JankovicV1, Ncbi, Merge, bibRecord, 000512

Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study.

Identifieur interne : 000512 ( Ncbi/Merge ); précédent : 000511; suivant : 000513

Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study.

Auteurs : Mike. Nalls [États-Unis] ; Cory. Mclean [États-Unis] ; Jacqueline Rick [États-Unis] ; Shirley Eberly [États-Unis] ; Samantha. Hutten [États-Unis] ; Katrina Gwinn [États-Unis] ; Margaret Sutherland [États-Unis] ; Maria Martinez [France] ; Peter Heutink [Allemagne] ; Nigel. Williams [Royaume-Uni] ; John Hardy [Royaume-Uni] ; Thomas Gasser [Allemagne] ; Alexis Brice [France] ; T Price [États-Unis] ; Aude Nicolas [États-Unis] ; Margaux. Keller [États-Unis] ; Cliona Molony [États-Unis] ; J Gibbs [États-Unis] ; Alice Chen [États-Unis] ; Eunran Suh [États-Unis] ; Christopher Letson [États-Unis] ; Massimo. Fiandaca [États-Unis] ; Mark Mapstone [États-Unis] ; Howard. Federoff [États-Unis] ; Alastair. Noyce [Royaume-Uni] ; Huw Morris [Royaume-Uni] ; Vivianna. Van [États-Unis] ; Daniel Weintraub [États-Unis] ; Cyrus Zabetian [États-Unis] ; Dena. Hernandez [États-Unis] ; Suzanne Lesage [France] ; Meghan Mullins [États-Unis] ; Emily Conley [États-Unis] ; Carrie. Northover [États-Unis] ; Mark Frasier [États-Unis] ; Ken Marek [États-Unis] ; Aaron. Day [États-Unis] ; David. Stone [États-Unis] ; John. Ioannidis [États-Unis] ; Andrew. Singleton [États-Unis]

Source :

The Lancet. Neurology ; 2015.

RBID : pubmed:26271532

English descriptors

KwdEn :
- Aged, Cohort Studies, Disease Progression, Female, Humans, Male, Middle Aged, Models, Statistical, Parkinson Disease (diagnosis), Parkinson Disease (genetics), Prodromal Symptoms.
MESH :
- diagnosis : Parkinson Disease.
- genetics : Parkinson Disease.
- Aged, Cohort Studies, Disease Progression, Female, Humans, Male, Middle Aged, Models, Statistical, Prodromal Symptoms.

Abstract

Accurate diagnosis and early detection of complex diseases, such as Parkinson's disease, has the potential to be of great benefit for researchers and clinical practice. We aimed to create a non-invasive, accurate classification model for the diagnosis of Parkinson's disease, which could serve as a basis for future disease prediction studies in longitudinal cohorts.

