary indicator of disease progression.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">After adjusting for baseline confounding variables with regard to the Unified Parkinson's Disease Rating Scale (UPDRS) Part II score, the UPDRS Part III score, the modified Rankin Scale score, level of education, and treatment group, we assessed the rate of change for the following measurements: the UPDRS Part II score; the UPDRS Part III score; the Schwab and England Independence Scale score (which measures activities of daily living); the Total Functional Capacity scale; the 39-item Parkinson's Disease Questionnaire, summary index, and activities of daily living subscale; and version 2 of the 12-item Short Form Health Survey Physical Summary and Mental Summary. Variables reaching the statistical threshold in univariate analysis were entered into a multivariable Cox proportional hazards model using time to symptomatic treatment as the dependent variable. More rapid change (ie, worsening) in the UPDRS Part II score (hazard ratio, 1.15 [95% CI, 1.08-1.22] for 1 scale unit change per 6 months), the UPDRS Part III score (hazard ratio, 1.09 [95% CI, 1.06-1.13] for 1 scale unit change per 6 months), and the Schwab and England Independence Scale score (hazard ratio, 1.29 [95% CI, 1.12-1.48] for 5 percentage point change per 6 months) was associated with earlier need for symptomatic therapy.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">AND RELEVANCE In early PD, the UPDRS Part II score and Part III score and the Schwab and England Independence Scale score can be used to measure disease progression, whereas the 39-item Parkinson's Disease Questionnaire and summary index, Total Functional Capacity scale, and the 12-item Short Form Health Survey Physical Summary and Mental Summary are not sensitive to change.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">clinicaltrials.gov Identifiers: NCT00063193 and NCT00076492.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Parashos</LastName><ForeName>Sotirios A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Struthers Parkinson's Center, Golden Valley, Minnesota.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luo</LastName><ForeName>Sheng</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, University of Texas at Houston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biglan</LastName><ForeName>Kevin M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Rochester, Rochester, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bodis-Wollner</LastName><ForeName>Ivan</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>State University of New York, Downstate Medical Center, Brooklyn.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Bo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, University of Texas at Houston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Grace S</ForeName><Initials>GS</Initials><AffiliationInfo><Affiliation>The Parkinson's Institute and Clinical Center, Sunnyvale, California.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ross</LastName><ForeName>G Webster</ForeName><Initials>GW</Initials><AffiliationInfo><Affiliation>VA Pacific Islands Health Care System, Honolulu, Hawaii.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tilley</LastName><ForeName>Barbara C</ForeName><Initials>BC</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, University of Texas at Houston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shulman</LastName><ForeName>Lisa M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Maryland School of Medicine, Baltimore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>NET-PD Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00063193</AccessionNumber><AccessionNumber>NCT00076492</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>P50 NS038377</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 NS043127</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 NS043128</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 NS044466</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>JAMA Neurol</MedlineTA><NlmUniqueID>101589536</NlmUniqueID><ISSNLinking>2168-6149</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C486238">GPI 1485</NameOfSubstance></Chemical><Chemical><RegistryNumber>WM0HAQ4WNM</RegistryNumber><NameOfSubstance 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RefType="Cites"><RefSource>Ann Neurol. 2005 Feb;57(2):197-203</RefSource><PMID Version="1">15668964</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018450">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004311">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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Michael</ForeName><Initials>KM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Beal</LastName><ForeName>M Flint</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cummings</LastName><ForeName>Jeffrey L</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Geffen</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fahn</LastName><ForeName>Stanley</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Levin</LastName><ForeName>Bruce</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Katz</LastName><ForeName>Russell G</ForeName><Initials>RG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marin</LastName><ForeName>Deborah B</ForeName><Initials>DB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Olanow</LastName><ForeName>C Warren</ForeName><Initials>CW</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martin</LastName><ForeName>Jeffrey C</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>McDonald</LastName><ForeName>William</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Murphy</LastName><ForeName>Diane</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Piantadosi</LastName><ForeName>Steven</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Powers</LastName><ForeName>William J</ForeName><Initials>WJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Thal</LastName><ForeName>Leon J</ForeName><Initials>LJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wichman</LastName><ForeName>Alison</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marler</LastName><ForeName>John</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Odenkirchen</LastName><ForeName>Joanne</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ravina</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kieburtz</LastName><ForeName>Karl</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tilley</LastName><ForeName>Barbara</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shannon</LastName><ForeName>Kathleen</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tanner</LastName><ForeName>Caroline</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Deppen</LastName><ForeName>Patricia</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dewey</LastName><ForeName>Richard B</ForeName><Initials>RB</Initials><Suffix>Jr</Suffix></Investigator><Investigator