Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease
Identifieur interne : 000013 ( Main/Exploration ); précédent : 000012; suivant : 000014Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease
Auteurs : Marta Esteves [Portugal] ; Ana Crist [Portugal] ; Tatiana Saraiva [Portugal] ; Sandra Rocha [Portugal] ; Graça Baltazar [Portugal] ; Lino Ferreira [Portugal] ; Liliana Bernardino [Portugal]Source :
- Frontiers in Aging Neuroscience ; 2015.
Abstract
Retinoic acid (RA) plays an important role in the commitment, maturation and survival of neural cells. Recently, RA was pointed as a therapeutic option for some neurodegenerative diseases, including Parkinson's disease (PD). The administration of RA has been defying, and in this sense we have previously developed novel RA-loaded polymeric nanoparticles (RA-NPs) that ensure the efficient intracellular transport and controlled release of RA. Herein, we show that nanoformulation as an efficient neuroprotective effect on dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced mouse model for PD. The results showed that the RA-NPs administration induced a significant reduction of DA neuron loss in the substantia nigra (SN) as well as their neuronal fiber/axonal innervations in the striatum. Furthermore, we observed an increase in the expression levels of the transcription factors Pitx3 and Nurr1 induced by RA-NPs, showing its supportive effect on the development and functional maintenance of DA neurons in PD. This is the first study showing that RA-NPs can be an innovative strategy to halt the progression of PD pathogenesis, suggesting that this nanoformulation could be of particular interest for the development of new approaches for PD therapeutics.
Url:
DOI: 10.3389/fnagi.2015.00020
PubMed: 25798108
PubMed Central: 4351630
Affiliations:
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xml:lang="en" level="a" type="main">Retinoic acid-loaded polymeric nanoparticles induce neuroprotection in a mouse model for Parkinson's disease</title><author><name sortKey="Esteves, Marta" sort="Esteves, Marta" uniqKey="Esteves M" first="Marta" last="Esteves">Marta Esteves</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Faculty of Health Sciences, Health Sciences Research Centre, University of Beira Interior</institution><country>Covilhã, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Crist Vao, Ana C" sort="Crist Vao, Ana C" uniqKey="Crist Vao A" first="Ana" last="Crist">Ana Crist</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Faculty of Health Sciences, Health Sciences Research Centre, University of Beira Interior</institution><country>Covilhã, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Saraiva, Tatiana" sort="Saraiva, Tatiana" uniqKey="Saraiva T" first="Tatiana" last="Saraiva">Tatiana Saraiva</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Faculty of Health Sciences, Health Sciences Research Centre, University of Beira Interior</institution><country>Covilhã, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Rocha, Sandra M" sort="Rocha, Sandra M" uniqKey="Rocha S" first="Sandra" last="Rocha">Sandra Rocha</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Faculty of Health Sciences, Health Sciences Research Centre, University of Beira Interior</institution><country>Covilhã, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Baltazar, Graca" sort="Baltazar, Graca" uniqKey="Baltazar G" first="Graça" last="Baltazar">Graça Baltazar</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Faculty of Health Sciences, Health Sciences Research Centre, University of Beira Interior</institution><country>Covilhã, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Ferreira, Lino" sort="Ferreira, Lino" uniqKey="Ferreira L" first="Lino" last="Ferreira">Lino Ferreira</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Center for Neuroscience and Cell Biology, University of Coimbra</institution><country>Coimbra, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Biocant – Center of Innovation in Biotechnology</institution><country>Cantanhede, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author><author><name sortKey="Bernardino, Liliana" sort="Bernardino, Liliana" uniqKey="Bernardino L" first="Liliana" last="Bernardino">Liliana Bernardino</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Faculty of Health Sciences, Health Sciences Research Centre, University of Beira Interior</institution><country>Covilhã, Portugal</country></nlm:aff><country