DOI: 10.1016/S1474-4422(15)00178-7
PubMed: 26271532

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pubmed:26271532

Le document en format XML

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<author><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name>
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<author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name>
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<author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name>
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<author><name sortKey="Williams, Nigel M" sort="Williams, Nigel M" uniqKey="Williams N" first="Nigel" last="Williams">Nigel. Williams</name>
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<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
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<wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea>
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<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
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<author><name sortKey="Price, T Ryan" sort="Price, T Ryan" uniqKey="Price T" first="T" last="Price">T Price</name>
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<author><name sortKey="Nicolas, Aude" sort="Nicolas, Aude" uniqKey="Nicolas A" first="Aude" last="Nicolas">Aude Nicolas</name>
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</placeName>
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</author>
<author><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux" last="Keller">Margaux. Keller</name>
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<author><name sortKey="Molony, Cliona" sort="Molony, Cliona" uniqKey="Molony C" first="Cliona" last="Molony">Cliona Molony</name>
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</placeName>
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</author>
<author><name sortKey="Gibbs, J Raphael" sort="Gibbs, J Raphael" uniqKey="Gibbs J" first="J" last="Gibbs">J Gibbs</name>
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<author><name sortKey="Chen Plotkin, Alice" sort="Chen Plotkin, Alice" uniqKey="Chen Plotkin A" first="Alice" last="Chen">Alice Chen</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suh, Eunran" sort="Suh, Eunran" uniqKey="Suh E" first="Eunran" last="Suh">Eunran Suh</name>
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<author><name sortKey="Letson, Christopher" sort="Letson, Christopher" uniqKey="Letson C" first="Christopher" last="Letson">Christopher Letson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Fiandaca, Massimo S" sort="Fiandaca, Massimo S" uniqKey="Fiandaca M" first="Massimo" last="Fiandaca">Massimo. Fiandaca</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Georgetown University Medical Center, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mapstone, Mark" sort="Mapstone, Mark" uniqKey="Mapstone M" first="Mark" last="Mapstone">Mark Mapstone</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Federoff, Howard J" sort="Federoff, Howard J" uniqKey="Federoff H" first="Howard" last="Federoff">Howard. Federoff</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Georgetown University Medical Center, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Noyce, Alastair J" sort="Noyce, Alastair J" uniqKey="Noyce A" first="Alastair" last="Noyce">Alastair. Noyce</name>
<affiliation wicri:level="3"><nlm:affiliation>Reta Lila Weston Institute, University College London Institute of Neurology, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute, University College London Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morris, Huw" sort="Morris, Huw" uniqKey="Morris H" first="Huw" last="Morris">Huw Morris</name>
<affiliation wicri:level="3"><nlm:affiliation>Reta Lila Weston Institute, University College London Institute of Neurology, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute, University College London Institute of Neurology, London</wicri:regionArea>
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<region type="région" nuts="1">Grand Londres</region>
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<author><name sortKey="Van Deerlin, Vivianna M" sort="Van Deerlin, Vivianna M" uniqKey="Van Deerlin V" first="Vivianna" last="Van">Vivianna. Van</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
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<author><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
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<author><name sortKey="Zabetian, Cyrus" sort="Zabetian, Cyrus" uniqKey="Zabetian C" first="Cyrus" last="Zabetian">Cyrus Zabetian</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Division of Neurogenetics, VA Puget Sound Health Care System, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Neurogenetics, VA Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena" last="Hernandez">Dena. Hernandez</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
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</author>
<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
<affiliation wicri:level="1"><nlm:affiliation>Sorbonne Université, UPMC Univ Paris 06, UM 1127, ICM, Paris, France; INSERM, U 1127, and CNRS, UMR 7225, Institut du Cerveau et de la Moelle Epinière, Paris, France; AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Université, UPMC Univ Paris 06, UM 1127, ICM, Paris, France; INSERM, U 1127, and CNRS, UMR 7225, Institut du Cerveau et de la Moelle Epinière, Paris, France; AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
