Incorporating genetics and genomics in risk assessment for inhaled manganese: From data to policy
Identifieur interne : 000188 ( Pmc/Checkpoint ); précédent : 000187; suivant : 000189Incorporating genetics and genomics in risk assessment for inhaled manganese: From data to policy
Auteurs : Christine Curran [États-Unis] ; Robert Park [États-Unis] ; Shuk Ho [États-Unis] ; Erin Haynes [États-Unis]Source :
- Neurotoxicology [ 0161-813X ] ; 2009.
Abstract
Manganese is an essential nutrient, and a healthy human with good liver and kidney function can easily excrete excess dietary manganese. Inhaled manganese is a greater concern, because it bypasses the body’s normal homeostatic mechanisms and can accumulate in the brain. Prolonged exposure to high manganese concentrations (>1 mg/m3) in air leads to a Parkinsonian syndrome known as “manganism.” Of greatest concern are recent studies which indicate that neurological and neurobehavioral deficits can occur when workers are exposed to much lower levels (<0.2 mg/m3) of inhaled manganese in welding fumes. Consequently, researchers at NIOSH are conducting a risk assessment for inhaled manganese. Novel components of this risk assessment include an attempt to quantify the range of inter-individual differences using data generated by the Human Genome Project and experimental work to identify genetically based biomarkers of exposure, disease and susceptibility. The difficulties involved in moving from epidemiological and in vivo data to health-based quantitative risk assessment and ultimately enforceable government standards are discussed.
Url:
DOI: 10.1016/j.neuro.2009.07.013
PubMed: 19646473
PubMed Central: 2765692
Affiliations:
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National Institute for Occupational Safety and Health</wicri:regionArea><wicri:noRegion>National Institute for Occupational Safety and Health</wicri:noRegion></affiliation></author><author><name sortKey="Ho, Shuk Mei" sort="Ho, Shuk Mei" uniqKey="Ho S" first="Shuk" last="Ho">Shuk Ho</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Environmental Health, University of Cincinnati College of Medicine, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, University of Cincinnati College of Medicine</wicri:regionArea><wicri:noRegion>University of Cincinnati College of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Haynes, Erin N" sort="Haynes, Erin N" uniqKey="Haynes E" first="Erin" last="Haynes">Erin Haynes</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Environmental Health, University of Cincinnati College of Medicine, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, University of Cincinnati College of Medicine</wicri:regionArea><wicri:noRegion>University of Cincinnati College of Medicine</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neurotoxicology</title><idno type="ISSN">0161-813X</idno><idno type="e-ISSN">1872-9711</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Manganese is an essential nutrient, and a healthy human with good liver and kidney function can easily excrete excess dietary manganese. Inhaled manganese is a greater concern, because it bypasses the body’s normal homeostatic mechanisms and can accumulate in the brain. Prolonged exposure to high manganese concentrations (>1 mg/m<sup>3</sup>) in air leads to a Parkinsonian syndrome known as “manganism.” Of greatest concern are recent studies which indicate that neurological and neurobehavioral deficits can occur when workers are exposed to much lower levels (<0.2 mg/m<sup>3</sup>) of inhaled manganese in welding fumes. Consequently, researchers at NIOSH are conducting a risk assessment for inhaled manganese. Novel components of this risk assessment include an attempt to quantify the range of inter-individual differences using data generated by the Human Genome Project and experimental work to identify genetically based biomarkers of exposure, disease and susceptibility. The difficulties involved in moving from epidemiological and in vivo data to health-based quantitative risk assessment and ultimately enforceable government standards are discussed.