Atomoxetine for freezing of gait in Parkinson disease.
Identifieur interne : 000859 ( Main/Exploration ); précédent : 000858; suivant : 000860Atomoxetine for freezing of gait in Parkinson disease.
Auteurs : Joseph Jankovic [États-Unis]Source :
- Journal of the neurological sciences ; 2009.
English descriptors
- KwdEn :
- Adrenergic Uptake Inhibitors (therapeutic use), Aged, Antiparkinson Agents (therapeutic use), Atomoxetine Hydrochloride, Double-Blind Method, Female, Gait Disorders, Neurologic (drug therapy), Gait Disorders, Neurologic (etiology), Humans, Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Propylamines (therapeutic use), Severity of Illness Index.
- MESH :
- chemical , therapeutic use : Adrenergic Uptake Inhibitors, Antiparkinson Agents, Levodopa, Propylamines.
- complications : Parkinson Disease.
- drug therapy : Gait Disorders, Neurologic, Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- Aged, Atomoxetine Hydrochloride, Double-Blind Method, Female, Humans, Male, Middle Aged, Severity of Illness Index.
Abstract
Freezing of gait (FoG) is one of the most troublesome symptoms associated with Parkinson disease (PD). This symptom usually does not respond to dopaminergic therapy, possibly because it is mediated via noradrenergic, rather than dopaminergic, deficiency. As atomoxetine enhances noradrenergic transmission we postulated that it may be effective in the treatment of FoG and enrolled 5 PD patients who had this gait abnormality, both when "on" or "off" levodopa, into a double-blind, randomized trial. Although an improvement in total Gait and Balance Scale (GABS) score was noted in patients treated with atomoxetine as compared to placebo, this did not reach statistical significance, possibly because of a small sample size. Further studies in a larger population of patients with FoG are needed to determine whether atomoxetine is a useful drug in the treatment of this, often disabling, feature of PD.
DOI: 10.1016/j.jns.2009.03.022
PubMed: 19361809
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000122
- to stream PubMed, to step Curation: 000122
- to stream PubMed, to step Checkpoint: 000126
- to stream Ncbi, to step Merge: 000226
- to stream Ncbi, to step Curation: 000226
- to stream Ncbi, to step Checkpoint: 000226
- to stream Main, to step Merge: 000870
- to stream Main, to step Curation: 000859
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Atomoxetine for freezing of gait in Parkinson disease.</title><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, Texas 77030, United States. josephj@bcm.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="doi">10.1016/j.jns.2009.03.022</idno><idno type="RBID">pubmed:19361809</idno><idno type="pmid">19361809</idno><idno type="wicri:Area/PubMed/Corpus">000122</idno><idno type="wicri:Area/PubMed/Curation">000122</idno><idno type="wicri:Area/PubMed/Checkpoint">000126</idno><idno type="wicri:Area/Ncbi/Merge">000226</idno><idno type="wicri:Area/Ncbi/Curation">000226</idno><idno type="wicri:Area/Ncbi/Checkpoint">000226</idno><idno type="wicri:Area/Main/Merge">000870</idno><idno type="wicri:Area/Main/Curation">000859</idno><idno type="wicri:Area/Main/Exploration">000859</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Atomoxetine for freezing of gait in Parkinson disease.</title><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, Texas 77030, United States. josephj@bcm.edu</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, Texas 77030</wicri:regionArea><wicri:noRegion>Texas 77030</wicri:noRegion><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><series><title level="j">Journal of the neurological sciences</title><idno type="e-ISSN">1878-5883</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic Uptake Inhibitors (therapeutic use)</term><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Atomoxetine Hydrochloride</term><term>Double-Blind Method</term><term>Female</term><term>Gait Disorders, Neurologic (drug therapy)</term><term>Gait Disorders, Neurologic (etiology)</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Propylamines (therapeutic use)</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenergic Uptake Inhibitors</term><term>Antiparkinson Agents</term><term>Levodopa</term><term>Propylamines</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Atomoxetine Hydrochloride</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Freezing of gait (FoG) is one of the most troublesome symptoms associated with Parkinson disease (PD). This symptom usually does not respond to dopaminergic therapy, possibly because it is mediated via noradrenergic, rather than dopaminergic, deficiency. As atomoxetine enhances noradrenergic transmission we postulated that it may be effective in the treatment of FoG and enrolled 5 PD patients who had this gait abnormality, both when "on" or "off" levodopa, into a double-blind, randomized trial. Although an improvement in total Gait and Balance Scale (GABS) score was noted in patients treated with atomoxetine as compared to placebo, this did not reach statistical significance, possibly because of a small sample size. Further studies in a larger population of patients with FoG are needed to determine whether atomoxetine is a useful drug in the treatment of this, often disabling, feature of PD.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/JankovicV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000859 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000859 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= JankovicV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:19361809
|texte= Atomoxetine for freezing of gait in Parkinson disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19361809" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a JankovicV1
| This area was generated with Dilib version V0.6.19. |  |