JankovicV1, PascalFrancis, Corpus, bibRecord, 000164

Weight gain following unilateral pallidotomy in Parkinson's disease

Identifieur interne : 000164 ( PascalFrancis/Corpus ); précédent : 000163; suivant : 000165

Weight gain following unilateral pallidotomy in Parkinson's disease

Auteurs : W Ondo ; L Ben ; J Jankovic ; E Lai ; C Contant ; R Grossman

Source :

Acta neurologica scandinavica [ 0001-6314 ] ; 2000.

RBID : Pascal:00-0061594

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Pallidum, Section chirurgicale, Unilatéral, Prise poids, Etude longitudinale, Evolution, Traitement, Postopératoire, Homme, Modèle.

English descriptors

KwdEn :
- Evolution, Follow up study, Human, Models, Pallidum, Parkinson disease, Postoperative, Surgical section, Treatment, Unilateral, Weight gain.

Abstract

Objective - To determine the clinical correlates and infer pathogenesis of weight gain following pallidotomy in patients with Parkinson's disease (PD). Background - Surgical ablation of the globus pallidus internus (GPi) improves levodopa induced dyskinesias, moderately improves most other "cardinal' manifestations of PD, and has been noted to result in increased weight. Methods - We incorporated Unified Parkinson's Disease Rating Scales (UPDRS) subscales, the Beck depression inventory and feeding questionnaire data into a linear regression model in order to determine which post-surgical change(s) may lead to weight gain over the first year following pallidotomy, n = 60. Results - The mean weight gain 1 year after pallidotomy was 4.0±4.1 kg. Improvement in "off" motor scores (P < 0.005), especially gait subscores (P < 0.0001), and to a lesser extent improvement in "on' motor scores (P<0.05) predicted weight gain. Changes in dyskinesia ratings, mood, food intake, dysphagia, levodopa dose, weight loss in the year prior to pallidotomy, age, and duration of PD did not correlate with subsequent weight gain. Conclusion - The high correlation between post-pallidotomy weight gain and "off" motor scores, suggests that this phenomenon is related to some change in underlying homeostasis associated with changes in the cardinal manifestations of PD itself, rather than secondary changes resultant from the surgery.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`03`	`1`		`@1 JANKOVIC (J.)`
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A11	`05`	`1`		`@1 CONTANT (C.)`
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A14	`01`			`@1 Department of Neurology, Baylor College of Medicine @2 Houston, TX @3 USA @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut.`
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C01	`01`		`ENG`	@0 Objective - To determine the clinical correlates and infer pathogenesis of weight gain following pallidotomy in patients with Parkinson's disease (PD). Background - Surgical ablation of the globus pallidus internus (GPi) improves levodopa induced dyskinesias, moderately improves most other "cardinal' manifestations of PD, and has been noted to result in increased weight. Methods - We incorporated Unified Parkinson's Disease Rating Scales (UPDRS) subscales, the Beck depression inventory and feeding questionnaire data into a linear regression model in order to determine which post-surgical change(s) may lead to weight gain over the first year following pallidotomy, n = 60. Results - The mean weight gain 1 year after pallidotomy was 4.0±4.1 kg. Improvement in "off" motor scores (P < 0.005), especially gait subscores (P < 0.0001), and to a lesser extent improvement in "on' motor scores (P<0.05) predicted weight gain. Changes in dyskinesia ratings, mood, food intake, dysphagia, levodopa dose, weight loss in the year prior to pallidotomy, age, and duration of PD did not correlate with subsequent weight gain. Conclusion - The high correlation between post-pallidotomy weight gain and "off" motor scores, suggests that this phenomenon is related to some change in underlying homeostasis associated with changes in the cardinal manifestations of PD itself, rather than secondary changes resultant from the surgery.
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C03	`04`	`X`	`ENG`	`@0 Unilateral @5 08`
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Format Inist (serveur)

