Apolipoprotein E controls the risk and age at onset of Parkinson disease
Identifieur interne : 001310 ( Main/Exploration ); précédent : 001309; suivant : 001311Apolipoprotein E controls the risk and age at onset of Parkinson disease
Auteurs : Y Li [États-Unis] ; M Hauser [États-Unis] ; W Scott [États-Unis] ; E Martin [États-Unis] ; M Booze [États-Unis] ; X Qin [États-Unis] ; J Walter [États-Unis] ; M Nance [États-Unis] ; J Hubble [États-Unis] ; W Koller [États-Unis] ; R Pahwa [États-Unis] ; M Stern [États-Unis] ; B Hiner [États-Unis] ; J Jankovic [États-Unis] ; C Goetz [États-Unis] ; G Small [États-Unis] ; F Mastaglia [Australie] ; J Haines [États-Unis] ; M Pericak [États-Unis] ; J Vance [États-Unis]Source :
- Neurology [ 0028-3878 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Background: Similarities between Alzheimer disease (AD) and Parkinson disease (PD) suggest a possible role for apolipoprotein E (APOE) in PD. Most previous studies seeking to establish such a link used case-control datasets and results have been inconsistent. Objective: To investigate APOE's role in PD using family-based association analyses. Methods: APOE functional polymorphisms were genotyped for 658 PD affected families, including 282 multiplex and 376 singleton families. The pedigree disequilibrium test (PDT) and the genotype-PDT were used to test the risk effect of APOE. The Monks-Kaplan test was used to evaluate the effect of APOE on age at onset of PD. Results: APOE was significantly associated with risk of developing PD. Stratified analysis revealed that APOE was most strongly associated with families with a positive PD family history (global p = 0.003). Like AD, the APOE-4 allele increases disease risk while the APOE-3 allele decreases risk. We detected a positive association of APOE-3 (p = 0.019) and a negative association of APOE-4 (p = 0.015) with age at onset in PD. Conclusions: The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment.
Affiliations:
- Australie, États-Unis
- Californie, Caroline du Nord, Floride, Illinois, Minnesota, Tennessee, Texas, Wisconsin
- Los Angeles
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000096
- to stream PascalFrancis, to step Curation: 000070
- to stream PascalFrancis, to step Checkpoint: 000095
- to stream Main, to step Merge: 001358
- to stream Main, to step Curation: 001310
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Apolipoprotein E controls the risk and age at onset of Parkinson disease</title><author><name sortKey="Li, Y J" sort="Li, Y J" uniqKey="Li Y" first="Y" last="Li">Y Li</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hauser, M A" sort="Hauser, M A" uniqKey="Hauser M" first="M" last="Hauser">M Hauser</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Scott, W K" sort="Scott, W K" uniqKey="Scott W" first="W" last="Scott">W Scott</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Martin, E R" sort="Martin, E R" uniqKey="Martin E" first="E" last="Martin">E Martin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Booze, M W" sort="Booze, M W" uniqKey="Booze M" first="M" last="Booze">M Booze</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Qin, X J" sort="Qin, X J" uniqKey="Qin X" first="X" last="Qin">X Qin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Walter, J W" sort="Walter, J W" uniqKey="Walter J" first="J" last="Walter">J Walter</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Nance, M A" sort="Nance, M A" uniqKey="Nance M" first="M" last="Nance">M Nance</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Struthers Parkinson Center</s1><s2>Golden Valley, MN</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Hubble, J P" sort="Hubble, J P" uniqKey="Hubble J" first="J" last="Hubble">J Hubble</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Ohio State University</s1><s2>Columbus</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus</wicri:noRegion></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W" last="Koller">W Koller</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurology, University of Miami School of Medicine</s1><s2>FL</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Pahwa, R" sort="Pahwa, R" uniqKey="Pahwa R" first="R" last="Pahwa">R Pahwa</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Kansas Medical Center</s1><s2>Kansas City</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Kansas City</wicri:noRegion></affiliation></author><author><name sortKey="Stern, M B" sort="Stern, M B" uniqKey="Stern M" first="M" last="Stern">M Stern</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, University of Pennsylvania Health System</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia</wicri:noRegion></affiliation></author><author><name sortKey="Hiner, B C" sort="Hiner, B C" uniqKey="Hiner B" first="B" last="Hiner">B Hiner</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurology, Marshfield Clinic</s1><s2>Marshfield, WI</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J Jankovic</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Goetz, C G" sort="Goetz, C G" uniqKey="Goetz C" first="C" last="Goetz">C Goetz</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Hospital</s1><s2>Chicago, IL</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Small, G W" sort="Small, G W" uniqKey="Small G" first="G" last="Small">G