Rapid Eye Movement Sleep Behavioral Events: A New Marker for Neurodegeneration in Early Parkinson Disease?
Identifieur interne : 000036 ( Pmc/Checkpoint ); précédent : 000035; suivant : 000037Rapid Eye Movement Sleep Behavioral Events: A New Marker for Neurodegeneration in Early Parkinson Disease?
Auteurs : Friederike Sixel [Allemagne] ; Ellen Trautmann [Allemagne] ; Brit Mollenhauer [Allemagne] ; Claudia Trenkwalder [Allemagne]Source :
- Sleep [ 0161-8105 ] ; 2014.
Abstract
To analyze potential markers in sleep for early recognition of neurodegenerative disease in newly diagnosed, unmedicated patients with Parkinson disease (PD) compared to controls.
Videopolysomnography (vPSG) was available in 158 newly diagnosed, unmedicated patients with PD and 110 age-, sex-, and education-matched healthy controls (HC). Rapid eye movement (REM) sleep was analyzed for REM without atonia (RWA) and studied by review of time-synchronized video. Motor behaviors and/or vocalizations in REM sleep with a purposeful component other than comfort moves were identified as REM sleep behavioral events (RBE). Two or more events had to be present to be classified as “RBE positive.” RBE subjects included rapid eye movement sleep behavior disorder (RBD) and non-RBD subjects based on the presence or absence of RWA > 18.2%.
RBE were detected in 81 of 158 patients with
This first description of REM sleep behavioral events (RBE) shows it occurs more frequently in patients with
Sixel-Döring F; Trautmann E; Mollenhauer B; Trenkwalder C. Rapid eye movement sleep behavioral events: a new marker for neurodegeneration in early Parkinson disease?
Url:
DOI: 10.5665/sleep.3468
PubMed: 24587564
PubMed Central: 3920307
Affiliations:
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type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3920307</idno><idno type="RBID">PMC:3920307</idno><idno type="doi">10.5665/sleep.3468</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000238</idno><idno type="wicri:Area/Pmc/Curation">000238</idno><idno type="wicri:Area/Pmc/Checkpoint">000036</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rapid Eye Movement Sleep Behavioral Events: A New Marker for Neurodegeneration in Early Parkinson Disease?</title><author><name sortKey="Sixel Doring, Friederike" sort="Sixel Doring, Friederike" uniqKey="Sixel Doring F" first="Friederike" last="Sixel">Friederike Sixel</name><affiliation wicri:level="3"><nlm:aff id="aff1">Paracelsus-Elena-Klinik, Kassel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena-Klinik, Kassel</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" 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nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Psychology, University Kassel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, University Kassel</wicri:regionArea><wicri:noRegion>University Kassel</wicri:noRegion><wicri:noRegion>University Kassel</wicri:noRegion><wicri:noRegion>University Kassel</wicri:noRegion></affiliation></author><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><affiliation wicri:level="3"><nlm:aff id="aff1">Paracelsus-Elena-Klinik, Kassel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena-Klinik, Kassel</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Neurosurgery, Georg-August University Goettingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Georg-August University Goettingen</wicri:regionArea><wicri:noRegion>Georg-August University Goettingen</wicri:noRegion><wicri:noRegion>Georg-August University Goettingen</wicri:noRegion><wicri:noRegion>Georg-August University Goettingen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Neuropathology, Georg-August University, Goettingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neuropathology, Georg-August University, Goettingen</wicri:regionArea><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><affiliation wicri:level="3"><nlm:aff id="aff1">Paracelsus-Elena-Klinik, Kassel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Paracelsus-Elena-Klinik, Kassel</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">Department of Neurosurgery, Georg-August University Goettingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Georg-August University Goettingen</wicri:regionArea><wicri:noRegion>Georg-August University Goettingen</wicri:noRegion><wicri:noRegion>Georg-August University Goettingen</wicri:noRegion><wicri:noRegion>Georg-August University Goettingen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Sleep</title><idno type="ISSN">0161-8105</idno><idno type="e-ISSN">1550-9109</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To analyze potential markers in sleep for early recognition of neurodegenerative disease in newly diagnosed, unmedicated patients with Parkinson disease (PD) compared to controls.