NO :	PASCAL 00-0061594 INIST
ET :	Weight gain following unilateral pallidotomy in Parkinson's disease
AU :	ONDO (W. G.); BEN-AIRE (L.); JANKOVIC (J.); LAI (E.); CONTANT (C.); GROSSMAN (R.)
AF :	Department of Neurology, Baylor College of Medicine/Houston, TX/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut.); Department of Neurosurgery, Baylor College of Medicine/Houston, TX/Etats-Unis (5 aut., 6 aut.)
DT :	Publication en série; Niveau analytique
SO :	Acta neurologica scandinavica; ISSN 0001-6314; Coden ANRSAS; Danemark; Da. 2000; Vol. 101; No. 2; Pp. 79-84; Bibl. 38 ref.
LA :	Anglais
EA :	Objective - To determine the clinical correlates and infer pathogenesis of weight gain following pallidotomy in patients with Parkinson's disease (PD). Background - Surgical ablation of the globus pallidus internus (GPi) improves levodopa induced dyskinesias, moderately improves most other "cardinal' manifestations of PD, and has been noted to result in increased weight. Methods - We incorporated Unified Parkinson's Disease Rating Scales (UPDRS) subscales, the Beck depression inventory and feeding questionnaire data into a linear regression model in order to determine which post-surgical change(s) may lead to weight gain over the first year following pallidotomy, n = 60. Results - The mean weight gain 1 year after pallidotomy was 4.0±4.1 kg. Improvement in "off" motor scores (P < 0.005), especially gait subscores (P < 0.0001), and to a lesser extent improvement in "on' motor scores (P<0.05) predicted weight gain. Changes in dyskinesia ratings, mood, food intake, dysphagia, levodopa dose, weight loss in the year prior to pallidotomy, age, and duration of PD did not correlate with subsequent weight gain. Conclusion - The high correlation between post-pallidotomy weight gain and "off" motor scores, suggests that this phenomenon is related to some change in underlying homeostasis associated with changes in the cardinal manifestations of PD itself, rather than secondary changes resultant from the surgery.
CC :	002B17G
FD :	Parkinson maladie; Pallidum; Section chirurgicale; Unilatéral; Prise poids; Etude longitudinale; Evolution; Traitement; Postopératoire; Homme; Modèle
FG :	Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Encéphale; Chirurgie
ED :	Parkinson disease; Pallidum; Surgical section; Unilateral; Weight gain; Follow up study; Evolution; Treatment; Postoperative; Human; Models
EG :	Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Brain (vertebrata); Surgery
SD :	Parkinson enfermedad; Pallidum; Sección quirúrgica; Unilateral; Ganancia peso; Estudio longitudinal; Evolución; Tratamiento; Postoperatorio; Hombre; Modelo
LO :	INIST-3203A.354000081082510020
ID :	00-0061594

