The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease.
Identifieur interne : 000102 ( Ncbi/Checkpoint ); précédent : 000101; suivant : 000103The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease.
Auteurs : Joseph Jankovic [États-Unis] ; S. Chen ; W LeSource :
- Progress in neurobiology [ 0301-0082 ]
English descriptors
- KwdEn :
- Animals, Brain (metabolism), Brain (pathology), Cell Differentiation, DNA-Binding Proteins (metabolism), Dopamine (metabolism), Humans, Neurons (metabolism), Neurons (pathology), Nuclear Receptor Subfamily 4, Group A, Member 2, Parkinson Disease (metabolism), Signal Transduction, Transcription Factors (metabolism).
- MESH :
- chemical , metabolism : DNA-Binding Proteins, Dopamine, Transcription Factors.
- metabolism : Brain, Neurons, Parkinson Disease.
- pathology : Brain, Neurons.
- Animals, Cell Differentiation, Humans, Nuclear Receptor Subfamily 4, Group A, Member 2, Signal Transduction.
Abstract
Nurr1, a transcription factor belonging to the orphan nuclear receptor superfamily, is critical in the development and maintenance of the dopaminergic system and as such it may have role in the pathogenesis of Parkinson' disease (PD). Human Nurr1 gene has been mapped to chromosome 2q22-23 and Nurr1 protein is predominantly expressed in central dopaminergic neurons. Nurr1 interacts with other factors critical for the survival of mensencephalic dopaminergic neurons and it appears to regulate the expression of tyrosine hydroxylase (TH), dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2), and l-aromatic amino acid decarboxylase (AADC), all of which are important in the synthesis and storage of dopamine. Experimental studies in Nurr1 knock-out mice indicate that Nurr1 deficiency results in impaired dopaminergic function and increased vulnerability of those midbrain dopaminergic neurons that degenerate in PD. Decreased Nurr1 expression is found in the autopsied PD midbrains, particularly in neurons containing Lewy bodies, as well as in peripheral lymphocytes of patients with parkinsonian disorders. Several variants in Nurr1 gene have been reported in association with PD. All these studies suggest that Nurr1 is not only essential in the development of mensencephalic dopaminergic neurons and maintenance of their functions, but it may also play a role in the pathogenesis of PD.
DOI: 10.1016/j.pneurobio.2005.09.001
PubMed: 16243425
Affiliations:
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Chen</name></author><author><name sortKey="Le, W D" sort="Le, W D" uniqKey="Le W" first="W" last="Le">W Le</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2005 Sep-Oct</MedlineDate></PubDate></date><idno type="doi">10.1016/j.pneurobio.2005.09.001</idno><idno type="RBID">pubmed:16243425</idno><idno type="pmid">16243425</idno><idno type="wicri:Area/PubMed/Corpus">000188</idno><idno type="wicri:Area/PubMed/Curation">000188</idno><idno type="wicri:Area/PubMed/Checkpoint">000343</idno><idno type="wicri:Area/Ncbi/Merge">000102</idno><idno type="wicri:Area/Ncbi/Curation">000102</idno><idno type="wicri:Area/Ncbi/Checkpoint">000102</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease.</title><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Parkinson Disease Research Lab, Baylor College of Medicine, Houston, TX 77030, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Parkinson Disease Research Lab, Baylor College of Medicine, Houston, TX 77030</wicri:regionArea><placeName><region type="state">Texas</region></placeName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Chen, S" sort="Chen, S" uniqKey="Chen S" first="S" last="Chen">S. Chen</name></author><author><name sortKey="Le, W D" sort="Le, W D" uniqKey="Le W" first="W" last="Le">W Le</name></author></analytic><series><title level="j">Progress in neurobiology</title><idno type="ISSN">0301-0082</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Brain (metabolism)</term><term>Brain (pathology)</term><term>Cell Differentiation</term><term>DNA-Binding Proteins (metabolism)</term><term>Dopamine (metabolism)</term><term>Humans</term><term>Neurons (metabolism)</term><term>Neurons (pathology)</term><term>Nuclear Receptor Subfamily 4, Group A, Member 2</term><term>Parkinson Disease (metabolism)</term><term>Signal Transduction</term><term>Transcription Factors (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA-Binding Proteins</term><term>Dopamine</term><term>Transcription Factors</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Neurons</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Differentiation</term><term>Humans</term><term>Nuclear Receptor Subfamily 4, Group A, Member 2</term><term>Signal Transduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nurr1, a transcription factor belonging to the orphan nuclear receptor superfamily, is critical in the development and maintenance of the dopaminergic system and as such it may have role in the pathogenesis of Parkinson' disease (PD). Human Nurr1 gene has been mapped to chromosome 2q22-23 and Nurr1 protein is predominantly expressed in central dopaminergic neurons. Nurr1 interacts with other factors critical for the survival of mensencephalic dopaminergic neurons and it appears to regulate the expression of tyrosine hydroxylase (TH), dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2), and l-aromatic amino acid decarboxylase (AADC), all of which are important in the synthesis and storage of dopamine. Experimental studies in Nurr1 knock-out mice indicate that Nurr1 deficiency results in impaired dopaminergic function and increased vulnerability of those midbrain dopaminergic neurons that degenerate in PD. Decreased Nurr1 expression is found in the autopsied PD midbrains, particularly in neurons containing Lewy bodies, as well as in peripheral lymphocytes of patients with parkinsonian disorders. Several variants in Nurr1 gene have been reported in association with PD. All these studies suggest that Nurr1 is not only essential in the development of mensencephalic dopaminergic neurons and maintenance of their functions, but it may also play a role in the pathogenesis of PD.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><noCountry><name sortKey="Chen, S" sort="Chen, S" uniqKey="Chen S" first="S" last="Chen">S. Chen</name><name sortKey="Le, W D" sort="Le, W D" uniqKey="Le W" first="W" last="Le">W Le</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">Joseph Jankovic</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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