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7905589</journal-id><journal-id journal-id-type="pubmed-jr-id">6173</journal-id><journal-id journal-id-type="nlm-ta">Neurotoxicology</journal-id><journal-title>Neurotoxicology</journal-title><issn pub-type="ppub">0161-813X</issn><issn pub-type="epub">1872-9711</issn></journal-meta><article-meta><article-id pub-id-type="pmid">19646473</article-id><article-id pub-id-type="pmc">2765692</article-id><article-id pub-id-type="doi">10.1016/j.neuro.2009.07.013</article-id><article-id pub-id-type="manuscript">NIHMS135710</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Incorporating genetics and genomics in risk assessment for inhaled manganese: From data to policy</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Curran</surname><given-names>Christine P.</given-names></name><xref rid="A1" ref-type="aff">a</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Robert M.</given-names></name><xref rid="A2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Ho</surname><given-names>Shuk-mei</given-names></name><xref rid="A3" ref-type="aff">c</xref></contrib><contrib contrib-type="author"><name><surname>Haynes</surname><given-names>Erin N.</given-names></name><xref rid="A3" ref-type="aff">c</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Biological Sciences, Northern Kentucky University, SC342 Nunn Drive, Highland Heights, KY 41099, United States</aff><aff id="A2"><label>b</label>Risk Evaluation Branch, National Institute for Occupational Safety and Health, United States</aff><aff id="A3"><label>c</label>Department of Environmental Health, University of Cincinnati College of Medicine, United States</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author. Fax: +1 859 572 5639. <email>curranc1@nku.edu</email> (C.P. Curran)</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>16</day><month>9</month><year>2009</year></pub-date><pub-date pub-type="epub"><day>29</day><month>7</month><year>2009</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2009</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>9</month><year>2010</year></pub-date><volume>30</volume><issue>5</issue><fpage>754</fpage><lpage>760</lpage><permissions><copyright-statement>© 2009 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2009</copyright-year></permissions><abstract><p id="P1">Manganese is an essential nutrient, and a healthy human with good liver and kidney function can easily excrete excess dietary manganese. Inhaled manganese is a greater concern, because it bypasses the body’s normal homeostatic mechanisms and can accumulate in the brain. Prolonged exposure to high manganese concentrations (>1 mg/m<sup>3</sup>) in air leads to a Parkinsonian syndrome known as “manganism.” Of greatest concern are recent studies which indicate that neurological and neurobehavioral deficits can occur when workers are exposed to much lower levels (<0.2 mg/m<sup>3</sup>) of inhaled manganese in welding fumes. Consequently, researchers at NIOSH are conducting a risk assessment for inhaled manganese. Novel components of this risk assessment include an attempt to quantify the range of inter-individual differences using data generated by the Human Genome Project and experimental work to identify genetically based biomarkers of exposure, disease and susceptibility. The difficulties involved in moving from epidemiological and in vivo data to health-based quantitative risk assessment and ultimately enforceable government standards are discussed.</p></abstract><kwd-group><kwd>Manganese</kwd><kwd>Occupational health</kwd><kwd>Epidemiology</kwd><kwd>Genetic susceptibility</kwd><kwd>DNA</kwd><kwd>Policy</kwd></kwd-group><contract-num rid="ES1">R21 ES013524-02</contract-num><contract-num rid="ES1">R21 ES013524-01</contract-num><contract-num rid="ES1">P30 ES006096-15</contract-num><contract-sponsor id="ES1">National Institute of Environmental Health Sciences : NIEHS</contract-sponsor></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country><region><li>Kentucky</li></region></list><tree><country name="États-Unis"><region name="Kentucky"><name sortKey="Curran, Christine P" sort="Curran, Christine P" uniqKey="Curran C" first="Christine" last="Curran">Christine Curran</name></region><name sortKey="Haynes, Erin N" sort="Haynes, Erin N" uniqKey="Haynes E" first="Erin" last="Haynes">Erin Haynes</name><name sortKey="Ho, Shuk Mei" sort="Ho, Shuk Mei" uniqKey="Ho S" first="Shuk" last="Ho">Shuk Ho</name><name sortKey="Park, Robert M" sort="Park, Robert M" uniqKey="Park R" first="Robert" last="Park">Robert Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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