Modafinil for daytime somnolence in Parkinson’s disease: double blind, placebo controlled parallel trial
Identifieur interne : 001095 ( Main/Exploration ); précédent : 001094; suivant : 001096Modafinil for daytime somnolence in Parkinson’s disease: double blind, placebo controlled parallel trial
Auteurs : W Ondo [États-Unis] ; R. Fayle [États-Unis] ; F. Atassi [États-Unis] ; Joseph Jankovic [États-Unis]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2005-12.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Benzhydryl Compounds (therapeutic use), Central Nervous System Stimulants (therapeutic use), Disorders of Excessive Somnolence (drug therapy), Disorders of Excessive Somnolence (etiology), Double-Blind Method, EDS, excessive daytime somnolence, ES, Epworth Sleepiness (score), Female, Humans, MSLT, multiple sleep latency test, Male, Middle Aged, Modafinil, Nervous system diseases, PD, Parkinson’s disease, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson disease, Parkinson’s disease, Placebo, Placebos, Severity of Illness Index, Somnolence, Treatment Outcome, UPDRS, Unified Parkinson’s Disease Rating Scale, excessive daytime sleepiness, modafinil, multiple sleep latency tests.
- MESH :
- chemical , therapeutic use : Benzhydryl Compounds, Central Nervous System Stimulants.
- complications : Parkinson Disease.
- drug therapy : Disorders of Excessive Somnolence, Parkinson Disease.
- etiology : Disorders of Excessive Somnolence.
- Aged, Double-Blind Method, Female, Humans, Male, Middle Aged, Placebos, Severity of Illness Index, Treatment Outcome.
Abstract
Background: Excessive daytime somnolence (EDS) commonly complicates Parkinson’s disease (PD). The aetiology of EDS is probably multifactorial but is probably exacerbated by dopaminergic medications. Modafinil is a wake-promoting agent approved for use in narcolepsy, but it is often used to treat a variety of somnolent conditions. Method: A double blind, placebo controlled parallel design trial was conducted to assess the efficacy of modafinil (200–400 mg/day) for the treatment of EDS in PD. The primary efficacy measure was the Epworth Sleepiness (ES) scale score. Secondary efficacy points included the Unified Parkinson’s Disease Rating Scale (UPDRS), the Fatigue Severity Scale, the Hamilton Depression Scale, and the multiple sleep latency test (MSLT). Results: Of a total of 40 subjects (29 men, mean (SD) age 64.8 (11.3) years), randomised to modafinil or placebo, 37 completed the study. Modafinil failed to significantly improve ES scores compared with placebo (2.7 v 1.5 points improvement, respectively, p = 0.28). MSLT failed to improve with modafinil relative to placebo (−0.16 v −0.70, respectively, p = 0.14). UPDRS, global impressions, Fatigue Severity Scale, and Hamilton Depression Scale scores were unchanged. Adverse events were minimal. Conclusion: Modafinil failed to significantly improve EDS in PD compared with placebo. The drug did not alter motor symptoms in PD and was well tolerated.
Url:
- https://api.istex.fr/document/A59F319272BB8D4F4894ED4216BEBB9793D54C3A/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1739456
DOI: 10.1136/jnnp.2005.065870
Affiliations:
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<term>Disorders of Excessive Somnolence (drug therapy)</term>
<term>Disorders of Excessive Somnolence (etiology)</term>
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<front><div type="abstract" xml:lang="en">Background: Excessive daytime somnolence (EDS) commonly complicates Parkinson’s disease (PD). The aetiology of EDS is probably multifactorial but is probably exacerbated by dopaminergic medications. Modafinil is a wake-promoting agent approved for use in narcolepsy, but it is often used to treat a variety of somnolent conditions. Method: A double blind, placebo controlled parallel design trial was conducted to assess the efficacy of modafinil (200–400 mg/day) for the treatment of EDS in PD. The primary efficacy measure was the Epworth Sleepiness (ES) scale score. Secondary efficacy points included the Unified Parkinson’s Disease Rating Scale (UPDRS), the Fatigue Severity Scale, the Hamilton Depression Scale, and the multiple sleep latency test (MSLT). Results: Of a total of 40 subjects (29 men, mean (SD) age 64.8 (11.3) years), randomised to modafinil or placebo, 37 completed the study. Modafinil failed to significantly improve ES scores compared with placebo (2.7 v 1.5 points improvement, respectively, p = 0.28). MSLT failed to improve with modafinil relative to placebo (−0.16 v −0.70, respectively, p = 0.14). UPDRS, global impressions, Fatigue Severity Scale, and Hamilton Depression Scale scores were unchanged. Adverse events were minimal. Conclusion: Modafinil failed to significantly improve EDS in PD compared with placebo. The drug did not alter motor symptoms in PD and was well tolerated.</div>
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