Polymorphism of NACP-Rep1 in Parkinson's disease : An etiologic link with essential tremor?
Identifieur interne : 000155 ( PascalFrancis/Checkpoint ); précédent : 000154; suivant : 000156Polymorphism of NACP-Rep1 in Parkinson's disease : An etiologic link with essential tremor?
Auteurs : E Tan [États-Unis] ; T Matsuura [États-Unis] ; S Nagamitsu [États-Unis] ; M Khajavi [États-Unis] ; J Jankovic [États-Unis] ; T Ashizawa [États-Unis]Source :
- Neurology [ 0028-3878 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
An allele (263bp) of the nonamyloid component of plaques (NACP)-Repl polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.
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uniqKey="Tan E" first="E" last="Tan">E Tan</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Matsuura, T" sort="Matsuura, T" uniqKey="Matsuura T" first="T" last="Matsuura">T Matsuura</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Neurology Service, VA Medical Center</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>2 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sort="Khajavi, M" uniqKey="Khajavi M" first="M" last="Khajavi">M Khajavi</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Neurology Service, VA Medical Center</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J Jankovic</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>1 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type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Exploration</term><term>Genotype</term><term>Human</term><term>Parkinson disease</term><term>Polymorphism</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Génotype</term><term>Polymorphisme</term><term>Exploration</term><term>Homme</term><term>Gène NACP-Rep1</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">An allele (263bp) of the nonamyloid component of plaques (NACP)-Repl polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-3878</s0></fA01><fA02 i1="01"><s0>NEURAI</s0></fA02><fA03 i2="1"><s0>Neurology</s0></fA03><fA05><s2>54</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Polymorphism of NACP-Rep1 in Parkinson's disease : An etiologic link with essential tremor?</s1></fA08><fA11 i1="01" i2="1"><s1>TAN (E. K.)</s1></fA11><fA11 i1="02" i2="1"><s1>MATSUURA (T.)</s1></fA11><fA11 i1="03" i2="1"><s1>NAGAMITSU (S.)</s1></fA11><fA11 i1="04" i2="1"><s1>KHAJAVI (M.)</s1></fA11><fA11 i1="05" i2="1"><s1>JANKOVIC (J.)</s1></fA11><fA11 i1="06" i2="1"><s1>ASHIZAWA (T.)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Neurology Service, VA Medical Center</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></fA14><fA20><s1>1195-1198</s1></fA20><fA21><s1>2000</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6345</s2><s5>354000082099350330</s5></fA43><fA44><s0>0000</s0><s1>© 2000 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>10 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>00-0169739</s0></fA47><fA60><s1>P</s1><s3>CC</s3></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Neurology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>An allele (263bp) of the nonamyloid component of plaques (NACP)-Repl polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Génotype</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Genotype</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Genotipo</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Polymorphisme</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Polymorphism</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Polimorfismo</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Exploration</s0><s5>17</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Exploration</s0><s5>17</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Exploración</s0><s5>17</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0><s5>20</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Human</s0><s5>20</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0><s5>20</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Gène NACP-Rep1</s0><s4>INC</s4><s5>86</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fN21><s1>122</s1></fN21></pA></standard></inist><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Tan, E K" sort="Tan, E K" uniqKey="Tan E" first="E" last="Tan">E Tan</name></region><name sortKey="Ashizawa, T" sort="Ashizawa, T" uniqKey="Ashizawa T" first="T" last="Ashizawa">T Ashizawa</name><name sortKey="Ashizawa, T" sort="Ashizawa, T" uniqKey="Ashizawa T" first="T" last="Ashizawa">T Ashizawa</name><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J Jankovic</name><name sortKey="Khajavi, M" sort="Khajavi, M" uniqKey="Khajavi M" first="M" last="Khajavi">M Khajavi</name><name sortKey="Khajavi, M" sort="Khajavi, M" uniqKey="Khajavi M" first="M" last="Khajavi">M Khajavi</name><name sortKey="Matsuura, T" sort="Matsuura, T" uniqKey="Matsuura T" first="T" last="Matsuura">T Matsuura</name><name sortKey="Matsuura, T" sort="Matsuura, T" uniqKey="Matsuura T" first="T" last="Matsuura">T Matsuura</name><name sortKey="Nagamitsu, S" sort="Nagamitsu, S" uniqKey="Nagamitsu S" first="S" last="Nagamitsu">S Nagamitsu</name><name sortKey="Nagamitsu, S" sort="Nagamitsu, S" uniqKey="Nagamitsu S" first="S" last="Nagamitsu">S Nagamitsu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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