Nonlinear temporal organization of neuronal discharge in the basal ganglia of Parkinson's disease patients.
Identifieur interne : 000508 ( Main/Exploration ); précédent : 000507; suivant : 000509Nonlinear temporal organization of neuronal discharge in the basal ganglia of Parkinson's disease patients.
Auteurs : Jongil Lim [États-Unis] ; Manjit. Sanghera ; Olivier Darbin ; R Stewart ; Joseph Jankovic [États-Unis] ; Richard SimpsonSource :
- Experimental neurology ; 2010.
English descriptors
- KwdEn :
- MESH :
- physiology : Neurons.
- physiopathology : Basal Ganglia, Globus Pallidus, Parkinson Disease, Subthalamic Nucleus.
- Action Potentials, Humans, Information Theory, Linear Models.
Abstract
Previous electrophysiological studies of the basal ganglia in Parkinson's disease (PD) patients have utilized linear analyses in time-or-frequency domains to characterize neuronal discharge patterns. However, these measures do not fully describe the non-linear features of discharge rates and oscillatory activities of basal ganglia neurons. In this original research, we investigate whether non-linear temporal organizations exist in the inter-spike interval series of neurons recorded in the globus pallidus or the subthalamic nucleus in PD patients undergoing surgery for the implantation of deep brain stimulating electrodes. Our data indicate that in approximately 80% of globus pallidus and subthalamic neurons, the raw inter-spike interval sequences have lower entropy values than those observed after shuffling of the original series. This is the first report establishing non-linear temporal organization as a common feature of neuronal discharge in the basal ganglia of PD patients.
PubMed: 20653074
Affiliations:
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Le document en format XML
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Sanghera</name></author><author><name sortKey="Darbin, Olivier" sort="Darbin, Olivier" uniqKey="Darbin O" first="Olivier" last="Darbin">Olivier Darbin</name></author><author><name sortKey="Stewart, R Malcolm" sort="Stewart, R Malcolm" uniqKey="Stewart R" first="R" last="Stewart">R Stewart</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Simpson, Richard" sort="Simpson, Richard" uniqKey="Simpson R" first="Richard" last="Simpson">Richard Simpson</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20653074</idno><idno type="pmid">20653074</idno><idno type="wicri:Area/PubMed/Corpus">000088</idno><idno type="wicri:Area/PubMed/Curation">000088</idno><idno type="wicri:Area/PubMed/Checkpoint">000089</idno><idno type="wicri:Area/Ncbi/Merge">000295</idno><idno type="wicri:Area/Ncbi/Curation">000295</idno><idno type="wicri:Area/Ncbi/Checkpoint">000295</idno><idno type="wicri:Area/Main/Merge">000513</idno><idno type="wicri:Area/Main/Curation">000508</idno><idno type="wicri:Area/Main/Exploration">000508</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nonlinear temporal organization of neuronal discharge in the basal ganglia of Parkinson's disease patients.</title><author><name sortKey="Lim, Jongil" sort="Lim, Jongil" uniqKey="Lim J" first="Jongil" last="Lim">Jongil Lim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosurgery, S & W Hospital, Temple, TX 76508, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, S & W Hospital, Temple, TX 76508</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Sanghera, Manjit K" sort="Sanghera, Manjit K" uniqKey="Sanghera M" first="Manjit" last="Sanghera">Manjit. Sanghera</name></author><author><name sortKey="Darbin, Olivier" sort="Darbin, Olivier" uniqKey="Darbin O" first="Olivier" last="Darbin">Olivier Darbin</name></author><author><name sortKey="Stewart, R Malcolm" sort="Stewart, R Malcolm" uniqKey="Stewart R" first="R" last="Stewart">R Stewart</name></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation><country>États-Unis</country><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author><author><name sortKey="Simpson, Richard" sort="Simpson, Richard" uniqKey="Simpson R" first="Richard" last="Simpson">Richard Simpson</name></author></analytic><series><title level="j">Experimental neurology</title><idno type="e-ISSN">1090-2430</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials</term><term>Basal Ganglia (physiopathology)</term><term>Globus Pallidus (physiopathology)</term><term>Humans</term><term>Information Theory</term><term>Linear Models</term><term>Neurons (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Subthalamic Nucleus (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Globus Pallidus</term><term>Parkinson Disease</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Action Potentials</term><term>Humans</term><term>Information Theory</term><term>Linear Models</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous electrophysiological studies of the basal ganglia in Parkinson's disease (PD) patients have utilized linear analyses in time-or-frequency domains to characterize neuronal discharge patterns. However, these measures do not fully describe the non-linear features of discharge rates and oscillatory activities of basal ganglia neurons. In this original research, we investigate whether non-linear temporal organizations exist in the inter-spike interval series of neurons recorded in the globus pallidus or the subthalamic nucleus in PD patients undergoing surgery for the implantation of deep brain stimulating electrodes. Our data indicate that in approximately 80% of globus pallidus and subthalamic neurons, the raw inter-spike interval sequences have lower entropy values than those observed after shuffling of the original series. This is the first report establishing non-linear temporal organization as a common feature of neuronal discharge in the basal ganglia of PD patients.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><noCountry><name sortKey="Darbin, Olivier" sort="Darbin, Olivier" uniqKey="Darbin O" first="Olivier" last="Darbin">Olivier Darbin</name><name sortKey="Sanghera, Manjit K" sort="Sanghera, Manjit K" uniqKey="Sanghera M" first="Manjit" last="Sanghera">Manjit. Sanghera</name><name sortKey="Simpson, Richard" sort="Simpson, Richard" uniqKey="Simpson R" first="Richard" last="Simpson">Richard Simpson</name><name sortKey="Stewart, R Malcolm" sort="Stewart, R Malcolm" uniqKey="Stewart R" first="R" last="Stewart">R Stewart</name></noCountry><country name="États-Unis"><region name="Texas"><name sortKey="Lim, Jongil" sort="Lim, Jongil" uniqKey="Lim J" first="Jongil" last="Lim">Jongil Lim</name></region><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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