The effects of subthalamic nucleus deep brain stimulation on parkinsonian tremor.
Identifieur interne : 000D57 ( Main/Merge ); précédent : 000D56; suivant : 000D58The effects of subthalamic nucleus deep brain stimulation on parkinsonian tremor.
Auteurs : Alan Diamond [États-Unis] ; Joohi Shahed ; Joseph Jankovic [États-Unis]Source :
- Journal of the neurological sciences [ 0022-510X ] ; 2007.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Basal Ganglia (physiopathology), Deep Brain Stimulation (methods), Deep Brain Stimulation (trends), Electrodes (standards), Female, Humans, Male, Middle Aged, Neural Pathways (physiopathology), Parkinson Disease (complications), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Prospective Studies, Stereotaxic Techniques, Subthalamic Nucleus (physiology), Treatment Outcome, Tremor (etiology), Tremor (physiopathology), Tremor (therapy), Ventral Thalamic Nuclei (physiopathology).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- complications : Parkinson Disease.
- etiology : Tremor.
- methods : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- physiopathology : Basal Ganglia, Neural Pathways, Parkinson Disease, Tremor, Ventral Thalamic Nuclei.
- standards : Electrodes.
- therapy : Parkinson Disease, Tremor.
- trends : Deep Brain Stimulation.
- Aged, Female, Humans, Male, Middle Aged, Prospective Studies, Stereotaxic Techniques, Treatment Outcome.
Abstract
Deep brain stimulation (DBS) of the ventral intermediate (Vim) nucleus of the thalamus has been the target of choice for patients with disabling essential tremor or medication refractory parkinsonian tremor. Recently there is evidence that the subthalamic nucleus (STN) should be the targets for patients with tremor associated with Parkinson's disease (PD). To assess the effects of STN DBS on parkinsonian tremor, eight consecutive patients with PD and disabling tremor were videotaped using a standardized tremor protocol. Evaluations were performed at least 12 h after last dose of medication with the DBS turned off followed by optimal DBS on state. A rater blinded to DBS status evaluated randomized video segments with the tremor components of the Unified Parkinson Disease Rating Scale (UPDRS) and Tremor Rating Scale (TRS). Compared with DBS off state there were significant improvements in mean UPDRS tremor score 79.4% (p=0.008), total TRS score 69.9% (p=0.008) and upper extremity 92.5% (p=0.008) TRS subscore. Functional improvement was noted with pouring liquids. Our findings provide support that STN DBS is an effective treatment of tremor associated with PD.
DOI: 10.1016/j.jns.2007.05.002
PubMed: 17561121
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last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2007">2007</date><idno type="doi">10.1016/j.jns.2007.05.002</idno><idno type="RBID">pubmed:17561121</idno><idno type="pmid">17561121</idno><idno type="wicri:Area/PubMed/Corpus">000161</idno><idno type="wicri:Area/PubMed/Curation">000161</idno><idno type="wicri:Area/PubMed/Checkpoint">000154</idno><idno type="wicri:Area/Ncbi/Merge">000146</idno><idno type="wicri:Area/Ncbi/Curation">000146</idno><idno type="wicri:Area/Ncbi/Checkpoint">000146</idno><idno type="wicri:doubleKey">0022-510X:2007:Diamond A:the:effects:of</idno><idno type="wicri:Area/Main/Merge">000D57</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effects of subthalamic nucleus deep brain stimulation on parkinsonian tremor.</title><author><name sortKey="Diamond, Alan" sort="Diamond, Alan" uniqKey="Diamond A" first="Alan" last="Diamond">Alan Diamond</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, Baylor College of Medicine, United States. neurodoc01@sbcglobal.net</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Baylor College of Medicine</wicri:regionArea><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Shahed, Joohi" sort="Shahed, Joohi" uniqKey="Shahed J" first="Joohi" last="Shahed">Joohi Shahed</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j">Journal of the neurological sciences</title><idno type="ISSN">0022-510X</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Basal Ganglia (physiopathology)</term><term>Deep Brain Stimulation (methods)</term><term>Deep Brain Stimulation (trends)</term><term>Electrodes (standards)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neural Pathways (physiopathology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Prospective Studies</term><term>Stereotaxic Techniques</term><term>Subthalamic Nucleus (physiology)</term><term>Treatment Outcome</term><term>Tremor (etiology)</term><term>Tremor (physiopathology)</term><term>Tremor (therapy)</term><term>Ventral Thalamic Nuclei (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Neural Pathways</term><term>Parkinson Disease</term><term>Tremor</term><term>Ventral Thalamic Nuclei</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Electrodes</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Stereotaxic Techniques</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the ventral intermediate (Vim) nucleus of the thalamus has been the target of choice for patients with disabling essential tremor or medication refractory parkinsonian tremor. Recently there is evidence that the subthalamic nucleus (STN) should be the targets for patients with tremor associated with Parkinson's disease (PD). To assess the effects of STN DBS on parkinsonian tremor, eight consecutive patients with PD and disabling tremor were videotaped using a standardized tremor protocol. Evaluations were performed at least 12 h after last dose of medication with the DBS turned off followed by optimal DBS on state. A rater blinded to DBS status evaluated randomized video segments with the tremor components of the Unified Parkinson Disease Rating Scale (UPDRS) and Tremor Rating Scale (TRS). Compared with DBS off state there were significant improvements in mean UPDRS tremor score 79.4% (p=0.008), total TRS score 69.9% (p=0.008) and upper extremity 92.5% (p=0.008) TRS subscore. Functional improvement was noted with pouring liquids. Our findings provide support that STN DBS is an effective treatment of tremor associated with PD.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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