PINK1 function in health and disease
Identifieur interne : 000830 ( Main/Exploration ); précédent : 000829; suivant : 000831PINK1 function in health and disease
Auteurs : Emma Deas ; Helene Plun ; Nicholas. WoodSource :
- EMBO Molecular Medicine [ 1757-4676 ] ; 2009.
Abstract
The role of mitochondria in sporadic Parkinson's disease (PD) has been debated for a little over 20 years since the description of complex I deficiency in the substantia nigra pars compacta (SNpc) of PD patients. However, the identification of recessive pathogenic mutations in the
Url:
DOI: 10.1002/emmm.200900024
PubMed: 20049715
PubMed Central: 3378127
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">PINK1 function in health and disease</title><author><name sortKey="Deas, Emma" sort="Deas, Emma" uniqKey="Deas E" first="Emma" last="Deas">Emma Deas</name></author><author><name sortKey="Plun Favreau, Helene" sort="Plun Favreau, Helene" uniqKey="Plun Favreau H" first="Helene" last="Plun">Helene Plun</name></author><author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas" last="Wood">Nicholas. Wood</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20049715</idno><idno type="pmc">3378127</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378127</idno><idno type="RBID">PMC:3378127</idno><idno type="doi">10.1002/emmm.200900024</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000266</idno><idno type="wicri:Area/Pmc/Curation">000266</idno><idno type="wicri:Area/Pmc/Checkpoint">000179</idno><idno type="wicri:Area/Ncbi/Merge">000269</idno><idno type="wicri:Area/Ncbi/Curation">000269</idno><idno type="wicri:Area/Ncbi/Checkpoint">000269</idno><idno type="wicri:doubleKey">1757-4676:2009:Deas E:pink:function:in</idno><idno type="wicri:Area/Main/Merge">000840</idno><idno type="wicri:Area/Main/Curation">000830</idno><idno type="wicri:Area/Main/Exploration">000830</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">PINK1 function in health and disease</title><author><name sortKey="Deas, Emma" sort="Deas, Emma" uniqKey="Deas E" first="Emma" last="Deas">Emma Deas</name></author><author><name sortKey="Plun Favreau, Helene" sort="Plun Favreau, Helene" uniqKey="Plun Favreau H" first="Helene" last="Plun">Helene Plun</name></author><author><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas" last="Wood">Nicholas. Wood</name></author></analytic><series><title level="j">EMBO Molecular Medicine</title><idno type="ISSN">1757-4676</idno><idno type="e-ISSN">1757-4684</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The role of mitochondria in sporadic Parkinson's disease (PD) has been debated for a little over 20 years since the description of complex I deficiency in the substantia nigra pars compacta (SNpc) of PD patients. However, the identification of recessive pathogenic mutations in the <italic>pink1</italic> gene in familial PD cases firmly re-ignited interest in the pathophysiology of mitochondria in PD. PINK1 is a putative mitochondrial serine/threonine kinase, which protects cells against oxidative stress induced apoptosis. The mechanism by which this is achieved and the effect of the pathogenic mutations has been an area of intensive research over the past five years. Significant progress has been made and, in this review, we summarize the physiological roles that have been assigned to PINK1 and the potential mechanisms behind pathogenesis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abou Sleiman, Pm" uniqKey="Abou Sleiman P">PM Abou-Sleiman</name></author><author><name sortKey="Muqit, Mm" uniqKey="Muqit M">MM Muqit</name></author><author><name sortKey="Mcdonald, Nq" uniqKey="Mcdonald N">NQ McDonald</name></author><author><name sortKey="Yang, Yx" uniqKey="Yang Y">YX Yang</name></author><author><name sortKey="Gandhi, S" uniqKey="Gandhi S">S Gandhi</name></author><author><name sortKey="Healy, Dg" uniqKey="Healy D">DG Healy</name></author><author><name sortKey="Harvey, K" uniqKey="Harvey K">K Harvey</name></author><author><name sortKey="Harvey, Rj" uniqKey="Harvey R">RJ Harvey</name></author><author><name sortKey="Deas, E" uniqKey="Deas E">E Deas</name></author><author><name sortKey="Bhatia, 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Przedborski</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Deas, Emma" sort="Deas, Emma" uniqKey="Deas E" first="Emma" last="Deas">Emma Deas</name><name sortKey="Plun Favreau, Helene" sort="Plun Favreau, Helene" uniqKey="Plun Favreau H" first="Helene" last="Plun">Helene Plun</name><name sortKey="Wood, Nicholas W" sort="Wood, Nicholas W" uniqKey="Wood N" first="Nicholas" last="Wood">Nicholas. 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