Screening for Lrrk2 G2019S and clinical comparison of tunisian and North American caucasian Parkinson's disease families
Identifieur interne : 000063 ( PascalFrancis/Corpus ); précédent : 000062; suivant : 000064Screening for Lrrk2 G2019S and clinical comparison of tunisian and North American caucasian Parkinson's disease families
Auteurs : Lianna Ishihara ; Rachel Gibson ; Liling Warren ; Rim Amouri ; Kelly Lyons ; Catherine Wielinski ; Christine Hunter ; Jina Swartz ; Ramu Elango ; P Akkari ; David Leppert ; Linda Surh ; Kevin Reeves ; Siwan Thomas ; Leigh Ragone ; Nobutaka Hattori ; Rajesh Pahwa ; Joseph Jankovic ; Martha Nance ; Alan Freeman ; Neziha Gouider ; Mounir Kefi ; Mourad Zouari ; Samia Ben ; Samia Ben ; Ghada El ; Lefkos Middleton ; David Burn ; Ray Watts ; Faycal HentatiSource :
- Movement disorders [ 0885-3185 ] ; 2007.
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Abstract
Mutations in the leucine-rich repeat kinase-2 gene (LRRK2) are responsible for some forms of familial as well as sporadic Parkinson's disease (PD). The purpose of this study was to examine the frequency of a single pathogenic mutation (6055G>A) in the kinase domain of this gene in United States and Tunisian familial PD and to compare clinical characteristics between patients with and without the mutation. Standardized case report forms were used for clinical and demographic data collection. We investigated the frequency of the most common substitution of LRRK2 (G2019S, 6055G>A) and its impact on epidemiological and phenotypic features. The frequency of mutations in Tunisian families was 42% (38/91) and in U.S. families 2.6% (1/39), with the unique opportunity to compare homozygous (n = 23) and heterozygous (n = 109) Tunisian carriers of G2019S substitutions. Individuals with G2019S substitutions had an older age at onset but few other differences compared with families negative for the substitution. Patients with LRRK2 mutations had typical clinical features of PD. Comparisons between individuals with heterozygous and homozygous LRRK2 mutations suggested that gene dosage was not correlated with phenotypic differences; however, the estimated penetrance was greater in homozygotes across all age groups.
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NO : | PASCAL 07-0133217 INIST |
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ET : | Screening for Lrrk2 G2019S and clinical comparison of tunisian and North American caucasian Parkinson's disease families |
AU : | ISHIHARA (Lianna); GIBSON (Rachel A.); WARREN (Liling); AMOURI (Rim); LYONS (Kelly); WIELINSKI (Catherine); HUNTER (Christine); SWARTZ (Jina E.); ELANGO (Ramu); AKKARI (P. Anthony); LEPPERT (David); SURH (Linda); REEVES (Kevin H.); THOMAS (Siwan); RAGONE (Leigh); HATTORI (Nobutaka); PAHWA (Rajesh); JANKOVIC (Joseph); NANCE (Martha); FREEMAN (Alan); GOUIDER-KHOUJA (Neziha); KEFI (Mounir); ZOUARI (Mourad); BEN SASSI (Samia); BEN YAHMED (Samia); EL EUCH-FAYECHE (Ghada); MIDDLETON (Lefkos); BURN (David J.); WATTS (Ray L.); HENTATI (Faycal) |
AF : | Department of Public Health and Primary Care, University of Cambridge/Cambridge/Royaume-Uni (1 aut.); Research and Development, GlaxoSmithKline Pharmaceuticals/Greenford/Royaume-Uni (2 aut., 8 aut., 9 aut., 11 aut., 12 aut., 14 aut., 27 aut.); Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park/Durham, North Carolina/Etats-Unis (3 aut., 10 aut., 13 aut., 15 aut.); Service de Neurologie, Institut National de Neurologie/La Rabta, Tunis/Tunisie (4 aut., 21 aut., 22 aut., 23 aut., 24 aut., 25 aut., 26 aut., 30 aut.); Department of Neurology, University of Kansas Medical Center/Kansas City, Kansas/Etats-Unis (5 aut., 17 aut.); Struthers Parkinson's Center/Golden Valley, Minnesota/Etats-Unis (6 aut., 19 aut.); Department of Neurology, Baylor College of Medicine/Houston, Texas/Etats-Unis (7 aut., 18 aut.); Department of Neurology, Juntendo University School of Medicine/Tokyo/Japon (16 aut.); Department of Neurology, Emory University/Atlanta, Georgia/Etats-Unis (20 aut.); Department of Neurology, Newcastle General Hospital/Newcastle-upon-Tyne/Royaume-Uni (28 aut.); Department of Neurology, University of Alabama at Birmingham/Birmingham, Alabama/Etats-Unis (29 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 1; Pp. 55-61; Bibl. 35 ref. |
LA : | Anglais |
