JankovicV1, Main, Merge, bibRecord, 000133

Animal Models of Parkinson’s Disease: A Gateway to Therapeutics?

Identifieur interne : 000133 ( Main/Merge ); précédent : 000132; suivant : 000134

Animal Models of Parkinson’s Disease: A Gateway to Therapeutics?

Auteurs : Weidong Le [République populaire de Chine] ; Pavani Sayana ; Joseph Jankovic [États-Unis]

Source :

Neurotherapeutics [ 1933-7213 ] ; 2013.

RBID : PMC:3899493

English descriptors

KwdEn :
- Animals, Antiparkinson Agents (therapeutic use), Disease Models, Animal, Drug Evaluation, Preclinical, Humans, Parkinson Disease (etiology), Parkinson Disease (therapy).
MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- etiology : Parkinson Disease.
- therapy : Parkinson Disease.
- Animals, Disease Models, Animal, Drug Evaluation, Preclinical, Humans.

Abstract

Parkinson’s disease (PD) is a progressive, neurodegenerative disorder of unknown etiology, although a complex interaction between environmental and genetic factors has been implicated as a pathogenic mechanism of selected neuronal loss. A better understanding of the etiology, pathogenesis, and molecular mechanisms underlying the disease process may be gained from research on animal models. While cell and tissue models are helpful in unraveling involved molecular pathways, animal models are much better suited to study the pathogenesis and potential treatment strategies. The animal models most relevant to PD include those generated by neurotoxic chemicals that selectively disrupt the catecholaminergic system such as 6-hydroxydopamine; 1-methyl-1,2,3,6-tetrahydropiridine; agricultural pesticide toxins, such as rotenone and paraquat; the ubiquitin proteasome system inhibitors; inflammatory modulators; and several genetically manipulated models, such as α-synuclein, DJ-1, PINK1, Parkin, and leucine-rich repeat kinase 2 transgenic or knock-out animals. Genetic and nongenetic animal models have their own unique advantages and limitations, which must be considered when they are employed in the study of pathogenesis or treatment approaches. This review provides a summary and a critical review of our current knowledge about various in vivo models of PD used to test novel therapeutic strategies.

Electronic supplementary material

The online version of this article (doi:10.1007/s13311-013-0234-1) contains supplementary material, which is available to authorized users.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3899493

DOI: 10.1007/s13311-013-0234-1
PubMed: 24158912
PubMed Central: 3899493

Links to Exploration step

PMC:3899493

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p>Parkinson’s disease (PD) is a progressive, neurodegenerative disorder of unknown etiology, although a complex interaction between environmental and genetic factors has been implicated as a pathogenic mechanism of selected neuronal loss. A better understanding of the etiology, pathogenesis, and molecular mechanisms underlying the disease process may be gained from research on animal models. While cell and tissue models are helpful in unraveling involved molecular pathways, animal models are much better suited to study the pathogenesis and potential treatment strategies. The animal models most relevant to PD include those generated by neurotoxic chemicals that selectively disrupt the catecholaminergic system such as 6-hydroxydopamine; 1-methyl-1,2,3,6-tetrahydropiridine; agricultural pesticide toxins, such as rotenone and paraquat; the ubiquitin proteasome system inhibitors; inflammatory modulators; and several genetically manipulated models, such as α-synuclein, DJ-1, PINK1, Parkin, and leucine-rich repeat kinase 2 transgenic or knock-out animals. Genetic and nongenetic animal models have their own unique advantages and limitations, which must be considered when they are employed in the study of pathogenesis or treatment approaches. This review provides a summary and a critical review of our current knowledge about various <italic>in vivo</italic>
 models of PD used to test novel therapeutic strategies.</p>
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Serveur d'exploration autour de Joseph Jankovic

Animal Models of Parkinson’s Disease: A Gateway to Therapeutics?

Animal Models of Parkinson’s Disease: A Gateway to Therapeutics?

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration autour de Joseph Jankovic
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