Small</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Departments of Psychiatry & Biobehavioral Sciences and Neurology, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mastaglia, F" sort="Mastaglia, F" uniqKey="Mastaglia F" first="F" last="Mastaglia">F Mastaglia</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth</s2><s3>AUS</s3><sZ>17 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Haines, J L" sort="Haines, J L" uniqKey="Haines J" first="J" last="Haines">J Haines</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Center for Human Genetics Research, Vanderbilt University Medical Center</s1><s2>Nashville, TN</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Pericak Vance, M A" sort="Pericak Vance, M A" uniqKey="Pericak Vance M" first="M" last="Pericak">M Pericak</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Vance, J M" sort="Vance, J M" uniqKey="Vance J" first="J" last="Vance">J Vance</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">04-0342618</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 04-0342618 INIST</idno><idno type="RBID">Pascal:04-0342618</idno><idno type="wicri:Area/PascalFrancis/Corpus">000096</idno><idno type="wicri:Area/PascalFrancis/Curation">000070</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000095</idno><idno type="wicri:doubleKey">0028-3878:2004:Li Y:apolipoprotein:e:controls</idno><idno type="wicri:Area/Main/Merge">001358</idno><idno type="wicri:Area/Main/Curation">001310</idno><idno type="wicri:Area/Main/Exploration">001310</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Apolipoprotein E controls the risk and age at onset of Parkinson disease</title><author><name sortKey="Li, Y J" sort="Li, Y J" uniqKey="Li Y" first="Y" last="Li">Y Li</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Hauser, M A" sort="Hauser, M A" uniqKey="Hauser M" first="M" last="Hauser">M Hauser</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Scott, W K" sort="Scott, W K" uniqKey="Scott W" first="W" last="Scott">W Scott</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Martin, E R" sort="Martin, E R" uniqKey="Martin E" first="E" last="Martin">E Martin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Booze, M W" sort="Booze, M W" uniqKey="Booze M" first="M" last="Booze">M Booze</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Qin, X J" sort="Qin, X J" uniqKey="Qin X" first="X" last="Qin">X Qin</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Walter, J W" sort="Walter, J W" uniqKey="Walter J" first="J" last="Walter">J Walter</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Nance, M A" sort="Nance, M A" uniqKey="Nance M" first="M" last="Nance">M Nance</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Struthers Parkinson Center</s1><s2>Golden Valley, MN</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Hubble, J P" sort="Hubble, J P" uniqKey="Hubble J" first="J" last="Hubble">J Hubble</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Neurology, Ohio State University</s1><s2>Columbus</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Columbus</wicri:noRegion></affiliation></author><author><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W" last="Koller">W Koller</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Neurology, University of Miami School of Medicine</s1><s2>FL</s2><s3>USA</s3><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Floride</region></placeName></affiliation></author><author><name sortKey="Pahwa, R" sort="Pahwa, R" uniqKey="Pahwa R" first="R" last="Pahwa">R Pahwa</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neurology, University of Kansas Medical Center</s1><s2>Kansas City</s2><s3>USA</s3><sZ>11 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Kansas City</wicri:noRegion></affiliation></author><author><name sortKey="Stern, M B" sort="Stern, M B" uniqKey="Stern M" first="M" last="Stern">M Stern</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Neurology, University of Pennsylvania Health System</s1><s2>Philadelphia</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Philadelphia</wicri:noRegion></affiliation></author><author><name sortKey="Hiner, B C" sort="Hiner, B C" uniqKey="Hiner B" first="B" last="Hiner">B Hiner</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Neurology, Marshfield Clinic</s1><s2>Marshfield, WI</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Wisconsin</region></placeName></affiliation></author><author><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J Jankovic</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Department of Neurology, Baylor College of Medicine</s1><s2>Houston, TX</s2><s3>USA</s3><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Goetz, C G" sort="Goetz, C G" uniqKey="Goetz C" first="C" last="Goetz">C Goetz</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Hospital</s1><s2>Chicago, IL</s2><s3>USA</s3><sZ>15 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Small, G W" sort="Small, G W" uniqKey="Small G" first="G" last="Small">G Small</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Departments of Psychiatry & Biobehavioral Sciences and Neurology, University of California</s1><s2>Los Angeles</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Mastaglia, F" sort="Mastaglia, F" uniqKey="Mastaglia F" first="F" last="Mastaglia">F