ValidYN="Y"><LastName>Hayward</LastName><ForeName>Brigid</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Scott</LastName><ForeName>Burton</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Field</LastName><ForeName>Joanne</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brodsky</LastName><ForeName>Matthew</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Andrews</LastName><ForeName>Pamela</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Manyam</LastName><ForeName>Bala</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Whetteckey</LastName><ForeName>Jacqueline</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rao</LastName><ForeName>Jayaraman</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cook</LastName><ForeName>Maureen</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Aminoff</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Christine</LastName><ForeName>Chadwick</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Roth</LastName><ForeName>Jessie</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Parashos</LastName><ForeName>Sotirios</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shannon</LastName><ForeName>Kathleen</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jaglin</LastName><ForeName>Jeana</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Singer</LastName><ForeName>Carlos</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Perez</LastName><ForeName>Marian A</ForeName><Initials>MA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Blenke</LastName><ForeName>Anita</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hauser</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dunlop</LastName><ForeName>Becky</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lyons</LastName><ForeName>Kelly</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Parsons</LastName><ForeName>Amy</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leehey</LastName><ForeName>Maureen</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shulman</LastName><ForeName>Lisa</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pabst</LastName><ForeName>Katharine</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Elble</LastName><ForeName>Rodger</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Young</LastName><ForeName>Charlene</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sethi</LastName><ForeName>Kapil</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martin</LastName><ForeName>Wayne</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>McInnes</LastName><ForeName>Germaine</ForeName><Initials>G</Initials></Investigator><Investigator ValidYN="Y"><LastName>Calabrese</LastName><ForeName>Vincent P</ForeName><Initials>VP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Roberge</LastName><ForeName>Peggy</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hamill</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Homan</LastName><ForeName>Clare</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bodis-Wollner</LastName><ForeName>Ivan G</ForeName><Initials>IG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hayes</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ross</LastName><ForeName>Webster G</ForeName><Initials>WG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Terashita</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Trugman</LastName><ForeName>Joel</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Keller</LastName><ForeName>Margaret F</ForeName><Initials>MF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sage</LastName><ForeName>Jacob I</ForeName><Initials>JI</Initials></Investigator><Investigator ValidYN="Y"><LastName>Caputo</LastName><ForeName>Debbie</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shearon</LastName><ForeName>Dorothy</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kelsey</LastName><ForeName>Tammie</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Feigin</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Watts</LastName><ForeName>Ray L</ForeName><Initials>RL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stover</LastName><ForeName>Natividad</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>McMurray</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Reichwein</LastName><ForeName>Sue</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Simon</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tarsy</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Scollins</LastName><ForeName>Lisa</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tintner</LastName><ForeName>Ron</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hunter</LastName><ForeName>Christine</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>DeAngelis</LastName><ForeName>Maryan</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Burns</LastName><ForeName>Richard S</ForeName><Initials>RS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shill</LastName><ForeName>Holly</ForeName><Initials>H</Initials></Investigator><Investigator ValidYN="Y"><LastName>Danielson</LastName><ForeName>Jill</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marlor</LastName><ForeName>Lynn</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Adler</LastName><ForeName>Charles</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lind</LastName><ForeName>Marlene</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gorell</LastName><ForeName>Jay</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Krstevska</LastName><ForeName>Shana</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Schneider</LastName><ForeName>Jay</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gollomp</LastName><ForeName>Stephen</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jefferson</LastName><ForeName>Thomas</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Coffey</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lew</LastName><ForeName>Mark F</ForeName><Initials>MF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kawai</LastName><ForeName>Connie</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Turk</LastName><ForeName>Margaret</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bower</LastName><ForeName>James</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Handler</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Greenbaum</LastName><ForeName>Kathleen</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sabbagh</LastName><ForeName>Marwan</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Obradov</LastName><ForeName>Zoran</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Huang</LastName><ForeName>Peng</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Palesch</LastName><ForeName>Yuko</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kamp</LastName><ForeName>Cornelia</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shinaman</LastName><ForeName>Aileen</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Johnsen</LastName><ForeName>Debbie</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brocht</LastName><ForeName>Alicia</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Goetz</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fagan</LastName><ForeName>Susan</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gross</LastName><ForeName>Cynthia R</ForeName><Initials>CR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chen</LastName><ForeName>Donna T</ForeName><Initials>DT</Initials></Investigator><Investigator ValidYN="Y"><LastName>Levy</LastName><ForeName>David E</ForeName><Initials>DE</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marder</LastName><ForeName>Karen</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodnitzky</LastName><ForeName>Robert L</ForeName><Initials>RL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Welch</LastName><ForeName>K Michael</ForeName><Initials>KM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Beal</LastName><ForeName>M Flint</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fahn</LastName><ForeName>Stanley</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Levin</LastName><ForeName>Bruce</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Katz</LastName><ForeName>Russell G</ForeName><Initials>RG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marin</LastName><ForeName>Deborah