Mood fluctuations in Parkinson’s disease: a pilot study comparing the effects of intravenous and oral levodopa administration
Identifieur interne : 000184 ( Ncbi/Curation ); précédent : 000183; suivant : 000185Mood fluctuations in Parkinson’s disease: a pilot study comparing the effects of intravenous and oral levodopa administration
Auteurs : Irene Richard [États-Unis] ; Samuel Frank [États-Unis] ; Kori. Ladonna [États-Unis] ; Hongkun Wang [États-Unis] ; Michael. Mcdermott [États-Unis] ; Roger Kurlan [États-Unis]Source :
- Neuropsychiatric Disease and Treatment [ 1176-6328 ] ; 2005.
Abstract
Parkinson’s disease (PD) is associated with motor fluctuations that have been shown to improve when stable plasma levodopa levels are achieved with continuous levodopa infusions. Many patients also develop mood fluctuations. In this pilot study, we gathered preliminary information about the relationship between changing mood states and plasma levodopa levels.
Six patients with idiopathic PD and histories of motor and mood fluctuations participated in a double-blind levodopa infusion study. Subjects received active oral carbidopa/levodopa and a placebo levodopa infusion on one day and placebo oral carbidopa/levodopa and an active levodopa infusion on the other day, in a randomly determined order. Evaluations included serial plasma levodopa levels and assessments of mood and motor states.
Only 4 of the 6 subjects demonstrated mood fluctuations on at least one of the treatment days. All subjects achieved more stable plasma levodopa levels on the active infusion day. Two subjects experienced fewer mood fluctuations on the active infusion day and two experienced fewer on the oral day.
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PubMed: 18568104
PubMed Central: 2416757
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Ladonna</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Departments of Neurology, University of Rochester School of Medicine and Dentistry</institution><addr-line>Rochester, NY, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Wang, Hongkun" sort="Wang, Hongkun" uniqKey="Wang H" first="Hongkun" last="Wang">Hongkun Wang</name><affiliation wicri:level="2"><nlm:aff id="au2"><institution>Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry</institution><addr-line>Rochester, NY, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mcdermott, Michael P" sort="Mcdermott, Michael P" uniqKey="Mcdermott M" first="Michael" last="Mcdermott">Michael. Mcdermott</name><affiliation wicri:level="2"><nlm:aff id="au2"><institution>Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry</institution><addr-line>Rochester, NY, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kurlan, Roger" sort="Kurlan, Roger" uniqKey="Kurlan R" first="Roger" last="Kurlan">Roger Kurlan</name><affiliation wicri:level="2"><nlm:aff id="au1"><institution>Departments of Neurology, University of Rochester School of Medicine and Dentistry</institution><addr-line>Rochester, NY, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rochester, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Neuropsychiatric Disease and Treatment</title><idno type="ISSN">1176-6328</idno><idno type="e-ISSN">1178-2021</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>Parkinson’s disease (PD) is associated with motor fluctuations that have been shown to improve when stable plasma levodopa levels are achieved with continuous levodopa infusions. Many patients also develop mood fluctuations. In this pilot study, we gathered preliminary information about the relationship between changing mood states and plasma levodopa levels.</p></sec><sec sec-type="methods"><title>Methods</title><p>Six patients with idiopathic PD and histories of motor and mood fluctuations participated in a double-blind levodopa infusion study. Subjects received active oral carbidopa/levodopa and a placebo levodopa infusion on one day and placebo oral carbidopa/levodopa and an active levodopa infusion on the other day, in a randomly determined order. Evaluations included serial plasma levodopa levels and assessments of mood and motor states.</p></sec><sec><title>Results</title><p>Only 4 of the 6 subjects demonstrated mood fluctuations on at least one of the treatment days. All subjects achieved more stable plasma levodopa levels on the active infusion day. Two subjects experienced fewer mood fluctuations on the active infusion day and two experienced fewer on the oral day.</p><p><bold>Conclusions</bold> The results of this pilot study suggest that the relationship between mood state and plasma levodopa level may vary among PD patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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