Effect of Tetrabenazine on Motor Function in Patients with Huntington Disease
Identifieur interne : 000499 ( Ncbi/Merge ); précédent : 000498; suivant : 000500Effect of Tetrabenazine on Motor Function in Patients with Huntington Disease
Auteurs : Joseph Ferrara [États-Unis] ; Giovanni Mostile [États-Unis] ; Christine Hunter [États-Unis] ; Octavian Adam ; Joseph Jankovic [États-Unis]Source :
- Neurology and Therapy [ 2193-8253 ] ; 2012.
Abstract
Tetrabenazine (TBZ) reduces chorea related to Huntington disease (HD); however, it is uncertain whether this effect improves functionally relevant motor skills such as hand coordination and balance. The objective of this study was to provide pilot data regarding three motor function tests, which might be useful in monitoring symptom progression and therapeutic response, pending formal validation.
The authors assessed 11 ambulatory patients with HD-related chorea on two occasions: (1) while off TBZ (either prior to starting therapy or following a >24 h washout) and (2) when on a stable dose of TBZ, titrated to optimal effect. Study evaluations included the Jebsen-Taylor Hand Function Test (JTHFT) and Berg Balance Scale, a timed 25-foot walk, the Montreal Cognitive Assessment (MoCA) and the complete United Huntington Disease Rating Scale (UHDRS).
Maximal chorea scores (UHDRS item 12) improved from 11.1 ± 2.9 to 8.5 ± 3.9 while on TBZ (
This pilot study did not detect significant functional gains with chorea suppression. The fact that performance on tests of hand function correlates with MoCA but not UHDRS chorea scores highlights the need for additional treatments targeted toward the cognitive aspects of HD.
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DOI: 10.1007/s40120-012-0005-7
PubMed: 26000211
PubMed Central: 4389035
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of Tetrabenazine on Motor Function in Patients with Huntington Disease</title><author><name sortKey="Ferrara, Joseph M" sort="Ferrara, Joseph M" uniqKey="Ferrara J" first="Joseph" last="Ferrara">Joseph Ferrara</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, VA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke</wicri:cityArea></affiliation></author><author><name sortKey="Mostile, Giovanni" sort="Mostile, Giovanni" uniqKey="Mostile G" first="Giovanni" last="Mostile">Giovanni Mostile</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Adam, Octavian R" sort="Adam, Octavian R" uniqKey="Adam O" first="Octavian" last="Adam">Octavian Adam</name><affiliation><nlm:aff id="Aff3">Division of Neurology, Naval Medical Center, Portsmouth, VI USA</nlm:aff><wicri:noCountry code="subfield">VI USA</wicri:noCountry></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26000211</idno><idno type="pmc">4389035</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389035</idno><idno type="RBID">PMC:4389035</idno><idno type="doi">10.1007/s40120-012-0005-7</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000033</idno><idno type="wicri:Area/Pmc/Curation">000033</idno><idno type="wicri:Area/Pmc/Checkpoint">000104</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000050</idno><idno type="wicri:Area/PubMed/Curation">000050</idno><idno type="wicri:Area/PubMed/Checkpoint">000062</idno><idno type="wicri:Area/Ncbi/Merge">000499</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of Tetrabenazine on Motor Function in Patients with Huntington Disease</title><author><name sortKey="Ferrara, Joseph M" sort="Ferrara, Joseph M" uniqKey="Ferrara J" first="Joseph" last="Ferrara">Joseph Ferrara</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, VA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke</wicri:cityArea></affiliation></author><author><name sortKey="Mostile, Giovanni" sort="Mostile, Giovanni" uniqKey="Mostile G" first="Giovanni" last="Mostile">Giovanni Mostile</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Adam, Octavian R" sort="Adam, Octavian R" uniqKey="Adam O" first="Octavian" last="Adam">Octavian Adam</name><affiliation><nlm:aff id="Aff3">Division of Neurology, Naval Medical Center, Portsmouth, VI USA</nlm:aff><wicri:noCountry code="subfield">VI USA</wicri:noCountry></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j">Neurology and Therapy</title><idno type="ISSN">2193-8253</idno><idno type="e-ISSN">2193-6536</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Tetrabenazine (TBZ) reduces chorea related to Huntington disease (HD); however, it is uncertain whether this effect improves functionally relevant motor skills such as hand coordination and balance. The objective of this study was to provide pilot data regarding three motor function tests, which might be useful in monitoring symptom progression and therapeutic response, pending formal validation.