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<author><name sortKey="Mullins, Meghan" sort="Mullins, Meghan" uniqKey="Mullins M" first="Meghan" last="Mullins">Meghan Mullins</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>23andMe, Mountain View, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Conley, Emily Drabant" sort="Conley, Emily Drabant" uniqKey="Conley E" first="Emily" last="Conley">Emily Conley</name>
<affiliation wicri:level="2"><nlm:affiliation>23andMe, Mountain View, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>23andMe, Mountain View, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Northover, Carrie A M" sort="Northover, Carrie A M" uniqKey="Northover C" first="Carrie" last="Northover">Carrie. Northover</name>
<affiliation wicri:level="2"><nlm:affiliation>23andMe, Mountain View, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>23andMe, Mountain View, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frasier, Mark" sort="Frasier, Mark" uniqKey="Frasier M" first="Mark" last="Frasier">Mark Frasier</name>
<affiliation wicri:level="2"><nlm:affiliation>The Michael J Fox Foundation for Parkinson's Research, New York, NY 10018, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Michael J Fox Foundation for Parkinson's Research, New York, NY 10018</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute for Neurodegenerative Disorders, New Haven, CT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Neurodegenerative Disorders, New Haven, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Day Williams, Aaron G" sort="Day Williams, Aaron G" uniqKey="Day Williams A" first="Aaron" last="Day">Aaron. Day</name>
<affiliation wicri:level="2"><nlm:affiliation>Precision Medicine, Biogen, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Precision Medicine, Biogen, Cambridge, MA</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Stone, David J" sort="Stone, David J" uniqKey="Stone D" first="David" last="Stone">David. Stone</name>
<affiliation wicri:level="2"><nlm:affiliation>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John" last="Ioannidis">John. Ioannidis</name>
<affiliation wicri:level="2"><nlm:affiliation>Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA; Department of Medicine, Stanford Prevention Research Center, Stanford, CA, USA; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA; Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA; Department of Medicine, Stanford Prevention Research Center, Stanford, CA, USA; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA; Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
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</affiliation>
</author>
<author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew. Singleton</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Electronic address: singleta@mail.nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study.</title>
<author><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike" last="Nalls">Mike. Nalls</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
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<affiliation wicri:level="2"><nlm:affiliation>23andMe, Mountain View, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>23andMe, Mountain View, CA</wicri:regionArea>
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<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<author><name sortKey="Eberly, Shirley" sort="Eberly, Shirley" uniqKey="Eberly S" first="Shirley" last="Eberly">Shirley Eberly</name>
<affiliation wicri:level="2"><nlm:affiliation>Deptartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Deptartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
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<author><name sortKey="Hutten, Samantha J" sort="Hutten, Samantha J" uniqKey="Hutten S" first="Samantha" last="Hutten">Samantha. Hutten</name>
<affiliation wicri:level="2"><nlm:affiliation>The Michael J Fox Foundation for Parkinson's Research, New York, NY 10018, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Michael J Fox Foundation for Parkinson's Research, New York, NY 10018</wicri:regionArea>
<placeName><region type="state">État de New York</region>
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<author><name sortKey="Gwinn, Katrina" sort="Gwinn, Katrina" uniqKey="Gwinn K" first="Katrina" last="Gwinn">Katrina Gwinn</name>
<affiliation wicri:level="2"><nlm:affiliation>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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<author><name sortKey="Sutherland, Margaret" sort="Sutherland, Margaret" uniqKey="Sutherland M" first="Margaret" last="Sutherland">Margaret Sutherland</name>
<affiliation wicri:level="2"><nlm:affiliation>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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<author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name>
<affiliation wicri:level="1"><nlm:affiliation>INSERM, UMR 1043, Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France; Paul Sabatier University, Toulouse, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, UMR 1043, Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France; Paul Sabatier University, Toulouse</wicri:regionArea>
<placeName><settlement type="city">Toulouse</settlement>
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</affiliation>
</author>
<author><name sortKey="Heutink, Peter" sort="Heutink, Peter" uniqKey="Heutink P" first="Peter" last="Heutink">Peter Heutink</name>
<affiliation wicri:level="3"><nlm:affiliation>Genome Biology of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Genome Biology of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Williams, Nigel M" sort="Williams, Nigel M" uniqKey="Williams N" first="Nigel" last="Williams">Nigel. Williams</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Psychological Medicine and Clinical Neurosciences, MRCCentre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychological Medicine and Clinical Neurosciences, MRCCentre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff</wicri:regionArea>