Links to Exploration step

Pascal:00-0061594

Le document en format XML

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<front><div type="abstract" xml:lang="en">Objective - To determine the clinical correlates and infer pathogenesis of weight gain following pallidotomy in patients with Parkinson's disease (PD). Background - Surgical ablation of the globus pallidus internus (GPi) improves levodopa induced dyskinesias, moderately improves most other "cardinal' manifestations of PD, and has been noted to result in increased weight. Methods - We incorporated Unified Parkinson's Disease Rating Scales (UPDRS) subscales, the Beck depression inventory and feeding questionnaire data into a linear regression model in order to determine which post-surgical change(s) may lead to weight gain over the first year following pallidotomy, n = 60. Results - The mean weight gain 1 year after pallidotomy was 4.0±4.1 kg. Improvement in "off" motor scores (P < 0.005), especially gait subscores (P < 0.0001), and to a lesser extent improvement in "on' motor scores (P<0.05) predicted weight gain. Changes in dyskinesia ratings, mood, food intake, dysphagia, levodopa dose, weight loss in the year prior to pallidotomy, age, and duration of PD did not correlate with subsequent weight gain. Conclusion - The high correlation between post-pallidotomy weight gain and "off" motor scores, suggests that this phenomenon is related to some change in underlying homeostasis associated with changes in the cardinal manifestations of PD itself, rather than secondary changes resultant from the surgery.</div>
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<fC01 i1="01" l="ENG"><s0>Objective - To determine the clinical correlates and infer pathogenesis of weight gain following pallidotomy in patients with Parkinson's disease (PD). Background - Surgical ablation of the globus pallidus internus (GPi) improves levodopa induced dyskinesias, moderately improves most other "cardinal' manifestations of PD, and has been noted to result in increased weight. Methods - We incorporated Unified Parkinson's Disease Rating Scales (UPDRS) subscales, the Beck depression inventory and feeding questionnaire data into a linear regression model in order to determine which post-surgical change(s) may lead to weight gain over the first year following pallidotomy, n = 60. Results - The mean weight gain 1 year after pallidotomy was 4.0±4.1 kg. Improvement in "off" motor scores (P < 0.005), especially gait subscores (P < 0.0001), and to a lesser extent improvement in "on' motor scores (P<0.05) predicted weight gain. Changes in dyskinesia ratings, mood, food intake, dysphagia, levodopa dose, weight loss in the year prior to pallidotomy, age, and duration of PD did not correlate with subsequent weight gain. Conclusion - The high correlation between post-pallidotomy weight gain and "off" motor scores, suggests that this phenomenon is related to some change in underlying homeostasis associated with changes in the cardinal manifestations of PD itself, rather than secondary changes resultant from the surgery.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17G</s0>
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<s5>01</s5>
</fC03>
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<s5>01</s5>
</fC03>
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<s5>01</s5>
</fC03>
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<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Pallidum</s0>
<s5>04</s5>
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<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Section chirurgicale</s0>
<s5>07</s5>
</fC03>
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<s5>07</s5>
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<s5>07</s5>
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<s5>08</s5>
</fC03>
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<s5>08</s5>
</fC03>
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<s5>08</s5>
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<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Weight gain</s0>
<s5>10</s5>
</fC03>
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<s5>10</s5>
</fC03>
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<s5>16</s5>
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<s5>16</s5>
</fC03>
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<s5>16</s5>
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<s5>17</s5>
</fC03>
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<s5>18</s5>
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<s5>18</s5>
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<s5>18</s5>
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<s5>19</s5>
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<s5>19</s5>
</fC03>
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<s5>19</s5>
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<s5>20</s5>
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<s5>20</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Hombre</s0>
<s5>20</s5>
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<s5>23</s5>
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<s5>23</s5>
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<fC03 i1="11" i2="X" l="SPA"><s0>Modelo</s0>
<s5>23</s5>
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<s5>38</s5>
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<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
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<fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
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<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Brain (vertebrata)</s0>
<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>45</s5>
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<fC07 i1="07" i2="X" l="FRE"><s0>Chirurgie</s0>
<s5>53</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Surgery</s0>
<s5>53</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Cirugía</s0>
<s5>53</s5>
</fC07>
<fN21><s1>045</s1>
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<server><NO>PASCAL 00-0061594 INIST</NO>
<ET>Weight gain following unilateral pallidotomy in Parkinson's disease</ET>
<AU>ONDO (W. G.); BEN-AIRE (L.); JANKOVIC (J.); LAI (E.); CONTANT (C.); GROSSMAN (R.)</AU>
<AF>Department of Neurology, Baylor College of Medicine/Houston, TX/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut.); Department of Neurosurgery, Baylor College of Medicine/Houston, TX/Etats-Unis (5 aut., 6 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Acta neurologica scandinavica; ISSN 0001-6314; Coden ANRSAS; Danemark; Da. 2000; Vol. 101; No. 2; Pp. 79-84; Bibl. 38 ref.</SO>
<LA>Anglais</LA>
<EA>Objective - To determine the clinical correlates and infer pathogenesis of weight gain following pallidotomy in patients with Parkinson's disease (PD). Background - Surgical ablation of the globus pallidus internus (GPi) improves levodopa induced dyskinesias, moderately improves most other "cardinal' manifestations of PD, and has been noted to result in increased weight. Methods - We incorporated Unified Parkinson's Disease Rating Scales (UPDRS) subscales, the Beck depression inventory and feeding questionnaire data into a linear regression model in order to determine which post-surgical change(s) may lead to weight gain over the first year following pallidotomy, n = 60. Results - The mean weight gain 1 year after pallidotomy was 4.0±4.1 kg. Improvement in "off" motor scores (P < 0.005), especially gait subscores (P < 0.0001), and to a lesser extent improvement in "on' motor scores (P<0.05) predicted weight gain. Changes in dyskinesia ratings, mood, food intake, dysphagia, levodopa dose, weight loss in the year prior to pallidotomy, age, and duration of PD did not correlate with subsequent weight gain. Conclusion - The high correlation between post-pallidotomy weight gain and "off" motor scores, suggests that this phenomenon is related to some change in underlying homeostasis associated with changes in the cardinal manifestations of PD itself, rather than secondary changes resultant from the surgery.</EA>
<CC>002B17G</CC>
<FD>Parkinson maladie; Pallidum; Section chirurgicale; Unilatéral; Prise poids; Etude longitudinale; Evolution; Traitement; Postopératoire; Homme; Modèle</FD>
<FG>Système nerveux pathologie; Système nerveux central pathologie; Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Encéphale; Chirurgie</FG>
<ED>Parkinson disease; Pallidum; Surgical section; Unilateral; Weight gain; Follow up study; Evolution; Treatment; Postoperative; Human; Models</ED>
<EG>Nervous system diseases; Central nervous system disease; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Brain (vertebrata); Surgery</EG>
<SD>Parkinson enfermedad; Pallidum; Sección quirúrgica; Unilateral; Ganancia peso; Estudio longitudinal; Evolución; Tratamiento; Postoperatorio; Hombre; Modelo</SD>
<LO>INIST-3203A.354000081082510020</LO>
<ID>00-0061594</ID>
</server>
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Weight gain following unilateral pallidotomy in Parkinson's disease

Weight gain following unilateral pallidotomy in Parkinson's disease

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