A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's disease
Identifieur interne : 000185 ( Ncbi/Checkpoint ); précédent : 000184; suivant : 000186A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's disease
Auteurs : Spiridon Papapetropoulos [États-Unis] ; Heather Katzen [États-Unis] ; Anette Schrag [Royaume-Uni] ; Carlos Singer [États-Unis] ; Blake. Scanlon [États-Unis] ; Daniel Nation [États-Unis] ; Alexandra Guevara [États-Unis] ; Bonnie Levin [États-Unis]Source :
- BMC Neurology ; 2008.
Abstract
Hallucinations occur in 20–40% of PD patients and have been associated with unfavorable clinical outcomes (i.e., nursing home placement, increased mortality). Hallucinations, like other non-motor features of PD, are not well recognized in routine primary/secondary clinical practice. So far, there has been no instrument for uniform characterization of hallucinations in PD. To this end, we developed the University of Miami Parkinson's disease Hallucinations Questionnaire (UM-PDHQ) that allows comprehensive assessment of hallucinations in clinical or research settings.
The UM-PDHQ is composed of 6 quantitative and 14 qualitative items. For our study PD patients of all ages and in all stages of the disease were recruited over an 18-month period. The UPDRS, MMSE, and Beck Depression and Anxiety Inventories were used for comparisons.
Seventy consecutive PD patients were included in the analyses. Thirty-one (44.3%) were classified as hallucinators and 39 as non-hallucinators. No significant group differences were observed in terms of demographics, disease characteristics, stage, education, depressive/anxiety scores or cognitive functioning (MMSE) between hallucinators and non-hallucinators. Single mode hallucinations were reported in 20/31 (visual/14, auditory/4, olfactory/2) whereas multiple modalities were reported in 11/31 patients. The most common hallucinatory experience was a whole person followed by small animals, insects and reptiles.
Using the UM-PDHQ, we were able to define the key characteristics of hallucinations in PD in our cohort. Future directions include the validation of the quantitative part of the questionnaire than will serve as a rating scale for severity of hallucinations.
Url:
DOI: 10.1186/1471-2377-8-21
PubMed: 18570642
PubMed Central: 2443167
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000106
- to stream Pmc, to step Curation: 000106
- to stream Pmc, to step Checkpoint: 000235
- to stream Ncbi, to step Merge: 000185
- to stream Ncbi, to step Curation: 000185
Links to Exploration step
PMC:2443167Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's disease</title>
<author><name sortKey="Papapetropoulos, Spiridon" sort="Papapetropoulos, Spiridon" uniqKey="Papapetropoulos S" first="Spiridon" last="Papapetropoulos">Spiridon Papapetropoulos</name>
<affiliation wicri:level="2"><nlm:aff id="I1">Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Katzen, Heather" sort="Katzen, Heather" uniqKey="Katzen H" first="Heather" last="Katzen">Heather Katzen</name>
<affiliation wicri:level="2"><nlm:aff id="I2">Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
<affiliation wicri:level="3"><nlm:aff id="I3">Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<affiliation wicri:level="2"><nlm:aff id="I1">Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scanlon, Blake K" sort="Scanlon, Blake K" uniqKey="Scanlon B" first="Blake" last="Scanlon">Blake. Scanlon</name>
<affiliation wicri:level="2"><nlm:aff id="I2">Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nation, Daniel" sort="Nation, Daniel" uniqKey="Nation D" first="Daniel" last="Nation">Daniel Nation</name>
<affiliation wicri:level="2"><nlm:aff id="I2">Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guevara, Alexandra" sort="Guevara, Alexandra" uniqKey="Guevara A" first="Alexandra" last="Guevara">Alexandra Guevara</name>
<affiliation wicri:level="2"><nlm:aff id="I1">Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Levin, Bonnie" sort="Levin, Bonnie" uniqKey="Levin B" first="Bonnie" last="Levin">Bonnie Levin</name>
<affiliation wicri:level="2"><nlm:aff id="I2">Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18570642</idno>
<idno type="pmc">2443167</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2443167</idno>
<idno type="RBID">PMC:2443167</idno>
<idno type="doi">10.1186/1471-2377-8-21</idno>
<date when="2008">2008</date>
<idno type="wicri:Area/Pmc/Corpus">000106</idno>
<idno type="wicri:Area/Pmc/Curation">000106</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000235</idno>
<idno type="wicri:Area/Ncbi/Merge">000185</idno>
<idno type="wicri:Area/Ncbi/Curation">000185</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000185</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's disease</title>
<author><name sortKey="Papapetropoulos, Spiridon" sort="Papapetropoulos, Spiridon" uniqKey="Papapetropoulos S" first="Spiridon" last="Papapetropoulos">Spiridon Papapetropoulos</name>
<affiliation wicri:level="2"><nlm:aff id="I1">Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Katzen, Heather" sort="Katzen, Heather" uniqKey="Katzen H" first="Heather" last="Katzen">Heather Katzen</name>
<affiliation wicri:level="2"><nlm:aff id="I2">Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