</p></sec><sec><title>Methods</title><p>The authors assessed 11 ambulatory patients with HD-related chorea on two occasions: (1) while off TBZ (either prior to starting therapy or following a >24 h washout) and (2) when on a stable dose of TBZ, titrated to optimal effect. Study evaluations included the Jebsen-Taylor Hand Function Test (JTHFT) and Berg Balance Scale, a timed 25-foot walk, the Montreal Cognitive Assessment (MoCA) and the complete United Huntington Disease Rating Scale (UHDRS).</p></sec><sec><title>Results</title><p>Maximal chorea scores (UHDRS item 12) improved from 11.1 ± 2.9 to 8.5 ± 3.9 while on TBZ (<italic>P</italic> = 0.03), but we could not detect an improvement in functional measures while on TBZ in this small cohort. Scores of the JTHFT were globally slower than published normative data and correlated with MoCA summary scores, but not UHDRS chorea scores.</p></sec><sec><title>Conclusions</title><p>This pilot study did not detect significant functional gains with chorea suppression. The fact that performance on tests of hand function correlates with MoCA but not UHDRS chorea scores highlights the need for additional treatments targeted toward the cognitive aspects of HD.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fenney, A" uniqKey="Fenney A">A Fenney</name></author><author><name sortKey="Jog, Ms" uniqKey="Jog M">MS Jog</name></author><author><name sortKey="Duval, C" uniqKey="Duval C">C Duval</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reilmann, R" uniqKey="Reilmann R">R Reilmann</name></author><author><name sortKey="Kirsten, F" uniqKey="Kirsten F">F Kirsten</name></author><author><name sortKey="Quinn, L" uniqKey="Quinn L">L Quinn</name></author><author><name sortKey="Henningsen, H" uniqKey="Henningsen H">H Henningsen</name></author><author><name sortKey="Marder, K" uniqKey="Marder K">K Marder</name></author><author><name sortKey="Gordon, Am" uniqKey="Gordon 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Jankovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adam, Or" uniqKey="Adam O">OR Adam</name></author><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J Jankovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frank, S" uniqKey="Frank S">S Frank</name></author><author><name sortKey="Ondo, W" uniqKey="Ondo W">W Ondo</name></author><author><name sortKey="Fahn, S" uniqKey="Fahn S">S Fahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J Jankovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, Ak" uniqKey="Ho A">AK Ho</name></author><author><name sortKey="Gilbert, As" uniqKey="Gilbert A">AS Gilbert</name></author><author><name sortKey="Mason, Sl" uniqKey="Mason S">SL Mason</name></author><author><name sortKey="Goodman, Ao" uniqKey="Goodman A">AO Goodman</name></author><author><name sortKey="Barker, 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uniqKey="Snowden J">JS Snowden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cubo, E" uniqKey="Cubo E">E Cubo</name></author><author><name sortKey="Gonzalez, M" uniqKey="Gonzalez M">M González</name></author><author><name sortKey="Del Puerto, I" uniqKey="Del Puerto I">I Del Puerto</name></author><author><name sortKey="Fernandezarconada, O" uniqKey="Fernandezarconada O">O FernándezArconada</name></author><author><name sortKey="Garcia De Yebenes, J" uniqKey="Garcia De Yebenes J">J Garcia de Yebenes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quinn, Gp" uniqKey="Quinn G">GP Quinn</name></author><author><name sortKey="Shore, Pa" uniqKey="Shore P">PA Shore</name></author><author><name sortKey="Brodie, Bb" uniqKey="Brodie B">BB Brodie</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="26000211"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of Tetrabenazine on Motor Function in Patients with Huntington Disease</title><author><name sortKey="Ferrara, Joseph M" sort="Ferrara, Joseph M" uniqKey="Ferrara J" first="Joseph" last="Ferrara">Joseph Ferrara</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, VA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke</wicri:cityArea></affiliation></author><author><name sortKey="Mostile, Giovanni" sort="Mostile, Giovanni" uniqKey="Mostile G" first="Giovanni" last="Mostile">Giovanni Mostile</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Adam, Octavian R" sort="Adam, Octavian R" uniqKey="Adam O" first="Octavian" last="Adam">Octavian Adam</name><affiliation><nlm:aff id="Aff3">Division of Neurology, Naval Medical Center, Portsmouth, VI USA</nlm:aff><wicri:noCountry code="subfield">VI USA</wicri:noCountry></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26000211</idno><idno type="pmc">4389035</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389035</idno><idno type="RBID">PMC:4389035</idno><idno type="doi">10.1007/s40120-012-0005-7</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000033</idno><idno