EA : | Mutations in the leucine-rich repeat kinase-2 gene (LRRK2) are responsible for some forms of familial as well as sporadic Parkinson's disease (PD). The purpose of this study was to examine the frequency of a single pathogenic mutation (6055G>A) in the kinase domain of this gene in United States and Tunisian familial PD and to compare clinical characteristics between patients with and without the mutation. Standardized case report forms were used for clinical and demographic data collection. We investigated the frequency of the most common substitution of LRRK2 (G2019S, 6055G>A) and its impact on epidemiological and phenotypic features. The frequency of mutations in Tunisian families was 42% (38/91) and in U.S. families 2.6% (1/39), with the unique opportunity to compare homozygous (n = 23) and heterozygous (n = 109) Tunisian carriers of G2019S substitutions. Individuals with G2019S substitutions had an older age at onset but few other differences compared with families negative for the substitution. Patients with LRRK2 mutations had typical clinical features of PD. Comparisons between individuals with heterozygous and homozygous LRRK2 mutations suggested that gene dosage was not correlated with phenotypic differences; however, the estimated penetrance was greater in homozygotes across all age groups. |
CC : | 002B17; 002B17G; 002B17A03; 002B17F |
FD : | Système nerveux pathologie; Parkinson maladie; Dépistage; Etude comparative; Nord; Américain |
FG : | Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie |
ED : | Nervous system diseases; Parkinson disease; Medical screening; Comparative study; North; American |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Sistema nervioso patología; Parkinson enfermedad; Descubrimiento; Estudio comparativo; Norte; Americano |
LO : | INIST-20953.354000145483830080 |
ID : | 07-0133217 |
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Pascal:07-0133217Le document en format XML
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<author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name>
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<author><name sortKey="Surh, Linda" sort="Surh, Linda" uniqKey="Surh L" first="Linda" last="Surh">Linda Surh</name>
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<author><name sortKey="Reeves, Kevin H" sort="Reeves, Kevin H" uniqKey="Reeves K" first="Kevin" last="Reeves">Kevin Reeves</name>
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<author><name sortKey="Thomas, Siwan" sort="Thomas, Siwan" uniqKey="Thomas S" first="Siwan" last="Thomas">Siwan Thomas</name>
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<author><name sortKey="Ragone, Leigh" sort="Ragone, Leigh" uniqKey="Ragone L" first="Leigh" last="Ragone">Leigh Ragone</name>
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<author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name>
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<author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name>
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<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, Baylor College of Medicine</s1>
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<author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
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<author><name sortKey="Freeman, Alan" sort="Freeman, Alan" uniqKey="Freeman A" first="Alan" last="Freeman">Alan Freeman</name>
<affiliation><inist:fA14 i1="09"><s1>Department of Neurology, Emory University</s1>
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<author><name sortKey="Gouider Khouja, Neziha" sort="Gouider Khouja, Neziha" uniqKey="Gouider Khouja N" first="Neziha" last="Gouider">Neziha Gouider</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
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<author><name sortKey="Kefi, Mounir" sort="Kefi, Mounir" uniqKey="Kefi M" first="Mounir" last="Kefi">Mounir Kefi</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
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<author><name sortKey="Zouari, Mourad" sort="Zouari, Mourad" uniqKey="Zouari M" first="Mourad" last="Zouari">Mourad Zouari</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
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<author><name sortKey="Ben Sassi, Samia" sort="Ben Sassi, Samia" uniqKey="Ben Sassi S" first="Samia" last="Ben">Samia Ben</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
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<author><name sortKey="Ben Yahmed, Samia" sort="Ben Yahmed, Samia" uniqKey="Ben Yahmed S" first="Samia" last="Ben">Samia Ben</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
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<author><name sortKey="El Euch Fayeche, Ghada" sort="El Euch Fayeche, Ghada" uniqKey="El Euch Fayeche G" first="Ghada" last="El">Ghada El</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
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<sZ>21 aut.</sZ>
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</author>
<author><name sortKey="Middleton, Lefkos" sort="Middleton, Lefkos" uniqKey="Middleton L" first="Lefkos" last="Middleton">Lefkos Middleton</name>
<affiliation><inist:fA14 i1="02"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals</s1>