Mastaglia</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Centre for Neuromuscular and Neurological Disorders, University of Western Australia</s1><s2>Perth</s2><s3>AUS</s3><sZ>17 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Perth</wicri:noRegion></affiliation></author><author><name sortKey="Haines, J L" sort="Haines, J L" uniqKey="Haines J" first="J" last="Haines">J Haines</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Center for Human Genetics Research, Vanderbilt University Medical Center</s1><s2>Nashville, TN</s2><s3>USA</s3><sZ>18 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Pericak Vance, M A" sort="Pericak Vance, M A" uniqKey="Pericak Vance M" first="M" last="Pericak">M Pericak</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Vance, J M" sort="Vance, J M" uniqKey="Vance J" first="J" last="Vance">J Vance</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Medicine and Center for Human Genetics, Duke University Medical Center</s1><s2>Durham, NC</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of onset</term><term>Apolipoprotein E</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Apolipoprotéine E</term><term>Facteur risque</term><term>Système nerveux pathologie</term><term>Age apparition</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Similarities between Alzheimer disease (AD) and Parkinson disease (PD) suggest a possible role for apolipoprotein E (APOE) in PD. Most previous studies seeking to establish such a link used case-control datasets and results have been inconsistent. Objective: To investigate APOE's role in PD using family-based association analyses. Methods: APOE functional polymorphisms were genotyped for 658 PD affected families, including 282 multiplex and 376 singleton families. The pedigree disequilibrium test (PDT) and the genotype-PDT were used to test the risk effect of APOE. The Monks-Kaplan test was used to evaluate the effect of APOE on age at onset of PD. Results: APOE was significantly associated with risk of developing PD. Stratified analysis revealed that APOE was most strongly associated with families with a positive PD family history (global p = 0.003). Like AD, the APOE-4 allele increases disease risk while the APOE-3 allele decreases risk. We detected a positive association of APOE-3 (p = 0.019) and a negative association of APOE-4 (p = 0.015) with age at onset in PD. Conclusions: The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment.</div></front></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country><region><li>Californie</li><li>Caroline du Nord</li><li>Floride</li><li>Illinois</li><li>Minnesota</li><li>Tennessee</li><li>Texas</li><li>Wisconsin</li></region><settlement><li>Los Angeles</li></settlement></list><tree><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Li, Y J" sort="Li, Y J" uniqKey="Li Y" first="Y" last="Li">Y Li</name></region><name sortKey="Booze, M W" sort="Booze, M W" uniqKey="Booze M" first="M" last="Booze">M Booze</name><name sortKey="Goetz, C G" sort="Goetz, C G" uniqKey="Goetz C" first="C" last="Goetz">C Goetz</name><name sortKey="Haines, J L" sort="Haines, J L" uniqKey="Haines J" first="J" last="Haines">J Haines</name><name sortKey="Hauser, M A" sort="Hauser, M A" uniqKey="Hauser M" first="M" last="Hauser">M Hauser</name><name sortKey="Hiner, B C" sort="Hiner, B C" uniqKey="Hiner B" first="B" last="Hiner">B Hiner</name><name sortKey="Hubble, J P" sort="Hubble, J P" uniqKey="Hubble J" first="J" last="Hubble">J Hubble</name><name sortKey="Jankovic, J" sort="Jankovic, J" uniqKey="Jankovic J" first="J" last="Jankovic">J Jankovic</name><name sortKey="Koller, W C" sort="Koller, W C" uniqKey="Koller W" first="W" last="Koller">W Koller</name><name sortKey="Martin, E R" sort="Martin, E R" uniqKey="Martin E" first="E" last="Martin">E Martin</name><name sortKey="Nance, M A" sort="Nance, M A" uniqKey="Nance M" first="M" last="Nance">M Nance</name><name sortKey="Pahwa, R" sort="Pahwa, R" uniqKey="Pahwa R" first="R" last="Pahwa">R Pahwa</name><name sortKey="Pericak Vance, M A" sort="Pericak Vance, M A" uniqKey="Pericak Vance M" first="M" last="Pericak">M Pericak</name><name sortKey="Qin, X J" sort="Qin, X J" uniqKey="Qin X" first="X" last="Qin">X Qin</name><name sortKey="Scott, W K" sort="Scott, W K" uniqKey="Scott W" first="W" last="Scott">W Scott</name><name sortKey="Small, G W" sort="Small, G W" uniqKey="Small G" first="G" last="Small">G Small</name><name sortKey="Stern, M B" sort="Stern, M B" uniqKey="Stern M" first="M" last="Stern">M Stern</name><name sortKey="Vance, J M" sort="Vance, J M" uniqKey="Vance J" first="J" last="Vance">J Vance</name><name sortKey="Walter, J W" sort="Walter, J W" uniqKey="Walter J" first="J" last="Walter">J Walter</name></country><country name="Australie"><noRegion><name sortKey="Mastaglia, F" sort="Mastaglia, F" uniqKey="Mastaglia F" first="F" last="Mastaglia">F Mastaglia</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/JankovicV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001310 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001310 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= JankovicV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:04-0342618
|texte= Apolipoprotein E controls the risk and age at onset of Parkinson disease
}}
| This area was generated with Dilib version V0.6.19. |  |