Neuropsychological outcome after unilateral pallidotomy for the treatment of Parkinson's disease
Identifieur interne : 001A02 ( Main/Merge ); précédent : 001A01; suivant : 001A03Neuropsychological outcome after unilateral pallidotomy for the treatment of Parkinson's disease
Auteurs : G Rettig [États-Unis] ; M York [États-Unis] ; E Lai [États-Unis] ; J Jankovic [États-Unis] ; J Krauss [États-Unis] ; R Grossman [États-Unis] ; H Levin [États-Unis]Source :
- Journal of neurology, neurosurgery and psychiatry [ 0022-3050 ] ; 2000.
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- Pascal (Inist)
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Abstract
Objective-To assess the long term cognitive outcome of unilateral posteroventral pallidotomy (PVP) and the overall efficacy of the surgery. Methods-Forty two (29 left and 13 right PVP) patients with Parkinson's disease underwent neurological and neuropsychological testing before PVP and at 3 and 12 months after PVP. The neuropsychological testing battery emphasised measures of verbal learning and memory, visuospatial abilities, speed of information processing, executive functioning, and affective functioning. Results-All patients demonstrated motor improvements after surgery during their off state, and 86% of patients also showed improvements in motor functioning in their on state. Repeated measures ANOVA showed significant improvements in confrontational naming, visuospatial organisation, and affective functioning 3 months and 12 months after surgery, with inconsistent improvements in executive functioning 12 months post-PVP. Patients demonstrated a transient impairment in verbal memory, with verbal learning performance returning to baseline 12 months post-PVP after a significant decline 3 months after PVP. When three patients with lesions extending outside of the PVP were excluded from the analysis, a decline in verbal fluency performance after PVP was not found to be significant. Differences due to side of lesion placement were not found on any of the cognitive measures. Conclusions-In the largest long term follow up study reported to date, the cognitive changes found up to a year after PVP are minimal compared with the robust improvements in motor function. The findings highlight the need to investigate the relation between the specific fibre tracts affected by the lesions and cognitive outcome.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Neuropsychological outcome after unilateral pallidotomy for the treatment of Parkinson's disease</title><author><name sortKey="Rettig, G M" sort="Rettig, G M" uniqKey="Rettig G" first="G" last="Rettig">G Rettig</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="York, M K" sort="York, M K" uniqKey="York M" first="M" last="York">M York</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Lai, E C" sort="Lai, E C" uniqKey="Lai E" first="E" last="Lai">E Lai</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J Jankovic</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Krauss, J K" sort="Krauss, J K" uniqKey="Krauss J" first="J" last="Krauss">J Krauss</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Grossman, R G" sort="Grossman, R G" uniqKey="Grossman R" first="R" last="Grossman">R Grossman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Levin, H S" sort="Levin, H S" uniqKey="Levin H" first="H" last="Levin">H Levin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">00-0432072</idno><date when="2000">2000</date><idno type="stanalyst">PASCAL 00-0432072 INIST</idno><idno type="RBID">Pascal:00-0432072</idno><idno type="wicri:Area/PascalFrancis/Corpus">000159</idno><idno type="wicri:Area/PascalFrancis/Curation">000007</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000157</idno><idno type="wicri:doubleKey">0022-3050:2000:Rettig G:neuropsychological:outcome:after</idno><idno type="wicri:Area/Main/Merge">001A02</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Neuropsychological outcome after unilateral pallidotomy for the treatment of Parkinson's disease</title><author><name sortKey="Rettig, G M" sort="Rettig, G M" uniqKey="Rettig G" first="G" last="Rettig">G Rettig</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="York, M K" sort="York, M K" uniqKey="York M" first="M" last="York">M York</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Lai, E C" sort="Lai, E C" uniqKey="Lai E" first="E" last="Lai">E Lai</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J Jankovic</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurology, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Krauss, J K" sort="Krauss, J K" uniqKey="Krauss J" first="J" last="Krauss">J Krauss</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Grossman, R G" sort="Grossman, R G" uniqKey="Grossman R" first="R" last="Grossman">R Grossman</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author><author><name sortKey="Levin, H S" sort="Levin, H S" uniqKey="Levin H" first="H" last="Levin">H Levin</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Neurosurgery, Baylor College of Medicine and The Methodist Hospital, 6560 Fannin, Suite 944</s1><s2>Houston, Texas 77030</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Houston, Texas 77030</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognition</term><term>Evolution</term><term>Human</term><term>Long term</term><term>Pallidum</term><term>Parkinson disease</term><term>Surgery</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Pallidum</term><term>Chirurgie</term><term>Cognition</term><term>Long terme</term><term>Evolution</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective-To assess the long term cognitive outcome of unilateral posteroventral pallidotomy (PVP) and the overall efficacy of the surgery. Methods-Forty two (29 left and 13 right PVP) patients with Parkinson's disease underwent neurological and neuropsychological testing before PVP and at 3 and 12 months after PVP. The neuropsychological testing battery emphasised measures of verbal learning and memory, visuospatial abilities, speed of information processing, executive functioning, and affective functioning. Results-All patients demonstrated motor improvements after surgery during their off state, and 86% of patients also showed improvements in motor functioning in their on state. Repeated measures ANOVA showed significant improvements in confrontational naming, visuospatial organisation, and affective functioning 3 months and 12 months after surgery, with inconsistent improvements in executive functioning 12 months post-PVP. Patients demonstrated a transient impairment in verbal memory, with verbal learning performance returning to baseline 12 months post-PVP after a significant decline 3 months after PVP. When three patients with lesions extending outside of the PVP were excluded from the analysis, a decline in verbal fluency performance after PVP was not found to be significant. Differences due to side of lesion placement were not found on any of the cognitive measures. Conclusions-In the largest long term follow up study reported to date, the cognitive changes found up to a year after PVP are minimal compared with the robust improvements in motor function. The findings highlight the need to investigate the relation between the specific fibre tracts affected by the lesions and cognitive outcome.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Rettig, G M" sort="Rettig, G M" uniqKey="Rettig G" first="G" last="Rettig">G Rettig</name></noRegion><name sortKey="Grossman, R G" sort="Grossman, R G" uniqKey="Grossman R" first="R" last="Grossman">R Grossman</name><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J Jankovic</name><name sortKey="Krauss, J K" sort="Krauss, J K" uniqKey="Krauss J" first="J" last="Krauss">J Krauss</name><name sortKey="Lai, E C" sort="Lai, E C" uniqKey="Lai E" first="E" last="Lai">E Lai</name><name sortKey="Levin, H S" sort="Levin, H S" uniqKey="Levin H" first="H" last="Levin">H Levin</name><name sortKey="York, M K" sort="York, M K" uniqKey="York M" first="M" last="York">M York</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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