Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group.
Identifieur interne : 000349 ( Ncbi/Merge ); précédent : 000348; suivant : 000350Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group.
Auteurs : Joseph Jankovic [États-Unis] ; M. Mcdermott ; J. Carter ; S. Gauthier ; C. Goetz ; L. Golbe ; S. Huber ; W. Koller ; C. Olanow ; I. ShoulsonSource :
- Neurology [ 0028-3878 ] ; 1990.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease, Tremor.
- physiopathology : Parkinson Disease.
- Adult, Aged, Cohort Studies, Female, Gait, Humans, Male, Middle Aged, Posture, Severity of Illness Index, Time Factors.
Abstract
The DATATOP database, which includes clinical information on 800 patients with early untreated Parkinson's disease (PD), is well suited to explore clinical heterogeneity in PD. Patients with early-onset PD (less than or equal to 40 years, N = 33) reached the same level of disability as the late-onset PD (greater than or equal to 70 years, N = 85) group at a significantly slower rate (2.9 vs. 1.7 years). Early-onset PD patients functioned cognitively better than late-onset PD patients. Bradykinesia, and postural instability and gait difficulty (PIGD), were more common at onset in patients with a rapid rate of disease progression ("malignant PD"; duration of symptoms less than 1 year and Hoehn/Yahr stage of 2.5, N = 11) as compared with those with a relatively slow rate of progression ("benign PD"; duration of symptoms greater than 4 years, N = 65). Comparisons of tremor-dominant PD (mean tremor score/mean PIGD score less than or equal to 1.5, N = 441) with the PIGD-dominant type (mean tremor score/mean PIGD score greater than or equal to 1.0, N = 233) provided support for the existence of clinical subtypes. The PIGD group reported significantly greater subjective intellectual, motor, and occupational impairment than the tremor group. Stage II patients had higher depression scores than stage I patients. Among the patients participating in the DATATOP, older age at onset with bradykinesia, or with the PIGD form of PD, is associated with more functional disability than when the symptoms are dominated by tremor or begin at a younger age.
PubMed: 2215943
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group.</title><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX 77030.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Mcdermott, M" sort="Mcdermott, M" uniqKey="Mcdermott M" first="M" last="Mcdermott">M. Mcdermott</name></author><author><name sortKey="Carter, J" sort="Carter, J" uniqKey="Carter J" first="J" last="Carter">J. Carter</name></author><author><name sortKey="Gauthier, S" sort="Gauthier, S" uniqKey="Gauthier S" first="S" last="Gauthier">S. Gauthier</name></author><author><name sortKey="Goetz, C" sort="Goetz, C" uniqKey="Goetz C" first="C" last="Goetz">C. Goetz</name></author><author><name sortKey="Golbe, L" sort="Golbe, L" uniqKey="Golbe L" first="L" last="Golbe">L. Golbe</name></author><author><name sortKey="Huber, S" sort="Huber, S" uniqKey="Huber S" first="S" last="Huber">S. Huber</name></author><author><name sortKey="Koller, W" sort="Koller, W" uniqKey="Koller W" first="W" last="Koller">W. Koller</name></author><author><name sortKey="Olanow, C" sort="Olanow, C" uniqKey="Olanow C" first="C" last="Olanow">C. Olanow</name></author><author><name sortKey="Shoulson, I" sort="Shoulson, I" uniqKey="Shoulson I" first="I" last="Shoulson">I. Shoulson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:2215943</idno><idno type="pmid">2215943</idno><idno type="wicri:Area/PubMed/Corpus">000311</idno><idno type="wicri:Area/PubMed/Curation">000311</idno><idno type="wicri:Area/PubMed/Checkpoint">000304</idno><idno type="wicri:Area/Ncbi/Merge">000349</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group.</title><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX 77030.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Neurology, Baylor College of Medicine, Houston</wicri:cityArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Mcdermott, M" sort="Mcdermott, M" uniqKey="Mcdermott M" first="M" last="Mcdermott">M. Mcdermott</name></author><author><name sortKey="Carter, J" sort="Carter, J" uniqKey="Carter J" first="J" last="Carter">J. Carter</name></author><author><name sortKey="Gauthier, S" sort="Gauthier, S" uniqKey="Gauthier S" first="S" last="Gauthier">S. Gauthier</name></author><author><name sortKey="Goetz, C" sort="Goetz, C" uniqKey="Goetz C" first="C" last="Goetz">C. Goetz</name></author><author><name sortKey="Golbe, L" sort="Golbe, L" uniqKey="Golbe L" first="L" last="Golbe">L. Golbe</name></author><author><name sortKey="Huber, S" sort="Huber, S" uniqKey="Huber S" first="S" last="Huber">S. Huber</name></author><author><name sortKey="Koller, W" sort="Koller, W" uniqKey="Koller W" first="W" last="Koller">W. Koller</name></author><author><name sortKey="Olanow, C" sort="Olanow, C" uniqKey="Olanow C" first="C" last="Olanow">C. Olanow</name></author><author><name sortKey="Shoulson, I" sort="Shoulson, I" uniqKey="Shoulson I" first="I" last="Shoulson">I. Shoulson</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Gait</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term><term>Posture</term><term>Severity of Illness Index</term><term>Time Factors</term><term>Tremor (complications)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Gait</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Posture</term><term>Severity of Illness Index</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The DATATOP database, which includes clinical information on 800 patients with early untreated Parkinson's disease (PD), is well suited to explore clinical heterogeneity in PD. Patients with early-onset PD (less than or equal to 40 years, N = 33) reached the same level of disability as the late-onset PD (greater than or equal to 70 years, N = 85) group at a significantly slower