Rotigotine Transdermal Patch in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Identifieur interne : 000421 ( Ncbi/Checkpoint ); précédent : 000420; suivant : 000422Rotigotine Transdermal Patch in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Auteurs : Chang Zhou ; Shan Li ; Zhong Chen ; Feng Li ; Peng Lei ; Guo PengSource :
- PLoS ONE ; 2013.
Abstract
The efficacy and safety of rotigotine transdermal patch in Parkinson’s disease (PD) were studied in some clinical trials. We performed a systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy, tolerability, and safety of rotigotine transdermal patch versus placebo in PD.
Six randomized controlled trials (1789 patients) were included in this meta-analysis. As compared with placebo, the use of rotigotine resulted in greater improvements in Unified Parkinson’s Disease Rating Scale activities of daily living score (weighted mean difference [WMD] –1.69, 95% confidence interval [CI] –2.18 to –1.19), motor score (WMD –3.86, 95% CI –4.86 to –2.86), and the activities of daily living and motor subtotal score (WMD –4.52, 95% CI –5.86 to –3.17). Rotigotine was associated with a significantly higher rate of withdrawals due to adverse events (relative risk [RR] 1.82, 95% CI 1.29–2.59), and higher rates of application site reactions (RR 2.92, 95% CI 2.29–3.72), vomiting (RR 5.18, 95% CI 2.25–11.93), and dyskinesia (RR 2.52, 95% CI 1.47–4.32) compared with placebo. No differences were found in the relative risks of headache, constipation, back pain, diarrhea, or serious adverse events.
Our meta-analysis showed that the use of rotigotine can reduce the symptoms of PD. However, rotigotine was also associated with a higher incidence of adverse events, especially application site reactions, compared with placebo.
Url:
DOI: 10.1371/journal.pone.0069738
PubMed: 23936090
PubMed Central: 3720658
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Rotigotine Transdermal Patch in Parkinson’s Disease: A Systematic Review and Meta-Analysis</title><author><name sortKey="Zhou, Chang Qing" sort="Zhou, Chang Qing" uniqKey="Zhou C" first="Chang" last="Zhou">Chang Zhou</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Shan Shan" sort="Li, Shan Shan" uniqKey="Li S" first="Shan" last="Li">Shan Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Zhong Mei" sort="Chen, Zhong Mei" uniqKey="Chen Z" first="Zhong" last="Chen">Zhong Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Feng Qun" sort="Li, Feng Qun" uniqKey="Li F" first="Feng" last="Li">Feng Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lei, Peng" sort="Lei, Peng" uniqKey="Lei P" first="Peng" last="Lei">Peng Lei</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Peng, Guo Guang" sort="Peng, Guo Guang" uniqKey="Peng G" first="Guo" last="Peng">Guo Peng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23936090</idno><idno type="pmc">3720658</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3720658</idno><idno type="RBID">PMC:3720658</idno><idno type="doi">10.1371/journal.pone.0069738</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000292</idno><idno type="wicri:Area/Pmc/Curation">000292</idno><idno type="wicri:Area/Pmc/Checkpoint">000064</idno><idno type="wicri:Area/Ncbi/Merge">000421</idno><idno type="wicri:Area/Ncbi/Curation">000421</idno><idno type="wicri:Area/Ncbi/Checkpoint">000421</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rotigotine Transdermal Patch in Parkinson’s Disease: A Systematic Review and Meta-Analysis</title><author><name sortKey="Zhou, Chang Qing" sort="Zhou, Chang Qing" uniqKey="Zhou C" first="Chang" last="Zhou">Chang Zhou</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Shan Shan" sort="Li, Shan Shan" uniqKey="Li S" first="Shan" last="Li">Shan Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Chen, Zhong Mei" sort="Chen, Zhong Mei" uniqKey="Chen Z" first="Zhong" last="Chen">Zhong Chen</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Feng Qun" sort="Li, Feng Qun" uniqKey="Li F" first="Feng" last="Li">Feng Li</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lei, Peng" sort="Lei, Peng" uniqKey="Lei P" first="Peng" last="Lei">Peng Lei</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Peng, Guo Guang" sort="Peng, Guo Guang" uniqKey="Peng G" first="Guo" last="Peng">Guo Peng</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="e-ISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background and Methods</title><p>The efficacy and safety of rotigotine transdermal patch in Parkinson’s disease (PD) were studied in some clinical trials. We performed a systematic review and meta-analysis of randomized controlled trials to evaluate the efficacy, tolerability, and safety of rotigotine transdermal patch versus placebo in PD.</p></sec><sec><title>Results</title><p>Six randomized controlled trials (1789 patients) were included in this meta-analysis. As compared with placebo, the use of rotigotine resulted in greater improvements in Unified Parkinson’s Disease Rating Scale activities of daily living score (weighted mean difference [WMD] –1.69, 95% confidence interval [CI] –2.18 to –1.19), motor score (WMD –3.86, 95% CI –4.86 to –2.86), and the activities of daily living and motor subtotal score (WMD –4.52, 95% CI –5.86 to –3.17). Rotigotine was associated with a significantly higher rate of withdrawals due to adverse events (relative risk [RR] 1.82, 95% CI 1.29–2.59), and higher rates of application site reactions (RR 2.92, 95% CI 2.29–3.72), vomiting (RR 5.18, 95% CI 2.25–11.93), and dyskinesia (RR 2.52, 95% CI 1.47–4.32) compared with placebo. No differences were found in the relative risks of headache, constipation, back pain, diarrhea, or serious adverse events.</p></sec><sec><title>Conclusions</title><p>Our meta-analysis showed that the use of rotigotine can reduce the symptoms of PD. 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last="Chen">Zhong Chen</name><name sortKey="Lei, Peng" sort="Lei, Peng" uniqKey="Lei P" first="Peng" last="Lei">Peng Lei</name><name sortKey="Li, Feng Qun" sort="Li, Feng Qun" uniqKey="Li F" first="Feng" last="Li">Feng Li</name><name sortKey="Li, Shan Shan" sort="Li, Shan Shan" uniqKey="Li S" first="Shan" last="Li">Shan Li</name><name sortKey="Peng, Guo Guang" sort="Peng, Guo Guang" uniqKey="Peng G" first="Guo" last="Peng">Guo Peng</name><name sortKey="Zhou, Chang Qing" sort="Zhou, Chang Qing" uniqKey="Zhou C" first="Chang" last="Zhou">Chang Zhou</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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