<wicri:noRegion>Cardiff</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation wicri:level="3"><nlm:affiliation>Reta Lila Weston Institute, University College London Institute of Neurology, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute, University College London Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
<affiliation wicri:level="3"><nlm:affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<affiliation wicri:level="1"><nlm:affiliation>Sorbonne Université, UPMC Univ Paris 06, UM 1127, ICM, Paris, France; INSERM, U 1127, and CNRS, UMR 7225, Institut du Cerveau et de la Moelle Epinière, Paris, France; AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Université, UPMC Univ Paris 06, UM 1127, ICM, Paris, France; INSERM, U 1127, and CNRS, UMR 7225, Institut du Cerveau et de la Moelle Epinière, Paris, France; AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Price, T Ryan" sort="Price, T Ryan" uniqKey="Price T" first="T" last="Price">T Price</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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</affiliation>
</author>
<author><name sortKey="Nicolas, Aude" sort="Nicolas, Aude" uniqKey="Nicolas A" first="Aude" last="Nicolas">Aude Nicolas</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keller, Margaux F" sort="Keller, Margaux F" uniqKey="Keller M" first="Margaux" last="Keller">Margaux. Keller</name>
<affiliation wicri:level="2"><nlm:affiliation>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Molony, Cliona" sort="Molony, Cliona" uniqKey="Molony C" first="Cliona" last="Molony">Cliona Molony</name>
<affiliation wicri:level="2"><nlm:affiliation>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gibbs, J Raphael" sort="Gibbs, J Raphael" uniqKey="Gibbs J" first="J" last="Gibbs">J Gibbs</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
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</affiliation>
</author>
<author><name sortKey="Chen Plotkin, Alice" sort="Chen Plotkin, Alice" uniqKey="Chen Plotkin A" first="Alice" last="Chen">Alice Chen</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Suh, Eunran" sort="Suh, Eunran" uniqKey="Suh E" first="Eunran" last="Suh">Eunran Suh</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Letson, Christopher" sort="Letson, Christopher" uniqKey="Letson C" first="Christopher" last="Letson">Christopher Letson</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fiandaca, Massimo S" sort="Fiandaca, Massimo S" uniqKey="Fiandaca M" first="Massimo" last="Fiandaca">Massimo. Fiandaca</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Georgetown University Medical Center, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mapstone, Mark" sort="Mapstone, Mark" uniqKey="Mapstone M" first="Mark" last="Mapstone">Mark Mapstone</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Rochester Medical Center, Rochester, NY</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Federoff, Howard J" sort="Federoff, Howard J" uniqKey="Federoff H" first="Howard" last="Federoff">Howard. Federoff</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Georgetown University Medical Center, Washington, DC</wicri:regionArea>
<placeName><region type="state">District de Columbia</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Noyce, Alastair J" sort="Noyce, Alastair J" uniqKey="Noyce A" first="Alastair" last="Noyce">Alastair. Noyce</name>
<affiliation wicri:level="3"><nlm:affiliation>Reta Lila Weston Institute, University College London Institute of Neurology, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute, University College London Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morris, Huw" sort="Morris, Huw" uniqKey="Morris H" first="Huw" last="Morris">Huw Morris</name>
<affiliation wicri:level="3"><nlm:affiliation>Reta Lila Weston Institute, University College London Institute of Neurology, London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Reta Lila Weston Institute, University College London Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Deerlin, Vivianna M" sort="Van Deerlin, Vivianna M" uniqKey="Van Deerlin V" first="Vivianna" last="Van">Vivianna. Van</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weintraub, Daniel" sort="Weintraub, Daniel" uniqKey="Weintraub D" first="Daniel" last="Weintraub">Daniel Weintraub</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zabetian, Cyrus" sort="Zabetian, Cyrus" uniqKey="Zabetian C" first="Cyrus" last="Zabetian">Cyrus Zabetian</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Division of Neurogenetics, VA Puget Sound Health Care System, Seattle, WA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Division of Neurogenetics, VA Puget Sound Health Care System, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena" last="Hernandez">Dena. Hernandez</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lesage, Suzanne" sort="Lesage, Suzanne" uniqKey="Lesage S" first="Suzanne" last="Lesage">Suzanne Lesage</name>
<affiliation wicri:level="1"><nlm:affiliation>Sorbonne Université, UPMC Univ Paris 06, UM 1127, ICM, Paris, France; INSERM, U 1127, and CNRS, UMR 7225, Institut du Cerveau et de la Moelle Epinière, Paris, France; AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Sorbonne Université, UPMC Univ Paris 06, UM 1127, ICM, Paris, France; INSERM, U 1127, and CNRS, UMR 7225, Institut du Cerveau et de la Moelle Epinière, Paris, France; AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris</wicri:regionArea>
