The spectrum of nonmotor symptoms in early Parkinson disease
Identifieur interne : 000390 ( Ncbi/Curation ); précédent : 000389; suivant : 000391The spectrum of nonmotor symptoms in early Parkinson disease
Auteurs : Tien Khoo ; Alison Yarnall ; Gordon Duncan ; Shirley Coleman ; John O ; David Brooks ; Roger Barker ; David BurnSource :
- Neurology [ 0028-3878 ] ; 2013.
Abstract
Nonmotor symptoms (NMS) are common in patients with established Parkinson disease (PD) but their frequency in early PD has not been extensively studied. Our aim was to determine the frequency of NMS in a cohort of patients with newly diagnosed PD.
A total of 159 patients with early PD and 99 healthy controls participated in this study. NMS were screened for using the Nonmotor Symptom Questionnaire. Other assessments included measures of motor disability (Movement Disorders Society–revised Unified Parkinson's Disease Rating Scale [MDS-UPDRS]), disease severity (Hoehn & Yahr staging), depression (Geriatric Depression Scale), and global cognitive function (Mini-Mental State Examination and Montreal Cognitive Assessment).
The PD group reported a significantly greater number of NMS compared with controls (8.4 [4.3] vs 2.8 [2.6]). In the PD group, the most commonly experienced NMS were excessive saliva, forgetfulness, urinary urgency, hyposmia, and constipation. Patients with higher MDS-UPDRS III scores and those with the postural instability gait subtype experienced a greater number of NMS.
NMS are common in early PD and reflect the multisystem nature of the disorder. Even in the earliest stages of PD, NMS may be detrimental to patients' functional status and sense of well-being.
Url:
DOI: 10.1212/WNL.0b013e31827deb74
PubMed: 23319473
PubMed Central: 3589180
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The spectrum of nonmotor symptoms in early Parkinson disease</title><author><name sortKey="Khoo, Tien K" sort="Khoo, Tien K" uniqKey="Khoo T" first="Tien" last="Khoo">Tien Khoo</name></author><author><name sortKey="Yarnall, Alison J" sort="Yarnall, Alison J" uniqKey="Yarnall A" first="Alison" last="Yarnall">Alison Yarnall</name></author><author><name sortKey="Duncan, Gordon W" sort="Duncan, Gordon W" uniqKey="Duncan G" first="Gordon" last="Duncan">Gordon Duncan</name></author><author><name sortKey="Coleman, Shirley" sort="Coleman, Shirley" uniqKey="Coleman S" first="Shirley" last="Coleman">Shirley Coleman</name></author><author><name sortKey="O Rien, John T" sort="O Rien, John T" uniqKey="O Rien J" first="John" last="O">John O</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David" last="Brooks">David Brooks</name></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger" last="Barker">Roger Barker</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David" last="Burn">David Burn</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23319473</idno><idno type="pmc">3589180</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589180</idno><idno type="RBID">PMC:3589180</idno><idno type="doi">10.1212/WNL.0b013e31827deb74</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000236</idno><idno type="wicri:Area/Pmc/Curation">000236</idno><idno type="wicri:Area/Pmc/Checkpoint">000057</idno><idno type="wicri:Area/Ncbi/Merge">000390</idno><idno type="wicri:Area/Ncbi/Curation">000390</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The spectrum of nonmotor symptoms in early Parkinson disease</title><author><name sortKey="Khoo, Tien K" sort="Khoo, Tien K" uniqKey="Khoo T" first="Tien" last="Khoo">Tien Khoo</name></author><author><name sortKey="Yarnall, Alison J" sort="Yarnall, Alison J" uniqKey="Yarnall A" first="Alison" last="Yarnall">Alison Yarnall</name></author><author><name sortKey="Duncan, Gordon W" sort="Duncan, Gordon W" uniqKey="Duncan G" first="Gordon" last="Duncan">Gordon Duncan</name></author><author><name sortKey="Coleman, Shirley" sort="Coleman, Shirley" uniqKey="Coleman S" first="Shirley" last="Coleman">Shirley Coleman</name></author><author><name sortKey="O Rien, John T" sort="O Rien, John T" uniqKey="O Rien J" first="John" last="O">John O</name></author><author><name sortKey="Brooks, David J" sort="Brooks, David J" uniqKey="Brooks D" first="David" last="Brooks">David Brooks</name></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger" last="Barker">Roger Barker</name></author><author><name sortKey="Burn, David J" sort="Burn, David J" uniqKey="Burn D" first="David" last="Burn">David Burn</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="e-ISSN">1526-632X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>Nonmotor symptoms (NMS) are common in patients with established Parkinson disease (PD) but their frequency in early PD has not been extensively studied. Our aim was to determine the frequency of NMS in a cohort of patients with newly diagnosed PD.</p></sec><sec><title>Methods:</title><p>A total of 159 patients with early PD and 99 healthy controls participated in this study. NMS were screened for using the Nonmotor Symptom Questionnaire. Other assessments included measures of motor disability (Movement Disorders Society–revised Unified Parkinson's Disease Rating Scale [MDS-UPDRS]), disease severity (Hoehn & Yahr staging), depression (Geriatric Depression Scale), and global cognitive function (Mini-Mental State Examination and Montreal Cognitive Assessment).</p></sec><sec><title>Results:</title><p>The PD group reported a significantly greater number of NMS compared with controls (8.4 [4.3] vs 2.8 [2.6]). In the PD group, the most commonly experienced NMS were excessive saliva, forgetfulness, urinary urgency, hyposmia, and constipation. Patients with higher MDS-UPDRS III scores and those with the postural instability gait subtype experienced a greater number of NMS.</p></sec><sec><title>Conclusion:</title><p>NMS are common in early PD and reflect the multisystem nature of the disorder. Even in the earliest stages of PD, NMS may be detrimental to patients' functional status and sense of well-being.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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