LINGO1 variants in essential tremor and Parkinson's disease.
Identifieur interne : 000326 ( Ncbi/Checkpoint ); précédent : 000325; suivant : 000327LINGO1 variants in essential tremor and Parkinson's disease.
Auteurs : H. Deng [République populaire de Chine] ; S. Gu ; Joseph Jankovic [États-Unis]Source :
- Acta neurologica Scandinavica ; 2012.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Membrane Proteins, Nerve Tissue Proteins.
- genetics : Essential Tremor, Parkinson Disease.
- Gene Frequency, Genetic Variation, Genotype, Humans.
Abstract
The leucine-rich repeat and Ig domain containing 1 gene (LINGO1), recently considered to be conferred increased risk of essential tremor (ET), has been also implicated in Parkinson disease (PD). As the two common movement disorders have overlapping clinical and pathological features, it has been postulated that the LINGO1 gene may play a role in the pathogenesis of the two diseases. Here, we review published reports of the LINGO1 variants in ET and PD in an attempt to better understand the molecular and pathogenic relationship of LINGO1 to the two disorders.
DOI: 10.1111/j.1600-0404.2011.01516.x
PubMed: 21470193
Affiliations:
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pubmed:21470193Le document en format XML
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<front><div type="abstract" xml:lang="en">The leucine-rich repeat and Ig domain containing 1 gene (LINGO1), recently considered to be conferred increased risk of essential tremor (ET), has been also implicated in Parkinson disease (PD). As the two common movement disorders have overlapping clinical and pathological features, it has been postulated that the LINGO1 gene may play a role in the pathogenesis of the two diseases. Here, we review published reports of the LINGO1 variants in ET and PD in an attempt to better understand the molecular and pathogenic relationship of LINGO1 to the two disorders.</div>
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