Pure akinesia: an atypical manifestation of progressive supranuclear palsy.
Identifieur interne : 000057 ( Pmc/Curation ); précédent : 000056; suivant : 000058Pure akinesia: an atypical manifestation of progressive supranuclear palsy.
Auteurs : H. Matsuo ; H. Takashima ; M. Kishikawa ; I. Kinoshita ; M. Mori ; M. Tsujihata ; S. NagatakiSource :
- Journal of Neurology, Neurosurgery, and Psychiatry [ 0022-3050 ] ; 1991.
Abstract
Two patients with "pure akinesia" who showed the characteristic changes of progressive supranuclear palsy (PSP) at necropsy are described. They had akinesia but no rigidity or tremor, and ophthalmoplegia was not observed during the course of illness. The symptoms of "pure akinesia" was not improved by levodopa therapy but was considerably improved by L-threo-3,4-dihydroxy-phenylserine. At necropsy, pathological findings were not different from those reported for PSP. It is suggested that "pure akinesia" is an atypical manifestation of PSP, and that norepinephrinergic neurons may be involved in some types of PSP.
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PubMed: 1865200
PubMed Central: 488536
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Neurol Neurosurg Psychiatry</journal-id><journal-title>Journal of Neurology, Neurosurgery, and Psychiatry</journal-title><issn pub-type="ppub">0022-3050</issn><issn pub-type="epub">1468-330X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">1865200</article-id><article-id pub-id-type="pmc">488536</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Pure akinesia: an atypical manifestation of progressive supranuclear palsy.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Matsuo</surname><given-names>H</given-names></name></contrib><contrib contrib-type="author"><name><surname>Takashima</surname><given-names>H</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kishikawa</surname><given-names>M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kinoshita</surname><given-names>I</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mori</surname><given-names>M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tsujihata</surname><given-names>M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nagataki</surname><given-names>S</given-names></name></contrib></contrib-group><aff>First Department of Internal Medicine, Nagasaki University, School of Medicine, Japan.</aff><pub-date pub-type="ppub"><month>5</month><year>1991</year></pub-date><volume>54</volume><issue>5</issue><fpage>397</fpage><lpage>400</lpage><abstract><p>Two patients with "pure akinesia" who showed the characteristic changes of progressive supranuclear palsy (PSP) at necropsy are described. They had akinesia but no rigidity or tremor, and ophthalmoplegia was not observed during the course of illness. The symptoms of "pure akinesia" was not improved by levodopa therapy but was considerably improved by L-threo-3,4-dihydroxy-phenylserine. At necropsy, pathological findings were not different from those reported for PSP. It is suggested that "pure akinesia" is an atypical manifestation of PSP, and that norepinephrinergic neurons may be involved in some types of PSP.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><graphic xlink:href="jnnpsyc00503-0014-a" xlink:role="398"></graphic></fig><fig id="F2"><graphic xlink:href="jnnpsyc00503-0015-a" xlink:role="399"></graphic></fig><fig id="F3"><graphic xlink:href="jnnpsyc00503-0015-b" xlink:role="399"></graphic></fig></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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