<placeName><settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mullins, Meghan" sort="Mullins, Meghan" uniqKey="Mullins M" first="Meghan" last="Mullins">Meghan Mullins</name>
<affiliation wicri:level="2"><nlm:affiliation>23andMe, Mountain View, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>23andMe, Mountain View, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Conley, Emily Drabant" sort="Conley, Emily Drabant" uniqKey="Conley E" first="Emily" last="Conley">Emily Conley</name>
<affiliation wicri:level="2"><nlm:affiliation>23andMe, Mountain View, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>23andMe, Mountain View, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Northover, Carrie A M" sort="Northover, Carrie A M" uniqKey="Northover C" first="Carrie" last="Northover">Carrie. Northover</name>
<affiliation wicri:level="2"><nlm:affiliation>23andMe, Mountain View, CA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>23andMe, Mountain View, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Frasier, Mark" sort="Frasier, Mark" uniqKey="Frasier M" first="Mark" last="Frasier">Mark Frasier</name>
<affiliation wicri:level="2"><nlm:affiliation>The Michael J Fox Foundation for Parkinson's Research, New York, NY 10018, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Michael J Fox Foundation for Parkinson's Research, New York, NY 10018</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Marek, Ken" sort="Marek, Ken" uniqKey="Marek K" first="Ken" last="Marek">Ken Marek</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute for Neurodegenerative Disorders, New Haven, CT, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute for Neurodegenerative Disorders, New Haven, CT</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Day Williams, Aaron G" sort="Day Williams, Aaron G" uniqKey="Day Williams A" first="Aaron" last="Day">Aaron. Day</name>
<affiliation wicri:level="2"><nlm:affiliation>Precision Medicine, Biogen, Cambridge, MA, USA.</nlm:affiliation>
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<wicri:regionArea>Precision Medicine, Biogen, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stone, David J" sort="Stone, David J" uniqKey="Stone D" first="David" last="Stone">David. Stone</name>
<affiliation wicri:level="2"><nlm:affiliation>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ioannidis, John P A" sort="Ioannidis, John P A" uniqKey="Ioannidis J" first="John" last="Ioannidis">John. Ioannidis</name>
<affiliation wicri:level="2"><nlm:affiliation>Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA; Department of Medicine, Stanford Prevention Research Center, Stanford, CA, USA; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA; Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA, USA.</nlm:affiliation>
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<wicri:regionArea>Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA; Department of Medicine, Stanford Prevention Research Center, Stanford, CA, USA; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA; Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Singleton, Andrew B" sort="Singleton, Andrew B" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew. Singleton</name>
<affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Electronic address: singleta@mail.nih.gov.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
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<series><title level="j">The Lancet. Neurology</title>
<idno type="e-ISSN">1474-4465</idno>
<imprint><date when="2015" type="published">2015</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cohort Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Statistical</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (genetics)</term>
<term>Prodromal Symptoms</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Cohort Studies</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Statistical</term>
<term>Prodromal Symptoms</term>
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<front><div type="abstract" xml:lang="en">Accurate diagnosis and early detection of complex diseases, such as Parkinson's disease, has the potential to be of great benefit for researchers and clinical practice. We aimed to create a non-invasive, accurate classification model for the diagnosis of Parkinson's disease, which could serve as a basis for future disease prediction studies in longitudinal cohorts.</div>
</front>
</TEI>
<pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">26271532</PMID>
<DateCreated><Year>2015</Year>
<Month>09</Month>
<Day>17</Day>
</DateCreated>
<DateCompleted><Year>2015</Year>
<Month>12</Month>
<Day>22</Day>
</DateCompleted>
<DateRevised><Year>2016</Year>
<Month>01</Month>
<Day>05</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-4465</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>14</Volume>
<Issue>10</Issue>
<PubDate><Year>2015</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>The Lancet. Neurology</Title>
<ISOAbbreviation>Lancet Neurol</ISOAbbreviation>
</Journal>
<ArticleTitle>Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study.</ArticleTitle>