</p></sec><sec><title>Methods:</title><p>Videopolysomnography (vPSG) was available in 158 newly diagnosed, unmedicated patients with PD and 110 age-, sex-, and education-matched healthy controls (HC). Rapid eye movement (REM) sleep was analyzed for REM without atonia (RWA) and studied by review of time-synchronized video. Motor behaviors and/or vocalizations in REM sleep with a purposeful component other than comfort moves were identified as REM sleep behavioral events (RBE). Two or more events had to be present to be classified as “RBE positive.” RBE subjects included rapid eye movement sleep behavior disorder (RBD) and non-RBD subjects based on the presence or absence of RWA > 18.2%.</p></sec><sec><title>Results:</title><p>RBE were detected in 81 of 158 patients with <italic>de novo</italic> PD (51%) and 17 of 110 HC (15%) (P < 0.001). RBD was identified in 40/81 RBE-positive patients with PD (25% of all PD patients) and 2 of 17 RBE-positive HC (2% of all controls). RBE-positive patients showed no specific motor or neuropsychological features compared to RBE-negative patients. Patients with PD and HC with RBE had more REM sleep (P = 0.002) and a higher periodic leg movements in sleep index (P = 0.022) compared to subjects without RBE.</p></sec><sec><title>Conclusion:</title><p>This first description of REM sleep behavioral events (RBE) shows it occurs more frequently in patients with <italic>de novo</italic> Parkinson disease (PD) than in healthy controls and may be an early sign of neurodegeneration and precede rapid eye movement sleep behavior disorder (RBD). There is no specific phenotype of PD associated with newly defined RBE or RBD at this early stage.</p></sec><sec><title>Citation:</title><p>Sixel-Döring F; Trautmann E; Mollenhauer B; Trenkwalder C. Rapid eye movement sleep behavioral events: a new marker for neurodegeneration in early Parkinson disease? <italic>SLEEP</italic> 2014;37(3):431-438.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sleep</journal-id><journal-id journal-id-type="iso-abbrev">Sleep</journal-id><journal-id journal-id-type="publisher-id">Sleep</journal-id><journal-title-group><journal-title>Sleep</journal-title></journal-title-group><issn pub-type="ppub">0161-8105</issn><issn pub-type="epub">1550-9109</issn><publisher><publisher-name>Associated Professional Sleep Societies, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24587564</article-id><article-id pub-id-type="pmc">3920307</article-id><article-id pub-id-type="doi">10.5665/sleep.3468</article-id><article-categories><subj-group subj-group-type="heading"><subject>REM Sleep Behavioral Events: A New Marker for Early Parkinson Disease</subject></subj-group></article-categories><title-group><article-title>Rapid Eye Movement Sleep Behavioral Events: A New Marker for Neurodegeneration in Early Parkinson Disease?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Sixel-Döring</surname><given-names>Friederike</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Trautmann</surname><given-names>Ellen</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mollenhauer</surname><given-names>Brit</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Trenkwalder</surname><given-names>Claudia</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><aff id="aff1"><label>1</label>Paracelsus-Elena-Klinik, Kassel, Germany</aff><aff id="aff2"><label>2</label>Department of Neurology, Philipps-University Marburg, Germany</aff><aff id="aff3"><label>3</label>Department of Psychology, University Kassel, Germany</aff><aff id="aff4"><label>4</label>Department of Neurosurgery, Georg-August University Goettingen, Germany</aff><aff id="aff5"><label>5</label>Department of Neuropathology, Georg-August University, Goettingen, Germany</aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to: Friederike Sixel-Döring, <addr-line>Paracelsus-Elena-Klinik, Center of Parkinsonism and Movement Disorders, Klinikstr. 