Dietary intake in adults at risk for Huntington disease
Identifieur interne : 000196 ( Pmc/Checkpoint ); précédent : 000195; suivant : 000197Dietary intake in adults at risk for Huntington disease
Auteurs : K. Marder ; H. Zhao ; S. Eberly ; C Tanner ; D. Oakes ; I. ShoulsonSource :
- Neurology [ 0028-3878 ] ; 2009.
Abstract
To examine caloric intake, dietary composition, and body mass index (BMI) in participants in the Prospective Huntington At Risk Observational Study (PHAROS).
Caloric intake and macronutrient composition were measured using the National Cancer Institute Food Frequency Questionnaire (FFQ) in 652 participants at risk for Huntington disease (HD) who did not meet clinical criteria for HD. Logistic regression was used to examine the relationship between macronutrients, BMI, caloric intake, and genetic status (CAG <37 vs CAG ≥37), adjusting for age, gender, and education. Linear regression was used to determine the relationship between caloric intake, BMI, and CAG repeat length.
A total of 435 participants with CAG <37 and 217 with CAG ≥37 completed the FFQ. Individuals in the CAG ≥37 group had a twofold odds of being represented in the second, third, or fourth quartile of caloric intake compared to the lowest quartile adjusted for age, gender, education, and BMI. This relationship was attenuated in the highest quartile when additionally adjusted for total motor score. In subjects with CAG ≥37, higher caloric intake, but not BMI, was associated with both higher CAG repeat length (adjusted regression coefficient = 0.26,
Increased caloric intake may be necessary to maintain body mass index in clinically unaffected individuals with CAG repeat length ≥37. This may be related to increased energy expenditure due to subtle motor impairment or a hypermetabolic state.
= basal energy expenditure;
= body mass index;
= Food Frequency Questionnaire;
= Huntington disease;
= odds ratio;
= Parkinson disease;
= Prospective Huntington At Risk Observational Study;
= total energy expenditure;
= Unified Huntington’s Disease Rating Scale.
Url:
DOI: 10.1212/WNL.0b013e3181b04aa2
PubMed: 19652143
PubMed Central: 2725927
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Dietary intake in adults at risk for Huntington disease</title><author><name sortKey="Marder, K" sort="Marder, K" uniqKey="Marder K" first="K" last="Marder">K. Marder</name></author><author><name sortKey="Zhao, H" sort="Zhao, H" uniqKey="Zhao H" first="H" last="Zhao">H. Zhao</name></author><author><name sortKey="Eberly, S" sort="Eberly, S" uniqKey="Eberly S" first="S" last="Eberly">S. Eberly</name></author><author><name sortKey="Tanner, C M" sort="Tanner, C M" uniqKey="Tanner C" first="C" last="Tanner">C Tanner</name></author><author><name sortKey="Oakes, D" sort="Oakes, D" uniqKey="Oakes D" first="D" last="Oakes">D. Oakes</name></author><author><name sortKey="Shoulson, I" sort="Shoulson, I" uniqKey="Shoulson I" first="I" last="Shoulson">I. Shoulson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19652143</idno><idno type="pmc">2725927</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725927</idno><idno type="RBID">PMC:2725927</idno><idno type="doi">10.1212/WNL.0b013e3181b04aa2</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000097</idno><idno type="wicri:Area/Pmc/Curation">000097</idno><idno type="wicri:Area/Pmc/Checkpoint">000196</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dietary intake in adults at risk for Huntington disease</title><author><name sortKey="Marder, K" sort="Marder, K" uniqKey="Marder K" first="K" last="Marder">K. Marder</name></author><author><name sortKey="Zhao, H" sort="Zhao, H" uniqKey="Zhao H" first="H" last="Zhao">H. Zhao</name></author><author><name sortKey="Eberly, S" sort="Eberly, S" uniqKey="Eberly S" first="S" last="Eberly">S. Eberly</name></author><author><name sortKey="Tanner, C M" sort="Tanner, C M" uniqKey="Tanner C" first="C" last="Tanner">C Tanner</name></author><author><name sortKey="Oakes, D" sort="Oakes, D" uniqKey="Oakes D" first="D" last="Oakes">D. Oakes</name></author><author><name sortKey="Shoulson, I" sort="Shoulson, I" uniqKey="Shoulson I" first="I" last="Shoulson">I. Shoulson</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="e-ISSN">1526-632X</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To examine caloric intake, dietary composition, and body mass index (BMI) in participants in the Prospective Huntington At Risk Observational Study (PHAROS).