<Pagination><MedlinePgn>1002-9</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/S1474-4422(15)00178-7</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S1474-4422(15)00178-7</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Accurate diagnosis and early detection of complex diseases, such as Parkinson's disease, has the potential to be of great benefit for researchers and clinical practice. We aimed to create a non-invasive, accurate classification model for the diagnosis of Parkinson's disease, which could serve as a basis for future disease prediction studies in longitudinal cohorts.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We developed a model for disease classification using data from the Parkinson's Progression Marker Initiative (PPMI) study for 367 patients with Parkinson's disease and phenotypically typical imaging data and 165 controls without neurological disease. Olfactory function, genetic risk, family history of Parkinson's disease, age, and gender were algorithmically selected by stepwise logistic regression as significant contributors to our classifying model. We then tested the model with data from 825 patients with Parkinson's disease and 261 controls from five independent cohorts with varying recruitment strategies and designs: the Parkinson's Disease Biomarkers Program (PDBP), the Parkinson's Associated Risk Study (PARS), 23andMe, the Longitudinal and Biomarker Study in PD (LABS-PD), and the Morris K Udall Parkinson's Disease Research Center of Excellence cohort (Penn-Udall). Additionally, we used our model to investigate patients who had imaging scans without evidence of dopaminergic deficit (SWEDD).</AbstractText>
<AbstractText Label="FINDINGS" NlmCategory="RESULTS">In the population from PPMI, our initial model correctly distinguished patients with Parkinson's disease from controls at an area under the curve (AUC) of 0·923 (95% CI 0·900-0·946) with high sensitivity (0·834, 95% CI 0·711-0·883) and specificity (0·903, 95% CI 0·824-0·946) at its optimum AUC threshold (0·655). All Hosmer-Lemeshow simulations suggested that when parsed into random subgroups, the subgroup data matched that of the overall cohort. External validation showed good classification of Parkinson's disease, with AUCs of 0·894 (95% CI 0·867-0·921) in the PDBP cohort, 0·998 (0·992-1·000) in PARS, 0·955 (no 95% CI available) in 23andMe, 0·929 (0·896-0·962) in LABS-PD, and 0·939 (0·891-0·986) in the Penn-Udall cohort. Four of 17 SWEDD participants who our model classified as having Parkinson's disease converted to Parkinson's disease within 1 year, whereas only one of 38 SWEDD participants who were not classified as having Parkinson's disease underwent conversion (test of proportions, p=0·003).</AbstractText>
<AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Our model provides a potential new approach to distinguish participants with Parkinson's disease from controls. If the model can also identify individuals with prodromal or preclinical Parkinson's disease in prospective cohorts, it could facilitate identification of biomarkers and interventions.</AbstractText>
<AbstractText Label="FUNDING" NlmCategory="BACKGROUND">National Institute on Aging, National Institute of Neurological Disorders and Stroke, and the Michael J Fox Foundation.</AbstractText>
<CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nalls</LastName>
<ForeName>Mike A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McLean</LastName>
<ForeName>Cory Y</ForeName>
<Initials>CY</Initials>
<AffiliationInfo><Affiliation>23andMe, Mountain View, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rick</LastName>
<ForeName>Jacqueline</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eberly</LastName>
<ForeName>Shirley</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Deptartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hutten</LastName>
<ForeName>Samantha J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>The Michael J Fox Foundation for Parkinson's Research, New York, NY 10018, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gwinn</LastName>
<ForeName>Katrina</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sutherland</LastName>
<ForeName>Margaret</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martinez</LastName>
<ForeName>Maria</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>INSERM, UMR 1043, Centre de Physiopathologie de Toulouse-Purpan, Toulouse, France; Paul Sabatier University, Toulouse, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Heutink</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Genome Biology of Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Williams</LastName>
<ForeName>Nigel M</ForeName>
<Initials>NM</Initials>
<AffiliationInfo><Affiliation>Institute of Psychological Medicine and Clinical Neurosciences, MRCCentre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hardy</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Reta Lila Weston Institute, University College London Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gasser</LastName>
<ForeName>Thomas</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department for Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Brice</LastName>
<ForeName>Alexis</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Sorbonne Université, UPMC Univ Paris 06, UM 1127, ICM, Paris, France; INSERM, U 1127, and CNRS, UMR 7225, Institut du Cerveau et de la Moelle Epinière, Paris, France; AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Price</LastName>
<ForeName>T Ryan</ForeName>
<Initials>TR</Initials>
<AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nicolas</LastName>
<ForeName>Aude</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Keller</LastName>
<ForeName>Margaux F</ForeName>
<Initials>MF</Initials>
<AffiliationInfo><Affiliation>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Molony</LastName>
<ForeName>Cliona</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gibbs</LastName>
<ForeName>J Raphael</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen-Plotkin</LastName>
<ForeName>Alice</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Suh</LastName>
<ForeName>Eunran</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Letson</LastName>
<ForeName>Christopher</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fiandaca</LastName>
