Antiparkinsonian drug-induced sleepiness: a double-blind placebo-controlled study of L-dopa, bromocriptine and pramipexole in healthy subjects
Identifieur interne : 000131 ( Pmc/Corpus ); précédent : 000130; suivant : 000132Antiparkinsonian drug-induced sleepiness: a double-blind placebo-controlled study of L-dopa, bromocriptine and pramipexole in healthy subjects
Auteurs : Joëlle Micallef ; Marc Rey ; Alexandre Eusebio ; Christine Audebert ; Frank Rouby ; Elisabeth Jouve ; Sophie Tardieu ; Oliver BlinSource :
- British Journal of Clinical Pharmacology [ 0306-5251 ] ; 2009.
Abstract
To assess the sleepiness induced by pramipexole, a D2/D3-dopamine receptor agonist commonly used in Parkinson's disease and restless legs syndrome, without the problem of the confounding factors related to the disease.
Placebo, bromocriptine (2.5 mg), L-dopa (100 mg) and pramipexole (0.5 mg) were administered in a single oral dose on four separate days, with at least a 2-week wash-out period in a randomized cross-over design. Induced somnolence was assessed using Multiple Sleep Latency Test (MSLT) and subjective scaling of vigilance. Twelve male subjects (26.3 ± 5.5 years old) without anxiety, mood, sleep or sedation disorders were enrolled.
Pramipexole significantly reduced mean sleep latency compared with placebo 3 h 30 min [−6.1 min (−9.8, −2.4),
These results show that a single oral dose of pramipexole induces sleepiness as assessed by MSLT in healthy young subjects, independent of disease-related sleep dysfunction.
Url:
DOI: 10.1111/j.1365-2125.2008.03310.x
PubMed: 19220275
PubMed Central: 2675044
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