<s2>Greenford</s2>
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</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David" last="Burn">David Burn</name>
<affiliation><inist:fA14 i1="10"><s1>Department of Neurology, Newcastle General Hospital</s1>
<s2>Newcastle-upon-Tyne</s2>
<s3>GBR</s3>
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</affiliation>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray" last="Watts">Ray Watts</name>
<affiliation><inist:fA14 i1="11"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>29 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hentati, Faycal" sort="Hentati, Faycal" uniqKey="Hentati F" first="Faycal" last="Hentati">Faycal Hentati</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Screening for Lrrk2 G2019S and clinical comparison of tunisian and North American caucasian Parkinson's disease families</title>
<author><name sortKey="Ishihara, Lianna" sort="Ishihara, Lianna" uniqKey="Ishihara L" first="Lianna" last="Ishihara">Lianna Ishihara</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Public Health and Primary Care, University of Cambridge</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gibson, Rachel A" sort="Gibson, Rachel A" uniqKey="Gibson R" first="Rachel" last="Gibson">Rachel Gibson</name>
<affiliation><inist:fA14 i1="02"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals</s1>
<s2>Greenford</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
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<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Warren, Liling" sort="Warren, Liling" uniqKey="Warren L" first="Liling" last="Warren">Liling Warren</name>
<affiliation><inist:fA14 i1="03"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Amouri, Rim" sort="Amouri, Rim" uniqKey="Amouri R" first="Rim" last="Amouri">Rim Amouri</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lyons, Kelly" sort="Lyons, Kelly" uniqKey="Lyons K" first="Kelly" last="Lyons">Kelly Lyons</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, University of Kansas Medical Center</s1>
<s2>Kansas City, Kansas</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Wielinski, Catherine" sort="Wielinski, Catherine" uniqKey="Wielinski C" first="Catherine" last="Wielinski">Catherine Wielinski</name>
<affiliation><inist:fA14 i1="06"><s1>Struthers Parkinson's Center</s1>
<s2>Golden Valley, Minnesota</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Swartz, Jina E" sort="Swartz, Jina E" uniqKey="Swartz J" first="Jina" last="Swartz">Jina Swartz</name>
<affiliation><inist:fA14 i1="02"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals</s1>
<s2>Greenford</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Elango, Ramu" sort="Elango, Ramu" uniqKey="Elango R" first="Ramu" last="Elango">Ramu Elango</name>
<affiliation><inist:fA14 i1="02"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals</s1>
<s2>Greenford</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Akkari, P Anthony" sort="Akkari, P Anthony" uniqKey="Akkari P" first="P" last="Akkari">P Akkari</name>
<affiliation><inist:fA14 i1="03"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Leppert, David" sort="Leppert, David" uniqKey="Leppert D" first="David" last="Leppert">David Leppert</name>
<affiliation><inist:fA14 i1="02"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals</s1>
<s2>Greenford</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Surh, Linda" sort="Surh, Linda" uniqKey="Surh L" first="Linda" last="Surh">Linda Surh</name>
<affiliation><inist:fA14 i1="02"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals</s1>
<s2>Greenford</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Reeves, Kevin H" sort="Reeves, Kevin H" uniqKey="Reeves K" first="Kevin" last="Reeves">Kevin Reeves</name>
<affiliation><inist:fA14 i1="03"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Thomas, Siwan" sort="Thomas, Siwan" uniqKey="Thomas S" first="Siwan" last="Thomas">Siwan Thomas</name>
<affiliation><inist:fA14 i1="02"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals</s1>
<s2>Greenford</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ragone, Leigh" sort="Ragone, Leigh" uniqKey="Ragone L" first="Leigh" last="Ragone">Leigh Ragone</name>
<affiliation><inist:fA14 i1="03"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Neurology, Juntendo University School of Medicine</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Pahwa, Rajesh" sort="Pahwa, Rajesh" uniqKey="Pahwa R" first="Rajesh" last="Pahwa">Rajesh Pahwa</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, University of Kansas Medical Center</s1>
<s2>Kansas City, Kansas</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Nance, Martha" sort="Nance, Martha" uniqKey="Nance M" first="Martha" last="Nance">Martha Nance</name>
