Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease
Identifieur interne : 000117 ( Main/Merge ); précédent : 000116; suivant : 000118Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease
Auteurs : Michele Greg [Brésil] ; Marcela Pinhel [Brésil] ; Caroline Sado [Brésil] ; Gabriela Longo [Brésil] ; Fábio Oliveira [Brésil] ; Gisele Amorim [Brésil] ; Marcelo Nakazone [Brésil] ; Greiciane Florim [Brésil] ; Camila Mazeti [Brésil] ; Denise Martins [Brésil] ; Waldir Tognola [Brésil] ; Antonio Brandão [Brésil] ; Sidney Júnior [Brésil] ; Moacir De [Brésil] ; Dorotéia Souza [Brésil]Source :
- BioMed Research International [ 2314-6133 ] ; 2013.
Abstract
The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration.
Url:
DOI: 10.1155/2013/641515
PubMed: 24175296
PubMed Central: 3794554
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease</title><author><name sortKey="Greg Rio, Michele L" sort="Greg Rio, Michele L" uniqKey="Greg Rio M" first="Michele" last="Greg">Michele Greg</name><affiliation wicri:level="2"><nlm:aff id="I1">Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Pinhel, Marcela A S" sort="Pinhel, Marcela A S" uniqKey="Pinhel M" first="Marcela" last="Pinhel">Marcela Pinhel</name><affiliation wicri:level="2"><nlm:aff id="I1">Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I2">Sao Jose do Rio Preto Medical School (FAMERP), Center of Research in Biochemistry and Molecular Biology, NPBIM, Avenida Brigadeiro Faria Lima 5416, Vila Sao Pedro, 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Jose do Rio Preto Medical School (FAMERP), Center of Research in Biochemistry and Molecular Biology, NPBIM, Avenida Brigadeiro Faria Lima 5416, Vila Sao Pedro, 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Sado, Caroline L" sort="Sado, Caroline L" uniqKey="Sado C" first="Caroline" last="Sado">Caroline Sado</name><affiliation wicri:level="2"><nlm:aff id="I3">Federal University of São Paulo (UNIFESP), 04021001 São Paulo, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Federal University of São Paulo (UNIFESP), 04021001 São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Longo, Gabriela S" sort="Longo, Gabriela S" uniqKey="Longo G" first="Gabriela" last="Longo">Gabriela Longo</name><affiliation wicri:level="2"><nlm:aff id="I4">Hospital de Base, 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Base, 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Oliveira, Fabio N" sort="Oliveira, Fabio N" uniqKey="Oliveira F" first="Fábio" last="Oliveira">Fábio Oliveira</name><affiliation wicri:level="2"><nlm:aff id="I4">Hospital de Base, 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Base, 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Amorim, Gisele S" sort="Amorim, Gisele S" uniqKey="Amorim G" first="Gisele" last="Amorim">Gisele Amorim</name><affiliation wicri:level="2"><nlm:aff id="I5">Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Nakazone, Marcelo A" sort="Nakazone, Marcelo A" uniqKey="Nakazone M" first="Marcelo" last="Nakazone">Marcelo Nakazone</name><affiliation wicri:level="2"><nlm:aff id="I1">Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Florim, Greiciane M" sort="Florim, Greiciane M" uniqKey="Florim G" first="Greiciane" last="Florim">Greiciane Florim</name><affiliation wicri:level="2"><nlm:aff id="I5">Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Mazeti, Camila M" sort="Mazeti, Camila M" uniqKey="Mazeti C" first="Camila" last="Mazeti">Camila Mazeti</name><affiliation wicri:level="2"><nlm:aff id="I5">Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Martins, Denise P" sort="Martins, Denise P" uniqKey="Martins D" first="Denise" last="Martins">Denise Martins</name><affiliation wicri:level="2"><nlm:aff id="I5">Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Tognola, Waldir A" sort="Tognola, Waldir A" uniqKey="Tognola W" first="Waldir" last="Tognola">Waldir Tognola</name><affiliation wicri:level="2"><nlm:aff id="I6">Department of Neuroscience/Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neuroscience/Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Brandao, Antonio C" sort="Brandao, Antonio C" uniqKey="Brandao A" first="Antonio" last="Brandão">Antonio Brandão</name><affiliation wicri:level="2"><nlm:aff id="I6">Department of Neuroscience/Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neuroscience/Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Junior, Sidney Pinheiro" sort="Junior, Sidney Pinheiro" uniqKey="Junior S" first="Sidney" last="Júnior">Sidney