Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease
Identifieur interne : 000286 ( Pmc/Corpus ); précédent : 000285; suivant : 000287Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease
Auteurs : Chuong Do ; Joyce Tung ; Elizabeth Dorfman ; Amy Kiefer ; Emily Drabant ; Uta Francke ; Joanna Mountain ; Samuel Goldman ; Caroline Tanner ; J Langston ; Anne Wojcicki ; Nicholas ErikssonSource :
- PLoS Genetics [ 1553-7390 ] ; 2011.
Abstract
Although the causes of Parkinson's disease (PD) are thought to be primarily environmental, recent studies suggest that a number of genes influence susceptibility. Using targeted case recruitment and online survey instruments, we conducted the largest case-control genome-wide association study (GWAS) of PD based on a single collection of individuals to date (3,426 cases and 29,624 controls). We discovered two novel, genome-wide significant associations with PD–rs6812193 near
Url:
DOI: 10.1371/journal.pgen.1002141
PubMed: 21738487
PubMed Central: 3121750
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