Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease
Identifieur interne : 000156 ( Pmc/Corpus ); précédent : 000155; suivant : 000157Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease
Auteurs : Todd Edwards ; William Scott ; Cherylyn Almonte ; Amber Burt ; Eric Powell ; Gary Beecham ; Liyong Wang ; Stephan Züchner ; Ioanna Konidari ; Gaofeng Wang ; Carlos Singer ; Fatta Nahab ; Burton Scott ; Jeffrey Stajich ; Margaret Pericak ; Jonathan Haines ; Jeffery Vance ; Eden MartinSource :
- Annals of human genetics [ 0003-4800 ] ; 2010.
Abstract
Parkinson disease (PD) is a chronic neurodegenerative disorder with a cumulative prevalence of greater than one per thousand. To date three independent genome-wide association studies (GWAS) have investigated the genetic susceptibility to PD. These studies have also implicated several genes as PD risk loci with strong, but not genome-wide significant, associations.
In this study, we combined data from two previously published GWAS of Caucasian subjects with our GWAS of 604 cases and 619 controls for a joint analysis with a combined sample size of 1752 cases and 1745 controls. SNPs in
Url:
DOI: 10.1111/j.1469-1809.2009.00560.x
PubMed: 20070850
PubMed Central: 2853717
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