Júnior</name><affiliation wicri:level="2"><nlm:aff id="I7">Department of Molecular Biology, Sao Jose do Rio Preto Medical School—FAMERP, 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Molecular Biology, Sao Jose do Rio Preto Medical School—FAMERP, 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="De Godoy, Moacir F" sort="De Godoy, Moacir F" uniqKey="De Godoy M" first="Moacir" last="De">Moacir De</name><affiliation wicri:level="2"><nlm:aff id="I4">Hospital de Base, 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Base, 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Souza, Doroteia R S" sort="Souza, Doroteia R S" uniqKey="Souza D" first="Dorotéia" last="Souza">Dorotéia Souza</name><affiliation wicri:level="2"><nlm:aff id="I3">Federal University of São Paulo (UNIFESP), 04021001 São Paulo, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Federal University of São Paulo (UNIFESP), 04021001 São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24175296</idno><idno type="pmc">3794554</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3794554</idno><idno type="RBID">PMC:3794554</idno><idno type="doi">10.1155/2013/641515</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000129</idno><idno type="wicri:Area/Pmc/Curation">000129</idno><idno type="wicri:Area/Pmc/Checkpoint">000075</idno><idno type="wicri:Area/Ncbi/Merge">000431</idno><idno type="wicri:Area/Ncbi/Curation">000431</idno><idno type="wicri:Area/Ncbi/Checkpoint">000431</idno><idno type="wicri:doubleKey">2314-6133:2013:Greg Rio M:impact:of:genetic</idno><idno type="wicri:Area/Main/Merge">000117</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of Genetic Variants of Apolipoprotein E on Lipid Profile in Patients with Parkinson's Disease</title><author><name sortKey="Greg Rio, Michele L" sort="Greg Rio, Michele L" uniqKey="Greg Rio M" first="Michele" last="Greg">Michele Greg</name><affiliation wicri:level="2"><nlm:aff id="I1">Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Pinhel, Marcela A S" sort="Pinhel, Marcela A S" uniqKey="Pinhel M" first="Marcela" last="Pinhel">Marcela Pinhel</name><affiliation wicri:level="2"><nlm:aff id="I1">Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="I2">Sao Jose do Rio Preto Medical School (FAMERP), Center of Research in Biochemistry and Molecular Biology, NPBIM, Avenida Brigadeiro Faria Lima 5416, Vila Sao Pedro, 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Jose do Rio Preto Medical School (FAMERP), Center of Research in Biochemistry and Molecular Biology, NPBIM, Avenida Brigadeiro Faria Lima 5416, Vila Sao Pedro, 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Sado, Caroline L" sort="Sado, Caroline L" uniqKey="Sado C" first="Caroline" last="Sado">Caroline Sado</name><affiliation wicri:level="2"><nlm:aff id="I3">Federal University of São Paulo (UNIFESP), 04021001 São Paulo, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Federal University of São Paulo (UNIFESP), 04021001 São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Longo, Gabriela S" sort="Longo, Gabriela S" uniqKey="Longo G" first="Gabriela" last="Longo">Gabriela Longo</name><affiliation wicri:level="2"><nlm:aff id="I4">Hospital de Base, 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Base, 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Oliveira, Fabio N" sort="Oliveira, Fabio N" uniqKey="Oliveira F" first="Fábio" last="Oliveira">Fábio Oliveira</name><affiliation wicri:level="2"><nlm:aff id="I4">Hospital de Base, 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Base, 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Amorim, Gisele S" sort="Amorim, Gisele S" uniqKey="Amorim G" first="Gisele" last="Amorim">Gisele Amorim</name><affiliation wicri:level="2"><nlm:aff id="I5">Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Nakazone, Marcelo A" sort="Nakazone, Marcelo A" uniqKey="Nakazone M" first="Marcelo" last="Nakazone">Marcelo Nakazone</name><affiliation wicri:level="2"><nlm:aff id="I1">Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Florim, Greiciane M" sort="Florim, Greiciane M" uniqKey="Florim G" first="Greiciane" last="Florim">Greiciane Florim</name><affiliation wicri:level="2"><nlm:aff id="I5">Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Mazeti, Camila M" sort="Mazeti, Camila M" uniqKey="Mazeti C" first="Camila" last="Mazeti">Camila Mazeti</name><affiliation wicri:level="2"><nlm:aff id="I5">Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Martins, Denise P" sort="Martins, Denise P" uniqKey="Martins