B</ForeName><Initials>DB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Olanow</LastName><ForeName>C Warren</ForeName><Initials>CW</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martin</LastName><ForeName>Jeffrey C</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Murphy</LastName><ForeName>Diane</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Powers</LastName><ForeName>William J</ForeName><Initials>WJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Thal</LastName><ForeName>Leon J</ForeName><Initials>LJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wichman</LastName><ForeName>Alison</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marler</LastName><ForeName>John</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Odenkirchen</LastName><ForeName>Joanne</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shults</LastName><ForeName>Cliff</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kieburtz</LastName><ForeName>Karl</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ravina</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Galpern</LastName><ForeName>Wendy R</ForeName><Initials>WR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tilley</LastName><ForeName>Barbara</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shannon</LastName><ForeName>Kathleen</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tanner</LastName><ForeName>Caroline</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Wooten</LastName><ForeName>G Frederick</ForeName><Initials>GF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sage</LastName><ForeName>Jacob I</ForeName><Initials>JI</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kosa</LastName><ForeName>Emily</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Watts</LastName><ForeName>Ray L</ForeName><Initials>RL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stover</LastName><ForeName>Natividad R</ForeName><Initials>NR</Initials></Investigator><Investigator ValidYN="Y"><LastName>McMurray</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lew</LastName><ForeName>Mark F</ForeName><Initials>MF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kawai</LastName><ForeName>Connie</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Coffey</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>LeBlanc</LastName><ForeName>Pauline</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brodsky</LastName><ForeName>Matthew</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Andrews</LastName><ForeName>Pamela</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Siderowf</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shulman</LastName><ForeName>Lisa</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Weiner</LastName><ForeName>William J</ForeName><Initials>WJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pabst</LastName><ForeName>Katharine</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jaglin</LastName><ForeName>Jeana</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Suchowersky</LastName><ForeName>Oksana</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Derwent</LastName><ForeName>Lorelei</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rao</LastName><ForeName>Jayaraman</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cook</LastName><ForeName>Maureen</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Aminoff</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Christine</LastName><ForeName>Chad</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Roth</LastName><ForeName>Jessie</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leehey</LastName><ForeName>Maureen</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ross</LastName><ForeName>G Webster</ForeName><Initials>GW</Initials></Investigator><Investigator ValidYN="Y"><LastName>Terashita</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Perez</LastName><ForeName>Marian A</ForeName><Initials>MA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Blenke</LastName><ForeName>Anita</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Racette</LastName><ForeName>Brad</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Deppen</LastName><ForeName>Patricia</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Elble</LastName><ForeName>Rodger</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Young</LastName><ForeName>Charlene</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Stewart</LastName><ForeName>Tracy</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sethi</LastName><ForeName>Kapil</ForeName><Initials>K</Initials></Investigator><Investigator ValidYN="Y"><LastName>Taylor</LastName><ForeName>John</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Roberge</LastName><ForeName>Peggy</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dewey</LastName><ForeName>Richard B</ForeName><Initials>RB</Initials><Suffix>Jr</Suffix></Investigator><Investigator ValidYN="Y"><LastName>Hayward</LastName><ForeName>Brigid</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jankovic</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hunter</LastName><ForeName>Christine</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Keller</LastName><ForeName>Margaret F</ForeName><Initials>MF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jennings</LastName><ForeName>Danna</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Kelsey</LastName><ForeName>Tammie</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martin</LastName><ForeName>Wayne</ForeName><Initials>W</Initials></Investigator><Investigator ValidYN="Y"><LastName>Savitt</LastName><ForeName>Joseph</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Dunlop</LastName><ForeName>Becky</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pahwa</LastName><ForeName>Rajesh</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lyons</LastName><ForeName>Kelly E</ForeName><Initials>KE</Initials></Investigator><Investigator ValidYN="Y"><LastName>Parsons</LastName><ForeName>Amy</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fang</LastName><ForeName>John</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Shearon</LastName><ForeName>Dorothy</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Feigin</LastName><ForeName>Andrew</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marie</LastName><ForeName>Margaret</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Adler</LastName><ForeName>Charles</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lind</LastName><ForeName>Marlene</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Scott</LastName><ForeName>Burton</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Field</LastName><ForeName>Joanne</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nance</LastName><ForeName>Martha</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Peterson</LastName><ForeName>Susan</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Burns</LastName><ForeName>Richard S</ForeName><Initials>RS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marlor</LastName><ForeName>Lynn</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bodis-Wollner</LastName><ForeName>Ivan</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hayes</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sendek</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gollomp</LastName><ForeName>Stephen</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vernon</LastName><ForeName>Gwyn</ForeName><Initials>G</Initials></Investigator><Investigator 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