type="wicri:Area/Pmc/Curation">000033</idno><idno type="wicri:Area/Pmc/Checkpoint">000104</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of Tetrabenazine on Motor Function in Patients with Huntington Disease</title><author><name sortKey="Ferrara, Joseph M" sort="Ferrara, Joseph M" uniqKey="Ferrara J" first="Joseph" last="Ferrara">Joseph Ferrara</name><affiliation wicri:level="2"><nlm:aff id="Aff1">Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, VA USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke</wicri:cityArea></affiliation></author><author><name sortKey="Mostile, Giovanni" sort="Mostile, Giovanni" uniqKey="Mostile G" first="Giovanni" last="Mostile">Giovanni Mostile</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Adam, Octavian R" sort="Adam, Octavian R" uniqKey="Adam O" first="Octavian" last="Adam">Octavian Adam</name><affiliation><nlm:aff id="Aff3">Division of Neurology, Naval Medical Center, Portsmouth, VI USA</nlm:aff><wicri:noCountry code="subfield">VI USA</wicri:noCountry></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:aff id="Aff2">Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA</nlm:aff><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j">Neurology and Therapy</title><idno type="ISSN">2193-8253</idno><idno type="e-ISSN">2193-6536</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Tetrabenazine (TBZ) reduces chorea related to Huntington disease (HD); however, it is uncertain whether this effect improves functionally relevant motor skills such as hand coordination and balance. The objective of this study was to provide pilot data regarding three motor function tests, which might be useful in monitoring symptom progression and therapeutic response, pending formal validation.</p></sec><sec><title>Methods</title><p>The authors assessed 11 ambulatory patients with HD-related chorea on two occasions: (1) while off TBZ (either prior to starting therapy or following a >24 h washout) and (2) when on a stable dose of TBZ, titrated to optimal effect. Study evaluations included the Jebsen-Taylor Hand Function Test (JTHFT) and Berg Balance Scale, a timed 25-foot walk, the Montreal Cognitive Assessment (MoCA) and the complete United Huntington Disease Rating Scale (UHDRS).</p></sec><sec><title>Results</title><p>Maximal chorea scores (UHDRS item 12) improved from 11.1 ± 2.9 to 8.5 ± 3.9 while on TBZ (<italic>P</italic> = 0.03), but we could not detect an improvement in functional measures while on TBZ in this small cohort. Scores of the JTHFT were globally slower than published normative data and correlated with MoCA summary scores, but not UHDRS chorea scores.</p></sec><sec><title>Conclusions</title><p>This pilot study did not detect significant functional gains with chorea suppression. The fact that performance on tests of hand function correlates with MoCA but not UHDRS chorea scores highlights the need for additional treatments targeted toward the cognitive aspects of HD.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fenney, A" uniqKey="Fenney A">A Fenney</name></author><author><name sortKey="Jog, Ms" uniqKey="Jog M">MS Jog</name></author><author><name sortKey="Duval, C" uniqKey="Duval C">C Duval</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reilmann, R" uniqKey="Reilmann R">R Reilmann</name></author><author><name sortKey="Kirsten, F" uniqKey="Kirsten F">F Kirsten</name></author><author><name sortKey="Quinn, L" uniqKey="Quinn L">L Quinn</name></author><author><name sortKey="Henningsen, H" uniqKey="Henningsen H">H Henningsen</name></author><author><name sortKey="Marder, K" uniqKey="Marder K">K Marder</name></author><author><name sortKey="Gordon, Am" uniqKey="Gordon 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Ra" uniqKey="Barker R">RA Barker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marder, K" uniqKey="Marder K">K Marder</name></author><author><name sortKey="Zhao, H" uniqKey="Zhao H">H Zhao</name></author><author><name sortKey="Myers, Rh" uniqKey="Myers R">RH Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feigin, A" uniqKey="Feigin A">A Feigin</name></author><author><name sortKey="Kieburtz, K" uniqKey="Kieburtz K">K Kieburtz</name></author><author><name sortKey="Bordwell, K" uniqKey="Bordwell K">K Bordwell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamilton, Jm" uniqKey="Hamilton J">JM Hamilton</name></author><author><name sortKey="Salmon, Dp" uniqKey="Salmon D">DP Salmon</name></author><author><name sortKey="Corey Bloom, J" uniqKey="Corey Bloom J">J Corey-Bloom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delval, A" uniqKey="Delval A">A Delval</name></author><author><name sortKey="Krystkowiak, P" uniqKey="Krystkowiak P">P Krystkowiak</name></author><author><name sortKey="Delliaux, M" uniqKey="Delliaux