<ForeName>Massimo S</ForeName>
<Initials>MS</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mapstone</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Federoff</LastName>
<ForeName>Howard J</ForeName>
<Initials>HJ</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Georgetown University Medical Center, Washington, DC, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Noyce</LastName>
<ForeName>Alastair J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>Reta Lila Weston Institute, University College London Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morris</LastName>
<ForeName>Huw</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Reta Lila Weston Institute, University College London Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Van Deerlin</LastName>
<ForeName>Vivianna M</ForeName>
<Initials>VM</Initials>
<AffiliationInfo><Affiliation>Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Weintraub</LastName>
<ForeName>Daniel</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zabetian</LastName>
<ForeName>Cyrus</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Division of Neurogenetics, VA Puget Sound Health Care System, Seattle, WA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hernandez</LastName>
<ForeName>Dena G</ForeName>
<Initials>DG</Initials>
<AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lesage</LastName>
<ForeName>Suzanne</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Sorbonne Université, UPMC Univ Paris 06, UM 1127, ICM, Paris, France; INSERM, U 1127, and CNRS, UMR 7225, Institut du Cerveau et de la Moelle Epinière, Paris, France; AP-HP, Hôpital de la Salpêtrière, Département de Génétique et Cytogénétique, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mullins</LastName>
<ForeName>Meghan</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>23andMe, Mountain View, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Conley</LastName>
<ForeName>Emily Drabant</ForeName>
<Initials>ED</Initials>
<AffiliationInfo><Affiliation>23andMe, Mountain View, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Northover</LastName>
<ForeName>Carrie A M</ForeName>
<Initials>CA</Initials>
<AffiliationInfo><Affiliation>23andMe, Mountain View, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Frasier</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>The Michael J Fox Foundation for Parkinson's Research, New York, NY 10018, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marek</LastName>
<ForeName>Ken</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Institute for Neurodegenerative Disorders, New Haven, CT, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Day-Williams</LastName>
<ForeName>Aaron G</ForeName>
<Initials>AG</Initials>
<AffiliationInfo><Affiliation>Precision Medicine, Biogen, Cambridge, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stone</LastName>
<ForeName>David J</ForeName>
<Initials>DJ</Initials>
<AffiliationInfo><Affiliation>Genetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA; Merck Research Laboratories, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ioannidis</LastName>
<ForeName>John P A</ForeName>
<Initials>JP</Initials>
<AffiliationInfo><Affiliation>Meta-Research Innovation Center at Stanford (METRICS), Stanford University, Stanford, CA, USA; Department of Medicine, Stanford Prevention Research Center, Stanford, CA, USA; Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, USA; Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Singleton</LastName>
<ForeName>Andrew B</ForeName>
<Initials>AB</Initials>
<AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Electronic address: singleta@mail.nih.gov.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>Parkinson's Disease Biomarkers Program and Parkinson's Progression Marker Initiative investigators</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>F-1201</GrantID>
<Agency>Parkinson's UK</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>G0700943</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>G1100643</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>P50 NS053488</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P50 NS062684</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P50 NS062684</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P50NS053488</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01NS082133</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01NS082134</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01NS082137</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01NS082148</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01NS082151</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01NS082157</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>WT089698</GrantID>
<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>Z01 AG000949-02</GrantID>
<Agency>Intramural NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>Z01-AG000949-02</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
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<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>08</Month>
<Day>10</Day>
</ArticleDate>
</Article>
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<MedlineTA>Lancet Neurol</MedlineTA>
<NlmUniqueID>101139309</NlmUniqueID>
<ISSNLinking>1474-4422</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
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	Serveur d'exploration autour de Joseph Jankovic
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Serveur d'exploration autour de Joseph Jankovic

Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study.

Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study.

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