</p></sec><sec><title>Methods:</title><p>Caloric intake and macronutrient composition were measured using the National Cancer Institute Food Frequency Questionnaire (FFQ) in 652 participants at risk for Huntington disease (HD) who did not meet clinical criteria for HD. Logistic regression was used to examine the relationship between macronutrients, BMI, caloric intake, and genetic status (CAG <37 vs CAG ≥37), adjusting for age, gender, and education. Linear regression was used to determine the relationship between caloric intake, BMI, and CAG repeat length.</p></sec><sec><title>Results:</title><p>A total of 435 participants with CAG <37 and 217 with CAG ≥37 completed the FFQ. Individuals in the CAG ≥37 group had a twofold odds of being represented in the second, third, or fourth quartile of caloric intake compared to the lowest quartile adjusted for age, gender, education, and BMI. This relationship was attenuated in the highest quartile when additionally adjusted for total motor score. In subjects with CAG ≥37, higher caloric intake, but not BMI, was associated with both higher CAG repeat length (adjusted regression coefficient = 0.26, <italic>p</italic> = 0.032) and 5-year probability of onset of HD (adjusted regression coefficient = 0.024; <italic>p</italic> = 0.013). Adjusted analyses showed no differences in macronutrient composition between groups.</p></sec><sec><title>Conclusions:</title><p>Increased caloric intake may be necessary to maintain body mass index in clinically unaffected individuals with CAG repeat length ≥37. This may be related to increased energy expenditure due to subtle motor impairment or a hypermetabolic state.</p></sec><sec><title>GLOSSARY</title><def-list list-type="abr"><def-item><term><bold>BEE</bold></term><def><p> = basal energy expenditure; </p></def></def-item><def-item><term><bold>BMI</bold></term><def><p> = body mass index; </p></def></def-item><def-item><term><bold>FFQ</bold></term><def><p> = Food Frequency Questionnaire; </p></def></def-item><def-item><term><bold>HD</bold></term><def><p> = Huntington disease; </p></def></def-item><def-item><term><bold>OR</bold></term><def><p> = odds ratio; </p></def></def-item><def-item><term><bold>PD</bold></term><def><p> = Parkinson disease; </p></def></def-item><def-item><term><bold>PHAROS</bold></term><def><p> = Prospective Huntington At Risk Observational Study; </p></def></def-item><def-item><term><bold>TEE</bold></term><def><p> = total energy expenditure; </p></def></def-item><def-item><term><bold>UHDRS</bold></term><def><p> = Unified Huntington’s Disease Rating Scale.</p></def></def-item></def-list></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurology</journal-id><journal-title>Neurology</journal-title><issn pub-type="ppub">0028-3878</issn><issn pub-type="epub">1526-632X</issn><publisher><publisher-name>American Academy of Neurology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19652143</article-id><article-id pub-id-type="pmc">2725927</article-id><article-id pub-id-type="publisher-id">znl02909000385</article-id><article-id pub-id-type="doi">10.1212/WNL.0b013e3181b04aa2</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Dietary intake in adults at risk for Huntington disease</article-title><subtitle>Analysis of PHAROS Research Participants</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Marder</surname><given-names>K</given-names></name><degrees>MD, MPH</degrees></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>H</given-names></name><degrees>ScD</degrees></contrib><contrib contrib-type="author"><name><surname>Eberly</surname><given-names>S</given-names></name><degrees>MS</degrees></contrib><contrib contrib-type="author"><name><surname>Tanner</surname><given-names>C M.</given-names></name><degrees>MD, PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Oakes</surname><given-names>D</given-names></name><degrees>PhD</degrees></contrib><contrib contrib-type="author"><name><surname>Shoulson</surname><given-names>I</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><collab>On behalf of the Huntington Study Group</collab><xref ref-type="aff" rid="N0x1c72920N0x2ba51c8">*</xref></contrib></contrib-group><aff id="N0x1c72920N0x2ba51c8">From the Departments of Neurology and Psychiatry, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center (K.M.), Columbia University, New York, NY; Department of Epidemiology and Biostatistics (H.Z.), Texas A&M Health Science Center, College Station; Departments of Biostatistics (S.E., D.O.) and Neurology (I.S.), University of Rochester, NY; and Parkinson’s Institute (C.M.T.), Sunnyvale, CA.