Serveur d'exploration autour de Joseph Jankovic

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Effects of combined MAO-B inhibitors and levodopa vs. monotherapy in Parkinson’s disease

Identifieur interne : 000079 ( Main/Exploration ); précédent : 000078; suivant : 000080

Effects of combined MAO-B inhibitors and levodopa vs. monotherapy in Parkinson’s disease

Auteurs : Rakhee Krishna [États-Unis] ; Manal Ali [Égypte] ; Ahmed Moustafa [Australie]

Source :

RBID : PMC:4111079

Abstract

Background: Prior studies report that monoamine oxidases inhibitors (MAO-I) when used as an adjunct to levodopa ameliorate motor symptoms in Parkinson’s disease (PD), but this was not tested in relation to cognitive or psychiatric measures.

Objective: Here, we tested the effects of MAO-I as an adjunct to levodopa, in comparison to levodopa or dopamine (DA) agonists alone, on various cognitive, affective and quality of life measures.

Methods: We studied three groups of subjects: healthy controls, PD patients on combined levodopa and MAO-I, and PD patients on levodopa or DA agonists only.

Results: We found that compared to monotherapy, combined MAO-I and levodopa seemed to improve cognition, including probabilistic learning, working memory and executive functions. There were no differences between the different medication regimes on deterministic learning, attention or memory recall. It was also found that MAO-I as an adjunct to levodopa improves affective measures such as depression, apathy, anxiety and quality of life. Interestingly, this enhancing effect of combined levodopa and MAO-I was more pronounced in PD patients with severe akinesia, compared to patients with severe tremor.

Conclusion: Our data are in agreement with (a) the Continuous Dopaminergic Stimulation (CDS) theory which states that continuous stimulation of the basal ganglia enhances motor, psychiatric and cognitive functions in PD patients; and/or (b) findings that MAO-I increase the bioavailability of monoamines that have beneficial effects on motor and behavioral dysfunction in PD.


Url:
DOI: 10.3389/fnagi.2014.00180
PubMed: 25120478
PubMed Central: 4111079


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<bold>Background</bold>
: Prior studies report that monoamine oxidases inhibitors (MAO-I) when used as an adjunct to levodopa ameliorate motor symptoms in Parkinson’s disease (PD), but this was not tested in relation to cognitive or psychiatric measures.</p>
<p>
<bold>Objective</bold>
: Here, we tested the effects of MAO-I as an adjunct to levodopa, in comparison to levodopa or dopamine (DA) agonists alone, on various cognitive, affective and quality of life measures.</p>
<p>
<bold>Methods</bold>
: We studied three groups of subjects: healthy controls, PD patients on combined levodopa and MAO-I, and PD patients on levodopa or DA agonists only.</p>
<p>
<bold>Results</bold>
: We found that compared to monotherapy, combined MAO-I and levodopa seemed to improve cognition, including probabilistic learning, working memory and executive functions. There were no differences between the different medication regimes on deterministic learning, attention or memory recall. It was also found that MAO-I as an adjunct to levodopa improves affective measures such as depression, apathy, anxiety and quality of life. Interestingly, this enhancing effect of combined levodopa and MAO-I was more pronounced in PD patients with severe akinesia, compared to patients with severe tremor.</p>
<p>
<bold>Conclusion</bold>
: Our data are in agreement with (a) the Continuous Dopaminergic Stimulation (CDS) theory which states that continuous stimulation of the basal ganglia enhances motor, psychiatric and cognitive functions in PD patients; and/or (b) findings that MAO-I increase the bioavailability of monoamines that have beneficial effects on motor and behavioral dysfunction in PD.</p>
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<name sortKey="Voon, V" uniqKey="Voon V">V. Voon</name>
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<name sortKey="Wylie, S A" uniqKey="Wylie S">S. A. Wylie</name>
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<name sortKey="Wooten, G F" uniqKey="Wooten G">G. F. Wooten</name>
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<author>
<name sortKey="Goldberg, S R" uniqKey="Goldberg S">S. R. Goldberg</name>
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<name sortKey="Israel, Z" uniqKey="Israel Z">Z. Israel</name>
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<name sortKey="Bergman, H" uniqKey="Bergman H">H. Bergman</name>
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