JankovicV1, Main, Merge, bibRecord, 001998

Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl- phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice

Identifieur interne : 001998 ( Main/Merge ); précédent : 001997; suivant : 001999

Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl- phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice

Auteurs : L Zou [États-Unis] ; JING XU [États-Unis] ; J Jankovic [États-Unis] ; YI HE [États-Unis] ; S Appel [États-Unis] ; W Le [États-Unis]

Source :

Neuroscience letters [ 0304-3940 ] ; 2000.

RBID : Pascal:00-0187522

Descripteurs français

Pascal (Inist)
- Peroxydation, Lipide, Neurotoxine, Dopamine, Locus niger, Pramipexole, Antiparkinsonien, Parkinson maladie, Antioxydant, Neuroprotecteur, Modèle animal, Souris.

English descriptors

KwdEn :
- Animal model, Antioxidant, Antiparkinson agent, Dopamine, Lipids, Locus niger, Mouse, Neuroprotective agent, Neurotoxin, Parkinson disease, Peroxidation, Pramipexole.

Abstract

Pramipexole has been showed to protect cultured dopaminergic (DAergic) cells against free radical-induced cytotoxicity. To test if pramipexole is protective against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated nigral DAergic injury in vivo and if such protection is related to inhibition of lipid peroxidation, DAergic function and lipid peroxidation were determined in MPTP-treated C57BU6 mice. We reported that MPTP administration induced a 38.1% increase of lipid peroxidation product thiobarbituric acid reactive substance (TBARS) in nigra, a 46.7% decrease of tyrosine hydroxylase -positive nigral DAergic neurons and a 59.4% reduction of striatal DA levels. However, pramipexole treatment significantly inhibited the TBARS production by 76%, and attenuated the MPTP-induced decreases in nigral DAergic neurons and striatal DA levels by about 50%. This study suggests that pramipexole can inhibit free radical-mediated lipid peroxidation and protect MPTP-induced nigral injury.

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Pascal:00-0187522

Le document en format XML

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<front><div type="abstract" xml:lang="en">Pramipexole has been showed to protect cultured dopaminergic (DAergic) cells against free radical-induced cytotoxicity. To test if pramipexole is protective against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated nigral DAergic injury in vivo and if such protection is related to inhibition of lipid peroxidation, DAergic function and lipid peroxidation were determined in MPTP-treated C57BU6 mice. We reported that MPTP administration induced a 38.1% increase of lipid peroxidation product thiobarbituric acid reactive substance (TBARS) in nigra, a 46.7% decrease of tyrosine hydroxylase -positive nigral DAergic neurons and a 59.4% reduction of striatal DA levels. However, pramipexole treatment significantly inhibited the TBARS production by 76%, and attenuated the MPTP-induced decreases in nigral DAergic neurons and striatal DA levels by about 50%. This study suggests that pramipexole can inhibit free radical-mediated lipid peroxidation and protect MPTP-induced nigral injury.</div>
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Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl- phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice

Pramipexole inhibits lipid peroxidation and reduces injury in the substantia nigra induced by the dopaminergic neurotoxin 1-methyl- phenyl-1,2,3,6-tetrahydropyridine in C57BL/6 mice

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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