Mitochondrial Abnormalities in the Putamen in Parkinson’s Disease Dyskinesia
Identifieur interne : 000154 ( Pmc/Curation ); précédent : 000153; suivant : 000155Mitochondrial Abnormalities in the Putamen in Parkinson’s Disease Dyskinesia
Auteurs : Alipi Naydenov ; Fair Vassoler ; Andrew Luksik ; Joanna Kaczmarska ; Christine KonradiSource :
- Acta neuropathologica [ 0001-6322 ] ; 2010.
Abstract
Prolonged treatment of Parkinson’s disease with levodopa leads to disabling side effects collectively referred to as ‘dyskinesias’. We hypothesized that bioenergetic function in the putamen might play a crucial role in the development of dyskinesias. To test this hypothesis we used post-mortem samples of the human putamen and applied real time-PCR approaches and gene expression microarrays. We found that mitochondrial DNA levels are decreased in patients who have developed dyskinesias, and mitochondrial DNA damage is concomitantly increased. These pathologies were not observed in Parkinson’s disease subjects without signs of dyskinesias. The group of nuclear mRNA transcripts coding for the proteins of the mitochondrial electron transfer chain was decreased in patients with dyskinesias to a larger extent than in patients who had not developed dyskinesias. To examine if dopamine fluctuations affect mitochondrial DNA levels in dopaminoceptive neurons, rat striatal neurons in culture were repeatedly exposed to levodopa, dopamine or their metabolites. Mitochondrial DNA levels were reduced after treatment with dopamine, but not after treatment with dopamine metabolites. Levodopa led to an increase in mitochondrial DNA levels. We conclude that mitochondrial susceptibility in the putamen plays a role in the development of dyskinesias.
Url:
DOI: 10.1007/s00401-010-0740-8
PubMed: 20740286
PubMed Central: 2955799
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Alipi Naydenov<affiliation><nlm:aff id="A1">Departments of Pharmacology and Psychiatry, Vanderbilt University, Nashville, Tennessee, 37232</nlm:aff>
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<affiliation><nlm:aff id="A2">Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee, 37232</nlm:aff>
<wicri:noCountry code="subfield">37232</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A1">Departments of Pharmacology and Psychiatry, Vanderbilt University, Nashville, Tennessee, 37232</nlm:aff>
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<affiliation><nlm:aff id="A1">Departments of Pharmacology and Psychiatry, Vanderbilt University, Nashville, Tennessee, 37232</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p id="P1">Prolonged treatment of Parkinson’s disease with levodopa leads to disabling side effects collectively referred to as ‘dyskinesias’. We hypothesized that bioenergetic function in the putamen might play a crucial role in the development of dyskinesias. To test this hypothesis we used post-mortem samples of the human putamen and applied real time-PCR approaches and gene expression microarrays. We found that mitochondrial DNA levels are decreased in patients who have developed dyskinesias, and mitochondrial DNA damage is concomitantly increased. These pathologies were not observed in Parkinson’s disease subjects without signs of dyskinesias. The group of nuclear mRNA transcripts coding for the proteins of the mitochondrial electron transfer chain was decreased in patients with dyskinesias to a larger extent than in patients who had not developed dyskinesias. To examine if dopamine fluctuations affect mitochondrial DNA levels in dopaminoceptive neurons, rat striatal neurons in culture were repeatedly exposed to levodopa, dopamine or their metabolites. Mitochondrial DNA levels were reduced after treatment with dopamine, but not after treatment with dopamine metabolites. Levodopa led to an increase in mitochondrial DNA levels. We conclude that mitochondrial susceptibility in the putamen plays a role in the development of dyskinesias.</p>
</div>
</front>
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<title-group><article-title>Mitochondrial Abnormalities in the Putamen in Parkinson’s Disease Dyskinesia</article-title>
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Departments of Pharmacology and Psychiatry, Vanderbilt University, Nashville, Tennessee, 37232</aff>
<aff id="A2"><label>2</label>
Center for Molecular Neuroscience, Vanderbilt University, Nashville, Tennessee, 37232</aff>
<aff id="A3"><label>3</label>
Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, Tennessee, 37203</aff>
<author-notes><corresp id="cor1">Send correspondence to: Christine Konradi, Ph.D., Vanderbilt University, Department of Pharmacology, MRB 3, Room 8160, 465 21st Avenue South, Nashville TN 37232-8548; USA, Tel: 615-936-1021, Fax: 615-936-0484, <email>christine.konradi@vanderbilt.edu</email>
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<abstract><p id="P1">Prolonged treatment of Parkinson’s disease with levodopa leads to disabling side effects collectively referred to as ‘dyskinesias’. We hypothesized that bioenergetic function in the putamen might play a crucial role in the development of dyskinesias. To test this hypothesis we used post-mortem samples of the human putamen and applied real time-PCR approaches and gene expression microarrays. We found that mitochondrial DNA levels are decreased in patients who have developed dyskinesias, and mitochondrial DNA damage is concomitantly increased. These pathologies were not observed in Parkinson’s disease subjects without signs of dyskinesias. The group of nuclear mRNA transcripts coding for the proteins of the mitochondrial electron transfer chain was decreased in patients with dyskinesias to a larger extent than in patients who had not developed dyskinesias. To examine if dopamine fluctuations affect mitochondrial DNA levels in dopaminoceptive neurons, rat striatal neurons in culture were repeatedly exposed to levodopa, dopamine or their metabolites. Mitochondrial DNA levels were reduced after treatment with dopamine, but not after treatment with dopamine metabolites. Levodopa led to an increase in mitochondrial DNA levels. We conclude that mitochondrial susceptibility in the putamen plays a role in the development of dyskinesias.</p>
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