<affiliation wicri:level="3"><nlm:aff id="I3">Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neurosciences, Royal Free and University College Medical School, University College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
<affiliation wicri:level="2"><nlm:aff id="I1">Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Scanlon, Blake K" sort="Scanlon, Blake K" uniqKey="Scanlon B" first="Blake" last="Scanlon">Blake. Scanlon</name>
<affiliation wicri:level="2"><nlm:aff id="I2">Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nation, Daniel" sort="Nation, Daniel" uniqKey="Nation D" first="Daniel" last="Nation">Daniel Nation</name>
<affiliation wicri:level="2"><nlm:aff id="I2">Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guevara, Alexandra" sort="Guevara, Alexandra" uniqKey="Guevara A" first="Alexandra" last="Guevara">Alexandra Guevara</name>
<affiliation wicri:level="2"><nlm:aff id="I1">Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Divisions of Movement Disorders Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Levin, Bonnie" sort="Levin, Bonnie" uniqKey="Levin B" first="Bonnie" last="Levin">Bonnie Levin</name>
<affiliation wicri:level="2"><nlm:aff id="I2">Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Neuropsychology Department of Neurology, University of Miami, Miller School of Medicine Miami, FL</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Neurology</title>
<idno type="e-ISSN">1471-2377</idno>
<imprint><date when="2008">2008</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Hallucinations occur in 20–40% of PD patients and have been associated with unfavorable clinical outcomes (i.e., nursing home placement, increased mortality). Hallucinations, like other non-motor features of PD, are not well recognized in routine primary/secondary clinical practice. So far, there has been no instrument for uniform characterization of hallucinations in PD. To this end, we developed the University of Miami Parkinson's disease Hallucinations Questionnaire (UM-PDHQ) that allows comprehensive assessment of hallucinations in clinical or research settings.</p>
</sec>
<sec sec-type="methods"><title>Methods</title>
<p>The UM-PDHQ is composed of 6 quantitative and 14 qualitative items. For our study PD patients of all ages and in all stages of the disease were recruited over an 18-month period. The UPDRS, MMSE, and Beck Depression and Anxiety Inventories were used for comparisons.</p>
</sec>
<sec><title>Results and Discussion</title>
<p>Seventy consecutive PD patients were included in the analyses. Thirty-one (44.3%) were classified as hallucinators and 39 as non-hallucinators. No significant group differences were observed in terms of demographics, disease characteristics, stage, education, depressive/anxiety scores or cognitive functioning (MMSE) between hallucinators and non-hallucinators. Single mode hallucinations were reported in 20/31 (visual/14, auditory/4, olfactory/2) whereas multiple modalities were reported in 11/31 patients. The most common hallucinatory experience was a whole person followed by small animals, insects and reptiles.</p>
</sec>
<sec><title>Conclusion</title>
<p>Using the UM-PDHQ, we were able to define the key characteristics of hallucinations in PD in our cohort. Future directions include the validation of the quantitative part of the questionnaire than will serve as a rating scale for severity of hallucinations.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Floride</li>
<li>Grand Londres</li>
</region>
<settlement><li>Londres</li>
</settlement>
</list>
<tree><country name="États-Unis"><region name="Floride"><name sortKey="Papapetropoulos, Spiridon" sort="Papapetropoulos, Spiridon" uniqKey="Papapetropoulos S" first="Spiridon" last="Papapetropoulos">Spiridon Papapetropoulos</name>
</region>
<name sortKey="Guevara, Alexandra" sort="Guevara, Alexandra" uniqKey="Guevara A" first="Alexandra" last="Guevara">Alexandra Guevara</name>
<name sortKey="Katzen, Heather" sort="Katzen, Heather" uniqKey="Katzen H" first="Heather" last="Katzen">Heather Katzen</name>
<name sortKey="Levin, Bonnie" sort="Levin, Bonnie" uniqKey="Levin B" first="Bonnie" last="Levin">Bonnie Levin</name>
<name sortKey="Nation, Daniel" sort="Nation, Daniel" uniqKey="Nation D" first="Daniel" last="Nation">Daniel Nation</name>
<name sortKey="Scanlon, Blake K" sort="Scanlon, Blake K" uniqKey="Scanlon B" first="Blake" last="Scanlon">Blake. Scanlon</name>
<name sortKey="Singer, Carlos" sort="Singer, Carlos" uniqKey="Singer C" first="Carlos" last="Singer">Carlos Singer</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Schrag, Anette" sort="Schrag, Anette" uniqKey="Schrag A" first="Anette" last="Schrag">Anette Schrag</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/JankovicV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000185 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 000185 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= JankovicV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:2443167 |texte= A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's disease }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:18570642" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a JankovicV1
This area was generated with Dilib version V0.6.19. |