<break></break></aff><pub-date pub-type="ppub"><day>4</day><month>8</month><year>2009</year></pub-date><volume>73</volume><issue>5</issue><fpage>385</fpage><lpage>392</lpage><copyright-statement>Copyright © 2009 by AAN Enterprises, Inc.</copyright-statement><abstract><sec><title>Objective:</title><p>To examine caloric intake, dietary composition, and body mass index (BMI) in participants in the Prospective Huntington At Risk Observational Study (PHAROS).</p></sec><sec><title>Methods:</title><p>Caloric intake and macronutrient composition were measured using the National Cancer Institute Food Frequency Questionnaire (FFQ) in 652 participants at risk for Huntington disease (HD) who did not meet clinical criteria for HD. Logistic regression was used to examine the relationship between macronutrients, BMI, caloric intake, and genetic status (CAG <37 vs CAG ≥37), adjusting for age, gender, and education. Linear regression was used to determine the relationship between caloric intake, BMI, and CAG repeat length.</p></sec><sec><title>Results:</title><p>A total of 435 participants with CAG <37 and 217 with CAG ≥37 completed the FFQ. Individuals in the CAG ≥37 group had a twofold odds of being represented in the second, third, or fourth quartile of caloric intake compared to the lowest quartile adjusted for age, gender, education, and BMI. This relationship was attenuated in the highest quartile when additionally adjusted for total motor score. In subjects with CAG ≥37, higher caloric intake, but not BMI, was associated with both higher CAG repeat length (adjusted regression coefficient = 0.26, <italic>p</italic> = 0.032) and 5-year probability of onset of HD (adjusted regression coefficient = 0.024; <italic>p</italic> = 0.013). Adjusted analyses showed no differences in macronutrient composition between groups.</p></sec><sec><title>Conclusions:</title><p>Increased caloric intake may be necessary to maintain body mass index in clinically unaffected individuals with CAG repeat length ≥37. This may be related to increased energy expenditure due to subtle motor impairment or a hypermetabolic state.</p></sec><sec><title>GLOSSARY</title><def-list list-type="abr"><def-item><term><bold>BEE</bold></term><def><p> = basal energy expenditure; </p></def></def-item><def-item><term><bold>BMI</bold></term><def><p> = body mass index; </p></def></def-item><def-item><term><bold>FFQ</bold></term><def><p> = Food Frequency Questionnaire; </p></def></def-item><def-item><term><bold>HD</bold></term><def><p> = Huntington disease; </p></def></def-item><def-item><term><bold>OR</bold></term><def><p> = odds ratio; </p></def></def-item><def-item><term><bold>PD</bold></term><def><p> = Parkinson disease; </p></def></def-item><def-item><term><bold>PHAROS</bold></term><def><p> = Prospective Huntington At Risk Observational Study; </p></def></def-item><def-item><term><bold>TEE</bold></term><def><p> = total energy expenditure; </p></def></def-item><def-item><term><bold>UHDRS</bold></term><def><p> = Unified Huntington’s Disease Rating Scale.</p></def></def-item></def-list></sec></abstract></article-meta><notes><p>Address correspondence and reprint requests to Dr. Karen Marder, 630 W. 168th St. Unit 16, Columbia University College of Physicians and Surgeons, New York, NY 10032 <email>ksm1@columbia.edu</email></p><p>*PHAROS co-investigators are listed in the <xref rid="a1-6786" ref-type="app">appendix</xref>.</p><p><italic>Disclosure:</italic> Author disclosures are provided at the end of the article.</p><p>Received September 2, 2008. Accepted in final form May 1, 2009.</p></notes></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Eberly, S" sort="Eberly, S" uniqKey="Eberly S" first="S" last="Eberly">S. Eberly</name><name sortKey="Marder, K" sort="Marder, K" uniqKey="Marder K" first="K" last="Marder">K. Marder</name><name sortKey="Oakes, D" sort="Oakes, D" uniqKey="Oakes D" first="D" last="Oakes">D. Oakes</name><name sortKey="Shoulson, I" sort="Shoulson, I" uniqKey="Shoulson I" first="I" last="Shoulson">I. Shoulson</name><name sortKey="Tanner, C M" sort="Tanner, C M" uniqKey="Tanner C" first="C" last="Tanner">C Tanner</name><name sortKey="Zhao, H" sort="Zhao, H" uniqKey="Zhao H" first="H" last="Zhao">H. Zhao</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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