16, 34128 Kassel, Germany</addr-line><phone>++49-0561-60090</phone><fax>++49-0561-6009126</fax><email>friederike.sixel@paracelsus-kliniken.de</email></corresp></author-notes><pub-date pub-type="epub"><day>1</day><month>3</month><year>2014</year></pub-date><volume>37</volume><issue>3</issue><fpage>431</fpage><lpage>438</lpage><history><date date-type="received"><month>4</month><year>2013</year></date><date date-type="rev-recd"><month>7</month><year>2013</year></date><date date-type="accepted"><month>7</month><year>2013</year></date></history><permissions><copyright-statement>© 2014 Associated Professional Sleep Societies, LLC.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><sec><title>Objective:</title><p>To analyze potential markers in sleep for early recognition of neurodegenerative disease in newly diagnosed, unmedicated patients with Parkinson disease (PD) compared to controls.</p></sec><sec><title>Methods:</title><p>Videopolysomnography (vPSG) was available in 158 newly diagnosed, unmedicated patients with PD and 110 age-, sex-, and education-matched healthy controls (HC). Rapid eye movement (REM) sleep was analyzed for REM without atonia (RWA) and studied by review of time-synchronized video. Motor behaviors and/or vocalizations in REM sleep with a purposeful component other than comfort moves were identified as REM sleep behavioral events (RBE). Two or more events had to be present to be classified as “RBE positive.” RBE subjects included rapid eye movement sleep behavior disorder (RBD) and non-RBD subjects based on the presence or absence of RWA > 18.2%.</p></sec><sec><title>Results:</title><p>RBE were detected in 81 of 158 patients with <italic>de novo</italic> PD (51%) and 17 of 110 HC (15%) (P < 0.001). RBD was identified in 40/81 RBE-positive patients with PD (25% of all PD patients) and 2 of 17 RBE-positive HC (2% of all controls). RBE-positive patients showed no specific motor or neuropsychological features compared to RBE-negative patients. Patients with PD and HC with RBE had more REM sleep (P = 0.002) and a higher periodic leg movements in sleep index (P = 0.022) compared to subjects without RBE.</p></sec><sec><title>Conclusion:</title><p>This first description of REM sleep behavioral events (RBE) shows it occurs more frequently in patients with <italic>de novo</italic> Parkinson disease (PD) than in healthy controls and may be an early sign of neurodegeneration and precede rapid eye movement sleep behavior disorder (RBD). There is no specific phenotype of PD associated with newly defined RBE or RBD at this early stage.</p></sec><sec><title>Citation:</title><p>Sixel-Döring F; Trautmann E; Mollenhauer B; Trenkwalder C. Rapid eye movement sleep behavioral events: a new marker for neurodegeneration in early Parkinson disease? <italic>SLEEP</italic> 2014;37(3):431-438.</p></sec></abstract><kwd-group><kwd>Parkinson disease</kwd><kwd>REM sleep behavior disorder</kwd><kwd>REM sleep behavioral events</kwd><kwd>somnological marker</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li></country><region><li>District de Kassel</li><li>Hesse (Land)</li></region><settlement><li>Cassel (Hesse)</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Sixel Doring, Friederike" sort="Sixel Doring, Friederike" uniqKey="Sixel Doring F" first="Friederike" last="Sixel">Friederike Sixel</name></region><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><name sortKey="Sixel Doring, Friederike" sort="Sixel Doring, Friederike" uniqKey="Sixel Doring F" first="Friederike" last="Sixel">Friederike Sixel</name><name sortKey="Trautmann, Ellen" sort="Trautmann, Ellen" uniqKey="Trautmann E" first="Ellen" last="Trautmann">Ellen Trautmann</name><name sortKey="Trautmann, Ellen" sort="Trautmann, Ellen" uniqKey="Trautmann E" first="Ellen" last="Trautmann">Ellen Trautmann</name><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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