<affiliation><inist:fA14 i1="06"><s1>Struthers Parkinson's Center</s1>
<s2>Golden Valley, Minnesota</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Freeman, Alan" sort="Freeman, Alan" uniqKey="Freeman A" first="Alan" last="Freeman">Alan Freeman</name>
<affiliation><inist:fA14 i1="09"><s1>Department of Neurology, Emory University</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gouider Khouja, Neziha" sort="Gouider Khouja, Neziha" uniqKey="Gouider Khouja N" first="Neziha" last="Gouider">Neziha Gouider</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kefi, Mounir" sort="Kefi, Mounir" uniqKey="Kefi M" first="Mounir" last="Kefi">Mounir Kefi</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Zouari, Mourad" sort="Zouari, Mourad" uniqKey="Zouari M" first="Mourad" last="Zouari">Mourad Zouari</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ben Sassi, Samia" sort="Ben Sassi, Samia" uniqKey="Ben Sassi S" first="Samia" last="Ben">Samia Ben</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ben Yahmed, Samia" sort="Ben Yahmed, Samia" uniqKey="Ben Yahmed S" first="Samia" last="Ben">Samia Ben</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="El Euch Fayeche, Ghada" sort="El Euch Fayeche, Ghada" uniqKey="El Euch Fayeche G" first="Ghada" last="El">Ghada El</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Middleton, Lefkos" sort="Middleton, Lefkos" uniqKey="Middleton L" first="Lefkos" last="Middleton">Lefkos Middleton</name>
<affiliation><inist:fA14 i1="02"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals</s1>
<s2>Greenford</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David" last="Burn">David Burn</name>
<affiliation><inist:fA14 i1="10"><s1>Department of Neurology, Newcastle General Hospital</s1>
<s2>Newcastle-upon-Tyne</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Watts, Ray L" sort="Watts, Ray L" uniqKey="Watts R" first="Ray" last="Watts">Ray Watts</name>
<affiliation><inist:fA14 i1="11"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>29 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hentati, Faycal" sort="Hentati, Faycal" uniqKey="Hentati F" first="Faycal" last="Hentati">Faycal Hentati</name>
<affiliation><inist:fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>American</term>
<term>Comparative study</term>
<term>Medical screening</term>
<term>Nervous system diseases</term>
<term>North</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Dépistage</term>
<term>Etude comparative</term>
<term>Nord</term>
<term>Américain</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Mutations in the leucine-rich repeat kinase-2 gene (LRRK2) are responsible for some forms of familial as well as sporadic Parkinson's disease (PD). The purpose of this study was to examine the frequency of a single pathogenic mutation (6055G>A) in the kinase domain of this gene in United States and Tunisian familial PD and to compare clinical characteristics between patients with and without the mutation. Standardized case report forms were used for clinical and demographic data collection. We investigated the frequency of the most common substitution of LRRK2 (G2019S, 6055G>A) and its impact on epidemiological and phenotypic features. The frequency of mutations in Tunisian families was 42% (38/91) and in U.S. families 2.6% (1/39), with the unique opportunity to compare homozygous (n = 23) and heterozygous (n = 109) Tunisian carriers of G2019S substitutions. Individuals with G2019S substitutions had an older age at onset but few other differences compared with families negative for the substitution. Patients with LRRK2 mutations had typical clinical features of PD. Comparisons between individuals with heterozygous and homozygous LRRK2 mutations suggested that gene dosage was not correlated with phenotypic differences; however, the estimated penetrance was greater in homozygotes across all age groups.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0>
</fA01>
<fA03 i2="1"><s0>Mov. disord.</s0>
</fA03>
<fA05><s2>22</s2>
</fA05>
<fA06><s2>1</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Screening for Lrrk2 G2019S and clinical comparison of tunisian and North American caucasian Parkinson's disease families</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>ISHIHARA (Lianna)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>GIBSON (Rachel A.)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>WARREN (Liling)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>AMOURI (Rim)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>LYONS (Kelly)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>WIELINSKI (Catherine)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>HUNTER (Christine)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>SWARTZ (Jina E.)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>ELANGO (Ramu)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>AKKARI (P. Anthony)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>LEPPERT (David)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>SURH (Linda)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>REEVES (Kevin H.)</s1>