M">M Delliaux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rodrigues, Gr" uniqKey="Rodrigues G">GR Rodrigues</name></author><author><name sortKey="Souza, Cp" uniqKey="Souza C">CP Souza</name></author><author><name sortKey="Cetlin, Rs" uniqKey="Cetlin R">RS Cetlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thompson, Jc" uniqKey="Thompson J">JC Thompson</name></author><author><name sortKey="Poliakoff, E" uniqKey="Poliakoff E">E Poliakoff</name></author><author><name sortKey="Sollom, Ac" uniqKey="Sollom A">AC Sollom</name></author><author><name sortKey="Howard, E" uniqKey="Howard E">E Howard</name></author><author><name sortKey="Craufurd, D" uniqKey="Craufurd D">D Craufurd</name></author><author><name sortKey="Snowden, Js" uniqKey="Snowden J">JS Snowden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cubo, E" uniqKey="Cubo E">E Cubo</name></author><author><name sortKey="Gonzalez, M" uniqKey="Gonzalez M">M González</name></author><author><name sortKey="Del Puerto, I" uniqKey="Del Puerto I">I Del Puerto</name></author><author><name sortKey="Fernandezarconada, O" uniqKey="Fernandezarconada O">O FernándezArconada</name></author><author><name sortKey="Garcia De Yebenes, J" uniqKey="Garcia De Yebenes J">J Garcia de Yebenes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quinn, Gp" uniqKey="Quinn G">GP Quinn</name></author><author><name sortKey="Shore, Pa" uniqKey="Shore P">PA Shore</name></author><author><name sortKey="Brodie, Bb" uniqKey="Brodie B">BB Brodie</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of tetrabenazine on motor function in patients with huntington disease.</title><author><name sortKey="Ferrara, Joseph M" sort="Ferrara, Joseph M" uniqKey="Ferrara J" first="Joseph" last="Ferrara">Joseph. Ferrara</name><affiliation wicri:level="2"><nlm:affiliation>Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, VA USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke</wicri:cityArea></affiliation></author><author><name sortKey="Mostile, Giovanni" sort="Mostile, Giovanni" uniqKey="Mostile G" first="Giovanni" last="Mostile">Giovanni Mostile</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Adam, Octavian R" sort="Adam, Octavian R" uniqKey="Adam O" first="Octavian" last="Adam">Octavian. Adam</name><affiliation><nlm:affiliation>Division of Neurology, Naval Medical Center, Portsmouth, VI USA.</nlm:affiliation><wicri:noCountry code="subField">VI USA</wicri:noCountry></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1007/s40120-012-0005-7</idno><idno type="RBID">pubmed:26000211</idno><idno type="pmid">26000211</idno><idno type="wicri:Area/PubMed/Corpus">000050</idno><idno type="wicri:Area/PubMed/Curation">000050</idno><idno type="wicri:Area/PubMed/Checkpoint">000062</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of tetrabenazine on motor function in patients with huntington disease.</title><author><name sortKey="Ferrara, Joseph M" sort="Ferrara, Joseph M" uniqKey="Ferrara J" first="Joseph" last="Ferrara">Joseph. Ferrara</name><affiliation wicri:level="2"><nlm:affiliation>Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke, VA USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Movement Disorder Clinic, Virginia Tech Carilion School of Medicine and Research Institute, Roanoke</wicri:cityArea></affiliation></author><author><name sortKey="Mostile, Giovanni" sort="Mostile, Giovanni" uniqKey="Mostile G" first="Giovanni" last="Mostile">Giovanni Mostile</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Hunter, Christine" sort="Hunter, Christine" uniqKey="Hunter C" first="Christine" last="Hunter">Christine Hunter</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Adam, Octavian R" sort="Adam, Octavian R" uniqKey="Adam O" first="Octavian" last="Adam">Octavian. Adam</name><affiliation><nlm:affiliation>Division of Neurology, Naval Medical Center, Portsmouth, VI USA.</nlm:affiliation><wicri:noCountry code="subField">VI USA</wicri:noCountry></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston, TX USA.</nlm:affiliation><country>États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Parkinson Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j">Neurology and therapy</title><idno type="ISSN">2193-8253</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Tetrabenazine (TBZ) reduces chorea related to Huntington disease (HD); however, it is uncertain whether this effect improves functionally relevant motor skills such as hand coordination and balance. The objective of this study was to provide pilot data regarding three motor function tests, which might be useful in monitoring symptom progression and therapeutic response, pending formal validation.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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