The Neurotoxic Effects of Manganese on the Dopaminergic Innervation of the Gill of the Bivalve Mollusc, Crassostrea virginica
Identifieur interne : 000B38 ( Main/Exploration ); précédent : 000B37; suivant : 000B39The Neurotoxic Effects of Manganese on the Dopaminergic Innervation of the Gill of the Bivalve Mollusc, Crassostrea virginica
Auteurs : Kesha Martin ; Turkesha Huggins ; Candice King ; Margaret Carroll ; Edward CatapaneSource :
- Comparative biochemistry and physiology. Toxicology & pharmacology : CBP [ 1532-0456 ] ; 2008.
Abstract
We examined effects of manganese on the nervous system and innervation of lateral cilia of
Url:
DOI: 10.1016/j.cbpc.2008.05.004
PubMed: 18547869
PubMed Central: 2533860
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000157
- to stream Pmc, to step Curation: 000157
- to stream Pmc, to step Checkpoint: 000212
- to stream Ncbi, to step Merge: 000183
- to stream Ncbi, to step Curation: 000183
- to stream Ncbi, to step Checkpoint: 000183
- to stream Main, to step Merge: 000B51
- to stream Main, to step Curation: 000B38
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Neurotoxic Effects of Manganese on the Dopaminergic Innervation of the Gill of the Bivalve Mollusc, <italic>Crassostrea virginica</italic></title><author><name sortKey="Martin, Kesha" sort="Martin, Kesha" uniqKey="Martin K" first="Kesha" last="Martin">Kesha Martin</name></author><author><name sortKey="Huggins, Turkesha" sort="Huggins, Turkesha" uniqKey="Huggins T" first="Turkesha" last="Huggins">Turkesha Huggins</name></author><author><name sortKey="King, Candice" sort="King, Candice" uniqKey="King C" first="Candice" last="King">Candice King</name></author><author><name sortKey="Carroll, Margaret A" sort="Carroll, Margaret A" uniqKey="Carroll M" first="Margaret" last="Carroll">Margaret Carroll</name></author><author><name sortKey="Catapane, Edward J" sort="Catapane, Edward J" uniqKey="Catapane E" first="Edward" last="Catapane">Edward Catapane</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18547869</idno><idno type="pmc">2533860</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533860</idno><idno type="RBID">PMC:2533860</idno><idno type="doi">10.1016/j.cbpc.2008.05.004</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000157</idno><idno type="wicri:Area/Pmc/Curation">000157</idno><idno type="wicri:Area/Pmc/Checkpoint">000212</idno><idno type="wicri:Area/Ncbi/Merge">000183</idno><idno type="wicri:Area/Ncbi/Curation">000183</idno><idno type="wicri:Area/Ncbi/Checkpoint">000183</idno><idno type="wicri:doubleKey">1532-0456:2008:Martin K:the:neurotoxic:effects</idno><idno type="wicri:Area/Main/Merge">000B51</idno><idno type="wicri:Area/Main/Curation">000B38</idno><idno type="wicri:Area/Main/Exploration">000B38</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Neurotoxic Effects of Manganese on the Dopaminergic Innervation of the Gill of the Bivalve Mollusc, <italic>Crassostrea virginica</italic></title><author><name sortKey="Martin, Kesha" sort="Martin, Kesha" uniqKey="Martin K" first="Kesha" last="Martin">Kesha Martin</name></author><author><name sortKey="Huggins, Turkesha" sort="Huggins, Turkesha" uniqKey="Huggins T" first="Turkesha" last="Huggins">Turkesha Huggins</name></author><author><name sortKey="King, Candice" sort="King, Candice" uniqKey="King C" first="Candice" last="King">Candice King</name></author><author><name sortKey="Carroll, Margaret A" sort="Carroll, Margaret A" uniqKey="Carroll M" first="Margaret" last="Carroll">Margaret Carroll</name></author><author><name sortKey="Catapane, Edward J" sort="Catapane, Edward J" uniqKey="Catapane E" first="Edward" last="Catapane">Edward Catapane</name></author></analytic><series><title level="j">Comparative biochemistry and physiology. Toxicology & pharmacology : CBP</title><idno type="ISSN">1532-0456</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We examined effects of manganese on the nervous system and innervation of lateral cilia of <italic>Crassostrea virginica</italic>. While essential in trace amounts, tissue manganese accumulation is neurotoxic, inducing Manganism, a Parkinson’s-like disease in humans. Lateral cilia of the gill of <italic>C. virginica</italic> are controlled by a reciprocal serotonergic-dopaminergic innervation from their ganglia. Oysters were incubated 3 days in the presence of up to 1 mM manganese, followed by superfusion of the cerebral ganglia, visceral ganglia or gill with dopamine or serotonin. Beating rates of cilia were measured by stroboscopic microscopy of isolated gill preparations or gill preparations with the ipsilateral cerebral and/or visceral ganglia attached. Acute manganese treatments impaired the dopaminergic, cilio-inhibitory system, while having no effect on the serotonergic, cilio-excitatory system, which is in agreement with the proposed mechanism of manganese toxicity in humans. Manganese treatments also decreased endogenous dopamine levels in the cerebral and visceral ganglia, and gills, but not serotonin levels. We demonstrated that manganese disrupts the animal’s dopaminergic system, and also that this preparation can be used to investigate mechanisms that underlie manganese neurotoxcity. It also may serve as a model in pharmacological studies of drugs to treat or prevent Manganism and other dopaminergic cell disorders.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Carroll, Margaret A" sort="Carroll, Margaret A" uniqKey="Carroll M" first="Margaret" last="Carroll">Margaret Carroll</name><name sortKey="Catapane, Edward J" sort="Catapane, Edward J" uniqKey="Catapane E" first="Edward" last="Catapane">Edward Catapane</name><name sortKey="Huggins, Turkesha" sort="Huggins, Turkesha" uniqKey="Huggins T" first="Turkesha" last="Huggins">Turkesha Huggins</name><name sortKey="King, Candice" sort="King, Candice" uniqKey="King C" first="Candice" last="King">Candice King</name><name sortKey="Martin, Kesha" sort="Martin, Kesha" uniqKey="Martin K" first="Kesha" last="Martin">Kesha Martin</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/JankovicV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B38 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B38 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= JankovicV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2533860
|texte= The Neurotoxic Effects of Manganese on the Dopaminergic Innervation of the Gill of the Bivalve Mollusc, Crassostrea virginica
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:18547869" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a JankovicV1
| This area was generated with Dilib version V0.6.19. |  |