</fA11>
<fA11 i1="14" i2="1"><s1>THOMAS (Siwan)</s1>
</fA11>
<fA11 i1="15" i2="1"><s1>RAGONE (Leigh)</s1>
</fA11>
<fA11 i1="16" i2="1"><s1>HATTORI (Nobutaka)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>PAHWA (Rajesh)</s1>
</fA11>
<fA11 i1="18" i2="1"><s1>JANKOVIC (Joseph)</s1>
</fA11>
<fA11 i1="19" i2="1"><s1>NANCE (Martha)</s1>
</fA11>
<fA11 i1="20" i2="1"><s1>FREEMAN (Alan)</s1>
</fA11>
<fA11 i1="21" i2="1"><s1>GOUIDER-KHOUJA (Neziha)</s1>
</fA11>
<fA11 i1="22" i2="1"><s1>KEFI (Mounir)</s1>
</fA11>
<fA11 i1="23" i2="1"><s1>ZOUARI (Mourad)</s1>
</fA11>
<fA11 i1="24" i2="1"><s1>BEN SASSI (Samia)</s1>
</fA11>
<fA11 i1="25" i2="1"><s1>BEN YAHMED (Samia)</s1>
</fA11>
<fA11 i1="26" i2="1"><s1>EL EUCH-FAYECHE (Ghada)</s1>
</fA11>
<fA11 i1="27" i2="1"><s1>MIDDLETON (Lefkos)</s1>
</fA11>
<fA11 i1="28" i2="1"><s1>BURN (David J.)</s1>
</fA11>
<fA11 i1="29" i2="1"><s1>WATTS (Ray L.)</s1>
</fA11>
<fA11 i1="30" i2="1"><s1>HENTATI (Faycal)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Public Health and Primary Care, University of Cambridge</s1>
<s2>Cambridge</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals</s1>
<s2>Greenford</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>27 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park</s1>
<s2>Durham, North Carolina</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Service de Neurologie, Institut National de Neurologie</s1>
<s2>La Rabta, Tunis</s2>
<s3>TUN</s3>
<sZ>4 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>25 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>30 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Neurology, University of Kansas Medical Center</s1>
<s2>Kansas City, Kansas</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Struthers Parkinson's Center</s1>
<s2>Golden Valley, Minnesota</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Neurology, Baylor College of Medicine</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>18 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Department of Neurology, Juntendo University School of Medicine</s1>
<s2>Tokyo</s2>
<s3>JPN</s3>
<sZ>16 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Department of Neurology, Emory University</s1>
<s2>Atlanta, Georgia</s2>
<s3>USA</s3>
<sZ>20 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Department of Neurology, Newcastle General Hospital</s1>
<s2>Newcastle-upon-Tyne</s2>
<s3>GBR</s3>
<sZ>28 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Department of Neurology, University of Alabama at Birmingham</s1>
<s2>Birmingham, Alabama</s2>
<s3>USA</s3>
<sZ>29 aut.</sZ>
</fA14>
<fA20><s1>55-61</s1>
</fA20>
<fA21><s1>2007</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>20953</s2>
<s5>354000145483830080</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>35 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>07-0133217</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Movement disorders</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Mutations in the leucine-rich repeat kinase-2 gene (LRRK2) are responsible for some forms of familial as well as sporadic Parkinson's disease (PD). The purpose of this study was to examine the frequency of a single pathogenic mutation (6055G>A) in the kinase domain of this gene in United States and Tunisian familial PD and to compare clinical characteristics between patients with and without the mutation. Standardized case report forms were used for clinical and demographic data collection. We investigated the frequency of the most common substitution of LRRK2 (G2019S, 6055G>A) and its impact on epidemiological and phenotypic features. The frequency of mutations in Tunisian families was 42% (38/91) and in U.S. families 2.6% (1/39), with the unique opportunity to compare homozygous (n = 23) and heterozygous (n = 109) Tunisian carriers of G2019S substitutions. Individuals with G2019S substitutions had an older age at onset but few other differences compared with families negative for the substitution. Patients with LRRK2 mutations had typical clinical features of PD. Comparisons between individuals with heterozygous and homozygous LRRK2 mutations suggested that gene dosage was not correlated with phenotypic differences; however, the estimated penetrance was greater in homozygotes across all age groups.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B17</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B17G</s0>
</fC02>
<fC02 i1="03" i2="X"><s0>002B17A03</s0>
</fC02>