xml:lang="fr">Portugal</country><wicri:regionArea></wicri:regionArea><wicri:regionArea># see nlm:aff region in country</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Aging Neuroscience</title><idno type="e-ISSN">1663-4365</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Retinoic acid (RA) plays an important role in the commitment, maturation and survival of neural cells. Recently, RA was pointed as a therapeutic option for some neurodegenerative diseases, including Parkinson's disease (PD). The administration of RA has been defying, and in this sense we have previously developed novel RA-loaded polymeric nanoparticles (RA-NPs) that ensure the efficient intracellular transport and controlled release of RA. Herein, we show that nanoformulation as an efficient neuroprotective effect on dopaminergic (DA) neurons in the 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) induced mouse model for PD. The results showed that the RA-NPs administration induced a significant reduction of DA neuron loss in the substantia nigra (SN) as well as their neuronal fiber/axonal innervations in the striatum. Furthermore, we observed an increase in the expression levels of the transcription factors Pitx3 and Nurr1 induced by RA-NPs, showing its supportive effect on the development and functional maintenance of DA neurons in PD. This is the first study showing that RA-NPs can be an innovative strategy to halt the progression of PD pathogenesis, suggesting that this nanoformulation could be of particular interest for the development of new approaches for PD therapeutics.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bastien, J" uniqKey="Bastien J">J. Bastien</name></author><author><name sortKey="Rochette Egly, C" uniqKey="Rochette Egly C">C. Rochette-Egly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blasko, I" uniqKey="Blasko I">I. Blasko</name></author><author><name sortKey="Stampfer Kountchev, M" uniqKey="Stampfer Kountchev M">M. Stampfer-Kountchev</name></author><author><name sortKey="Robatscher, P" uniqKey="Robatscher P">P. Robatscher</name></author><author><name sortKey="Veerhuis, R" uniqKey="Veerhuis R">R. Veerhuis</name></author><author><name sortKey="Eikelenboom, P" uniqKey="Eikelenboom P">P. 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Matsuoka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, J" uniqKey="Xu J">J. Xu</name></author><author><name sortKey="Drew, P D" uniqKey="Drew P">P. D. Drew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yin, L H" uniqKey="Yin L">L. H. Yin</name></author><author><name sortKey="Shen, H" uniqKey="Shen H">H. Shen</name></author><author><name sortKey="Diaz Ruiz, O" uniqKey="Diaz Ruiz O">O. Diaz-Ruiz</name></author><author><name sortKey="Backman, C M" uniqKey="Backman C">C. M. Backman</name></author><author><name sortKey="Bae, E" uniqKey="Bae E">E. Bae</name></author><author><name sortKey="Yu, S J" uniqKey="Yu S">S. J. Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zetterstrom, R H" uniqKey="Zetterstrom R">R. H. Zetterstrom</name></author><author><name sortKey="Williams, R" uniqKey="Williams R">R. Williams</name></author><author><name sortKey="Perlmann, T" uniqKey="Perlmann T">T. Perlmann</name></author><author><name sortKey="Olson, L" uniqKey="Olson L">L. Olson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Portugal</li></country></list><tree><country name="Portugal"><noRegion><name sortKey="Esteves, Marta" sort="Esteves, Marta" uniqKey="Esteves M" first="Marta" last="Esteves">Marta Esteves</name></noRegion><name sortKey="Baltazar, Graca" sort="Baltazar, Graca" uniqKey="Baltazar G" first="Graça" last="Baltazar">Graça Baltazar</name><name sortKey="Bernardino, Liliana" sort="Bernardino, Liliana" uniqKey="Bernardino L" first="Liliana" last="Bernardino">Liliana Bernardino</name><name sortKey="Crist Vao, Ana C" sort="Crist Vao, Ana C" uniqKey="Crist Vao A" first="Ana" last="Crist">Ana Crist</name><name sortKey="Ferreira, Lino" sort="Ferreira, Lino" uniqKey="Ferreira L" first="Lino" last="Ferreira">Lino Ferreira</name><name sortKey="Ferreira, Lino" sort="Ferreira, Lino" uniqKey="Ferreira L" first="Lino" last="Ferreira">Lino Ferreira</name><name sortKey="Rocha, Sandra M" sort="Rocha, Sandra M" uniqKey="Rocha S" first="Sandra" last="Rocha">Sandra Rocha</name><name sortKey="Saraiva, Tatiana" sort="Saraiva, Tatiana" uniqKey="Saraiva T" first="Tatiana" last="Saraiva">Tatiana Saraiva</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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