REM Sleep Behavior and Motor Findings in Parkinson's Disease: A Cross-sectional Analysis
Identifieur interne : 000063 ( Main/Merge ); précédent : 000062; suivant : 000064REM Sleep Behavior and Motor Findings in Parkinson's Disease: A Cross-sectional Analysis
Auteurs : Abhimanyu Mahajan [États-Unis] ; Liana Rosenthal [États-Unis] ; Charlene Gamaldo [États-Unis] ; Rachel Salas [États-Unis] ; Gregory Pontone [États-Unis] ; Arita Mccoy [États-Unis] ; Chizoba Umeh [États-Unis] ; Zoltan Mari [États-Unis]Source :
- Tremor and Other Hyperkinetic Movements ; 2014.
Abstract
Parkinson's disease (PD) represents a major public health challenge that will only grow in our aging population. Understanding the connection between PD and associated prodromal conditions, such as rapid eye movement sleep behavioral disorder (RBD), is critical to identifying prevention strategies. However, the relationship between RBD and severity of motor findings in early PD is unknown. This study aims to examine this relationship.
The study population consisted of 418 PD patients who completed the Movement Disorders Society-United Parkinson's Disease Rating Scale (MDS-UPDRS) and rapid eye movement sleep (REM) disorder questionnaires at the baseline visit of the Michael J. Fox's Parkinson's Progression Markers Initiative (PPMI). Cross-sectional analysis was carried out to assess the association between REM Sleep Behavior Screening Questionnaire score and MDS UPDRS-3 (motor) score categories. Correlation with a higher score category was described as “worse motor findings”. A score of 5 on the REM disorder questionnaire was defined as predictive of RBD.
Out of the 418 PD patients, 113 (27.0%) had RBD. With univariate logistic regression analysis, individuals with scores predictive of RBD were 1.66 times more likely to have worse motor findings (p = 0.028). Even with age, gender, and Geriatric Depression Scale scores taken into account, individuals with scores predictive of RBD were 1.69 times more likely to have worse motor findings (p = 0.025).
PD patients with RBD symptoms had worse motor findings than those unlikely to have RBD. This association provides further evidence for the relationship between RBD and PD.
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DOI: 10.7916/D84B2ZDF
PubMed: 25009765
PubMed Central: 4070091
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type="wicri:Area/Main/Merge">000063</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">REM Sleep Behavior and Motor Findings in Parkinson's Disease: A Cross-sectional Analysis</title><author><name sortKey="Mahajan, Abhimanyu" sort="Mahajan, Abhimanyu" uniqKey="Mahajan A" first="Abhimanyu" last="Mahajan">Abhimanyu Mahajan</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Neurology Johns Hopkins University, Baltimore, MD, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Rosenthal, Liana S" sort="Rosenthal, Liana S" uniqKey="Rosenthal L" first="Liana" last="Rosenthal">Liana Rosenthal</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Neurology Johns Hopkins University, Baltimore, MD, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Gamaldo, Charlene" sort="Gamaldo, Charlene" uniqKey="Gamaldo C" first="Charlene" last="Gamaldo">Charlene Gamaldo</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Neurology Johns Hopkins University, Baltimore, MD, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Salas, Rachel E" sort="Salas, Rachel E" uniqKey="Salas R" first="Rachel" last="Salas">Rachel Salas</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Neurology Johns Hopkins University, Baltimore, MD, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Pontone, Gregory M" sort="Pontone, Gregory M" uniqKey="Pontone G" first="Gregory" last="Pontone">Gregory Pontone</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Department of Psychiatry and Behavioral Sciences Johns Hopkins University, Baltimore, MD, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Behavioral Sciences Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Mccoy, Arita" sort="Mccoy, Arita" uniqKey="Mccoy A" first="Arita" last="Mccoy">Arita Mccoy</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Neurology Johns Hopkins University, Baltimore, MD, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Umeh, Chizoba" sort="Umeh, Chizoba" uniqKey="Umeh C" first="Chizoba" last="Umeh">Chizoba Umeh</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Neurology Johns Hopkins University, Baltimore, MD, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Mari, Zoltan" sort="Mari, Zoltan" uniqKey="Mari Z" first="Zoltan" last="Mari">Zoltan Mari</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Neurology Johns Hopkins University, Baltimore, MD, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology Johns Hopkins University, Baltimore, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><series><title level="j">Tremor and Other Hyperkinetic Movements</title><idno type="e-ISSN">2160-8288</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Parkinson's disease (PD) represents a major public health challenge that will only grow in our aging population. Understanding the connection between PD and associated prodromal conditions, such as rapid eye movement sleep behavioral disorder (RBD), is critical to identifying prevention strategies. However, the relationship between RBD and severity of motor findings in early PD is unknown. This study aims to examine this relationship.</p></sec><sec><title>Methods</title><p>The study population consisted of 418 PD patients who completed the Movement Disorders Society-United Parkinson's Disease Rating Scale (MDS-UPDRS) and rapid eye movement sleep (REM) disorder questionnaires at the baseline visit of the Michael J. Fox's Parkinson's Progression Markers Initiative (PPMI). Cross-sectional analysis was carried out to assess the association between REM Sleep Behavior Screening Questionnaire score and MDS UPDRS-3 (motor) score categories. Correlation with a higher score category was described as “worse motor findings”. A score of 5 on the REM disorder questionnaire was defined as predictive of RBD.</p></sec><sec><title>Results</title><p>Out of the 418 PD patients, 113 (27.0%) had RBD. With univariate logistic regression analysis, individuals with scores predictive of RBD were 1.66 times more likely to have worse motor findings (p = 0.028). Even with age, gender, and Geriatric Depression Scale scores taken into account, individuals with scores predictive of RBD were 1.69 times more likely to have worse motor findings (p = 0.025).</p></sec><sec><title>Discussion</title><p>PD patients with RBD symptoms had worse motor findings than those unlikely to have RBD. 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