Visual Hallucinations in Posterior Cortical Atrophy
Identifieur interne : 000146 ( Pmc/Curation ); précédent : 000145; suivant : 000147Visual Hallucinations in Posterior Cortical Atrophy
Auteurs : Keith Josephs [États-Unis] ; Jennifer Whitwell [États-Unis] ; Bradley Boeve [États-Unis] ; David Knopman [États-Unis] ; David Tang ; Daniel Drubach [États-Unis] ; Clifford Jack [États-Unis] ; Ronald Petersen [États-Unis]Source :
- Archives of neurology [ 0003-9942 ] ; 2006.
Abstract
To compare clinical and imaging features of patients with posterior cortical atrophy (PCA) with and without well-formed visual hallucinations.
Tertiary care medical center
Fifty-nine patients fulfilling criteria for PCA were retrospectively identified, and divided into two groups based on the presence (N=13) and absence (N=46) of visual hallucinations. Both groups were then compared statistically for clinical differences, as well as with voxel-based morphometry (VBM) for imaging differences.
In PCA patients with hallucinations, parkinsonism and rapid eye movement sleep behavior disorder occurred more frequently (p<0.0001), as did myoclonic jerks (p=0.0002). VBM analysis showed greater atrophy in a network of structures, including the primary visual cortex, lentiform nuclei, thalamus, basal forebrain and midbrain in the patients with hallucinations.
Hallucinations in patients with PCA are associated with parkinsonism, rapid eye movement sleep behavior disorder, and myoclonic jerks. The results from the VBM analysis suggest that hallucinations in PCA cannot be exclusively attributed to atrophy of the posterior association cortices and may involve a circuit of thalamocortical connections.
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DOI: 10.1001/archneur.63.10.1427
PubMed: 17030659
PubMed Central: 2748870
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David Tang<affiliation><nlm:aff id="A4"> Department of Medicine (Neurology), University of Toronto, Toronto ON</nlm:aff><wicri:noCountry code="subfield">Toronto ON</wicri:noCountry></affiliation>Le document en format XML
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(Behavioral Neurology), Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford" last="Jack">Clifford Jack</name><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Radiology Research, Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Radiology Research, Mayo Clinic Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald" last="Petersen">Ronald Petersen</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17030659</idno><idno type="pmc">2748870</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748870</idno><idno type="RBID">PMC:2748870</idno><idno type="doi">10.1001/archneur.63.10.1427</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">000146</idno><idno type="wicri:Area/Pmc/Curation">000146</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Visual Hallucinations in Posterior Cortical Atrophy</title><author><name sortKey="Josephs, Keith A" sort="Josephs, Keith A" uniqKey="Josephs K" first="Keith" last="Josephs">Keith Josephs</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Whitwell, Jennifer L" sort="Whitwell, Jennifer L" uniqKey="Whitwell J" first="Jennifer" last="Whitwell">Jennifer Whitwell</name><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Radiology Research, Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Radiology Research, Mayo Clinic Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley" last="Boeve">Bradley Boeve</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Sleep Medicine, Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Sleep Medicine, Mayo Clinic Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David" last="Knopman">David Knopman</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Tang Wai, David F" sort="Tang Wai, David F" uniqKey="Tang Wai D" first="David" last="Tang">David Tang</name><affiliation><nlm:aff id="A4"> Department of Medicine (Neurology), University of Toronto, Toronto ON</nlm:aff><wicri:noCountry code="subfield">Toronto ON</wicri:noCountry></affiliation></author><author><name sortKey="Drubach, Daniel A" sort="Drubach, Daniel A" uniqKey="Drubach D" first="Daniel" last="Drubach">Daniel Drubach</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford" last="Jack">Clifford Jack</name><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Radiology Research, Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Radiology Research, Mayo Clinic Rochester</wicri:cityArea></affiliation></author><author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald" last="Petersen">Ronald Petersen</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester, MN</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester</wicri:cityArea></affiliation></author></analytic><series><title level="j">Archives of neurology</title><idno type="ISSN">0003-9942</idno><idno type="e-ISSN">1538-3687</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To compare clinical and imaging features of patients with posterior cortical atrophy (PCA) with and without well-formed visual hallucinations.</p></sec><sec id="S2"><title>Setting</title><p id="P2">Tertiary care medical center</p></sec><sec sec-type="methods" id="S3"><title>Methods</title><p id="P3">Fifty-nine patients fulfilling criteria for PCA were retrospectively identified, and divided into two groups based on the presence (N=13) and absence (N=46) of visual hallucinations. Both groups were then compared statistically for clinical differences, as well as with voxel-based morphometry (VBM) for imaging differences.