Cerebrospinal Fluid α-Synuclein Predicts Cognitive Decline in Parkinson Disease Progression in the DATATOP Cohort
Identifieur interne : 000221 ( Pmc/Corpus ); précédent : 000220; suivant : 000222Cerebrospinal Fluid α-Synuclein Predicts Cognitive Decline in Parkinson Disease Progression in the DATATOP Cohort
Auteurs : Tessandra Stewart ; Changqin Liu ; Carmen Ginghina ; Kevin Cain ; Peggy Auinger ; Brenna Cholerton ; Min Shi ; Jing ZhangSource :
- The American Journal of Pathology [ 0002-9440 ] ; 2014.
Abstract
Most patients with Parkinson disease (PD) develop both cognitive and motor impairment, and biomarkers for progression are urgently needed. Although α-synuclein is altered in cerebrospinal fluid of patients with PD, it is not known whether it predicts motor or cognitive deterioration. We examined clinical data and α-synuclein in >300 unmedicated patients with PD who participated in the deprenyl and tocopherol antioxidative therapy of parkinsonism (DATATOP) study, with up to 8 years of follow-up. Longitudinal measures of motor and cognitive function were studied before (phase 1) and during (phase 2) levodopa therapy; cerebrospinal fluid was collected at the beginning of each phase. Correlations and linear mixed models were used to assess α-synuclein association with disease severity and prediction of progression in the subsequent follow-up period. Despite decreasing α-synuclein (phase 1 to phase 2 change of −0.05 ± 0.21 log-transformed values,
Url:
DOI: 10.1016/j.ajpath.2013.12.007
PubMed: 24625392
PubMed Central: 3969999
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