rate (2.9 vs. 1.7 years). Early-onset PD patients functioned cognitively better than late-onset PD patients. Bradykinesia, and postural instability and gait difficulty (PIGD), were more common at onset in patients with a rapid rate of disease progression ("malignant PD"; duration of symptoms less than 1 year and Hoehn/Yahr stage of 2.5, N = 11) as compared with those with a relatively slow rate of progression ("benign PD"; duration of symptoms greater than 4 years, N = 65). Comparisons of tremor-dominant PD (mean tremor score/mean PIGD score less than or equal to 1.5, N = 441) with the PIGD-dominant type (mean tremor score/mean PIGD score greater than or equal to 1.0, N = 233) provided support for the existence of clinical subtypes. The PIGD group reported significantly greater subjective intellectual, motor, and occupational impairment than the tremor group. Stage II patients had higher depression scores than stage I patients. Among the patients participating in the DATATOP, older age at onset with bradykinesia, or with the PIGD form of PD, is associated with more functional disability than when the symptoms are dominated by tremor or begin at a younger age.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">2215943</PMID><DateCreated><Year>1990</Year><Month>11</Month><Day>14</Day></DateCreated><DateCompleted><Year>1990</Year><Month>11</Month><Day>14</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3878</ISSN><JournalIssue CitedMedium="Print"><Volume>40</Volume><Issue>10</Issue><PubDate><Year>1990</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Variable expression of Parkinson's disease: a base-line analysis of the DATATOP cohort. The Parkinson Study Group.</ArticleTitle><Pagination><MedlinePgn>1529-34</MedlinePgn></Pagination><Abstract><AbstractText>The DATATOP database, which includes clinical information on 800 patients with early untreated Parkinson's disease (PD), is well suited to explore clinical heterogeneity in PD. Patients with early-onset PD (less than or equal to 40 years, N = 33) reached the same level of disability as the late-onset PD (greater than or equal to 70 years, N = 85) group at a significantly slower rate (2.9 vs. 1.7 years). Early-onset PD patients functioned cognitively better than late-onset PD patients. Bradykinesia, and postural instability and gait difficulty (PIGD), were more common at onset in patients with a rapid rate of disease progression ("malignant PD"; duration of symptoms less than 1 year and Hoehn/Yahr stage of 2.5, N = 11) as compared with those with a relatively slow rate of progression ("benign PD"; duration of symptoms greater than 4 years, N = 65). Comparisons of tremor-dominant PD (mean tremor score/mean PIGD score less than or equal to 1.5, N = 441) with the PIGD-dominant type (mean tremor score/mean PIGD score greater than or equal to 1.0, N = 233) provided support for the existence of clinical subtypes. The PIGD group reported significantly greater subjective intellectual, motor, and occupational impairment than the tremor group. Stage II patients had higher depression scores than stage I patients. Among the patients participating in the DATATOP, older age at onset with bradykinesia, or with the PIGD form of PD, is associated with more functional disability than when the symptoms are dominated by tremor or begin at a younger age.</AbstractText></Abstract><AuthorList CompleteYN="N"><Author ValidYN="Y"><LastName>Jankovic</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX 77030.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McDermott</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Carter</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Gauthier</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Goetz</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Golbe</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Huber</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Koller</LastName><ForeName>W</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Olanow</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Shoulson</LastName><ForeName>I</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>NS 24778</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>UNITED STATES</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015331">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005684">Gait</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011187">Posture</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012720">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014202">Tremor</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1990</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1990</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1990</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">2215943</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><noCountry><name sortKey="Carter, J" sort="Carter, J" uniqKey="Carter J" first="J" last="Carter">J. Carter</name><name sortKey="Gauthier, S" sort="Gauthier, S" uniqKey="Gauthier S" first="S" last="Gauthier">S. Gauthier</name><name sortKey="Goetz, C" sort="Goetz, C" uniqKey="Goetz C" first="C" last="Goetz">C. Goetz</name><name sortKey="Golbe, L" sort="Golbe, L" uniqKey="Golbe L" first="L" last="Golbe">L. Golbe</name><name sortKey="Huber, S" sort="Huber, S" uniqKey="Huber S" first="S" last="Huber">S. Huber</name><name sortKey="Koller, W" sort="Koller, W" uniqKey="Koller W" first="W" last="Koller">W. Koller</name><name sortKey="Mcdermott, M" sort="Mcdermott, M" uniqKey="Mcdermott M" first="M" last="Mcdermott">M. Mcdermott</name><name sortKey="Olanow, C" sort="Olanow, C" uniqKey="Olanow C" first="C" last="Olanow">C. Olanow</name><name sortKey="Shoulson, I" sort="Shoulson, I" uniqKey="Shoulson I" first="I" last="Shoulson">I. Shoulson</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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