Electroconvulsive shock enhances striatal dopamine D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats
Identifieur interne : 000142 ( Ncbi/Checkpoint ); précédent : 000141; suivant : 000143Electroconvulsive shock enhances striatal dopamine D1 and D3 receptor binding and improves motor performance in 6-OHDA-lesioned rats
Auteurs : Elissa Strome ; Athanasios Zis ; Doris DoudetSource :
- Journal of Psychiatry & Neuroscience [ 1180-4882 ] ; 2007.
Abstract
Electroconvulsive therapy (ECT) is a widely used and effective treatment for mood disorders and appears to have positive effects on the motor symptoms of Parkinson's disease (PD), improving motor function for several weeks. Because repeated electroconvulsive shock (ECS) in normal animals enhances striatal dopamine (DA) D1 and D3 receptor binding, we hypothesized that upregulation of D1 and D3 receptors may also be occurring in the parkinsonian brain after repeated ECS treatment.
Rats were rendered hemiparkinsonian through unilateral infusion of the DA-specific neurotoxin 6-hydroxydopamine into the medial forebrain bundle and substantia nigra. The animals were tested for hindlimb and forelimb function before and 48 hours after the last of 10 daily treatments with ECS or sham. After sacrifice, DA receptor binding was determined autoradiographically.
While there was no increase in forelimb use in the cylinder test, ECS treatment significantly improved hindlimb motor performance on a tapered beam-walking test and enhanced striatal D1 and D3 receptor binding, without affecting D2 receptor binding.
This study suggests that at least part of the mechanism of action of ECT in PD may be enhanced DA function within the direct pathway of the basal ganglia and may support the further study and use of ECT as a potential adjunct treatment for PD.
Url:
PubMed: 17476366
PubMed Central: 1863551
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Electroconvulsive shock enhances striatal dopamine D<sub>1</sub> and D<sub>3</sub> receptor binding and improves motor performance in 6-OHDA-lesioned rats</title><author><name sortKey="Strome, Elissa M" sort="Strome, Elissa M" uniqKey="Strome E" first="Elissa" last="Strome">Elissa Strome</name></author><author><name sortKey="Zis, Athanasios P" sort="Zis, Athanasios P" uniqKey="Zis A" first="Athanasios" last="Zis">Athanasios Zis</name></author><author><name sortKey="Doudet, Doris J" sort="Doudet, Doris J" uniqKey="Doudet D" first="Doris" last="Doudet">Doris Doudet</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17476366</idno><idno type="pmc">1863551</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1863551</idno><idno type="RBID">PMC:1863551</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">000092</idno><idno type="wicri:Area/Pmc/Curation">000092</idno><idno type="wicri:Area/Pmc/Checkpoint">000249</idno><idno type="wicri:Area/Ncbi/Merge">000142</idno><idno type="wicri:Area/Ncbi/Curation">000142</idno><idno type="wicri:Area/Ncbi/Checkpoint">000142</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Electroconvulsive shock enhances striatal dopamine D<sub>1</sub> and D<sub>3</sub> receptor binding and improves motor performance in 6-OHDA-lesioned rats</title><author><name sortKey="Strome, Elissa M" sort="Strome, Elissa M" uniqKey="Strome E" first="Elissa" last="Strome">Elissa Strome</name></author><author><name sortKey="Zis, Athanasios P" sort="Zis, Athanasios P" uniqKey="Zis A" first="Athanasios" last="Zis">Athanasios Zis</name></author><author><name sortKey="Doudet, Doris J" sort="Doudet, Doris J" uniqKey="Doudet D" first="Doris" last="Doudet">Doris Doudet</name></author></analytic><series><title level="j">Journal of Psychiatry & Neuroscience</title><idno type="ISSN">1180-4882</idno><idno type="e-ISSN">1488-2434</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>Electroconvulsive therapy (ECT) is a widely used and effective treatment for mood disorders and appears to have positive effects on the motor symptoms of Parkinson's disease (PD), improving motor function for several weeks. Because repeated electroconvulsive shock (ECS) in normal animals enhances striatal dopamine (DA) D<sub>1</sub> and D<sub>3</sub> receptor binding, we hypothesized that upregulation of D<sub>1</sub> and D<sub>3</sub> receptors may also be occurring in the parkinsonian brain after repeated ECS treatment.</p></sec><sec><title>Methods</title><p>Rats were rendered hemiparkinsonian through unilateral infusion of the DA-specific neurotoxin 6-hydroxydopamine into the medial forebrain bundle and substantia nigra. The animals were tested for hindlimb and forelimb function before and 48 hours after the last of 10 daily treatments with ECS or sham. After sacrifice, DA receptor binding was determined autoradiographically.</p></sec><sec><title>Results</title><p>While there was no increase in forelimb use in the cylinder test, ECS treatment significantly improved hindlimb motor performance on a tapered beam-walking test and enhanced striatal D<sub>1</sub> and D<sub>3</sub> receptor binding, without affecting D<sub>2</sub> receptor binding.</p></sec><sec><title>Conclusion</title><p>This study suggests that at least part of the mechanism of action of ECT in PD may be enhanced DA function within the direct pathway of the basal ganglia and may support the further study and use of ECT as a potential adjunct treatment for PD.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Doudet, Doris J" sort="Doudet, Doris J" uniqKey="Doudet D" first="Doris" last="Doudet">Doris Doudet</name><name sortKey="Strome, Elissa M" sort="Strome, Elissa M" uniqKey="Strome E" first="Elissa" last="Strome">Elissa Strome</name><name sortKey="Zis, Athanasios P" sort="Zis, Athanasios P" uniqKey="Zis A" first="Athanasios" last="Zis">Athanasios Zis</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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