D" first="Denise" last="Martins">Denise Martins</name><affiliation wicri:level="2"><nlm:aff id="I5">Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Tognola, Waldir A" sort="Tognola, Waldir A" uniqKey="Tognola W" first="Waldir" last="Tognola">Waldir Tognola</name><affiliation wicri:level="2"><nlm:aff id="I6">Department of Neuroscience/Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neuroscience/Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Brandao, Antonio C" sort="Brandao, Antonio C" uniqKey="Brandao A" first="Antonio" last="Brandão">Antonio Brandão</name><affiliation wicri:level="2"><nlm:aff id="I6">Department of Neuroscience/Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neuroscience/Molecular Biology, Sao Jose do Rio Preto Medical School (FAMERP), 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Junior, Sidney Pinheiro" sort="Junior, Sidney Pinheiro" uniqKey="Junior S" first="Sidney" last="Júnior">Sidney Júnior</name><affiliation wicri:level="2"><nlm:aff id="I7">Department of Molecular Biology, Sao Jose do Rio Preto Medical School—FAMERP, 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Molecular Biology, Sao Jose do Rio Preto Medical School—FAMERP, 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="De Godoy, Moacir F" sort="De Godoy, Moacir F" uniqKey="De Godoy M" first="Moacir" last="De">Moacir De</name><affiliation wicri:level="2"><nlm:aff id="I4">Hospital de Base, 15090000 Sao Jose do Rio Preto, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital de Base, 15090000 Sao Jose do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Souza, Doroteia R S" sort="Souza, Doroteia R S" uniqKey="Souza D" first="Dorotéia" last="Souza">Dorotéia Souza</name><affiliation wicri:level="2"><nlm:aff id="I3">Federal University of São Paulo (UNIFESP), 04021001 São Paulo, SP, Brazil</nlm:aff><country xml:lang="fr">Brésil</country><wicri:regionArea>Federal University of São Paulo (UNIFESP), 04021001 São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="e-ISSN">2314-6141</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. <italic>APOE</italic> gene has been considered a risk factor for PD. This study aimed to evaluate the association of <italic>APOE</italic> polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. The studied polymorphism was analyzed by PCR/RFLP. The Fisher's exact test, chi-square, ANOVA, and <italic>t</italic>-test (<italic>P</italic> < 0.05) were applied. The <italic>APOE3/3</italic> genotype was prevalent in PD patients and Controls (<italic>P</italic> = 0.713) followed by <italic>APOE3/4</italic> (<italic>P</italic> = 0.772). Both groups showed recommended values for lipid profile, with increase in the values of total cholesterol and LDLc, as well as decreased values of triglycerides in PD patients compared with Controls (<italic>P</italic> < 0.05 for all of them). Increased levels of HDLc, in PD patients, were associated with the <italic>APOE3/3</italic> versus <italic>APOE-/4</italic> genotypes (<italic>P</italic> = 0.012). The <italic>APOE </italic>polymorphism does not distinguish PD patients from Controls, as opposed to the lipid profile alone or in association with <italic>APOE</italic>. Furthermore, a relationship between increase of HDLc levels and <italic>APOE3</italic> in homozygous was found in PD patients only.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Federoff, M" uniqKey="Federoff M">M Federoff</name></author><author><name sortKey="Jimenez Rolando, B" uniqKey="Jimenez Rolando B">B Jimenez-Rolando</name></author><author><name sortKey="Nalls, Ma" uniqKey="Nalls M">MA Nalls</name></author><author><name sortKey="Singleton, Ab" uniqKey="Singleton A">AB Singleton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J Jankovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shulman, Jm" uniqKey="Shulman J">JM Shulman</name></author><author><name sortKey="De Jager, Pl" uniqKey="De Jager P">PL de Jager</name></author><author><name sortKey="Feany, Mb" uniqKey="Feany M">MB 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Bornebroek</name></author><author><name sortKey="Witteman, Jcm" uniqKey="Witteman J">JCM Witteman</name></author><author><name sortKey="Hofman, A" uniqKey="Hofman A">A Hofman</name></author><author><name sortKey="Koudstaal, Pj" uniqKey="Koudstaal P">PJ Koudstaal</name></author><author><name sortKey="Breteler, Mmb" uniqKey="Breteler M">MMB Breteler</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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