<fC02 i1="04" i2="X"><s0>002B17F</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Parkinson maladie</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Dépistage</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Medical screening</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Descubrimiento</s0>
<s5>09</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Etude comparative</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Comparative study</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Estudio comparativo</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Nord</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>North</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Norte</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Américain</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>American</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Americano</s0>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fN21><s1>085</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 07-0133217 INIST</NO>
<ET>Screening for Lrrk2 G2019S and clinical comparison of tunisian and North American caucasian Parkinson's disease families</ET>
<AU>ISHIHARA (Lianna); GIBSON (Rachel A.); WARREN (Liling); AMOURI (Rim); LYONS (Kelly); WIELINSKI (Catherine); HUNTER (Christine); SWARTZ (Jina E.); ELANGO (Ramu); AKKARI (P. Anthony); LEPPERT (David); SURH (Linda); REEVES (Kevin H.); THOMAS (Siwan); RAGONE (Leigh); HATTORI (Nobutaka); PAHWA (Rajesh); JANKOVIC (Joseph); NANCE (Martha); FREEMAN (Alan); GOUIDER-KHOUJA (Neziha); KEFI (Mounir); ZOUARI (Mourad); BEN SASSI (Samia); BEN YAHMED (Samia); EL EUCH-FAYECHE (Ghada); MIDDLETON (Lefkos); BURN (David J.); WATTS (Ray L.); HENTATI (Faycal)</AU>
<AF>Department of Public Health and Primary Care, University of Cambridge/Cambridge/Royaume-Uni (1 aut.); Research and Development, GlaxoSmithKline Pharmaceuticals/Greenford/Royaume-Uni (2 aut., 8 aut., 9 aut., 11 aut., 12 aut., 14 aut., 27 aut.); Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park/Durham, North Carolina/Etats-Unis (3 aut., 10 aut., 13 aut., 15 aut.); Service de Neurologie, Institut National de Neurologie/La Rabta, Tunis/Tunisie (4 aut., 21 aut., 22 aut., 23 aut., 24 aut., 25 aut., 26 aut., 30 aut.); Department of Neurology, University of Kansas Medical Center/Kansas City, Kansas/Etats-Unis (5 aut., 17 aut.); Struthers Parkinson's Center/Golden Valley, Minnesota/Etats-Unis (6 aut., 19 aut.); Department of Neurology, Baylor College of Medicine/Houston, Texas/Etats-Unis (7 aut., 18 aut.); Department of Neurology, Juntendo University School of Medicine/Tokyo/Japon (16 aut.); Department of Neurology, Emory University/Atlanta, Georgia/Etats-Unis (20 aut.); Department of Neurology, Newcastle General Hospital/Newcastle-upon-Tyne/Royaume-Uni (28 aut.); Department of Neurology, University of Alabama at Birmingham/Birmingham, Alabama/Etats-Unis (29 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 1; Pp. 55-61; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>Mutations in the leucine-rich repeat kinase-2 gene (LRRK2) are responsible for some forms of familial as well as sporadic Parkinson's disease (PD). The purpose of this study was to examine the frequency of a single pathogenic mutation (6055G>A) in the kinase domain of this gene in United States and Tunisian familial PD and to compare clinical characteristics between patients with and without the mutation. Standardized case report forms were used for clinical and demographic data collection. We investigated the frequency of the most common substitution of LRRK2 (G2019S, 6055G>A) and its impact on epidemiological and phenotypic features. The frequency of mutations in Tunisian families was 42% (38/91) and in U.S. families 2.6% (1/39), with the unique opportunity to compare homozygous (n = 23) and heterozygous (n = 109) Tunisian carriers of G2019S substitutions. Individuals with G2019S substitutions had an older age at onset but few other differences compared with families negative for the substitution. Patients with LRRK2 mutations had typical clinical features of PD. Comparisons between individuals with heterozygous and homozygous LRRK2 mutations suggested that gene dosage was not correlated with phenotypic differences; however, the estimated penetrance was greater in homozygotes across all age groups.</EA>
<CC>002B17; 002B17G; 002B17A03; 002B17F</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Dépistage; Etude comparative; Nord; Américain</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Medical screening; Comparative study; North; American</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Descubrimiento; Estudio comparativo; Norte; Americano</SD>
<LO>INIST-20953.354000145483830080</LO>
<ID>07-0133217</ID>
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