</p></sec><sec id="S4"><title>Results</title><p id="P4">In PCA patients with hallucinations, parkinsonism and rapid eye movement sleep behavior disorder occurred more frequently (p<0.0001), as did myoclonic jerks (p=0.0002). VBM analysis showed greater atrophy in a network of structures, including the primary visual cortex, lentiform nuclei, thalamus, basal forebrain and midbrain in the patients with hallucinations.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">Hallucinations in patients with PCA are associated with parkinsonism, rapid eye movement sleep behavior disorder, and myoclonic jerks. The results from the VBM analysis suggest that hallucinations in PCA cannot be exclusively attributed to atrophy of the posterior association cortices and may involve a circuit of thalamocortical connections.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0372436</journal-id><journal-id journal-id-type="pubmed-jr-id">804</journal-id><journal-id journal-id-type="nlm-ta">Arch Neurol</journal-id><journal-title>Archives of neurology</journal-title><issn pub-type="ppub">0003-9942</issn><issn pub-type="epub">1538-3687</issn></journal-meta><article-meta><article-id pub-id-type="pmid">17030659</article-id><article-id pub-id-type="pmc">2748870</article-id><article-id pub-id-type="doi">10.1001/archneur.63.10.1427</article-id><article-id pub-id-type="manuscript">NIHMS138413</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Visual Hallucinations in Posterior Cortical Atrophy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Josephs</surname><given-names>Keith A.</given-names></name><degrees>MST, MD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Whitwell</surname><given-names>Jennifer L.</given-names></name><degrees>PhD</degrees><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Boeve</surname><given-names>Bradley F.</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref><xref rid="A3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Knopman</surname><given-names>David S.</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Tang-Wai</surname><given-names>David F.</given-names></name><degrees>MDCM, FRCPC</degrees><xref rid="A4" ref-type="aff">4</xref></contrib><contrib contrib-type="author"><name><surname>Drubach</surname><given-names>Daniel A.</given-names></name><degrees>MD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Jack</surname><given-names>Clifford R.</given-names><suffix>Jr</suffix></name><degrees>MD</degrees><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Petersen</surname><given-names>Ronald C.</given-names></name><degrees>MD, PhD</degrees><xref rid="A1" ref-type="aff">1</xref></contrib></contrib-group><aff id="A1"><label>1</label> Department of Neurology (Behavioral Neurology), Mayo Clinic Rochester, MN</aff><aff id="A2"><label>2</label> Department of Radiology Research, Mayo Clinic Rochester, MN</aff><aff id="A3"><label>3</label> Department of Sleep Medicine, Mayo Clinic Rochester, MN</aff><aff id="A4"><label>4</label> Department of Medicine (Neurology), University of Toronto, Toronto ON</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding Author: Keith A. Josephs, MST, MD, Department of Neurology, Divisions of Movement Disorders & Behavioral Neurology, Mayo Clinic, Rochester, MN 55905, Tele: (507) -538-1038, Fax: (507) -538-6012, <email>josephs.keith@mayo.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>25</day><month>8</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2006</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>9</month><year>2009</year></pub-date><volume>63</volume><issue>10</issue><fpage>1427</fpage><lpage>1432</lpage><abstract><sec id="S1"><title>Objective</title><p id="P1">To compare clinical and imaging features of patients with posterior cortical atrophy (PCA) with and without well-formed visual hallucinations.</p></sec><sec id="S2"><title>Setting</title><p id="P2">Tertiary care medical center</p></sec><sec sec-type="methods" id="S3"><title>Methods</title><p id="P3">Fifty-nine patients fulfilling criteria for PCA were retrospectively identified, and divided into two groups based on the presence (N=13) and absence (N=46) of visual hallucinations. Both groups were then compared statistically for clinical differences, as well as with voxel-based morphometry (VBM) for imaging differences.</p></sec><sec id="S4"><title>Results</title><p id="P4">In PCA patients with hallucinations, parkinsonism and rapid eye movement sleep behavior disorder occurred more frequently (p<0.0001), as did myoclonic jerks (p=0.0002). VBM analysis showed greater atrophy in a network of structures, including the primary visual cortex, lentiform nuclei, thalamus, basal forebrain and midbrain in the patients with hallucinations.</p></sec><sec id="S5"><title>Conclusions</title><p id="P5">Hallucinations in patients with PCA are associated with parkinsonism, rapid eye movement sleep behavior disorder, and myoclonic jerks. The results from the VBM analysis suggest that hallucinations in PCA cannot be exclusively attributed to atrophy of the posterior association cortices and may involve a circuit of thalamocortical connections.</p></sec></abstract><kwd-group><kwd>Parkinsonism</kwd><kwd>Thalamus</kwd><kwd>Myoclonic jerks</kwd><kwd>REM sleep</kwd><kwd>Voxel based morphometry</kwd></kwd-group><contract-num rid="AG1">U01 AG006786-23</contract-num><contract-num rid="AG1">R01 AG011378-15</contract-num><contract-num rid="AG1">P50 AG016574-080004</contract-num><contract-num rid="HD1">K12 HD049078-01</contract-num><contract-sponsor id="AG1">National Institute on Aging : NIA</contract-sponsor><contract-sponsor id="HD1">National Institute of Child Health & Human Development : NICHD</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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